Emerging In Vitro Models for Safety Screening of High-Volume Production Nanomaterials under Environmentally Relevant Exposure Conditions

Surface Defects on Plate-Shaped Silver Nanoparticles Contribute to Its Hazard Potential in a Fish Gill Cell Line and Zebrafish Embryos

(2012) Saji George et al.   ACS Nano

Designed Synthesis of CeO2 Nanorods and Nanowires for Studying Toxicological Effects of High Aspect Ratio Nanomaterials

(2012) Zhaoxia Ji et al.   ACS Nano

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system

(2012) Liang Ma et al.   BIOMATERIALS

Zinc oxide particles: Synthesis, properties and applications

(2012) Amir Moezzi et al.   CHEMICAL ENGINEERING JOURNAL

Intrinsic therapeutic applications of noble metal nanoparticles: past, present and future

(2012) Rochelle R. Arvizo et al.   CHEMICAL SOCIETY REVIEWS

Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I)

(2012) Christine Götz et al.   EXPERIMENTAL DERMATOLOGY

Spontaneous origin from human embryonic stem cells of liver cells displaying conjoint meso-endodermal phenotype with hepatic functions

(2012) S. Bandi et al.   JOURNAL OF CELL SCIENCE

Biodistribution of Aqueous Suspensions of Carbon Nanotubes in Mice and Their Biocompatibility

(2012) Shigeaki Abe et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Novel developmental biology-based protocol of embryonic stem cell differentiation to morphologically sound and functional yet immature hepatocytes

(2012) Terence N. Bukong et al.   LIVER INTERNATIONAL

Oxidative stress and apoptosis induced by ZnO nanoparticles in HaCaT cells

(2012) Hyun Cheol Bae et al.   Molecular & Cellular Toxicology

Acute vascular effects of nanoparticle infusion in isolated perfused skin

(2012) Jim E. Riviere et al.   Nanomedicine-Nanotechnology Biology and Medicine

Size dependent cellular uptake, in vivo fate and light–heat conversion efficiency of gold nanoshells on silica nanorattles

(2012) Huiyu Liu et al.   Nanoscale

Fabrication of functional three-dimensional tissues by stacking cell sheets in vitro

(2012) Yuji Haraguchi et al.   Nature Protocols

TiO2 Nanoparticles Are Phototoxic to Marine Phytoplankton

(2012) Robert J. Miller et al.   PLoS One

Automated Phenotype Recognition for Zebrafish Embryo Based In Vivo High Throughput Toxicity Screening of Engineered Nano-Materials

(2012) Rong Liu et al.   PLoS One

Use of a High-Throughput Screening Approach Coupled with In Vivo Zebrafish Embryo Screening To Develop Hazard Ranking for Engineered Nanomaterials

(2011) Saji George et al.   ACS Nano

High Content Screening in Zebrafish Speeds up Hazard Ranking of Transition Metal Oxide Nanoparticles

(2011) Sijie Lin et al.   ACS Nano

Differential Expression of Syndecan-1 Mediates Cationic Nanoparticle Toxicity in Undifferentiated versus Differentiated Normal Human Bronchial Epithelial Cells

(2011) Haiyuan Zhang et al.   ACS Nano

Dispersal State of Multiwalled Carbon Nanotubes Elicits Profibrogenic Cellular Responses That Correlate with Fibrogenesis Biomarkers and Fibrosis in the Murine Lung

(2011) Xiang Wang et al.   ACS Nano

The effect of polyethylene glycol structure on paclitaxel drug release and mechanical properties of PLGA thin films

(2011) Terry W.J. Steele et al.   Acta Biomaterialia

Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles

(2011) Boon Chin Heng et al.   ARCHIVES OF TOXICOLOGY

The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles

(2011) Margriet V.D.Z. Park et al.   BIOMATERIALS

The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticles

(2011) Kee Woei Ng et al.   BIOMATERIALS

A three-way synergy of triple-modified Bi2WO6/Ag/N–TiO2 nanojunction film for enhanced photogenerated charges utilization

