Neurobiology, Pathophysiology, and Treatment of Melatonin Deficiency and Dysfunction

Efficacy and Safety of 6-Month Nightly Ramelteon Administration in Adults with Chronic Primary Insomnia

(2017) Geert Mayer et al.   SLEEP

Sleep and Rhythm Consequences of a Genetically Induced Loss of Serotonin

(2017) Smaranda Leu-Semenescu et al.   SLEEP

Polymorphism in the PER3 Promoter Associates with Diurnal Preference and Delayed Sleep Phase Disorder

(2017) Simon N. Archer et al.   SLEEP

Congenital diaphragmatic hernia in Smith-Magenis syndrome: A possible locus at chromosome 17p11.2

(2011) E.F. Sanford et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A Benefit-Risk Assessment of Agomelatine in the Treatment of Major Depression

(2011) Robert H. Howland   DRUG SAFETY

Melatonin Receptor 1A Gene Polymorphism Associated with Polycystic Ovary Syndrome

(2011) Chao Li et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

Melatonin and Associated Signaling Pathways that Control Normal Breast Epithelium and Breast Cancer

(2011) Steven M. Hill et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Association of Polymorphism in the Promoter of the Melatonin Receptor 1A Gene with Schizophrenia and with Insomnia Symptoms in Schizophrenia Patients

(2011) Hae Jeong Park et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies

(2011) Michael Wilhelmsen et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as a natural ally against oxidative stress: a physicochemical examination

(2011) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling

(2011) Rüdiger Hardeland et al.   JOURNAL OF PINEAL RESEARCH

Publication Bias and Outcome Reporting Bias: Agomelatine as a Case Example

(2011) Robert H. Howland   JOURNAL OF PSYCHOSOCIAL NURSING AND MENTAL HEALTH SERVICES

Molecular Analysis of the Retinoic Acid Induced 1 Gene (RAI1) in Patients with Suspected Smith-Magenis Syndrome without the 17p11.2 Deletion

(2011) Thierry Vilboux et al.   PLoS One

Long-term safety and efficacy of ramelteon in Japanese patients with chronic insomnia

(2011) Makoto Uchiyama et al.   SLEEP MEDICINE

Association Study of BMP4, IL6, Leptin, MMP3, and MTNR1B Gene Promoter Polymorphisms and Adolescent Idiopathic Scoliosis

(2011) Mónika Mórocz et al.   SPINE

Genetic variants inMTNR1Baffecting insulin secretion

(2010) Karsten Müssig et al.   ANNALS OF MEDICINE

Ramelteon attenuates age-associated hypertension and weight gain in spontaneously hypertensive rats

(2010) Gregory F. Oxenkrug et al.   Annals of the New York Academy of Sciences

Prospective Study of Common Variants in the Retinoic Acid Receptor–Related Orphan Receptor α Gene and Risk of Neovascular Age-Related Macular Degeneration

(2010) Debra A. Schaumberg   ARCHIVES OF OPHTHALMOLOGY

Genome-Wide Association Scan of Trait Depression

(2010) Antonio Terracciano et al.   BIOLOGICAL PSYCHIATRY

Urinary 6-Sulphatoxymelatonin Levels and Risk of Breast Cancer in Premenopausal Women: The ORDET Cohort

(2010) E. S. Schernhammer et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Clinical Uses of Melatonin: Evaluation of Human Trials

(2010) E.J. Sanchez-Barcelo et al.   CURRENT MEDICINAL CHEMISTRY

Clinical Aspects of Melatonin Intervention in Alzheimers Disease Progression

(2010) Daniel P. Cardinali et al.   Current Neuropharmacology

Investigational melatonin receptor agonists

(2010) Rüdiger Hardeland   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The chronobiology, etiology and pathophysiology of obesity

(2010) M Garaulet et al.   INTERNATIONAL JOURNAL OF OBESITY

Rest-Activity Cycle and Melatonin Rhythm in Blind Free-Runners Have Similar Periods

(2010) Jonathan Emens et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Melatonin in septic shock: Some recent concepts

(2010) Venkataramanujan Srinivasan et al.   JOURNAL OF CRITICAL CARE

Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high fat-fed rats

(2010) María J. Ríos-Lugo et al.   JOURNAL OF PINEAL RESEARCH

Distinct Contributions of Rod, Cone, and Melanopsin Photoreceptors to Encoding Irradiance

(2010) Gurprit S. Lall et al.   NEURON

Removal of Melatonin Receptor Type 1 Induces Insulin Resistance in the Mouse

(2010) Susana Contreras-Alcantara et al.   Obesity

Circadian rhythms and treatment implications in depression

(2010) Palmiero Monteleone et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Melatonin—A pleiotropic, orchestrating regulator molecule

(2010) Rüdiger Hardeland et al.   PROGRESS IN NEUROBIOLOGY

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Spectral Responses of the Human Circadian System Depend on the Irradiance and Duration of Exposure to Light

