Article
Cell Biology
Kajohnkiart Janebodin, Rakchanok Chavanachat, Aislinn Hays, Morayma Reyes Gil
Summary: The study aimed to investigate the role of VEGFR-2 in odontoblast differentiation of dental pulp stem cells (DPSCs) by knocking down the expression of VEGFR-2. The results showed that VEGFR-2 is crucial for odontoblast differentiation in DPSCs, and deficiency of VEGFR-2 may impair the differentiation of odontoblast cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zheng Fang, Devi Atukorallaya
Summary: Tooth number anomalies are common congenital dental problems, and the precise number of teeth is crucial for proper function and aesthetics. This article proposes a regulatory network for tooth number based on the dentition formation process and summarizes recent studies on early tooth development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
S. M. Ziauddin, Misako Nakashima, Hideto Watanabe, Michiyo Tominaga, Koichiro Iohara
Summary: This study compared the stem cell properties and pulp regenerative potential of DT-DPSCs and PT-DPSCs from the same individual. The results showed that DT-DPSCs exhibited higher expression of stem cell markers and angiogenic factors compared to PT-DPSCs. DT-DPSC-derived conditioned medium also promoted increased cell proliferation, migration, and angiogenesis. Furthermore, the regenerated pulp tissues in both DT-DPSCs and PT-DPSCs groups were similar. Therefore, DT-DPSCs could be a potential alternative to PT-DPSCs for pulp regenerative therapy.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Rung-Shu Chen, Sheng-Hao Hsu, Hao-Hueng Chang, Min-Huey Chen
Summary: The study aimed to explore the feasibility of using adult dental pulp stem cells on polylactic acid scaffolds for tooth regeneration through experiments on dogs. The mineralization degree in the experimental group with cells seeded in the scaffolds was significantly higher than the control group, indicating the importance of dental pulp stem cells for tooth regeneration. However, there was incomplete absorption of the HA/PLA scaffolds in both groups, suggesting the need for a more rapidly absorbable material in scaffold design.
Article
Evolutionary Biology
Tyler A. Square, Shivani Sundaram, Emma J. Mackey, Craig T. Miller
Summary: The study found that a similar set of genes are expressed during tooth regeneration in zebrafish and stickleback, demonstrating a high degree of conservation in the process. This suggests that despite differences in morphology and regeneration mechanisms, two fish species still share common genetic programs in their tooth regeneration processes.
Review
Cell Biology
Kyu Hwan Kwack, Hyeon-Woo Lee
Summary: Dental caries is a common disease that causes damage to teeth and pulp tissue. Dental pulp stem cells have multipotency, high proliferation rate, and immunosuppressive properties, making them ideal for regenerating damaged pulp tissue.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Physiology
Huihui Ren, Quan Wen, Qingxuan Zhao, Nan Wang, Yuming Zhao
Summary: Dental pulp plays a crucial role in maintaining tooth function and pulp-regeneration therapy shows promise in clinical practice. However, the mechanisms of pulp regeneration and the role of dental stem cells are not fully understood. This study used single-cell RNA sequencing analysis to explore the development of dental pulp and stem cells at different stages. The results revealed temporal changes in the composition of pulp cells and identified subpopulations of odontoblasts and mesenchymal stem cells. These findings may provide insights into tooth development and improve the success of dental pulp regeneration.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Hiroki Nagai, Luis Augusto Eijy Nagai, Sohei Tasaki, Ryuichiro Nakato, Daiki Umetsu, Erina Kuranaga, Masayuki Miura, Yuichiro Nakajima
Summary: Nutrient fluctuation induces dedifferentiation in Drosophila adult midgut and drives adaptive intestinal growth by converting enteroendocrine cells into functional intestinal stem cells.
DEVELOPMENTAL CELL
(2023)
Article
Chemistry, Multidisciplinary
Anton L. Popov, Nadia M. Zholobak, Alexander B. Shcherbakov, Taisiya O. Kozlova, Danil D. Kolmanovich, Artem M. Ermakov, Nelli R. Popova, Nikita N. Chukavin, Ernest A. Bazikyan, Vladimir K. Ivanov
Summary: The toxic effects of cerium and fluoride species on human dental pulp stem cells and epithelial cells were studied. Cerium fluoride nanoparticles showed no cytotoxicity or genotoxicity to dental pulp stem cells and even increased cell proliferation and differentiation at certain concentrations. Furthermore, the formation of cerium fluoride provided protection against oral diseases.
Review
Biochemistry & Molecular Biology
Anastasia Ariano, Francesca Posa, Giuseppina Storlino, Giorgio Mori
Summary: Teeth contain mesenchymal stem cells (MSCs) that promote tooth growth and repair. Dental-derived stem cells (d-DSCs), including dental pulp stem cells (DPSCs) and dental bud stem cells (DBSCs), have shown great potential in bone tissue engineering. The use of bone-associated factors and small molecular compounds has been found to enhance stem cell differentiation and osteogenesis. Natural and non-natural compounds found in fruits, vegetables, and drugs have also been explored for their ability to enhance MSC osteogenic differentiation and bone formation. This review focuses on the research conducted in the past decade on DPSCs and DBSCs, aiming to identify compounds that can stimulate d-DSC proliferation and osteogenic differentiation for bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ancuta Goriuc, Liliana Foia, Karina Cojocaru, Diana Diaconu-Popa, Darius Sandu, Ionut Luchian
Summary: Periodontitis is a challenging inflammatory condition characterized by the deterioration of tooth support structures. Regeneration of periodontal tissues using stem cells, such as dental mesenchymal stem cells (DMSCs), non-dental stem cells, and induced pluripotent stem cells (IPSCs), shows promise but remains a challenge in clinical practice due to their complex physiological characteristics and the surrounding inflammatory microenvironment.
Review
Physiology
Bing-Dong Sui, Chen -Xi Zheng, Wan -Min Zhao, Kun Xuan, Bei Li, Yan Jin
Summary: Teeth are highly specialized organs that perform important functions for humans. However, they have limited ability to repair themselves, leading to a high prevalence of tooth loss and defects worldwide. Regenerative medicine offers the potential for restoring lost or damaged teeth, and recent advancements in developmental engineering have made tooth regeneration possible. Mesenchymal condensation, a key process in tooth development, has been studied and utilized for regenerative purposes, resulting in successful tooth regeneration in animals and humans. This review summarizes the process of mesenchymal condensation and highlights the achievements and mechanisms of tooth regeneration through condensation-mimetic engineering using dental stem cells.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Anatomy & Morphology
Keiffer L. Williams, Kory M. Evans, Andrew M. Simons
Summary: Traditional classification systems for teleost tooth replacement and attachment underestimate the diversity of teleost teeth. This study on the Pacific Leaping Blenny reveals novel modes of tooth replacement and attachment, challenging historical classification modes and providing a reliable framework for future comparative studies.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2022)
Review
Cell Biology
Cangwei Liu, Hao Guo, Ce Shi, Hongchen Sun
Summary: Short root anomaly (SRA) can cause tooth loss and affect patients' health. Dental implants have limitations compared to natural tooth roots, and tissue engineering-mediated root regeneration offers a more natural function. This article reviews the roles of Bone Morphogenetic Proteins (BMPs) in tooth root development and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yuyang Chen, Xiayi Wang, Zhuoxuan Wu, Shiyu Jia, Mian Wan
Summary: Dental-derived stem cells, such as DPSCs, SHEDs, SCAPs, DFPCs, and PDLSCs, have excellent proliferation ability and multi-directional differentiation potential. They have significant application prospects in tissue regeneration due to their abundance, biocompatibility, and effectiveness. Epigenetic regulation plays a crucial role in the biological functions of dental-derived stem cells, and their potential for pulp and periodontal regeneration is highly promising.
Article
Anatomy & Morphology
Fernanda de Paula, Abigail S. Tucker, Tathyane Harumi N. Teshima, Milena Monteiro de Souza, Claudia Malheiros Coutinho-Camillo, Marcello Menta S. Nico, Silvia Vanessa Lourenco
Summary: Aquaporins (AQPs) play essential roles in regulating water and ion transport through cell membranes. In salivary glands (SGs), different members of the AQP family exhibit distinct expression patterns during embryonic development, with AQP-1 and AQP-3 predominantly expressed during early stages of morphogenesis and associated with mitotic processes, while AQP-5 is predominantly expressed during late stages of morphogenesis. These complementary expression patterns of AQPs may contribute to the development of salivary glands.
JOURNAL OF ANATOMY
(2021)
Article
Biology
Morag A. Lewis, Neil J. Ingham, Jing Chen, Selina Pearson, Francesca Di Domenico, Sohinder Rekhi, Rochelle Allen, Matthew Drake, Annelore Willaert, Victoria Rook, Johanna Pass, Thomas Keane, David J. Adams, Abigail S. Tucker, Jacqueline K. White, Karen P. Steel
Summary: Our study demonstrates that spontaneous mutations with observable effects on phenotype are a common occurrence in intensive breeding programs, including targeted mutation programs. These spontaneous mutations within mutant lines can complicate phenotypic analyses, underscoring the importance of record-keeping and maintaining accurate pedigrees.
Article
Genetics & Heredity
Piranit Kantaputra, Yeliz Guven, Tugba Kalayci, Pelin Karaca Ozer, Wannakamon Panyarak, Worrachet Intachai, Bjorn Olsen, Bruce M. Carlson, Oranud Praditsap, Sissades Tongsima, Chumpol Ngamphiw, Peeranat Jatooratthawichot, Abigail S. Tucker, James R. Ketudat Cairns
Summary: Mutations in LTBP3 gene are associated with Dental Anomalies and Short Stature syndrome, causing dental problems, short stature, and prognathic mandible. We report novel and recurrent LTBP3 variants in a Turkish family affected with DASS. These variants result in abnormal LTPB3 protein, disrupting TGF beta secretion and activation.
Article
Cell Biology
Olivier Mauduit, Marit H. Aure, Vanessa Delcroix, Liana Basova, Amrita Srivastava, Takeshi Umazume, Jacqueline W. Mays, Saverio Bellusci, Abigail S. Tucker, Mohammad K. Hajihosseini, Matthew P. Hoffman, Helen P. Makarenkova
Summary: FGF10 plays a critical role in fetal organ development, and our study reveals that both mesenchymal and epithelial cells express FGF10 in the salivary gland. Specifically, epithelial FGF10 cells are specialized ionocytes important for the ionic modification of saliva.
Article
Dentistry, Oral Surgery & Medicine
Piranit Kantaputra, Peeranat Jatooratthawichot, Kanoknart Chintakanon, Worrachet Intachai, Prapat Pradermdutsadeeporn, Ploy Adisornkanj, Sissades Tongsima, Chumpol Ngamphiw, Bjorn Olsen, Abigail S. Tucker, James R. Ketudat Cairns
Summary: This study investigates the molecular causes of oral exostoses and dental anomalies in 14 patients from eight families. Mutations in the LRP6 gene were identified and found to be associated with various oral features such as oral exostoses, root defects, and tooth agenesis. The analysis of these mutations sheds light on their potential impact on the structure and function of the LRP6 protein.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Anatomy & Morphology
Tengyang Qiu, Abigail S. Tucker
Summary: This study followed the development of the vestibular lamina (VL) in mice, from embryonic stage to postnatal formation, and discovered the roles of proliferation, apoptosis, and terminal differentiation in vestibule formation. It also compared the VL development between mice and humans, providing insights into a lesser-known aspect of oral anatomy and shedding light on defects in this region.
JOURNAL OF ANATOMY
(2023)
Article
Genetics & Heredity
Juan M. Fons, Natalie J. Milmoe, Michael R. G. Dack, Leena Joshi, Hannah Thompson, Abigail S. Tucker
Summary: The incidence of chronic otitis media is higher in individuals with craniofacial syndromes, suggesting that defects in the formation of the middle ear can increase susceptibility to middle ear inflammation. Research on Eya1 heterozygous mice, which mimic defects found in branchio-oto-renal (BOR) syndrome patients, revealed cavitation defects and retained mesenchyme in the middle ear, leading to the development of chronic otitis media. The study also demonstrated the link between bulla size defects and the presence of retained mesenchyme.
FRONTIERS IN GENETICS
(2022)
Review
Biotechnology & Applied Microbiology
Hiba Asrar, Abigail S. Tucker
Summary: Major organs and tissues require close association with the vasculature during development and for later function. Recent research has revealed novel roles for endothelial cells in tissue morphogenesis and differentiation, highlighting the importance of providing a vasculature when constructing tissues and organs for tissue engineering. Important signaling pathways regulating the cross talk between endothelial cells and their environment have been identified in various organ systems.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Evolutionary Biology
Neal Anthwal, Abigail S. Tucker
Summary: The temporomandibular joint (TMJ) is an important feature of mammals, evolved early in the mammalian ancestral lineage and allowed the transfer of the ancestral jaw joint into the middle ear. This review discusses the evolutionary development of the TMJ, including the fossil record and embryonic development.
