N-acetylcysteine in COPD: why, how, and when?

Prevention of Acute Exacerbations of COPD

(2015) Gerard J. Criner et al.   CHEST

Benefits of High-Dose N-Acetylcysteine to Exacerbation-Prone Patients With COPD

(2014) Hoi Nam Tse et al.   CHEST

Oxidative Stress and Respiratory System: Pharmacological and Clinical Reappraisal of N-Acetylcysteine

(2014) Pierachille Santus et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

The clinical and integrated management of COPD. An official document of AIMAR (Interdisciplinary Association for Research in Lung Disease), AIPO (Italian Association of Hospital Pulmonologists), SIMER (Italian Society of Respiratory Medicine), SIMG (Italian Society of General Medicine)

(2014) Germano Bettoncelli et al.   MULTIDISCIPLINARY RESPIRATORY MEDICINE

Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease

(2014) Hoi Nam Tse et al.   International Journal of Chronic Obstructive Pulmonary Disease

Twice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial

(2014) Jin-Ping Zheng et al.   Lancet Respiratory Medicine

N-acetylcysteine in COPD may be beneficial, but for whom?

(2014) Mario Cazzola et al.   Lancet Respiratory Medicine

N-acetylcysteine for COPD: the evidence remains inconclusive

(2014) Richard D Turner et al.   Lancet Respiratory Medicine

Mechanisms and impact of the frequent exacerbator phenotype in chronic obstructive pulmonary disease

(2013) Jadwiga A Wedzicha et al.   BMC Medicine

High-Dose N-Acetylcysteine in Stable COPD

(2013) Hoi Nam Tse et al.   CHEST

Efficacy of Roflumilast in the COPD Frequent Exacerbator Phenotype

(2013) Jadwiga A. Wedzicha et al.   CHEST

Antioxidants and Mucolytics in COPD Management: When (if ever) and in Whom?

(2013) Georgios Hillas et al.   CURRENT DRUG TARGETS

Altered oxidant-antioxidant levels in the disease prognosis of chronic obstructive pulmonary disease

(2013) A. Ahmad et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Oxidant-Antioxidant Balance in the Blood of Patients with Chronic Obstructive Pulmonary Disease After Smoking Cessation

(2013) Alina Woźniak et al.   Oxidative Medicine and Cellular Longevity

Priming of beta-2 agonist and antimuscarinic induced physiological responses induced by 1200mg/day NAC in moderate to severe COPD patients: A pilot study

(2013) Ravikumar Sinojia et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Effect of high-dose N-acetylcysteine on airway geometry, inflammation, and oxidative stress in COPD patients

(2013) Jan De Backer et al.   International Journal of Chronic Obstructive Pulmonary Disease

Targeted treatment in COPD: a multi-system approach for a multi-system disease

(2012) David Anderson   International Journal of Chronic Obstructive Pulmonary Disease

N-Acetylcysteine mucolysis in the management of chronic obstructive pulmonary disease

(2012) Anna M. Sadowska   Therapeutic Advances in Respiratory Disease

Plasma Antioxidants Are Associated with Impaired Lung Function and COPD Exacerbations in Smokers

(2011) Michael E. Nicks et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Tiotropium versus Salmeterol for the Prevention of Exacerbations of COPD

(2011) Claus Vogelmeier et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation

(2011) Ivana Stanojkovic et al.   RESPIRATORY MEDICINE

Effects of oral N-acetylcysteine on fatigue, critical power, and W′ in exercising humans

(2011) Sarah D. Corn et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

(2011) Hongwei Yao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pathogenic triad in COPD: oxidative stress, protease–antiprotease imbalance, and inflammation

(2011) Bernard Fischer et al.   International Journal of Chronic Obstructive Pulmonary Disease

THE REDUCTION IN VITRO IN VISCOSITY OF MUCOPROTEIN SOLUTIONS BY A NEW MUCOLYTIC AGENT, N-ACETYL-L-CYSTEINE

(2010) A. L. Sheffner   Annals of the New York Academy of Sciences

Red blood cell permeability to thiol compounds following oxidative stress

(2010) D. Mazor et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Oxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathway

(2010) A Boutten et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease

(2010) John R. Hurst et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM

(2010) H. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of N-Acetylcysteine on Air Trapping in COPD

(2009) David Stav et al.   CHEST

Fluticasone and N-acetylcysteine in primary care patients with COPD or chronic bronchitis

(2009) Tjard Schermer et al.   RESPIRATORY MEDICINE

Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

(2008) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD

(2008) Ellen L. Robb et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Outcomes for COPD pharmacological trials: from lung function to biomarkers

(2008) M. Cazzola et al.   EUROPEAN RESPIRATORY JOURNAL

Oxidants and the pathogenesis of lung diseases

(2008) Jonathan Ciencewicki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Variation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteine

(2008) Eda Suer et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study

(2008) Jin-Ping Zheng et al.   LANCET

A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease

(2008) Donald P. Tashkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling

(2008) N M Reddy et al.   ONCOGENE

Impulse oscillometry in COPD: Identification of measurements related to airway obstruction, airway conductance and lung volumes

(2008) Umme Kolsum et al.   RESPIRATORY MEDICINE

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

(2007) Aruna Kode et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY