Article
Polymer Science
Nanticha Danmatam, Wanwipa Nakburee, John Pearce, Datchanee Pattavarakorn
Summary: This study fabricated electroactive hydrogels using carboxymethyl cellulose (CMC) biopolymer and conductive polythiophene (PTh). The PTh particles dispersed uniformly in the CMC matrix, leading to improved mechanical properties and thermal stability. The hydrogel with 6%wt PTh showed the highest tensile strength and elongation at break. The hydrogel with 10%wt PTh exhibited the highest bending angle under an applied electric field.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Ahmed Ali Nada, Anita Eckstein Andicsova, Jaroslav Mosnacek
Summary: This article reviews the significance of electrically conductive materials fabricated from natural polymers in various applications. It discusses the preparation methods and properties of conductive polymers and hydrogels, with a focus on those that can be synthesized from renewable resources. The article also presents the self-healing systems and electrical conductivity values of conductive hydrogels based on natural polymers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Polymer Science
Zexing Deng, Yi Guo, Xin Zhao, Tianming Du, Junxiong Zhu, Youlong Xie, Fashuai Wu, Yuheng Wang, Ming Guan
Summary: This paper reviews the design and applications of PNIPAM-based conductive hydrogels, and discusses their stimuli-responsive properties. PNIPAM-ECHs have a wide range of applications in human motion detection, actuators, controlled drug release, wound dressings, etc.
Article
Materials Science, Multidisciplinary
Mayank Goswami, Rajkumar Sadasivam, Gopinath Packirisamy
Summary: This study presents an Avastin loaded PHEMA hydrogel lens as a topical implant for the therapy of diabetic retinopathy (DR). The lens is designed using a novel and cost-effective 3D printed platform, with contours similar to a commercial contact lens for patient comfort and drug delivery capabilities. The release kinetics of the lens follows the Korsmeyer-Pappas (KP) release model, resulting in 40-60% anti-VEGF effects.
Article
Energy & Fuels
Jakub Bernat, Jakub Kolota
Summary: Dielectric electroactive polymers are widely used in smart materials applications due to their softness and responsiveness to electric stimuli, particularly in actuators. Research has been focused on improving the design of these actuators by modifying the bias mechanism or providing new configurations like double cones. This study analyzed the modification of actuator shape, using an elliptical shape to achieve a wider range of movement, with the new design and model of the device described and verified through measurements.
Article
Nanoscience & Nanotechnology
Yerin Shin, Moon-Young Choi, Jongseon Choi, Jun-Hee Na, So Yeon Kim
Summary: The study designed two electrically responsive hydrogels with fast response properties that can achieve bending deformation even under a low electric field.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
G. Huseynova, J. Lee, J. -h. Lee, J. -h. Lee
Summary: Organic semiconductors (OSCs) have unique mechanical and optical properties that make them suitable for developing lightweight and flexible electronic devices, but their inferior electrical conductivity compared to inorganic semiconductors (ISCs) limits commercial applications. This review article focuses on controlling and adjusting the electrical conductivity of OSCs through electrical doping, with an emphasis on charge generation efficiency (CGE) and charge separation efficiencies.
MATERIALS TODAY ENERGY
(2021)
Review
Chemistry, Multidisciplinary
Yizhou Yang, Karl Borjesson
Summary: Covalent organic frameworks (COFs) with covalent bond-supported crystallinity and high encapsulating ability have been widely utilized in organic electronics as conductive or semiconductive components for electronic devices like organic photodetectors, photovoltaics, transistors, light-emitting devices, sensors, and memory devices. General tactics to provide electroactive functionalities are also discussed, offering open considerations and inspiration for future electronic design.