(2011) Qing Chi Xu et al.   CHEMICAL COMMUNICATIONS

Comparative phototoxicity of nanoparticulate and bulk ZnO to a free-living nematode Caenorhabditis elegans: The importance of illumination mode and primary particle size

(2011) H. Ma et al.   ENVIRONMENTAL POLLUTION

Estimating Production Data for Five Engineered Nanomaterials As a Basis for Exposure Assessment

(2011) Christine Ogilvie Hendren et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Altering the drug release profiles of double-layered ternary-phase microparticles

(2011) Wei Li Lee et al.   JOURNAL OF CONTROLLED RELEASE

Designing drug-loaded multi-layered polymeric microparticles

(2011) Wei Li Lee et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

High-throughput screening of PLGA thin films utilizing hydrophobic fluorescent dyes for hydrophobic drug compounds

(2011) Terry W.J. Steele et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Role of Fe Doping in Tuning the Band Gap of TiO2for the Photo-Oxidation-Induced Cytotoxicity Paradigm

(2011) Saji George et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-matrix adhesions in 3D

(2011) Jill S. Harunaga et al.   MATRIX BIOLOGY

Comparison of cellular effects of titanium dioxide nanoparticles with different photocatalytic potential in human keratinocyte, HaCaT cells

(2011) Hee-Ok Park et al.   Molecular & Cellular Toxicology

In vivobiodistribution of nanoparticles

(2011) Joao Paulo Mattos Almeida et al.   Nanomedicine

Nanostructure control of graphene-composited TiO2 by a one-step solvothermal approach for high performance dye-sensitized solar cells

(2011) Ziming He et al.   Nanoscale

Effects of quantum dots on different renal proximal tubule cell models and on gel-free renal tubules generatedin vitro

(2011) Yao Li et al.   Nanotoxicology

Titanium dioxide nanoparticles produce phototoxicity in the developing zebrafish

(2011) Ofek Bar-Ilan et al.   Nanotoxicology

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

(2011)   NATURE BIOTECHNOLOGY

The validated embryonic stem cell test to predict embryotoxicity in vitro

(2011) Andrea E M Seiler et al.   Nature Protocols

Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors

(2011) R. Ardehali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc Oxide Nanoparticles Interfere With Zinc Ion Homeostasis to Cause Cytotoxicity

(2011) Yi-Yun Kao et al.   TOXICOLOGICAL SCIENCES

Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data

(2011) Nisha S. Sipes et al.   TOXICOLOGICAL SCIENCES

Titanium dioxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in human amnion epithelial (WISH) cells

(2011) Quaiser Saquib et al.   TOXICOLOGY IN VITRO

Comparing the toxic mechanism of synthesized zinc oxide nanomaterials by physicochemical characterization and reactive oxygen species properties

(2011) Soo Jin Park et al.   TOXICOLOGY LETTERS

A comparative analysis of DNA methylation across human embryonic stem cell lines

(2011) Pao-Yang Chen et al.   GENOME BIOLOGY

Use of a Rapid Cytotoxicity Screening Approach To Engineer a Safer Zinc Oxide Nanoparticle through Iron Doping

(2010) Saji George et al.   ACS Nano

Quantitative Techniques for Assessing and Controlling the Dispersion and Biological Effects of Multiwalled Carbon Nanotubes in Mammalian Tissue Culture Cells

(2010) Xiang Wang et al.   ACS Nano

Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549

(2010) Rasmus Foldbjerg et al.   ARCHIVES OF TOXICOLOGY

The relationship between terminal functionalization and molecular weight of a gene delivery polymer and transfection efficacy in mammary epithelial 2-D cultures and 3-D organotypic cultures

(2010) Nupura S. Bhise et al.   BIOMATERIALS

Effects of UV-irradiated titania nanoparticles on cell proliferation, cancer metastasis and promotion

(2010) Ekaterini Stefanou et al.   CATALYSIS TODAY

The application of titanium dioxide for deactivation of bioparticulates: An overview