EVOLUTION & DEVELOPMENT
(2023)
Article
Developmental Biology
Tengyang Qiu, Barbora Huteckova, Maisa Seppala, Martyn T. Cobourne, Zhi Chen, Maria Hovorakova, Marcela Buchtova, Abigail S. Tucker
Summary: The vestibular lamina (VL) is responsible for forming the oral vestibule and defects in its formation can lead to the creation of multiple frenula. Little is known about the genes that regulate the development of the VL. This study identifies several genes and signalling pathways, including the Sonic hedgehog (Shh) pathway, that play a role in VL development and shows that signals from the forming teeth control the development of the VL.
Article
Developmental Biology
Jane C. Fenelon, Abbie Bennetts, Neal Anthwal, Michael Pyne, Stephen D. Johnston, Alistair R. Evans, Abigail S. Tucker, Marilyn B. Renfree
Summary: Based on the research of pre- and post-hatching tissues of the echidna, it was found that the echidna egg tooth is similar to the first teeth in reptiles and fish, and it is ankylosed to the premaxilla rather than forming a tooth root like other mammals. The caruncle of the echidna is separate from the nasal capsule and expresses markers of cornification, similar to birds and turtles. These findings suggest that the monotreme egg tooth shares similarities with reptilian teeth, indicating a conservation from a common ancestor of mammals and reptiles.
DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Hung-Jhen Chen, Lindsey Barske, Jared C. Talbot, Olivia M. Dinwoodie, Ryan R. Roberts, D'Juan T. Farmer, Christian Jimenez, Amy E. Merrill, Abigail S. Tucker, J. Gage Crump
Summary: In this study, the pluripotency factor Nr5a2 was found to play a critical role in cell-fate decisions during jaw development. Nr5a2 was transiently expressed in a subset of postmigratory neural-crest-derived cells in zebrafish and mice. Loss of Nr5a2 in zebrafish resulted in excessive jaw cartilage at the expense of tendons, while in mice, neural-crest-specific Nr5a2 loss led to skeletal, tendon, and salivary gland defects in the jaw and middle ear. Single-cell profiling revealed that Nr5a2 regulates chromatin accessibility and gene expression specifically in jaw cells, promoting tendon and gland fates. Therefore, repurposing of Nr5a2 is crucial for generating the diverse derivatives required for proper jaw and middle ear function.
DEVELOPMENTAL CELL
(2023)
Article
Multidisciplinary Sciences
A. R. H. LeBlanc, A. Palci, N. Anthwal, A. S. Tucker, R. Araujo, M. F. C. Pereira, M. W. Caldwell
Summary: The central question in squamate evolution is whether snakes evolved their elongated, limbless bodies or their specialized skulls and teeth first. The authors use histology to show that odontoclasts resorb dentine internally and investigate this mechanism in fossil snakes, providing a method for identifying fossil snakes. They also detect internal tooth resorption in the fossil snake, Yurlunggur, suggesting it is one of the earliest innovations in Pan-Serpentes, likely preceding limb loss.
NATURE COMMUNICATIONS
(2023)
Article
Cell & Tissue Engineering
Rupali Lav, Jan Krivanek, Neal Anthwal, Abigail S. Tucker
Summary: In the murine molar, Wnt signals from Gli1+ stem/progenitor cells play a crucial role in coordinating root development and regulating interactions between mesenchymal and epithelial cells via the SOX9 pathway. Loss of Wnt production in Gli1+ cells leads to mis-regulation of key signaling pathways, resulting in truncation of root development and loss of epithelial identity. Stabilization of Wnt signaling in the apical papilla causes rapid differentiation of hard tissues and fragmentation of the epithelial root sheath.
Article
Biology
Ploy Adisornkanj, Rajit Chanprasit, Steven Eliason, Juan M. Fons, Worrachet Intachai, Sissades Tongsima, Bjorn Olsen, Stefan T. Arold, Chumpol Ngamphiw, Brad A. Amendt, Abigail S. Tucker, Piranit Kantaputra
Summary: Study identified an extremely rare mutation in the PTPN23 gene that is associated with mesiodens. This mutation was found in seven family members with mesiodens and six family members without the condition. Further research showed that the PTPN23 mutation reduces phosphatase activity, leading to the formation of mesiodens.
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
