Article
Chemistry, Physical
Maria Martinez-Negro, Guillermo Gonzalez-Rubio, Emilio Aicart, Katharina Landfester, Andres Guerrero-Martinez, Elena Junquera
Summary: This article discusses the formation of protein corona (PC) on colloidal nanoparticles (NPs) and its impact on the biological behavior of NPs. The focus is on the mechanisms of PC formation and strategies to control PC formation to ensure the successful application of NPs in medicine.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Erica Quagliarini, Luca Digiacomo, Serena Renzi, Daniela Pozzi, Giulio Caracciolo
Summary: The study of liposome-protein corona has evolved over the past decade with multidisciplinary efforts, aiming to understand its synthetic-biological duality and applications in nanomedicine, such as targeted drug delivery, vaccination, imaging, and diagnostics. Future research directions need more attention, and it is hoped to attract the attention of researchers, entrepreneurs, and policymakers.
Article
Food Science & Technology
Ronggang Liu, Deyang Yu, A. M. Abd El-Aty, Mingqian Tan
Summary: The protein corona has the capacity to modify the in vivo behavior and biological effects of FNPs. The effects of protein coronas on the cellular uptake and cytotoxicity of FNPs vary depending on the specific interaction circumstances. Additionally, changes in protein corona diversity and structure can lead to cellular pathway responses and immune responses.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Victoria Leiro, Ana Patricia Spencer, Natalia Magalhaes, Ana Paula Pego
Summary: This article introduces a novel, versatile, and fully biodegradable dendritic nanosystem that can efficiently load and release nucleic acids for gene therapy and other nanomedicine applications. These nanosystems exhibit excellent transfection efficiency and biosafety, offering new possibilities for the development of nanotechnology in theranostics.
Review
Pharmacology & Pharmacy
Mohammad Doroudian, Mohammad H. Azhdari, Nima Goodarzi, David O'Sullivan, Seamas C. Donnelly
Summary: Lung cancer is a significant global health issue, and current therapeutic strategies need to improve specificity and reduce side effects. Nanotechnology can enhance treatment efficiency, and advanced nanotechnology strategies are being used to overcome challenges in lung cancer treatments.
Article
Pharmacology & Pharmacy
Masoud Farshbaf, Hadi Valizadeh, Yunes Panahi, Yousef Fatahi, Meiwan Chen, Amir Zarebkohan, Huile Gao
Summary: In order to successfully translate targeting nanomedicines from bench to bedside, it is necessary to address the common issues of rapid clearance and off-target accumulation. This phenomenon, known as protein corona (PC) formation, occurs when targeting nanoparticles encounter the bloodstream and interact with plasma proteins. The present review discusses the impact of PC on the biological behavior of targeting nanomedicines, as well as the best simulated environment and latest characterization techniques for PC analysis. The article also highlights recent progress in manipulating nano-bio interfaces to achieve optimal therapeutic outcomes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Giulia Tarricone, Valentina Castagnola, Valentina Mastronardi, Lorenzo Cursi, Doriana Debellis, Dinu Zinovie Ciobanu, Andrea Armirotti, Fabio Benfenati, Luca Boselli, Pier Paolo Pompa
Summary: This study demonstrates the therapeutic potential of 5 nm platinum nanoparticles (PtNPs) in effectively scavenging reactive oxygen species (ROS) in different cellular models of the neurovascular unit. The protein corona plays a key role in switching off the catalytic properties of PtNPs, promoting their selective in situ activity. The lysosomal environment enhances the enzyme-like activity of PtNPs, leading to strong antioxidant functionalities.
Review
Nanoscience & Nanotechnology
Ziyuan Li, Yingwen Mu, Cheng Peng, Martin F. Lavin, Hua Shao, Zhongjun Du
Summary: Nanomedicine, a rapidly emerging discipline in biology, medicine, and pharmacology, utilizes silica nanoparticles (SNPs) for drug delivery and biomedical imaging due to their unique properties and biocompatibility. Adverse effects of SNPs in nanomedicine applications are reviewed, along with potential opportunities and challenges for future use.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Angela-Patricia Hernandez, Ania Micaelo, Rafael Pinol, Marina L. Garcia-Vaquero, Jose J. Aramayona, Julio J. Criado, Emilio Rodriguez, Jose Ignacio Sanchez-Gallego, Alicia Landeira-Vinuela, Pablo Juanes-Velasco, Paula Diez, Rafael Gongora, Ricardo Jara-Acevedo, Alberto Orfao, Javier Miana-Mena, Maria Jesus Munoz, Sergio Villanueva, Angel Millan, Manuel Fuentes
Summary: This study evaluated the potential applications of cisplatin-iron oxide nanoparticles and their different functionalization stages. Through both in vitro and in vivo experiments, it was found that these nanodrugs exhibited good biocompatibility and showed therapeutic effects in tumor cells. Animal model studies also confirmed the potential of these nanoparticles as drug delivery vehicles.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Zhenhuan Song, Weizhan Luo, Haichong Zheng, Yunxiang Zeng, Jinlin Wang, Tianfeng Chen
Summary: A translational selenium nanoparticles coated with immune-modulating macromolecule lentinan are designed to restore dysfunctional immune cells in patient-derived malignant pleural effusion microenvironment, enhancing immune responses and inhibiting tumor growth, thereby providing a potential therapeutic strategy for advanced lung cancer patients with MPE.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Medicinal
Marta Gozzi, Benedikt Schwarze, Evamarie Hey-Hawkins
Summary: This paper discusses the potential application of boron-based drugs in the field of nanomedicine and calls on medicinal boron chemists to bridge the gap between the chemistry laboratory and real applications in living systems to promote the development of boron cluster compounds.