(2010) A. Markowska-Szczupak et al.   CATALYSIS TODAY

Biomedical Applications of Hydroxyapatite Nanoparticles

(2010) S.C.J. Loo et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stress

(2010) Boon Chin Heng et al.   FOOD AND CHEMICAL TOXICOLOGY

Progress and Challenges in Quantifying Skin Permeability to Nanoparticles Using a Quantum Dot Model

(2010) Luke J. Mortensen et al.   Journal of Biomedical Nanotechnology

Generation of easily accessible human kidney tubules on two-dimensional surfaces in vitro

(2010) Huishi Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Drug Release From Irradiated PLGA and PLLA Multi-Layered Films

(2010) Say Chye Joachim Loo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Photo-induced treatment of breast epithelial cancer cells using nanostructured titanium dioxide solution

(2010) N. Lagopati et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY

Superhydrophilicity-assisted preparation of transparent and visible light activated N-doped titania film

(2010) Qing Chi Xu et al.   Nanoscale

Quantification of human skin barrier function and susceptibility to quantum dot skin penetration

(2010) Supriya Ravichandran et al.   Nanotoxicology

A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity

(2010) Na-Yu Chia et al.   NATURE

Biomaterials offer cancer research the third dimension

(2010) Dietmar W. Hutmacher   NATURE MATERIALS

Biomagnification of cadmium selenide quantum dots in a simple experimental microbial food chain

(2010) R. Werlin et al.   Nature Nanotechnology

Asbestos, carbon nanotubes and the pleural mesothelium: a review and the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma

(2010) Ken Donaldson et al.   Particle and Fibre Toxicology

Human safety review of “nano” titanium dioxide and zinc oxide

(2010) Karsten Schilling et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

One-Step Fabrication of Triple-Layered Polymeric Microparticles with Layer Localization of Drugs as a Novel Drug-Delivery System

(2010) Wei Li Lee et al.   Small

Silver Nanoparticles Disrupt GDNF/Fyn kinase Signaling in Spermatogonial Stem Cells

(2010) Laura K. Braydich-Stolle et al.   TOXICOLOGICAL SCIENCES

Silver nanoparticles: Evaluation of DNA damage, toxicity and functional impairment in human mesenchymal stem cells

(2010) Stephan Hackenberg et al.   TOXICOLOGY LETTERS

Can tissue engineering concepts advance tumor biology research?

(2010) Dietmar W. Hutmacher et al.   TRENDS IN BIOTECHNOLOGY

UV irradiation-induced zinc dissociation from commercial zinc oxide sunscreen and its action in human epidermal keratinocytes

(2010) Lisa M Martorano et al.   Journal of Cosmetic Dermatology

Formulation of sunscreens with enhancement sun protection factor response based on solid lipid nanoparticles

(2010) D. Nesseem   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

A Predictive Toxicological Paradigm for the Safety Assessment of Nanomaterials

(2009) Huan Meng et al.   ACS Nano

In vitro assessments of nanomaterial toxicity

(2009) Clinton F. Jones et al.   ADVANCED DRUG DELIVERY REVIEWS

Comparison of the photocatalytic disinfection of E. coli suspensions in slurry, wall and fixed-bed reactors

(2009) Rafael van Grieken et al.   CATALYSIS TODAY

Determination, characterization and cytotoxicity on HELF cells of ZnO nanoparticles

(2009) Jin-Hua Yuan et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Development of alternative photocatalysts to TiO2: Challenges and opportunities

(2009) María D. Hernández-Alonso et al.   Energy & Environmental Science

The Impact of Toxicity Testing Costs on Nanomaterial Regulation

(2009) Jae-Young Choi et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Liver tissue engineering in the evaluation of drug safety

(2009) Ajit Dash et al.   Expert Opinion on Drug Metabolism & Toxicology

Co-Synthesis and Drug Delivery Properties of Mesoporous Hydroxyapatite-Silica Composites

(2009) Y. F. Zhao et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Transparent visible light activated C–N–F-codoped TiO2 films for self-cleaning applications

(2009) Qing-chi Xu et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY

Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats

(2009) Yoshimitsu Sakamoto et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