TRENDS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Asghar Khan, Wajid Rehman, Mohammed M. Alanazi, Yaqoob Khan, Liaqat Rasheed, Abdul Saboor, Shahid Iqbal
Summary: A multifunctional hydrogel wound dressing with suitable mechanical properties, adhesiveness, self-healing ability, antibacterial properties, and radical scavenging ability, as well as the ability to retain moisture around the wound, has been designed in this study for clinical application in treating cutaneous wounds healing. The hydrogel showed favorable properties such as excellent tensile strength, suitable gelation time, adhesiveness, and interconnected porous structure. In addition, the hydrogel demonstrated excellent exudate uptake capacity, high swelling ratio, long-term antibacterial activity, promising antioxidant efficiency, wound moisturizing ability, hemostatic efficiency, and fast self-healing ability. In vivo experiments indicated that the hydrogel can significantly promote the healing rate of artificial wounds in rats. Histological analysis revealed higher granulation tissue thickness, collagen deposition, and marked increase in hydroxyproline at the wound site during the healing process. Based on the results from both in vivo and in vitro assays, the electroactive hydrogel with multifunctional properties holds great potential for treating chronic wound healing and skin regeneration.
Article
Polymer Science
Nanticha Danmatam, John T. H. Pearce, Datchanee Pattavarakorn
Summary: Self-healable electroactive carboxymethyl cellulose/polythiophene/acid hydrolyzed cellulose (CMC/PTh/AHC) hydrogels were fabricated and investigated for their electro-responsive and self-healing performances.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Teresa Marques-Almeida, Clarisse Ribeiro, Igor Irastorza, Patricia Miranda-Azpiazu, Ignacio Torres-Aleman, Unai Silvan, Senentxu Lanceros-Mendez
Summary: Since the first cultivation of neurons outside living organisms over a century ago, various experimental techniques have been developed for their in vitro maintenance. However, the impact of the properties of the surface to which neurons adhere in vitro has not been sufficiently considered.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Electrical & Electronic
Yongyi Zhao, Yunsik Ohm, Jiahe Liao, Yichi Luo, Huai-Yu Cheng, Phillip Won, Peter Roberts, Manuel Reis Carneiro, Mohammad F. F. Islam, Jung Hyun Ahn, Lynn M. M. Walker, Carmel Majidi
Summary: Self-healing hydrogels have the potential to recover from physical damage caused by extreme strain, pressure, or tearing. However, their low electrical conductivity limits their application in stretchable and mechanically robust circuits. In this study, we developed an organogel composite with high electrical conductivity, low stiffness, and high stretchability by embedding silver microflakes and gallium-based liquid metal microdroplets in a poly(vinyl alcohol)-sodium borate matrix. The composite also exhibited spontaneous mechanical and electrical self-healing. Furthermore, we addressed the rapid drying issue of hydrogel materials by using an organic solvent, which maintained the properties of the composite for over 24 hours in an ambient environment. We demonstrated the potential applications of the self-healing organogel composite in soft robotics, soft circuits, and reconfigurable bioelectrodes.
NATURE ELECTRONICS
(2023)
Article
Engineering, Biomedical
Mahima Bansal, Brad Raos, Zaid Aqrawe, Zimei Wu, Darren Svirskis
Summary: Recent advancements in drug delivery have enabled the specific release of bioactive agents from neural implants to local tissues. A stable conducting polymer hydrogel (CPH) composed of GelMA and PPy was developed for electrically controlled delivery of glutamate. The CPH showed significantly higher Glu release compared to conventional PPy/Glu films, making it suitable for implantable drug delivery applications.
ACTA BIOMATERIALIA
(2022)
Review
Chemistry, Multidisciplinary
Aokai Zhang, Feng Wang, Lian Chen, Xianshuo Wei, Maoquan Xue, Feng Yang, Shaohua Jiang
Summary: This review provides a comprehensive description of stimuli-responsive hydrogels fabricated using light-responsive and extrusion-based 3D printing technologies, discussing actuator mechanisms, applications, as well as recent advancements in enhancing toughness and design tools.
CHINESE CHEMICAL LETTERS
(2021)
Review
Electrochemistry
Abdullah, Katarzyna Krukiewicz
Summary: The application of conjugated polymers in electronics, particularly in charge storage devices, biosensors, and microbial fuel cells, has been increasing. Recent studies have shown that immobilization of electroactive bacteria within conjugated polymers can enhance their electrical conductivity and charge storage. This review summarizes recent attempts to immobilize whole bacterial cells and their proteins on the surface or within conjugated polymers, such as poly(3,4-ethylenedioxythiophene) and polypyrrole, in order to design novel electrically-conducting biohybrid materials with potential applications in organic electronics and bioelectronics.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Yaron Hillman, Jenia Gershberg, Dan Lustiger, Dan Even, Dor Braverman, Yael Dror, Idan Ashur, Sefi Vernick, Neta Sal-Man, Yariv Wine
Summary: The antibiotic resistance crisis is predicted to lead to 10 million deaths annually by 2050. To address this impending challenge, the development of novel and rapid diagnostic tools is urgently needed. Through the creation of the monoclonal antibody mAb-EspB-B7, effective and stable differentiation of pathogenic bacteria is possible, showing promise as a key component in future rapid diagnostic tools.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Electrical & Electronic
Tali Dotan, Yuval Berg, Lorenzo Migliorini, Sara Moon Villa, Tommaso Santaniello, Paolo Milani, Yosi Shacham-Diamand
Summary: Soft and flexible microelectrodes were fabricated by integrating gold nanoparticles onto PDMS using SCBD and femtosecond laser processing. This method allows for high resolution patterning on soft substrates and is suitable for applications requiring low-current signal transmission.
MICROELECTRONIC ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Leeya Engel, Claudia G. Vasquez, Elizabeth A. Montabana, Belle M. Sow, Marcin P. Walkiewicz, William Weis, Alexander R. Dunn
Summary: Using photo-micropatterning techniques, endothelial cells were optimally positioned on EM grids, increasing the distance between cell-cell contacts and thinning cell nuclei for direct imaging. This enhanced the rate of data acquisition for cellular cryo-electron tomography studies by allowing for high-throughput imaging of intercellular contacts.
JOURNAL OF STRUCTURAL BIOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Naftaly Krakover, B. Robert Ilic, Slava Krylov
Summary: We report on the architecture and operational principle of a resonant cantilever-type displacement sensor. The device is actuated electrostatically and its unique electrode geometry enhances the frequency sensitivity. The dependencies of the device frequency on the beam's deflections and actuation voltages were mapped using a reduced order model backed by numerical simulations. The suggested approach may find applications in a broad range of micro and potentially nano-scale applications.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Asaf Asher, Rivka Gilat, Slava Krylov
Summary: This study investigates the spectral behavior of initially curved circular microplates loaded by a distributed nonlinear electrostatic force and finds that the plates have interesting features of being initially bell-shaped with both positive and negative curvature, and exhibiting snap-through buckling and bistability. The results show that the modes of slightly curved bell-shaped unloaded plates differ significantly from those of initially flat plates, and the sensitivity of natural frequencies to plate deflection is higher near the critical configurations.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemical Research Methods
Ingrid Amer Cid, Lenny Van Daele, Peter Dubruel, Kristiaan Neyts, Filip Strubbe
Summary: Understanding the adsorption of polymers onto particles is crucial for many technological and biomedical applications. This study investigates the use of single-particle electrophoresis to directly analyze the adsorption kinetics of cationic polymers onto anionic particles. The results show that this technique enables accurate measurement and comparison of the kinetics of polymer adsorption on the single-particle level.
Article
Biochemistry & Molecular Biology
Manon Minsart, Nicolas Deroose, Laurens Parmentier, Sandra Van Vlierberghe, Arn Mignon, Peter Dubruel
Summary: This research focuses on the development of hydrogel-based wound dressings with high mechanical strength and exudate absorption capacities. The synthesized AUP materials show high gel fractions and strong swelling degrees, as well as tunable mechanical properties. They exhibit higher swelling degrees and mechanical resistance compared to commercial dressings. The materials also show excellent biocompatibility and have the potential to compete with commercially available dressings.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Materials Science, Biomaterials
Nathan Carpentier, Luca Urbani, Peter Dubruel, Sandra Van Vlierberghe
Summary: Drug induced liver injury (DILI) is a major reason for drug withdrawal during drug development. Currently, there is a lack of reliable in vitro models that can mimic the liver environment and function. This review discusses different approaches for the development of liver models in tissue engineering.
BIOMATERIALS SCIENCE
(2023)
Article
Electrochemistry
Tali Dotan, Michael Nazarenko, Yuval Atiya, Yosi Shacham-Diamand
Summary: We conducted a study on the transport effects of a microfluidic sensor-chip, where electrochemical sensing is enhanced by redox cycling using an interdigitated electrode array (IDA). We developed a comprehensive three-dimensional simulation model and a simple one-dimensional model to analyze the transition velocity between the two dominant regimes. The results show that one regime is limited by redox cycling diffusion (a unique feature of IDAs), while the other regime is limited by convection and has significant flow effects. The transition velocity between the two regimes is found to be vflow = 0.335 L[mu m] + 0.04, which matches the prediction of the one-dimensional model that vflow is proportional to 1/L.
ELECTROCHIMICA ACTA
(2023)
Article
Engineering, Electrical & Electronic
Omer HaLevy, Neta Melech, Stella Lulinsky, Slava Krylov
Summary: We present a theoretical and experimental study on the feasibility of a resonant sensing device with a compliant, parallel linkage-type, force amplification architecture. The device utilizes a resonator clamped at its ends to two proof masses connected to the substrate via oblique linkages, resulting in significant force amplification. The simple Manhattan geometry and low parasitic compliance of the device enable axial loading of the resonator without bending. Experimental results show good agreement with predicted sensitivity, indicating the potential for high-end robust inertial sensors.
IEEE SENSORS JOURNAL
(2023)
Article
Engineering, Mechanical
Nir Dick, Slava Krylov
Summary: This article investigates the spectral content and parametric resonant dynamics of an array of elastically and electrostatically coupled interdigitated micro cantilevers. The results show that the shape of eigenvectors and the frequencies can be influenced and tuned by voltage. Moreover, sub-critical electrostatic coupling requires lower actuating voltages for parametric resonance compared to strongly coupled arrays.
Article
Engineering, Electrical & Electronic
Erez Benjamin, Ronen Maimon, Slava Krylov
Summary: In this letter, a new design of an in-plane moving rotational device with integrated electrostatic actuation is reported. The device, based on three off-center anchored beams, allows tailoring of its bistability and achieving large tilting angles without actuation-related instabilities by combining high rotational compliance with high lateral stiffness. The fabricated devices from silicon on insulator wafers showed bistable behavior and rotation angles up to 11 degrees, consistent with the finite-elements model prediction.
IEEE SENSORS LETTERS
(2023)
Article
Materials Science, Biomaterials
Lenny Van Daele, Babs van de Voorde, Robin Colenbier, Lobke De Vos, Laurens Parmentier, Louis Van der Meeren, Andre Skirtach, Ruslan I. Dmitriev, Peter Dubruel, Sandra Van Vlierberghe
Summary: Cardiovascular diseases are the leading cause of death worldwide. Poly(alkylene terephthalate)s (PATs) with longer alkyl chain lengths show potential for improving compliance in vascular graft materials. This study investigated the effects of polymer molar mass and alkyl chain length on the surface properties of spin-coated PAT films, as well as endothelial cell adhesion and proliferation. The results showed that higher molar mass and longer alkyl chain lengths increased surface roughness, while no significant trend was observed for wettability. All investigated PATs were non-cytotoxic and supported endothelial cell adhesion and growth, with some PATs even promoting angiogenic maturation.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Engineering, Electrical & Electronic
Peleg Levin, Amit Yonaei, Slava Krylov
Summary: In this paper, the response of variously shaped parallel plates electrostatic MEMS actuators to a step-function actuation subject to squeeze-film damping is studied. A new lumped model is introduced, which enables rapid estimation of switching times and calibration of the effective viscosity correction function through direct measurement of dynamic response. Comparison with numerical simulations and experiments shows the accuracy of the model predictions.
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
(2023)
Review
Materials Science, Biomaterials
Jasper Delaey, Lobke De Vos, Carina Koppen, Peter Dubruel, Sandra Van Vlierberghe, Bert Van den Bogerd
Summary: Currently, the treatment of corneal diseases caused by damage to the corneal endothelium requires a donor cornea. Researchers are investigating alternative approaches, such as tissue engineered scaffolds, to overcome the limited availability of donor tissue. This review provides an overview of the characteristics of different materials and discusses their suitability as scaffolds for corneal endothelial cells. It also proposes a consistent approach for future research in membrane characterization to enable a scientific comparison of different materials and membranes.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
