miR-122 Targets Pyruvate Kinase M2 and Affects Metabolism of Hepatocellular Carcinoma
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Title
miR-122 Targets Pyruvate Kinase M2 and Affects Metabolism of Hepatocellular Carcinoma
Authors
Keywords
Hepatocellular carcinoma, Glycolysis, Transfection, Cell metabolism, Gene expression, Oxidative phosphorylation, Oxygen consumption, Small interfering RNAs
Journal
PLoS One
Volume 9, Issue 1, Pages e86872
Publisher
Public Library of Science (PLoS)
Online
2014-01-24
DOI
10.1371/journal.pone.0086872
References
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Note: Only part of the references are listed.- PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis
- (2012) Weiwei Yang et al. CELL
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- (2012) Wei-Chih Tsai et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2012) Barbara Chaneton et al. TRENDS IN BIOCHEMICAL SCIENCES
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- (2011) Martin J. Walsh et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Two-tiered Approach Identifies a Network of Cancer and Liver Disease-related Genes Regulated by miR-122
- (2011) Daniel R. Boutz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Koji Kitamura et al. JOURNAL OF HEPATOLOGY
- Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth
- (2011) Lei Lv et al. MOLECULAR CELL
- Epigenetic Modulation of miR-122 Facilitates Human Embryonic Stem Cell Self-Renewal and Hepatocellular Carcinoma Proliferation
- (2011) Christine J. Jung et al. PLoS One
- Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
- (2011) Q. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
- (2011) D. Anastasiou et al. SCIENCE
- MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties
- (2010) Angela M. Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma
- (2010) Julja Burchard et al. Molecular Systems Biology
- AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma
- (2010) M Z Xu et al. ONCOGENE
- Identification of small molecule inhibitors of pyruvate kinase M2
- (2009) Matthew G. Vander Heiden et al. BIOCHEMICAL PHARMACOLOGY
- Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma
- (2009) Michelle Z. Xu et al. CANCER
- Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma
- (2009) Ling Xiao Liu et al. HEPATOLOGY
- MicroRNA-122 Inhibits Tumorigenic Properties of Hepatocellular Carcinoma Cells and Sensitizes These Cells to Sorafenib
- (2009) Shoumei Bai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
- (2009) Charles J. David et al. NATURE
- Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
- (2009) C Coulouarn et al. ONCOGENE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
- (2009) T. Hitosugi et al. Science Signaling
- MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma
- (2008) Wei-Chih Tsai et al. HEPATOLOGY
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
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