GLUT3 and PKM2 regulate OCT4 expression and support the hypoxic culture of human embryonic stem cells

Core Pluripotency Factors Directly Regulate Metabolism in Embryonic Stem Cell to Maintain Pluripotency

(2015) Hyunsoo Kim et al.   STEM CELLS

Effect of Oxygen Tension on the Amino Acid Utilisation of Human Embryonic Stem Cells

(2014) David R. Christensen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

GLUT3 gene expression is critical for embryonic growth, brain development and survival

(2014) Mary O. Carayannopoulos et al.   MOLECULAR GENETICS AND METABOLISM

miR-122 Targets Pyruvate Kinase M2 and Affects Metabolism of Hepatocellular Carcinoma

(2014) Angela M. Liu et al.   PLoS One

HIF-2α Regulates NANOG Expression in Human Embryonic Stem Cells following Hypoxia and Reoxygenation through the Interaction with an Oct-Sox Cis Regulatory Element

(2014) Raffaella Petruzzelli et al.   PLoS One

Control of glioma cell death and differentiation by PKM2–Oct4 interaction

(2014) M Morfouace et al.   Cell Death & Disease

Metabolome and metaboproteome remodeling in nuclear reprogramming

(2013) Clifford DL Folmes et al.   CELL CYCLE

Environmental Oxygen Tension Regulates the Energy Metabolism and Self-Renewal of Human Embryonic Stem Cells

(2013) Catherine E. Forristal et al.   PLoS One

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism

(2013) H.-J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1-3 and PKM2

(2013) Alessandro Prigione et al.   STEM CELLS

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

(2012) Michael S. Goldberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity

(2012) Ben D. MacArthur et al.   NATURE CELL BIOLOGY

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Energy metabolism in nuclear reprogramming

(2011) Clifford DL Folmes et al.   Biomarkers in Medicine

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

(2011) Athanasia D Panopoulos et al.   CELL RESEARCH

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts

(2011) Sandra Varum et al.   PLoS One

Generation of Sheffield (Shef) human embryonic stem cell lines using a microdrop culture system

(2010) Behrouz Aflatoonian et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Hypoxic Culture Maintains Self-Renewal and Enhances Embryoid Body Formation of Human Embryonic Stem Cells

(2010) Hsin-Fu Chen et al.   TISSUE ENGINEERING PART A

Continuous hypoxic culturing maintains activation of Notch and allows long-term propagation of human embryonic stem cells without spontaneous differentiation

(2009) S. M. Prasad et al.   CELL PROLIFERATION

Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions

(2009) Catherine E Forristal et al.   REPRODUCTION

Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain

(2009) S. Varum et al.   Stem Cell Research

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Identification of Oxygen-Sensitive Transcriptional Programs in Human Embryonic Stem Cells

(2008) Suzanne D. Westfall et al.   STEM CELLS AND DEVELOPMENT

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

(2007) Jungwoon Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY