Article
Multidisciplinary Sciences
Vanessa Monteil, Hyesoo Kwon, Lijo John, Cristiano Salata, Gustav Jonsson, Sabine U. Vorrink, Sofia Appelberg, Sonia Youhanna, Matheus Dyczynski, Alexandra Leopoldi, Nicole Leeb, Jennifer Volz, Astrid Hagelkruys, Max J. Kellner, Stephanie Devignot, Georg Michlits, Michelle Foong-Sobis, Friedemann Weber, Volker M. Lauschke, Moritz Horn, Heinz Feldmann, Ulrich Elling, Josef M. Penninger, Ali Mirazimi
Summary: In this study, the researchers identified CCZ1 as a key host factor in the early stage of filovirus replication and demonstrated its critical role in regulating endosomal trafficking of the viruses. Inhibition of CCZ1 effectively blocked Marburg and Ebola infections, suggesting that targeting CCZ1 could be a promising approach for controlling viral infections caused by various viruses, including SARS-CoV-2, Marburg, and Ebola.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Qi Zhang, Shaoyang Sun, Yinglan Zhang, Xu Wang, Qiang Li
Summary: The gene Scd5 has been identified as a master regulator of fat distribution, affecting the deposition of visceral adipose tissue (VAT). Dietary supplementation of omega 3-polyunsaturated fatty acid (omega 3-PUFA) can decrease VAT accumulation. This research provides insight into the regulation of fat distribution and potential interventions to reduce VAT deposition.
Article
Medicine, Research & Experimental
Yujun Lin, Cheng Cui, Min Su, Lawrence K. Silbart, Haiyan Liu, Jin Zhao, Lang He, Yuanmao Huang, Dexin Xu, Xiaodan Wei, Qian Du, Laijun Lai
Summary: TAPBPL is a novel T cell co-inhibitory molecule that inhibits the proliferation, activation, and cytokine production of T cells, and has the potential to be used for the treatment of cancer, infections, autoimmune diseases, and transplant rejection.
EMBO MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Min Chen, Soochi Kim, Liang Li, Sourav Chattopadhyay, Thomas A. Rando, Brian J. Feldman
Summary: Through single-cell RNA sequencing, a population of CD31- CD45- cells with a specific expression profile is discovered in the stromal vascular fraction of adipose tissue. This population is placed on an epistatic pathway upstream of preadipocytes and functional properties with broad implications, including physiological mechanisms regulating adipogenesis, are revealed.
Article
Cell Biology
Feng Zhang, Xiong Zhao, Runmin Jiang, Yuying Wang, Xinli Wang, Yu Gu, Longyong Xu, Jing Ye, Charlie Degui Chen, Shuangping Guo, Dawei Zhang, Daqing Zhao
Summary: In this study, Jmjd3 was identified as an essential regulator of the temporal colinear activation of Hox genes in body axial patterning, with its H3K27me3 demethylase activity. This research provides new insights into the maintenance of temporal colinear expression of Hox genes in mice, without detecting any antagonistic roles between Jmjd3 and Ezh2 in the processes of axial skeletal patterning.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hailun Liu, Yuge Li, Yilong Hu, Yuhua Yang, Wenbin Zhang, Ming He, Xiaoming Li, Chunyu Zhang, Fanjiang Kong, Xu Liu, Xingliang Hou
Summary: EIJ1 acts as a negative regulator of plant immunity by interacting with EDS1 and inhibiting pathogen-triggered trafficking of EDS1 to the nucleus. As disease progresses, EIJ1 is degraded, allowing EDS1 to accumulate in the nucleus for enhanced resistance. The avirulent strain Pst DC3000 (AvrRps4) induces rapid degradation of EIJ1 to abolish its repressive effect during effector-triggered immunity.
Review
Immunology
Christoph Wilhelm, Jayagopi Surendar, Fotios Karagiannis
Summary: Nutrition is crucial for maintaining bodily functions, with emerging evidence showing the immunomodulatory effects of diet as a central aspect of human health. Dietary restriction may play a regulatory role by influencing immune cell functions, and it can have varying effects depending on the environment.
TRENDS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Renhe Wang, Haijun Zhao, Yingyu Zhang, Hai Zhu, Qiuju Su, Haiyan Qi, Jun Deng, Chengcheng Xiao
Summary: The inhibition of miR-92a-3p targeting Nrf1 alleviates tubular epithelial cell oxidative stress and pyroptosis in renal ischemia-reperfusion injury.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Hao Zhang, Shuangli Zhu, Haiting Zhou, Rui Li, Xiaohui Xia, Huihua Xiong
Summary: This study found that the expression of Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is upregulated in triple-negative breast cancer (TNBC) and is associated with poor prognosis. MTHFD2 is involved in various tumor-related processes and is closely related to immune cell infiltration. In vitro experiments showed that silencing MTHFD2 inhibits the proliferation, apoptosis, migration, and invasion of TNBC cells, and promotes ferroptosis. Therefore, MTHFD2 could serve as an important molecular biomarker for predicting prognosis and a potential therapeutic target in TNBC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Jeeyoon Chang, Hyun Jung Hwang, Byungju Kim, Yeon-Gil Choi, Joori Park, Yeonkyoung Park, Ban Seok Lee, Heedo Park, Min Ji Yoon, Jae-Sung Woo, Chungho Kim, Man-Seong Park, Jong-Bong Lee, Yoon Ki Kim
Summary: TRIM28 functions as a negative regulator of aggresome formation by inhibiting the efficient targeting of misfolded polypeptides, leading to suppression of viral proliferation. Phosphorylation of TRIM28 at S473 promotes its association with CTIF, which inhibits aggresome formation.
Article
Multidisciplinary Sciences
Jorge Marquez, Jianping Dong, Chun Dong, Changsheng Tian, Ginette Serrero
Summary: ADCs have emerged as effective therapeutics for hematopoietic and lymphoid tumors, but the search for new targets, especially for solid tumors, remains a challenge. Through screening antibody libraries, the study identified PTGFRN as a potential target for antibody-based therapy, showing promising results in inhibiting cancer cell proliferation in vitro and blocking tumor growth in vivo. This approach of screening for internalizing antibodies in cancer cell lines holds potential for identifying new targets for ADC development.
Article
Oncology
Zhuomin Liang, Wendong Fan, Hao Chen, Zhan-Peng Huang, Rong Fang, Bin Dong, Chen Chen, Jiayong Li, Gang Dai, Ruicong Xue, Yugang Dong, Chen Liu
Summary: This study identified a cytoplasmic lncRNA, Gm17501, which plays a crucial role in regulating cardiac hypertrophy, possibly by maintaining calcium signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Genghua Chen, Yunqian Yin, Zetong Lin, Huaqiang Wen, Jiahui Chen, Wen Luo
Summary: Recent studies have suggested that the Kelch-like gene KLHL30 plays key roles in myoblast physiology, promoting myogenic differentiation and myotube formation. Transcriptional data and quantitative PCR analysis showed that KLHL30 expression is upregulated during myoblast differentiation state. Additionally, KLHL30 was found to significantly decrease the numbers of cells in the S stage, thereby inhibiting myoblast proliferation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Fisheries
Jie Ren, Wenyang Lin, Hong Shi, Yiwen Jian, Lingwei Ruan
Summary: The Hippo signaling pathway, including its core molecule Yorkie, plays important roles in organ size control, development, tumorigenesis, and immunity. In this study, a Yorkie homolog named LvYKI was cloned and characterized from Litopenaeus vannamei. LvYKI showed different regulatory mechanisms in different tissues and was involved in white spot syndrome virus (WSSV) infection. Knocking down of LvYKI inhibited the transcription of WSSV genes and delayed shrimp mortality, while increasing hemocyte apoptosis. Moreover, LvYKI was found to interact with Lv beta-catenin, linking the Wnt and Hippo signaling pathways in innate immunity. This study provides insights into the role of LvYKI in the interaction between shrimp and virus, enhancing our understanding of the molecular mechanism in innate immunity.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Gelei Xiao, Kaiyue Wang, Zeyu Wang, Ziyu Dai, Xisong Liang, Weijie Ye, Peng Luo, Jian Zhang, Zaoqu Liu, Quan Cheng, Renjun Peng
Summary: Using machine learning, this study found that the SOX family has significant immune characteristics and genomic profiles in gliomas. It can be divided into two distinct clusters, with SOX10 identified as an excellent immune regulator of macrophage in gliomas. High expression of SOX10 is associated with shorter overall survival but benefits from immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Eugen Widmeier, Seyoung Yu, Anish Nag, Youn Wook Chung, Makiko Nakayama, Lucia Fernandez-del-Rio, Hannah Hugo, David Schapiro, Florian Buerger, Won-Il Choi, Martin Helmstaedter, Jae-woo Kim, Ji-Hwan Ryu, Min Goo Lee, Catherine F. Clarke, Friedhelm Hildebrandt, Heon Yung Gee
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Endocrinology & Metabolism
Jo Woon Seok, Daeun Kim, Bo Kyung Yoon, Yoseob Lee, Hyeon Ju Kim, Nahee Hwang, Sungsoon Fang, Hyo Jung Kim, Jae-woo Kim
METABOLISM-CLINICAL AND EXPERIMENTAL
(2020)
Article
Endocrinology & Metabolism
Young Jin, Yul Ji, Yaechan Song, Sung Sik Choe, Yong Geun Jeon, Heeju Na, Tae Wook Nam, Hye Jeong Kim, Hahn Nahmgoong, Sung Min Kim, Jae-woo Kim, Ki Taek Nam, Je Kyung Seong, Daehee Hwang, Chan Bae Park, In Hye Lee, Jae Bum Kim, Han-Woong Lee
Summary: This study demonstrates that adipocyte-specific deficiency of Becn1 results in severe lipodystrophy, adipose tissue inflammation, hepatic steatosis, and insulin resistance, suggesting that Becn1 plays a crucial role in adipocyte survival and adipose tissue homeostasis.
Article
Gastroenterology & Hepatology
Taekyeong Yoo, Sae Kyung Joo, Hyo Jung Kim, Hyun Young Kim, Hyungtai Sim, Jieun Lee, Hee-Hoon Kim, Sunhee Jung, Youngha Lee, Oveis Jamialahmadi, Stefano Romeo, Won-Il Jeong, Geum-Sook Hwang, Keon Wook Kang, Jae Woo Kim, Won Kim, Murim Choi
Summary: Using eQTL analysis in NAFLD patients, 242 NAFLD-specific eQTL loci were identified, with AGXT2-rs2291702 showing a protective role against liver fibrosis in a genotype-dependent manner.
JOURNAL OF HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bo Kyung Yoon, Nahee Hwang, Kyu-Hye Chun, Yoseob Lee, Tatiana Patricia Mendes Duarte, Jae-Won Kim, Tae-Hyun Kim, Jae-Ho Cheong, Sungsoon Fang, Jae-woo Kim
Summary: This study identifies FNBP1 as a key molecule in high-level cell motility, specifically present in aggressive gastric cancer cells. The transcription factor Sp1 is found to drive FNBP1 expression in EMT-type GC cells, leading to increased invasion ability. Inhibition of Sp1 results in down-regulation of FNBP1 and loss of invasive potential, suggesting a potential therapeutic target for aggressive gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Da Hea Seo, Eugene Shin, Yong-ho Lee, Se-Eun Park, Ki Taek Nam, Jae-woo Kim, Bong-Soo Cha
Summary: Cilostazol treatment promotes browning of visceral adipose tissue by activating the cAMP/PKA signaling pathway and improves overall metabolism in HFD-fed mice.
