Article
Agricultural Engineering
Ke Jin, Xun Shi, Jiaheng Liu, Wenwen Yu, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu
Summary: Ursolic acid (UA) and oleanolic acid (OA) were synthesized with titers of 7.4 and 3.0 mg/L, respectively, through the heterologous expression and optimization of CrAS, CrAO, and AtCPR1. By redirecting metabolic flux and enhancing the NADPH regeneration system, the titers of UA and OA were increased to 692.3 and 253.4 mg/L in a shake flask, and to 1132.9 and 433.9 mg/L in a 3-L fermenter, respectively, which are the highest reported to date. This study provides a reference for constructing microbial cell factories for efficient terpenoid synthesis.
BIORESOURCE TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anuj Kumar, Gourav Choudhir, Sanjeev Kumar Shukla, Mansi Sharma, Pankaj Tyagi, Arvind Bhushan, Madhu Rathore
Summary: The study identifies three natural metabolites, namely ursolic acid, carvacrol, and oleanolic acid, as potential inhibitors of the main protease (M-pro) of COVID-19. These molecules have stable and favorable energies, passing absorption and metabolism criteria, suggesting they could regulate M-protein function and control viral replication.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Plant Sciences
Juan Wu, Zhu-Jun Ye, Li-Juan Yu, Xuan-Qin Chen
Summary: Two new iridoid glycosides, along with nine known ones, were isolated from Hedyotis diffusa Willd. The structures of them were elucidated by extensive analysis. These compounds showed no significant cytotoxic activity against HeLa cells.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Chemistry, Analytical
Yingping Dai, Dasen Jiang, Xinhe Wang, Di Wu, Wenwen Dong, Qing Fu, Yu Jin, Xinmiao Liang
Summary: In this study, quality evaluations of Hedyotis diffusa (H. diffusa) batches were conducted using rapid fingerprint analysis based on supercritical fluid chromatography (SFC). The results showed that the SFC method is feasible for batch quality evaluation of H. diffitsa, as it allows for the effective extraction and separation of chemical components in H. diffusa. The fingerprint analysis revealed quality differences of H. diffusa based on origin and harvest year.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Food Science & Technology
Kartini Kartini, Nina Wati, Rabbindra Gustav, Risa Wahyuni, Yosua Fernaldi Anggada, Risna Hidayani, Antoni Raharjo, Ridho Islamie, Sulistyo Emantoko Dwi Putra
Summary: This study investigated the wound healing effects of P. major leaf extracts, ursolic acid, and oleanolic acid in hyperglycemic rats. The results showed that these substances can improve wound closure and accelerate healing time without causing acute dermal irritation. It was also found that UA and OA may have different mechanisms of action in promoting wound healing in diabetic conditions.
Article
Biochemistry & Molecular Biology
Natalia Wronska, Michal Szlaur, Katarzyna Zawadzka, Katarzyna Lisowska
Summary: Currently, there is a need for new antimicrobial drugs due to the excessive use of antibiotics and emerging resistance amongst bacteria. This study found that two triterpenoids and one flavonoid displayed antimicrobial activity and showed potential synergistic effects, enhancing the antimicrobial potential.
Review
Biochemistry & Molecular Biology
Marius Mioc, Andreea Milan, Daniel Malita, Alexandra Mioc, Alexandra Prodea, Roxana Racoviceanu, Roxana Ghiulai, Andreea Cristea, Florina Caruntu, Codruta Soica
Summary: This review summarizes recent literature on the mechanism of action of three triterpenic acids and their biological activities. The compounds share similar mechanisms in anticancer, anti-inflammatory, and antidiabetic activities, while also highlighting specific mechanisms for individual triterpenic acids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Karla Catalina Cruz-Torres, Samuel Estrada-Soto, Luis Arias-Duran, Gabriel Navarrete-Vazquez, Julio Cesar Almanza-Perez, Beatriz Mora-Ramiro, Irene Perea-Arango, Emanuel Hernandez-Nunez, Rafael Villalobos-Molina, Gabriela Carmona-Castro, Irma-Martha Medina-Diaz, Gabriela avila-Villarreal
Summary: This study evaluated the effects of a standardized precipitate of Agastache mexicana extract on vasorelaxation and blood pressure. The results showed that the extract induced significant antihypertensive effects by producing nitric oxide and blocking calcium channels to relax rat aortic rings.
Article
Food Science & Technology
Heyu Shen, Jun Wang, Jingfang Ao, Lixia Ye, Yubing Shi, Yujie Liu, Mengyang Li, Anwei Luo
Summary: Inhibition of pancreatic lipase (PL) and cholesterol esterase (CEase) can effectively control blood triglycerides and cholesterol levels. This study investigated the interaction characteristics of pentacyclic triterpenoid acids with PL and CEase and found that they effectively inhibited these enzymes in a competitive manner. The pentacyclic triterpenoid acids disrupted the protein structures of PL and CEase through hydrogen bonding and hydrophobic forces. Molecular docking and simulation confirmed their stable binding to the active sites of PL and CEase. These findings suggest that these compounds could be valuable as digestive enzyme inhibitors.
Article
Chemistry, Multidisciplinary
Zhaleh Khoshsima, Amir Abdolah Mehrdad Sharif, Ahmad Akrami
Summary: This study optimized the ultrasound-assisted extraction of pentacyclic triterpenic acids from jujube fruits using response surface methodology. The optimal conditions were a temperature of 40.34 degrees C, sonication time of 34.63 min, and liquid to solid ratio of 14.85 mL/g. The maximum yields for the triterpenic acids were 304.14 μg/g for betulinic acid, 170.61 μg/g for oleanolic acid, and 195.23 μg/g for ursolic acid.
JOURNAL OF THE MEXICAN CHEMICAL SOCIETY
(2023)
Review
Biochemistry & Molecular Biology
Svenja Wuepper, Kai Lueersen, Gerald Rimbach
Summary: Cyclodextrins are cyclic oligosaccharides with unique structures that enhance the water solubility and bioavailability of lipophilic substances. Complexation with cyclodextrins can improve the stability and bioactivity of natural compounds, while gamma CD itself exhibits metabolic activity, presenting new opportunities for applications.
Article
Biochemistry & Molecular Biology
Sophie Hoenke, Martin A. Christoph, Sander Friedrich, Niels Heise, Benjamin Brandes, Hans-Peter Deigner, Ahmed Al-Harrasi, Rene Csuk
Summary: Acetylated pentacyclic triterpenoids were converted into amides and tested for cytotoxicity, with betulinic acid/trans-1,4-cyclohexyldiamine amide showing excellent cytotoxicity with an EC50 of 0.6 mu M for HT29 colon adenocarcinoma cells.
Article
Biochemistry & Molecular Biology
Mateusz Piet, Roman Paduch
Summary: UA and OA were found to reduce the viability and migration of colorectal cancer cells, decrease the secretion and activity of cancer MMP-2 and-9, and increase the level of cellular E-cadherin. When administered in combination and combined with CPT-11, UA and OA enhanced the anti-tumorigenic activity of the drug. Furthermore, UA and OA exhibited a protective effect towards normal cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Marius Mioc, Alexandra Mioc, Roxana Racoviceanu, Roxana Ghiulai, Alexandra Prodea, Andreea Milan, Lucian Barbu Tudoran, Camelia Oprean, Viviana Ivan, Codruta Soica
Summary: Gold nanoparticle formulation is a promising strategy for enhancing the bioavailability and therapeutic potential of high-lipophilic biologically active compounds. In this study, three triterpen-functionalized gold nanoparticles were synthesized and evaluated for their biological antimelanoma activity. The conjugates exhibited dose-dependent cytotoxic effects on melanoma cells, but no significant toxicity on normal keratinocytes. The functionalized gold nanoparticles showed higher cytotoxicity compared to their parent compounds and induced morphological changes consistent with apoptosis in melanoma cells.
Article
Integrative & Complementary Medicine
Yajing Shi, Yufang Leng, Disheng Liu, Xin Liu, Yixing Ren, Jianmin Zhang, Feng Chen
Summary: The intestinal tract plays a crucial role in protecting tissues from external harmful substances, but damage to the intestinal barrier can lead to systemic complications. Research indicates that ursolic acid and oleanolic acid can alleviate intestinal pathological injury and restore intestinal barrier function.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yu-Chiao Yang, Ming-Chi Wei
FOOD AND BIOPRODUCTS PROCESSING
(2015)
Article
Engineering, Chemical
Ming-Chi Wei, Yu-Chiao Yang
SEPARATION AND PURIFICATION TECHNOLOGY
(2015)
Article
Chemistry, Applied
Ming-Chi Wei, Jianbo Xiao, Yu-Chiao Yang
Article
Agricultural Engineering
Yu-Chiao Yang, Ming-Chi Wei
INDUSTRIAL CROPS AND PRODUCTS
(2016)
Article
Ophthalmology
Kwou-Yeung Wu, Yu-Hung Lai, Yu-Chiao Yang, Wen-Chuan Wu, Show-Jen Hong
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2016)
Article
Chemistry, Multidisciplinary
Ming-Chi Wei, Pei-Hui Lin, Show-Jen Hong, Jin-Ming Chen, Yu-Chiao Yang
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2016)
Article
Food Science & Technology
Hui Teng, Qiyang Lin, Kang Li, Benyao Yuan, Hongbo Song, Hongquan Peng, Lunzhao Yi, Ming-Chi Wei, Yu-Chiao Yang, Maurizio Battino, Carlos L. Cespedes Acuna, Lei Chen, Jianbo Xiao
FOOD AND CHEMICAL TOXICOLOGY
(2017)
Article
Public, Environmental & Occupational Health
Yu-Chiao Yang, Ming-Chi Wei, Show-Jen Hong
INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
(2017)
Article
Chemistry, Multidisciplinary
Ming-Chi Wei, Show-Jen Hong, Yu-Chiao Yang
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2017)
Article
Agriculture, Multidisciplinary
Yu-Chiao Yang, Pei-Hui Lin, Ming-Chi Wei
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2017)
Article
Chemistry, Applied
Yu-Chiao Yang, Ming-Chi Wei
Article
Chemistry, Multidisciplinary
Yu-Chiao Yang, Chia-Sui Wang, Ming-Chi Wei
JOURNAL OF CO2 UTILIZATION
(2019)
Article
Biotechnology & Applied Microbiology
Yu-Chiao Yang, Chia-Sui Wang, Ming-Chi Wei
FOOD AND BIOPRODUCTS PROCESSING
(2019)
Article
Chemistry, Applied
Yu-Chiao Yang, Chia-Sui Wang, Ming-Chi Wei
Article
Food Science & Technology
Yu-Chiao Yang, Chia-Sui Wang, Ming-Chi Wei
LWT-FOOD SCIENCE AND TECHNOLOGY
(2020)
Article
Engineering, Chemical
Yunfei Yu, Xue Yang, Chenchen Zhang, Jie Chen, Wei Lin, Jianqiang Meng
Summary: This study reports an environmentally friendly and simple approach for preparing double-network (DN) ion gel membranes with high strength and excellent gas separation performance. By optimizing crosslinking density, mass ratio, and the type and content of free ionic liquid, the mechanical and gas separation properties of the DN membrane are improved.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Si-qi Jiang, Qiang Gao, Xi-guang Li, Chao-zhu Deng, Jun Qiu, Xiang-nan Zhu
Summary: A dual-strengthening pretreatment method is proposed to remove PVDF more efficiently and enhance the leaching of LiCoO2. Experimental results show that dual-strengthening pretreatment can effectively remove PVDF and significantly improve the leaching efficiency compared to single pretreatment methods.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Zengchi Hu, Xiaoyu Wang, Xiaohui Zhang, Xue Li, Jiangbin Xia
Summary: The rapid fabrication of high-performance composite membranes based on CMPs using simple and low-cost methods is challenging. In this study, three CMPs-based composite membranes were rapidly fabricated with adjustable size using unidirectional diffusion synthesis. The microstructural design enhanced the rejection rates of the membranes and they showed strong hydrolytic resistance, thermal stability, and acid-base resistance. Electrostatic adsorption and the adjustable microstructures significantly varied the repellence of the membranes to different charged molecules.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Farzaneh Rouhani, Matineh Ayedi, Nasser Safari
Summary: Introducing defects into porous metal-organic frameworks is important for improving their adsorption performance. Quasi-MOFs, an underutilized variant of large-scale, fundamentally deficient MOFs, have been found to have substantial amounts of unsaturated metal sites to offset the drawbacks of MOFs. In this study, a quasi-MOF was produced using a water-stable MOF and demonstrated significantly improved phosphate adsorption capability due to the presence of defect sites.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Valentin Reungoat, Morad Chadni, Louis M. M. Mouterde, Fanny Brunissen, Florent Allais, Helene Ducatel, Irina Ioannou
Summary: This study focuses on the recovery of sinapic acid using liquid-liquid extraction assisted by a hollow fiber membrane contactor from an aqueous feed obtained through the hydrolysis of mustard bran. The screening of solvents of different chemical nature showed that all tested solvents had an extraction efficiency of more than 80% for pH < 5. Four solvents were selected for use in the hollow fiber membrane contactor, and the volatile solvents showed higher mass transfer coefficients compared to non-volatile solvents. The extraction efficiency was intensified by increasing the initial concentration of sinapic acid and the feed-to-solvent ratio. CPME was found to have optimal recovery efficiency at a phase ratio of 8:1, yielding 0.9 g of sinapic acid per liter of CPME used.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Takahiro Sakamoto, Takafumi Hanada, Hayate Sato, Mayu Kamisono, Masahiro Goto
Summary: The emergence of the battery society has led to a high demand for battery metals, resulting in a strain on their supply. This study introduces a novel technique using a hydrophobic deep eutectic solvent (DES) for leaching and recovering battery metals from low-grade nickel laterite ores. The DES enables selective leaching and recovery of the metals, offering a promising pathway for the extraction of critical battery metals.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Rongrong He, Jiarui Chen, Chunyao Zhang, Dan Lu, Lin Zhang, Tao He
Summary: Researcher has developed a method to quantify the charge density in nanofiltration (NF) membrane separation layer and applied it in NF membranes that can separate Mg2+ and Li+. The results showed that overcompensated amine groups played a major role, and there was a linear relationship between charge density and coating bi-layers or PAH layers.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Zhijian Zhang, Min Chen, Zhe Lin, Zhichao Yang, Yafeng Du, Zhihui Chen, Zhenhao Yang, Kongyin Zhao, Ligang Lin
Summary: Membrane technology plays an important role in molecular/ion separation processes, but faces challenges such as membrane fouling. This study introduces a new ion-crosslinking method to fabricate copper alginate hydrogel membranes with improved mechanical strength and antimicrobial capabilities. The membranes exhibit excellent separation performance and enhanced long-term molecule/ion separation through improved anti-swelling properties. Molecular dynamics simulations and life cycle analysis highlight the pore structure and environmental friendliness of the hydrogel membranes. These findings provide valuable insights for developing sustainable hydrogel membranes with stable performance and high separation efficiency.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Dongmei Liu, Aiying Guo, Yanling Qi, Zhixin Ji, Hongjuan Li, Zhiwei Zhang, Xinyue Zhang, Kunze Wu, Aijun Cai
Summary: In this study, a stable magnetic Mg/Mn-layered double oxide-doped biochar composite (MgMnLDO-MBC) was prepared and successfully used for the removal of antibiotics and bacteria from wastewater. The composite exhibited enhanced surface areas, adsorption sites, and free radicals, leading to improved catalytic activity. The effects of different factors on the removal efficiency were evaluated, and the composite showed good reusability.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Feng Wang, Zhaoyong Bian, Yaru Zhang, Wenchao Yu, Qiang Zhang, Hui Wang
Summary: In this study, a nanofibrous layered structure of Ff-Ti3C2Tx-Co3O4 was prepared by self-assembling nanofibrous Co3O4 with lamellar fluorine-free MXene (Ff-Ti3C2Tx). The Ff-Ti3C2Tx-Co3O4 exhibited excellent catalytic activity for degradation, resistant to ionic interference, and maintained high removal efficiency of sulfamethoxazole (SMX) in municipal wastewater. The rapid SMX degradation involved fast electron transfer in redox cycles with PMS and the generation of 1O2 via PMS ->center dot O2 -> 1O2. This work provides new insights into antibiotic degradation mechanisms and electron transfer based on PMS activation.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Weipeng He, Jiacheng Luo, Yujie Wu, Tianhao Luo, Chen Tang
Summary: This study comparatively evaluated the role of cationic, anionic, and nonionic polyacrylamides (PAMs) in ballasted flocculation of clay suspensions under different aluminum sulfate (AS) coagulant dosages. The selection of PAMs and AS dosage had a significant influence on the size and shear resistance of ballasted floc aggregates.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Lixian Wang, Lizhi Zhao, Didi Si, Zhixin Li, Huiqin An, Hui Ye, Qingping Xin, Hong Li, Yuzhong Zhang
Summary: Metalloporphyrin-based nanozymes integrated with poly (vinylidene fluoride) membrane show high catalytic activity and reusability for the decolorization of Congo Red dye in continuous flow process.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Yongfei Ma, Chenyu Zeng, Yongzhen Ding, Jiayi Tang, Ondrej Masek, Zhikang Deng, Rui Mu, Zulin Zhang
Summary: In this study, sludge-derived biochar (SBC) was functionalized with various iron salts to enhance its adsorption ability for sulfamethoxazole (SMX) and magnetic collection performance. Ball milling was further employed to treat the optimal iron salt functionalized SBC (MSBC), resulting in ball milled SBC (BMSBC) with improved adsorption performance for SMX. The dominant driving mechanism for SMX adsorption onto BMSBC was confirmed to be multiple physicochemical forces, including 7C-7C conjugation, pore filling, H-bonding, Fe-O complexation, and electrostatic interactions. BMSBC exhibited favorable adsorption ability for SMX in actual waters and could be easily collected within 1 min due to its magnetic sensitivity.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Jinglin Tan, Xiaohui Mao, Wenjihao Hu, Hongbo Zeng
Summary: This study investigates the influence of PDMS chain architectures on surface properties and reveals that PDMS coatings with looped structures exhibit superior hydrophobicity, self-cleaning, and water sliding compared to coatings with linear structures. Additionally, both looped and linear PDMS coated stainless steel mesh/polyester fibers show efficient separation of oil/water mixture.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Wei-Liang Chen, Chih-Chia Cheng, Chien-Hsing Lu, Jem-Kun Chen
Summary: This study designs a novel sandwich-structured capacitor that reduces the absorption time of pollutants using dielectrophoresis force. By coating graphene oxide on polystyrene microspheres as adsorbents and encapsulating them within the capacitor, the adsorption rate is significantly enhanced. Additionally, frequency manipulation allows for the recycling of adsorbents and concentration of dyes, minimizing secondary pollution.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)