Article
Cell Biology
Yuhan Hu, Qingzu Gao, Shuai Ma, Pei Yu, Shuang Ding, Xiaofei Yao, Zheying Zhang, Shuya Lu, Manman Lu, Jinghang Zhang, Yanling Wang, Xinlai Qian, Jiateng Zhong
Summary: FMR1, a new m(6)A reader, is upregulated in colorectal cancer (CRC) and promotes tumor growth and metastasis by recognizing the m(6)A modification site in EGFR mRNA, thereby maintaining its stability and expression. This study identifies the METTL3/FMR1/EGFR axis as a potential target for early therapeutic intervention in CRC progression.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Yuan Hu, Jiexin Chen, Muyuan Liu, Qin Feng, Hanwei Peng
Summary: This study explored the clinical significance of 19 m6A regulators in head and neck squamous cell carcinoma (HNSC) using various data sources, and identified IGF2BP2 as a core m6A regulator with high expression in HNSC and the ability to independently predict poor prognosis in patients. IGF2BP2 may offer a new direction for the treatment of HNSC in the future.
BIOSCIENCE REPORTS
(2022)
Article
Oncology
Zixian Huang, Xi Rui, Chen Yi, Yongju Chen, Rui Chen, Yancan Liang, Yan Wang, Weicheng Yao, Xiaoding Xu, Zhiquan Huang
Summary: This study identified LCN2 as a potential target for the treatment of OSCC. Inhibition of LCN2 expression effectively inhibited OSCC proliferation and metastasis by inhibiting EGFR phosphorylation and downstream signaling activation. LCN2 enhances the recycling of EGFR, activating the EGFR-MEK-ERK cascade. Inhibition of LCN2 significantly inhibited EGFR activation, leading to significant inhibition of tumor growth and metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jue Huang, Jie-Gang Yang, Jian-Gang Ren, Hou-Fu Xia, Gao-Hong Chen, Qiu-Yun Fu, Lin-Zhou Zhang, Hai-Ming Liu, Kui-Ming Wang, Qi-Hui Xie, Gang Chen
Summary: This study examines the expression pattern of RAB27A in oral squamous cell carcinoma (OSCC) and explores its potential implications. The results show that RAB27A is significantly overexpressed in OSCC, particularly in metastatic lymph nodes, and it is correlated with poor clinical progression and survival prognosis. Silencing RAB27A can notably reduce the proliferation, migration, and invasion abilities of OSCC cells. Further investigations reveal that RAB27A regulates the palmitoylation of EGFR via ZDHHC13. These findings provide insights into OSCC progression and highlight RAB27A as a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Weiwen Zhu, Jie Wang, Xiang Liu, Yanbin Xu, Rundong Zhai, Jiayi Zhang, Mengqi Wang, Mengyao Wang, Laikui Liu
Summary: Oral squamous cell carcinoma (OSCC), the most common malignancy of the oral and maxillofacial region, severely affects human health. In this study, researchers identified a long non-coding RNA called CYTOR, which is highly expressed in oral cancer patients. They found that CYTOR promotes cell migration and invasion, and affects mitochondrial metabolism and RNA splicing in oral cancer cells.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Tao Liu, Wan Xiang, Zhizhuang Chen, Gang Wang, Rui Cao, Fenfang Zhou, Zhe Meng, Yongwen Luo, Liang Chen
Summary: This study found that hypoxia is elevated in ccRCC and may be an independent risk factor for prognosis in ccRCC patients. The study also revealed that PLOD2 is transcriptionally activated by HIF1A, interacts with EGFR, and ultimately promotes the malignant progression of ccRCC by activating the AKT signaling pathway.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Sindhu Nair, James A. Bonner, Markus Bredel
Summary: EGFR is overexpressed in head and neck squamous cell carcinoma and anti-EGFR strategies have shown some clinical benefit but often lead to resistance. Mutations in various domains of the EGFR gene can impact drug binding, radiation response, and overall survival in HNSCC patients. Understanding the EGFR mutational landscape and its effects on treatment resistance can help stratify patients for targeted therapies and maximize therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Ashley Wysong
Summary: Squamous-cell carcinoma is a common type of cancer in humans, with most cases being localized and treatable, but a small percentage of cases that recur or spread can be fatal. Immunocompromised patients are at particularly high risk.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Kento Okamoto, Toshinori Ando, Hiroki Izumi, Susumu S. Kobayashi, Tomoaki Shintani, J. Silvio Gutkind, Souichi Yanamoto, Mutsumi Miyauchi, Mikihito Kajiya
Summary: The Hippo signaling pathway and its downstream effector YAP play a central role in cell proliferation. Dysregulation of the Hippo pathway triggers YAP hyperactivation, thereby inducing head and neck squamous cell carcinoma (HNSCC). Our findings suggest that co-targeting both AXL and EGFR represent a promising therapeutic approach in patients with EGFR-altered cancers.
Article
Dermatology
Ashley Wysong, Jason G. Newman, Kyle R. Covington, Sarah J. Kurley, Sherrif F. Ibrahim, Aaron S. Farberg, Anna Bar, Nathan J. Cleaver, Ally-Khan Somani, David Panther, David G. Brodland, John Zitelli, Jennifer Toyohara, Ian A. Maher, Yang Xia, Kristin Bibee, Robert Griego, Darrell S. Rigel, Kristen Meldi Plasseraud, Sarah Estrada, Lauren Meldi Sholl, Clare Johnson, Robert W. Cook, Chrysalyne D. Schmults, Sarah T. Arron
Summary: A gene expression profile (GEP) test was developed and validated to predict metastasis risk in high-risk cutaneous squamous cell carcinoma (cSCC) patients, improving risk-directed patient management.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Cell Biology
Guorong Yan, Liang Li, Sibo Zhu, Yuhao Wu, Yeqiang Liu, Lude Zhu, Zijun Zhao, Fei Wu, Ning Jia, Caihe Liao, Long Jiang, Qingyu Zeng, Peiru Wang, Lei Shi, Zhe Zheng, Shan Fang, Guolong Zhang, Yichen Tang, Xiuli Wang
Summary: This study identified the molecular patterns of cutaneous squamous cell carcinoma (cSCC) at the single-cell level using single-cell transcriptome analysis. The results showed significant differences in gene expression and chromosomal copy number variation between cSCC cells and normal keratinocytes. The upregulation of S100A9 and FABP5 in cSCC cells was found to promote cell proliferation and migration through the NF-kappa B pathway.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Yuanwang Pan, Han Han, Hai Hu, Hua Wang, Yueqiang Song, Yuan Hao, Xinyuan Tong, Ayushi S. Patel, Selim Misirlioglu, Sittinon Tang, Hsin-Yi Huang, Ke Geng, Ting Chen, Angeliki Karatza, Fiona Sherman, Kristen E. Labbe, Fan Yang, Alison Chafitz, Chengwei Peng, Chenchen Guo, Andre L. Moreira, Vamsidhar Velcheti, Sally C. M. Lau, Pengfei Sui, Haiquan Chen, J. Alan Diehl, Anil K. Rustgi, Adam J. Bass, John T. Poirier, Xiaoyang Zhang, Hongbin Ji, Hua Zhang, Kwok-Kin Wong
Summary: This study identifies KMT2D as a key gene in LUSC lung cancer and reveals its role in oncogenesis. Loss of KMT2D promotes the development of lung cancer and increases tumor sensitivity, suggesting potential therapeutic targets for treatment.
Article
Cell Biology
Zhuo Bao, Ang Li, Xuebo Lu, Zitong Wang, Yin Yu, Wenjie Wu, Lili Zhao, Bo Li, Xiangyu Wu, Kyle Vaughn Laster, Chengjuan Zhang, Yanan Jiang, Zigang Dong, Kangdong Liu
Summary: Esophageal squamous cell carcinoma (ESCC) is a highly prevalent malignant tumor, and current treatment strategies have limited efficacy. This study found that oxethazaine can inhibit ESCC proliferation and metastasis by targeting AURKA.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Courtney M. Edwards, Rachelle W. Johnson
Summary: PTHrP is a multifaceted protein involved in various physiological processes through endocrine and paracrine actions. It has been investigated as a regulator of tumor dormancy and plays a crucial role in promoting tumor progression and metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alexander Michael Grandits, Sophie Bromberger, Gerwin Heller, Barbara Andrea Reinoehl, Erwin Tomasich, Klaudia Schossleitner, Anna Sophie Berghoff, Thorsten Fuereder, Rotraud Wieser
Summary: Head and neck squamous cell carcinoma (HNSCC) is a frequent malignancy with a poor prognosis. EVI1, a novel oncogene, promotes cellular proliferation and invasiveness in HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Shanthi Kanthala, Christopher P. Mill, David J. Riese, Mihir Jaiswal, Seetharama Jois
PROTEIN EXPRESSION AND PURIFICATION
(2016)
Article
Veterinary Sciences
Farruk M. Lutful Kabir, Patricia DeInnocentes, Payal Agarwal, Christopher P. Mill, David J. Riese, R. Curtis Bird
JOURNAL OF VETERINARY SCIENCE
(2017)
Article
Education, Scientific Disciplines
Rondall E. Allen, Jeffrey Copeland, Andrea S. Franks, Reza Karimi, Marianne McCollum, David J. Riese, Anne Y. F. Lin
AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION
(2013)
Article
Biochemistry & Molecular Biology
Kristy J. Wilson, Christopher P. Mill, Richard M. Gallo, Elizabeth M. Cameron, Henry VanBrocklin, Jeffrey Settleman, David J. Riese
BIOCHEMICAL JOURNAL
(2012)
Article
Biochemical Research Methods
Michael D. Zordan, Christopher P. Mill, David J. Riese, James F. Leary
Article
Oncology
Christopher P. Mill, Kathleen L. Gettinger, David J. Riese
EXPERIMENTAL CELL RESEARCH
(2011)
Review
Pharmacology & Pharmacy
David J. Riese
EXPERT OPINION ON DRUG DISCOVERY
(2011)
Article
Cell Biology
Kristy J. Wilson, Christopher Mill, Sydney Lambert, Jennifer Buchman, Timothy R. Wilson, Victor Hernandez-Gordillo, Richard M. Gallo, Laura M. C. Ades, Jeffrey Settleman, David J. Riese
Article
Oncology
Jennifer L. Gilmore, Ryan M. Gonterman, Keshav Menon, Gwendolen Lorch, David J. Riese, Alex Robling, John Foley
MOLECULAR CANCER RESEARCH
(2009)
Article
Oncology
Nicole K. Nickerson, Christopher P. Mill, Hsin-Jung Wu, David J. Riese, John Foley
Review
Cell Biology
David J. Riese, Richard L. Cullum
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2014)
Article
Multidisciplinary Sciences
Richard L. Cullum, Lauren M. Lucas, Jared I. Senfeld, John T. Piazza, Logan T. Neel, Kanupriya Whig, Ling Zhai, Mackenzie H. Harris, Cristina C. Rael, Darby C. Taylor, Laura J. Cook, David P. Kaufmann, Christopher P. Mill, Megan A. Jacobi, Forrest T. Smith, Mark Suto, Robert Bostwick, Ram B. Gupta, Allan E. David, David J. Riese
Review
Pharmacology & Pharmacy
Yi Shi, David J. Riese, Jianzhong Shen
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Pharmacology & Pharmacy
Lauren M. Lucas, Vipasha Dwivedi, Jared Senfeld, Richard L. Cullum, Christopher P. Mill, J. Tyler Piazza, Ianthe N. Bryant, Laura J. Cook, S. Tyler Miller, James H. Lott, Connor M. Kelley, Elizabeth L. Knerr, Jessica A. Markham, David P. Kaufmann, Megan A. Jacobi, Jianzhong Shen, David J. Riese
Summary: This review explores the function of ERBB4 in human malignancies, discussing its potential as both a tumor suppressor and an oncogene. It also examines the specific roles of ERBB4 in various tumors and evaluates the potential use of ERBB4 mutants as biomarkers and in tumor staging and treatment.
PHARMACOLOGICAL REVIEWS
(2022)