Review
Chemistry, Multidisciplinary
Yuwen Wang, Andy Tay
Summary: This review discusses the nano-scale properties of nanomaterials, focusing on nanoparticles, and their impact on nanomedicine. It explores the potential of manipulating the chirality of nanomaterials to enhance biomolecular interactions and improve nanotherapeutics. The review also examines the synthesis, characterization, and applications of chiral nanoparticles, particularly in cancer, immunomodulation, and neurodegenerative diseases, and proposes possible mechanisms for the interaction between chiral nanomaterials and cells for biological manipulation. This timely reminder emphasizes the importance of nanoscale modifications in advancing nanotherapeutics research.
Review
Pharmacology & Pharmacy
Anas Ahmad, Mohammad Imran, Nisha Sharma
Summary: The assessment of human and environmental risks of nanoparticulate material is crucial and requires the development of scientific tools and techniques. Challenges exist in toxicology assessment and regulatory guidance for nanocarriers. Nanotoxicology plays a significant role in pharmaceutical drug development and commercialization potential.
Review
Biotechnology & Applied Microbiology
Xue Bai, Jiali Wang, Qingxin Mu, Gaoxing Su
Summary: Understanding the interactions between engineered nanoparticles (ENPs) and biological systems is crucial for evaluating their safety and developing nanomedicine. Protein corona (PC) formation plays a key role in altering the properties and behaviors of ENPs, impacting their absorption, circulation, distribution, metabolism, and toxicity. In vivo studies on PC formation have shown differences in protein composition and structure compared to in vitro studies, highlighting the importance of considering real-life scenarios in nanomedical research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Yajuan Zou, Masahiro Nishikawa, Heon Gyu Kang, Guoqing Cheng, Wei Wang, Yuquan Wang, Naoki Komatsu
Summary: Functionalization of nanoparticles with triphenylphosphonium (TPP) targeting moiety was explored in this study, revealing the influence of protein corona from fetal bovine serum and human plasma on targeting ability and cytotoxicity. The findings demonstrated that the protein corona could mitigate cytotoxicity of nanoparticle functionalization, but high protein density might reduce the targeting specificity at the subcellular level.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biochemical Research Methods
Estefania Gonzalez-Garcia, Maria Luisa Marina, Maria Concepcion Garcia, Pier Giorgio Righetti, Elisa Fasoli
JOURNAL OF PROTEOMICS
(2016)
Article
Biochemical Research Methods
Maria Vergara-Barberan, Maria Jesus Lerma-Garcia, Maria Nicoletti, Ernesto Francisco Simo-Alfonso, Jose Manuel Herrero-Martinez, Elisa Fasoli, Pier Giorgio Righetti
JOURNAL OF PROTEOMICS
(2017)
Article
Biochemical Research Methods
Maria Jesus Lerma-Garcia, Maria Nicoletti, Ernesto Francisco Simo-Alfonso, Pier Giorgio Righetti, Elisa Fasoli
Article
Biochemistry & Molecular Biology
Maria Nicoletti, Cristian Gambarotti, Elisa Fasoli
Summary: This article discusses the potential application of carbon nanotubes in drug delivery systems, focusing on the characterization of protein corona as a crucial aspect in controlling the toxicity and cell targeting capabilities of nanotubes. The use of polyethylene glycol (PEG) to functionalize multiwalled carbon nanotubes (MWCNTs) and the subsequent incubation in human plasma to create the biocorona were key methods employed in the study. Analysis of the components of the biocorona was conducted through proteomic fingerprinting using methods like SDS-PAGE, 2D-PAGE separation, and mass spectrometry.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Marta Boreggio, Elena Rosini, Cristian Gambarotti, Loredano Pollegioni, Elisa Fasoli
Summary: Oxidation therapy, which involves the controlled production of Reactive Oxygen Species directly into the tumor site, has been introduced as an alternative antitumor approach. In this study, DAAO-functionalized nanotubes were used to produce H2O2 and induce toxic effects to tumor cells. The nanotubes showed potential for biocompatibility and interaction with dysopsonins, but PLGA or highly PEGylated nanotubes also promoted adsorption of immunoglobulins and possibly activated immune response.
MOLECULAR BIOTECHNOLOGY
(2022)
Article
Polymer Science
Filippo Moncalvo, Elisa Lacroce, Giulia Franzoni, Alessandra Altomare, Elisa Fasoli, Giancarlo Aldini, Alessandro Sacchetti, Francesco Cellesi
Summary: This study compares the performance of poly(glycerol monomethacrylate) (PGMA) and poly(poly(ethylene glycol) methyl ether methacrylate) (PPEGMA) as polymer platforms for protein-polymer conjugates. The results highlight the potential of PGMA as an alternative to poly(ethylene glycol) (PEG) for extending the half-life of biotherapeutics.
Article
Biotechnology & Applied Microbiology
Elena Rosini, Marta Boreggio, Matteo Verga, Laura Caldinelli, Loredano Pollegioni, Elisa Fasoli
Summary: The study explores a new cancer treatment strategy by using an external enzyme to convert prodrugs into active anticancer compounds directly in tumor sites. It is found that a D-amino acid oxidase variant with five aminoacidic substitutions (mDAAO) has better therapeutic efficacy than the wild-type DAAO (wtDAAO) in catalyzing the oxidative deamination of D-amino acids. Functionalized multi-walled carbon nanotubes (MWCNTs) with polyethylene glycol (PEG) enhance the activity and cytotoxicity of DAAO, with mDAAO showing higher cytotoxicity at low O-2 concentration.
