Blunted epidermal l-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: epidermal H2O2/ONOO−-mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low serotonin and melatonin levels

Six Decades of Vitiligo Genetics: Genome-Wide Studies Provide Insights into Autoimmune Pathogenesis

(2011) Richard A. Spritz   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Common variants in FOXP1 are associated with generalized vitiligo

(2010) Ying Jin et al.   NATURE GENETICS

Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else?

(2009) Lübeck Ralf Paus et al.   EXPERIMENTAL DERMATOLOGY

Enhanced DNA binding capacity on up-regulated epidermal wild-type p53 in vitiligo by H2O2-mediated oxidation: a possible repair mechanism for DNA damage

(2009) Mohamed M. A. E. L. Salem et al.   FASEB JOURNAL

Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair

(2009) J. M. Wood et al.   FASEB JOURNAL

The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19)

(2009) Michał A. Żmijewski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

LysRS Serves as a Key Signaling Molecule in the Immune Response by Regulating Gene Expression

(2009) Nurit Yannay-Cohen et al.   MOLECULAR CELL

Viewpoint 4

(2008) Andrzej Slominski et al.   EXPERIMENTAL DERMATOLOGY

Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair

(2008) Tobias W. Fischer et al.   EXPERIMENTAL DERMATOLOGY

Computer simulation of heterogeneous single nucleotide polymorphisms in the catalase gene indicates structural changes in the enzyme active site, NADPH-binding and tetramerization domains: a genetic predisposition for an altered catalase in patients with vitiligo?

(2008) John M. Wood et al.   EXPERIMENTAL DERMATOLOGY

Presence of epidermal allantoin further supports oxidative stress in vitiligo

(2008) Mohammad Shalbaf et al.   EXPERIMENTAL DERMATOLOGY

From basic research to the bedside: efficacy of topical treatment with pseudocatalase PC-KUS in 71 children with vitiligo

(2008) Karin U. Schallreuter et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Identification of epidermal L-tryptophan and its oxidation products byin vivoFT-Raman Spectroscopy further supports oxidative stress in patients with vitiligo

(2008) Hartmut Rokos et al.   JOURNAL OF RAMAN SPECTROSCOPY

Melatonin in the skin: synthesis, metabolism and functions

(2008) Andrzej Slominski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Methionine Sulfoxide Reductases A and B Are Deactivated by Hydrogen Peroxide (H2O2) in the Epidermis of Patients with Vitiligo

(2007) Karin U. Schallreuter et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland

(2007) Roseli Barbosa et al.   LIFE SCIENCES