The Influences of Cell Type and ZnO Nanoparticle Size on Immune Cell Cytotoxicity and Cytokine Induction

(2009) Cory Hanley et al.   Nanoscale Research Letters

Nanosized zinc oxide particles induce neural stem cell apoptosis

(2009) Xiaoyong Deng et al.   NANOTECHNOLOGY

The effect of zinc oxide and titanium dioxide nanoparticles in the Comet assay with UVA photoactivation of human sperm and lymphocytes

(2009) Rajendran C. Gopalan et al.   Nanotoxicology

Toxicity testing gets a makeover

(2009) Alison Abbott   NATURE

Toxicology for the twenty-first century

(2009) Thomas Hartung   NATURE

Testing in the third dimension

(2009) Molly M. Stevens   Nature Nanotechnology

A Three Dimensional Anchorage Independent In Vitro System for the Prolonged Growth of Embryoid Bodies to Study Cancer Cell Behaviour and Anticancer Agents

(2009) Chui-Yee Fong et al.   Stem Cell Reviews and Reports

Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster

(2009) Maqusood Ahamed et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: Involvement of extracellular matrix and cell adhesion

(2009) Katsuhide Fujita et al.   TOXICOLOGY LETTERS

A Review of Gene Expression Profiling of Human Embryonic Stem Cell Lines and their Differentiated Progeny

(2009) Bhaskar Bhattacharya et al.   Current Stem Cell Research & Therapy

Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties

(2008) Tian Xia et al.   ACS Nano

Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells

(2008) P. V. AshaRani et al.   ACS Nano

Studies of Photokilling of Bacteria Using Titanium Dioxide Nanoparticles

(2008) Yang-Hwei Tsuang et al.   ARTIFICIAL ORGANS

Enhancement of UVB-Induced Apoptosis by Apigenin in Human Keratinocytes and Organotypic Keratinocyte Cultures

(2008) A. O. Abu-Yousif et al.   CANCER RESEARCH

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

Defining Molecular Cornerstones during Fibroblast to iPS Cell Reprogramming in Mouse

(2008) Matthias Stadtfeld et al.   Cell Stem Cell

Raw Single-Wall Carbon Nanotubes Induce Oxidative Stress and Activate MAPKs, AP-1, NF-κB, and Akt in Normal and Malignant Human Mesothelial Cells

(2008) Maricica Pacurari et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Biodistribution of titanium dioxide from biologic compartments

(2008) Daniel G. Olmedo et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Nanorods and Nanotubes for Solar Cells

(2008) V. V. Kislyuk et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Synergistic cytotoxic effect of different sized ZnO nanoparticles and daunorubicin against leukemia cancer cells under UV irradiation

(2008) Dadong Guo et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Induction of mesothelioma in p53+/− mouse by intraperitoneal application of multi-wall carbon nanotube

(2008) Atsuya Takagi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Hydroxyl radicals (OH) are associated with titanium dioxide (TiO2) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells

(2008) James F. Reeves et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Titanium dioxide induced cell damage: A proposed role of the carboxyl radical

(2008) Nicholas J.F. Dodd et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

Generation of human-induced pluripotent stem cells

(2008) In-Hyun Park et al.   Nature Protocols

Influences of nanoparticle zinc oxide on acutely isolated rat hippocampal CA3 pyramidal neurons

(2008) Jingxia Zhao et al.   NEUROTOXICOLOGY

Nanotechnology: The coming revolution and its implications for consumers, clinicians, and informatics

(2008) Nancy Staggers et al.   NURSING OUTLOOK

Perturbational profiling of nanomaterial biologic activity

(2008) S. Y. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NANOTECHNOLOGY: Can High-Speed Tests Sort Out Which Nanomaterials Are Safe?

(2008) R. F. Service   SCIENCE

Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles

(2008) Jiangxue Wang et al.   TOXICOLOGY

DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells

(2008) Maqusood Ahamed et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nanoparticle–polymer photovoltaic cells

(2007) Brian R. Saunders et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE