Article
Food Science & Technology
Catherine P. Bondonno, Liezhou Zhong, Nicola P. Bondonno, Marc Sim, Lauren C. Blekkenhorst, Alex Liu, Anjana Rajendra, Pratik Pokharel, Dorit W. Erichsen, Oliver Neubauer, Kevin D. Croft, Jonathan M. Hodgson
Summary: Vegetables, meat, and water are the main sources of dietary nitrate, which has been regulated and monitored due to concerns over cancer risk. However, evidence suggests that nitrate from vegetables can actually protect against cardiovascular disease and other chronic illnesses. The potential formation of carcinogenic N-nitrosamines from nitrate is still a concern.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Immunology
Tahereh Hojjatipour, Saeed Aslani, Sevda Salimifard, Haleh Mikaeili, Maryam Hemmatzadeh, Jamshid Gholizadeh Navashenaq, Elham Ahangar Parvin, Farhad Jadidi-Niaragh, Hamed Mohammadi
Summary: NK cells play a critical role in the pathogenesis of autoimmune diseases, bridging the innate and adaptive immune responses. Their functions in regulating immune responses and affecting various immune cells have been investigated. NK cells can have both harmful and protective effects depending on the subset of NK cells, disease microenvironment, and disease phase or stimuli. Understanding the role of NK cells in autoimmune diseases can provide insights for therapeutic strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Cell Biology
Pureum Jeon, Jin A. Lee
Summary: Stress granules are membraneless cytosolic granules formed under stress conditions, containing RNA-binding proteins and RNAs. They play a role in inhibiting mRNA translation initiation and can accumulate in cytosolic inclusions associated with neurodegenerative diseases. The dysregulation of neuronal stress granules may lead to neurodegeneration, emphasizing the importance of understanding their dynamics in physiology and pathology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Albert Caballeria-Casals, Marc Mico-Carnero, Carlos Rojano-Alfonso, Cristina Maroto-Serrat, Arani Casillas-Ramirez, Ana I. Alvarez-Mercado, Jordi Gracia-Sancho, Carmen Peralta
Summary: This study discusses the role of FGF15/19 in liver surgeries, indicating that it can protect the liver from damage and promote regeneration, and has potential beneficial or harmful effects.
Review
Biochemistry & Molecular Biology
Sidrit Uruci, Calvin Shun Yu Lo, David Wheeler, Nitika Taneja
Summary: R-loops are associated with replication stress and genome instability, commonly seen in neurodegenerative disorders and cancer. Cells have evolved pathways to prevent R-loop accumulation and resolve them, while the role of chromatin modification and remodeling in R-loop homeostasis remains unclear. This review discusses the potential roles of RNA:DNA hybrids, replication fork preservation pathways, and chromatin modifiers and remodelers in differentiating between detrimental and beneficial R-loops for therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Simone Patergnani, Giampaolo Morciano, Marianna Carinci, Sara Leo, Paolo Pinton, Alessandro Rimessi
Summary: Neuronal disorders are closely associated with the loss of mitochondrial functions, and mitochondria activate stress responses to perceive and control dangerous conditions while rescuing the physiological state of nerve cells. This review primarily discusses the impact of compensatory mitochondrial hyperfusion, mitophagy, mitochondrial unfolding protein response, and apoptosis on neurological diseases, as well as the relevance of mitochondria-mediated inflammatory response in the pathogenesis of these diseases.
NEURAL REGENERATION RESEARCH
(2022)
Review
Biology
Lada Purvinsh, Andrey Gorshkov, Aleksandra Brodskaia, Andrey Vasin
Summary: Extracellular vesicles (EVs) are essential for cell-to-cell communication, playing a crucial role in regulating physiological processes and disease pathogenesis. Classified into microvesicles, apoptotic bodies, and exosomes based on size and composition, EVs have both pro-viral and anti-viral mechanisms in viral infections. The understanding of EV secretion by infected cells is crucial for developing new therapeutic strategies and vaccines.
Article
Biochemistry & Molecular Biology
Elisa Fasoli
Summary: Nanomedicine is a multidisciplinary field with various clinical applications, such as molecular imaging, medical diagnostics, targeted therapy, and image-guided surgery. Efforts are still needed to understand the complex behavior of nanoparticles under physiological conditions and the impact of protein corona on their toxicity and targeting capacity.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Magdalena Hurkacz, Lukasz Dobrek, Anna Wiela-Hojenska
Summary: Antibiotics, while having saved many lives, are now facing the challenges of reduced effectiveness due to widespread abuse and the development of bacterial resistance. Furthermore, irrational antibiotic therapy can contribute to gastrointestinal dysbiosis, increasing the risk of various diseases, including neurological and psychiatric disorders. Despite potential adverse effects on neurological and psychiatric health, antibiotics are also being studied for their potential neuroprotective properties in the treatment of neurodegenerative and neuroinflammatory diseases like Alzheimer's and Parkinson's diseases.
Review
Biochemistry & Molecular Biology
Irene Jimenez-Guerrero, Carlos Medina, Jose Maria Vinardell, Francisco Javier Ollero, Francisco Javier Lopez-Baena
Summary: Rhizobia establish a symbiotic association with legumes, forming plant nodules where they fix atmospheric nitrogen into ammonia. The type 3 secretion system (T3SS) plays a crucial role in several rhizobium-legume symbioses by injecting effectors into host cells to alter host pathways or suppress host defense responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ankita Sarkar, Nripa Kumari, Piyali Mukherjee
Summary: SARM1 is a unique member of the human TIR-containing adaptor protein family, which downregulates NF kappa B activity and negatively regulates TRIF function in immune activation, while mediating cell death responses. It plays a significant role in programmed axonal degeneration, particularly in peripheral neuropathy and traumatic injury models, making it a potential therapeutic target.
Review
Biotechnology & Applied Microbiology
Subhasmita Mahapatra, Radheshyam Yadav, Wusirika Ramakrishna
Summary: The increased dependence on chemical fertilizers by farmers poses a risk to soil fertility and ecosystem stability. Plant growth-promoting rhizobacteria (PGPR), such as Bacillus subtilis, play a key role in enhancing crop production and soil health. However, the presence of Bacillus subtilis can also have negative effects on beneficial rhizosphere microbes and soil health.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Infectious Diseases
Lorenzo Servitje
Summary: Literary-rhetorical devices, such as allusions and analogies, are increasingly used in scientific research to explain complex concepts, particularly in discussions of pathogens. Scientists utilize literary works like "Strange Case of Dr. Jekyll and Mr. Hyde" to explore topics such as virulence and antibiotics, not just for stylistic purposes, but to potentially generate new rhetorical and imaginative possibilities in research framing.
Review
Biochemistry & Molecular Biology
Alexey P. Bolshakov, Liya V. Tret'yakova, Alexey A. Kvichansky, Natalia V. Gulyaeva
Summary: GCs play a crucial role in adaptive response to stress, with both pro-inflammatory and anti-inflammatory effects in the hippocampus affecting neuroinflammation. Understanding the dual nature of GC effects and the mechanisms involved can provide effective approaches to prevent and treat brain diseases.
BIOCHEMISTRY-MOSCOW
(2021)
Article
Business
Francesco Castellaneta, Oliver Gottschalg, Aleksandra Kacperczyk, Mike Wright
Summary: This study reveals that experience with complete performance information can foster learning, while experience without complete performance feedback can impede learning. In the realm of private equity investments, experience can have both positive and negative impacts on the performance of subsequent investments, depending on the specific circumstances.
JOURNAL OF MANAGEMENT STUDIES
(2022)
Article
Orthopedics
Andreas M. Seitz, Janina Leiprecht, Jonas Schwer, Anita Ignatius, Heiko Reichel, Thomas Kappe
Summary: The purpose of this study was to investigate the potential of a doubled semitendinosus (ST) and a single gracilis tendon (GT) lateral meniscus autograft to restore knee joint kinematics and tibiofemoral contact after total lateral meniscectomy (LMM). The results showed that the ST autograft significantly improved knee joint kinematics and restored tibiofemoral contact mechanics, while the GT autograft had limited effectiveness.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Immunology
Melanie Haffner-Luntzer, Birte Weber, Kazuhito Morioka, Ina Lackner, Verena Fischer, Chelsea Bahney, Anita Ignatius, Miriam Kalbitz, Ralph Marcucio, Theodore Miclau
Summary: Clinical and preclinical data suggest accelerated bone fracture healing in subjects with an additional traumatic brain injury (TBI). Mechanistically, altered metabolism and neuro-endocrine regulations have been shown to influence bone formation after combined fracture and TBI, thereby increasing the bone content in the fracture callus. However, the early inflammatory response towards fracture and TBI has not been investigated in detail so far.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jana Riegger, Helga Joos, Valentin Moehler, Frank Leucht, Katrin Rading, Christian Kubisch, Anita Ignatius, Markus Huber-Lang, Rolf E. Brenner
Summary: The study suggests that the terminal complement complex (TCC) plays a role in the pathogenesis of posttraumatic osteoarthritis (PTOA). However, the absence of TCC may protect against OA progression and have minor effects on the micro-structure of the subchondral bone.
Article
Endocrinology & Metabolism
Mubashir Ahmad, Nadine Stirmlinger, Irfana Jan, Ulrich Stifel, Sooyeon Lee, Marcel Weingandt, Ulrike Kelp, Juergen Bockmann, Anita Ignatius, Tobias M. Boeckers, Jan Tuckermann
Summary: Mutations in the postsynaptic scaffold protein Shank2 are associated with autism spectrum disorders (ASD) and an increased risk of fractures in affected patients. This study investigates the direct role of Shank2 in regulating bone mass. The findings indicate that Shank2 is expressed in bone and plays a crucial role in osteoblast differentiation and bone formation. The interaction between Shank2 and proteins known from the central nervous system is identified as important for osteoblast differentiation.
Article
Biochemistry & Molecular Biology
Franziska Widmayer, Cornelia Neidlinger-Wilke, Fiona Witz, Jan U. Jansen, Anita Ignatius, Melanie Haffner-Luntzer, Graciosa Q. Teixeira
Summary: Postmenopausal women have an increased risk of intervertebral disc degeneration, possibly due to decreased estrogen levels. This study investigated the effects of 17-beta-estradiol (E2) and low-magnitude, high-frequency vibration (LMHFV) on intervertebral discs (IVDs). The results showed that E2 treatment had minor effects on gene expression, cellularity, and matrix metabolism, while LMHFV alone led to cell loss and increased production of IL-6. However, the combination of E2 and LMHFV had a protective effect against cell loss and decreased IL-6 production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Verena Fischer, Jasmin Maria Buelow, Benjamin Thilo Krueger, Deniz Ragipoglu, Anna Vikman, Melanie Haffner-Luntzer, Konstantinos Katsoulis-Dimitriou, Anne Dudeck, Anita Ignatius
Summary: Previous studies have shown that an increase in mast cells in the bone marrow is associated with age-related and post-menopausal osteoporosis. However, this study found that mast cell-derived RANKL does not contribute to the development of post-menopausal osteoporosis, suggesting that other factors may be responsible for this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Melanie Haffner-Luntzer, Deniz Ragipoglu, Mubashir Ahmad, Astrid Schoppa, Lena Steppe, Verena Fischer, Julia Luther, Timur Yorgan, Ernesto Bockamp, Michael Amling, Thorsten Schinke, Anita Ignatius
Summary: Despite improvements in fracture care, a percentage of fractures still heal poorly. The study investigated the potential of Wnt1 as a molecule to improve bone fracture healing. The results showed that Wnt1 promotes bone formation during fracture healing through YAP/BMP signaling. This suggests that Wnt1 could be used as a therapeutic agent for orthopedic complications.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Merle Stein, Florent Elefteriou, Bjorn Busse, Imke A. K. Fiedler, Ronald Young Kwon, Eric Farrell, Mubashir Ahmad, Anita Ignatius, Liam Grover, Liesbet Geris, Jan Tuckermann
Summary: Major achievements in bone research have relied on animal models and in vitro systems. However, the ethical debate surrounding animal experimentation and advancements in in vitro and in silico techniques have challenged their use. This review provides an overview of the strengths and limitations of animal models, as well as in vitro and in silico technologies, in skeletal research. The authors propose that a combination of the right animal model and state-of-the-art technology is essential for advancing bone research.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Engineering, Biomedical
Lena Schroeter, Friederike Kaiser, Anna-Lena Preissler, Philipp Wohlfahrt, Oliver Kueppers, Uwe Gbureck, Anita Ignatius
Summary: To address the challenges of time-consuming and error-prone preparation of hydroxyapatite (HA) cements for bone defect treatment, researchers have developed a prefabricated magnesium phosphate cement paste based on glycerol. This ready-to-use paste can be directly applied during surgery and shows a promising degradation rate and support for bone regeneration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Orthopedics
Matthias Sukopp, Maoz Shemesh, Elena Pruech, Eran Linder-Ganz, Scott Hacker, Vincenzo Condello, Jonas Schwer, Anita Ignatius, Lutz Duerselen, Andreas Martin Seitz
Summary: The purpose of this in-vitro study was to examine the kinematics of an artificial, free-floating medial meniscus replacement device under dynamic loading situations and different knee joint states. A dynamic knee simulator was used to perform dynamic loading exercises on left human cadaveric knee joints to investigate the knee joint and implant kinematics. The results showed that the non-anchored free-floating device remains within the medial knee joint gap under challenging dynamic loading situations without indicating any luxation tendencies.
JOURNAL OF EXPERIMENTAL ORTHOPAEDICS
(2023)
Article
Endocrinology & Metabolism
Lena Steppe, Benjamin Krueger, Miriam Eva Angelica Tschaffon-Mueller, Jan-Moritz Ramge, Astrid Schoppa, Anita Ignatius, Melanie Haffner-Luntzer
Summary: External mechanostimulation induced by LMHFV has different effects on fracture healing in estrogen-competent and estrogen-deficient rodents. ER alpha signaling in osteoblasts is required for these effects, with ligand-dependent and -independent ER alpha signaling playing different roles. The AF-2 domain of the ER alpha receptor is crucial for the negative effects of vibration during bone fracture healing in estrogen-competent mice, suggesting that the osteoanabolic effects of vibration are mediated by ligand-independent ER alpha signaling.
Article
Orthopedics
Luisa de Roy, Kerstin Eichhorn, Martin Faschingbauer, Klaus Schlickenrieder, Anita Ignatius, Andreas Martin Seitz
Summary: The purpose of this in vitro study was to investigate the effect of hyaluronic acid supplementation on knee joint friction during osteoarthritis progression. The results showed that knee joint friction does not increase with degeneration, and hyaluronic acid supplementation does not lead to an initial decrease in friction.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Meeting Abstract
Dermatology
P. Maity, K. Singh, L. Krug, A. Koroma, W. Bloch, S. Kochanek, M. Wlaschek, M. Schorpp-Kistner, P. Angel, A. Ignatius, H. Geiger, K. Scharffetter-Kochanek
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jana Riegger, Astrid Schoppa, Leonie Ruths, Melanie Haffner-Luntzer, Anita Ignatius
Summary: This article discusses oxidative stress as a major driver of pathophysiological processes in cartilage and bone, including aging, misdirected differentiation, cell death, mitochondrial dysfunction, and impaired mitophagy. It also elaborates on cellular defense mechanisms and therapeutic strategies to improve cell and tissue protection.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Meeting Abstract
Endocrinology & Metabolism
Lena Steppe, Benjamin Thilo Krueger, Miriam Eva Angelika Tschaffon, Verena Fischer, Jan Tuckermann, Anita Ignatius, Melanie Haffner-Luntzer
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)