(2010) J. J. Gooley et al.   Science Translational Medicine

Melatonin and tryptophan circadian profiles in patients with advanced non-small cell lung cancer

(2009) Shilian Hu et al.   ADVANCES IN THERAPY

Melatonin: Signaling mechanisms of a pleiotropic agent

(2009) Rüdiger Hardeland   BIOFACTORS

A Genomewide Association Study of Citalopram Response in Major Depressive Disorder

(2009) Holly A. Garriock et al.   BIOLOGICAL PSYCHIATRY

Evidence for genetic association of RORB with bipolar disorder

(2009) Casey L McGrath et al.   BMC Psychiatry

Timing Light Treatment for Eastward and Westward Travel Preparation

(2009) Michel A. Paul et al.   CHRONOBIOLOGY INTERNATIONAL

Disorders of mitochondrial function

(2009) François-Guillaume Debray et al.   CURRENT OPINION IN PEDIATRICS

Melatonin and Melatonergic Drugs on Sleep: Possible Mechanisms of Action

(2009) Venkataramanujan Srinivasan et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Safety and Subjective Sleep Effects of Ramelteon Administration in Adults and Older Adults With Chronic Primary Insomnia

(2009) Gary S. Richardson et al.   JOURNAL OF CLINICAL PSYCHIATRY

Mitochondrial medicine: entering the era of treatment

(2009) S. Koene et al.   JOURNAL OF INTERNAL MEDICINE

Batteries not included: diagnosis and management of mitochondrial disease

(2009) R. McFarland et al.   JOURNAL OF INTERNAL MEDICINE

Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCζ-Akt-GSK3β pathway in hepatic cells

(2009) Jiunn-Min Shieh et al.   JOURNAL OF PINEAL RESEARCH

Defining chronodisruption

(2009) Thomas C. Erren et al.   JOURNAL OF PINEAL RESEARCH

Key Research Opportunities in Immune System Aging

(2009) S. L. Swain et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

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(2009) Ahmet Korkmaz et al.   MOLECULAR MEDICINE

Neuroprotection by Radical Avoidance: Search for Suitable Agents

(2009) Rüdiger Hardeland   MOLECULES

MELATONIN DEFICIENCY AND DISRUPTED CIRCADIAN RHYTHMS IN PEDIATRIC SURVIVORS OF CRANIOPHARYNGIOMA

(2009) J. Lipton et al.   NEUROLOGY

NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats

(2009) Meihua She et al.   PHARMACOLOGICAL RESEARCH

Bidirectional communication between sleep and circadian rhythms and its implications for depression: Lessons from agomelatine

(2009) Seithikurippu R. Pandi-Perumal et al.   PROGRESS IN NEUROBIOLOGY

Paradoxical reactions to hypnotic agents in adolescents with free-running disorder

(2009) Masaru Echizenya et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Pathophysiology of depression: Role of sleep and the melatonergic system

(2009) Venkataramanujan Srinivasan et al.   PSYCHIATRY RESEARCH

Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: A systems biology based approach

(2009) Alexandra C. Silveira et al.   VISION RESEARCH

Membrane phospholipids, lipoxidative damage and molecular integrity: A causal role in aging and longevity

(2008) Reinald Pamplona   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Circadian photoreception: ageing and the eye's important role in systemic health

(2008) P L Turner et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites

(2008) R. Hardeland   CELLULAR AND MOLECULAR LIFE SCIENCES

Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice

(2008) María I. Rodríguez et al.   EXPERIMENTAL GERONTOLOGY

Effect of Bright Light and Melatonin on Cognitive and Noncognitive Function in Elderly Residents of Group Care Facilities

(2008) Rixt F. Riemersma-van der Lek   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Role of melatonin receptors in the effects of melatonin on BDNF and neuroprotection in mouse cerebellar neurons

(2008) Marta Imbesi et al.   JOURNAL OF NEURAL TRANSMISSION

The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders

(2008) James E. Jan et al.   JOURNAL OF PINEAL RESEARCH

The melatonin receptor MT1 is required for the differential regulatory actions of melatonin on neuronal ‘clock’ gene expression in striatal neurons in vitro

(2008) Marta Imbesi et al.   JOURNAL OF PINEAL RESEARCH

Endogenous melatonin provides an effective circadian message to both the suprachiasmatic nuclei and the pars tuberalis of the rat

(2008) Laurence Agez et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

(2008) Ana López et al.   JOURNAL OF PINEAL RESEARCH

The association of nocturnal serum melatonin levels with major depression in patients with acute multiple sclerosis

(2008) Zehra Akpınar et al.   PSYCHIATRY RESEARCH

The effect of melatonergic and non-melatonergic antidepressants on sleep: weighing the alternatives

(2008) Seithikurippu R. Pandi-Perumal et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

A three pulse phase response curve to three milligrams of melatonin in humans

(2007) Helen J. Burgess et al.   JOURNAL OF PHYSIOLOGY-LONDON