Mutations in LRP6 highlight the role of WNT signaling in oral exostoses and dental anomalies

Mutations in LRP5 and BMP4 are associated with mesiodens, tooth agenesis, root malformation, and oral exostoses

(2022) Piranit Nik Kantaputra et al.   CLINICAL GENETICS

LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence

(2021) Qian Ren et al.   Frontiers in Cell and Developmental Biology

WNT10A , dermatology and dentistry

(2021) B. J. Doolan et al.   BRITISH JOURNAL OF DERMATOLOGY

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Synergistic Mutations of LRP6 and WNT10A in Familial Tooth Agenesis

(2021) Kuan-Yu Chu et al.   Journal of Personalized Medicine

High Bone Mass From Mutation Of Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6)

(2020) María Lorena Brance et al.   BONE

A novel missense mutation of LRP6 identified by whole‐exome sequencing in a Chinese family with nonsyndromic tooth agenesis

(2020) Huijuan Wang et al.   Orthodontics & Craniofacial Research

Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains

(2020) Jinuk Kim et al.   Nature Communications

New explanation for autosomal dominant high bone mass: Mutation of low-density lipoprotein receptor-related protein 6

(2019) Michael P. Whyte et al.   BONE

Morphogenesis of the femur at different stages of normal human development

(2019) Yuko Suzuki et al.   PLoS One

Whole exome sequencing identifies mutations in 10% of patients with familial non-syndromic cleft lip and/or palate in genes mutated in well-known syndromes

(2018) Mirta Basha et al.   JOURNAL OF MEDICAL GENETICS

Genetic analysis: Wnt and other pathways in non-syndromic tooth agenesis

(2018) Miao Yu et al.   ORAL DISEASES

N-cadherin restrains PTH repressive effects on sclerostin/SOST by regulating LRP6-PTH1R interaction

(2016) Hailin Yang et al.   Annals of the New York Academy of Sciences

Novel mutations in LRP6 highlight the role of WNT signaling in tooth agenesis

(2016) Charlotte W. Ockeloen et al.   GENETICS IN MEDICINE

Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia

(2015) Maarten P.G. Massink et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rare LRP6 Variants Identified in Spina Bifida Patients

(2015) Yunping Lei et al.   HUMAN MUTATION

N-cadherin Restrains PTH Activation of Lrp6/β-catenin Signaling and Osteoanabolic Action

(2015) Leila Revollo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Oral bony outgrowths: Prevalence and genetic factor influence. Study of twins

(2015) Adomas Auškalnis et al.   Medicina-Lithuania

Oral bony outgrowths: Prevalence and genetic factor influence. Study of twins

(2015) Adomas Auškalnis et al.   Medicina-Lithuania

WNT7B Promotes Bone Formation in part through mTORC1

(2014) Jianquan Chen et al.   PLoS Genetics

Taurodontism, variations in tooth number, and misshapened crowns inWnt10anull mice and human kindreds

(2014) Jie Yang et al.   Molecular Genetics & Genomic Medicine

Structural Studies of Wnts and Identification of an LRP6 Binding Site

(2013) Matthew Ling-Hon Chu et al.   STRUCTURE

Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling

(2012) B. T. MacDonald et al.   Cold Spring Harbor Perspectives in Biology

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

(2011) Zhihong Cheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Two Structural and Functional Domains of MESD Required for Proper Folding and Trafficking of LRP5/6

(2011) Jianglei Chen et al.   STRUCTURE

Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies

(2010) Yan Gong et al.   PLoS One

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

(2010) S. A. Ettenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parathyroid hormone signaling through low-density lipoprotein-related protein 6

(2008) M. Wan et al.   GENES & DEVELOPMENT

Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone

(2008) Bart O Williams et al.   JOURNAL OF BONE AND MINERAL RESEARCH