Article
Immunology
Nahee Hwang, Yune Huh, Seonghyeon Bu, Kyung Jin Seo, Se Hwan Kwon, Jae-woo Kim, Bo Kyung Yoon, Hyo-Suk Ahn, Sungsoon Fang
Summary: This study conducted a time series analysis of peripheral blood mononuclear cells from a patient with BNT162b2-induced myocarditis, and found the importance of classical monocytes in the pathogenesis of myocarditis. The study also suggests that vaccination may affect monocytes and induce their infiltration into the heart.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Bo Kyung Yoon, Hyeonhui Kim, Tae Gyu Ohd, Se Kyu Oh, Sugyeong Jo, Minki Kim, Kyu-Hye Chun, Nahee Hwang, Suji Lee, Suyon Jin, Annette R. Atkins, Ruth T. Yu, Michael Downes, Jae-woo Kim, Hyunkyung Kim, Ronald M. Evans, Jae-Ho Cheong, Sungsoon Fang
Summary: Molecular classification of gastric cancer identified a subgroup of patients with poor prognosis and chemoresistance, called SEM type, which exhibits a distinct metabolic profile characterized by high levels of glutaminase. These SEM type gastric cancer cells are resistant to glutaminolysis inhibition due to the upregulation of the PHGDH-mediated mitochondrial folate cycle pathway under glutamine starvation. The metabolic plasticity in SEM type GC cells is associated with open chromatin structure and driven by ATF4/CEBPB. The coinhibition of GLS and PHGDH effectively eliminates stemness-high cancer cells, providing a potential treatment strategy for chemoresistant GC patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Hyeonhui Kim, Hyo-Suk Ahn, Nahee Hwang, Yune Huh, Seonghyeon Bu, Kyung Jin Seo, Se Hwan Kwon, Hae-Kyung Lee, Jae-woo Kim, Bo Kyung Yoon, Sungsoon Fang
Summary: After the outbreak of the SARS-CoV-2 pandemic, a novel mRNA vaccine (BNT162b2) was developed at an unprecedented speed. Although widespread immunity has been achieved through vaccination and infections, even individuals who have recovered from SARS-CoV-2 infection are recommended to receive BNT162b2 vaccination due to its effectiveness in lowering the risk of recurrent infection. However, the BNT162b2 vaccine has been reported to increase the risk of myocarditis. This study tracked changes in chromatin dynamics in peripheral blood mononuclear cells (PBMCs) of a patient who developed myocarditis after BNT162b2 vaccination, revealing alterations in interferon signaling and RUNX2/3 activity.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Kyu-Hye Chun, Ye-Chan Park, Nahee Hwang, Bo Kyung Yoon, Jae-woo Kim, Sungsoon Fang
Summary: Immune checkpoint inhibitors (ICIs) are promising for treating melanoma. By studying immune cells from autoimmune skin diseases, the effectiveness of ICIs in melanoma treatment can be validated. Gene expression signatures of T cells from autoimmune skin diseases exhibit complex immune responses in tumors that respond to immunotherapy.
SCIENTIFIC REPORTS
(2023)
Article
Emergency Medicine
Young In Lee, Jung Eun Shim, Jihee Kim, Won Jai Lee, Jae Woo Kim, Kee Hyun Nam, Ju Hee Lee
Summary: This study identified a partial mechanism of keloid pathogenesis, which involves intercellular communication via the WNT5A and STAT pathways leading to the occurrence of EMT-like phenomena. Improving our understanding of keloid development and the role of WNT5A in EMT could promote the development of targeted treatments for keloid scars.
Article
Biochemistry & Molecular Biology
Bo Kyung Yoon, Tae Gyu Oh, Seonghyeon Bu, Kyung Jin Seo, Se Hwan Kwon, Ji Yoon Lee, Yeumin Kim, Jae-Woo Kim, Hyo-Suk Ahn, Sungsoon Fang
Summary: This study used single-cell RNA sequencing and single-cell T cell receptor sequencing analyses to describe the changes in the peripheral immune landscape of a patient who developed myocarditis after receiving the BNT162b2 mRNA vaccine. The greatest changes were observed in the transcriptomic profile of monocytes, with increased expression levels of IL7R detected in multiple cell clusters. These findings contribute to the understanding of the pathogenesis of BNT162b2-induced myocarditis.
MOLECULES AND CELLS
(2022)
Article
Biochemistry & Molecular Biology
Hyeon Ju Kim, Yoseob Lee, Sungsoon Fang, Won Kim, Hyo Jung Kim, Jae-Woo Kim
Article
Multidisciplinary Sciences
Yoonjeong Choi, Hyeonjin Choi, Bo Kyung Yoon, Hyemin Lee, Jo Woon Seok, Hyo Jung Kim, Jae-woo Kim
Article
Endocrinology & Metabolism
JaeSang Ko, Ji-Young Kim, Jae-woo Kim, Jin Sook Yoon