Article
Biochemistry & Molecular Biology
Zaneta Dziegelewska-Sokolowska, Alicja Majewska, Adam Prostek, Malgorzata Gajewska
Summary: The mammary gland consists of epithelial tissue and stroma, with preadipocytes and adipocytes as important components of the stroma. This study investigated the effects of paracrine factors secreted by preadipocytes and adipocytes on the development of bovine mammary epithelial cells. The results showed that factors secreted by fully differentiated adipocytes and preadipocytes can decrease apoptosis and increase the size of spheroids formed by the mammary epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Agriculture, Dairy & Animal Science
Paulo V. Steagall, Hedie Bustamante, Craig B. Johnson, Patricia V. Turner
Summary: Pain is a common cause of compromised animal welfare in farm animals, necessitating better pain management and improved welfare for food animals. Recommendations include enhancing pain assessment and mitigation in husbandry practices, promoting better agricultural practices and ethical considerations.
Article
Veterinary Sciences
Weihao Chen, Xinyu Gu, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Shanhe Wang, Wei Sun
Summary: This study used RNA-seq technology to analyze the expression of miRNAs and circRNAs in sheep mammary gland during different lactation periods and identified potential miRNAs and circRNAs related to sheep mammary gland development through bioinformatics analysis.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cell Biology
Anna Kosenko, Tomer-Meir Salame, Gilgi Fridlander, Itamar Barash
Summary: Implanting close or far bovine stromal layers as an endogenous niche for transplanted stem cells into mouse fat pads enhances stem cell growth and development, with the close stroma better supporting stem cell take rate and outgrowth. RNA-Seq analysis revealed lower complement activity in this layer, favoring epithelial outgrowth development.
CELL AND TISSUE RESEARCH
(2022)
Review
Cell Biology
Katherine Hughes
Summary: Sheep, cows, cats, and rabbits are used by humans for agricultural purposes and as companion animals. These species may be valuable comparative models of breast development and disease.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Veterinary Sciences
Ewelina Kawecka-Grochocka, Magdalena Zalewska, Magdalena Rzewuska, Ewa Kosciuczuk, Tomasz Zabek, Tomasz Sakowski, Sylwester Marczak, Emilia Bagnicka
Summary: The study found no significant differences in the expression levels of seven genes and four proteins between CoPS and H groups, but a higher expression of CXCL5 gene in the CoPS group. Additionally, compared to H, the CoPS group had higher concentrations of IL-8 and CXCL5, while the CoNS group had higher levels of CCL2, and lower levels of Il-6 were found in the CoPS group.
VETERINARY RESEARCH
(2021)
Article
Food Science & Technology
Borja Munoz-Solano, Elena Gonzalez-Penas
Summary: Mycotoxins are a major concern for food safety, as their exposure in animals can lead to health problems, economic losses, and contamination of animal-derived foods. This study used a revalidated methodology to analyze mycotoxins in animal plasma samples, finding that the prevalence of STER was high but levels were low in the analyzed feed. Animal biomonitoring can be a useful tool in assessing mycotoxin exposure, but more research is needed on appropriate biomarkers and analytical methods.
Article
Agriculture, Dairy & Animal Science
Jiqing Wang, Huitong Zhou, Jon G. H. Hickford, Zhiyun Hao, Hua Gong, Jiang Hu, Xiu Liu, Shaobin Li, Jiyuan Shen, Na Ke, Yize Song, Lirong Qiao, Yuzhu Luo
Summary: Circular RNAs are a widespread class of noncoding RNA in eukaryote tissues, with some having clear biological functions. A study in sheep showed the expression profiles of circular RNAs in mammary gland tissue at peak lactation and nonlactating stages, confirming the expression and identity of multiple circular RNAs. In peak lactation, 40 up-regulated and 1 downregulated circular RNAs were identified, with parental genes related to various molecular functions. Furthermore, five differentially expressed circular RNAs were analyzed to predict their target microRNAs, revealing some microRNAs associated with mammary gland development.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Syed Mudasir Ahmad, Basharat Bhat, Zainab Manzoor, Mashooq Ahmad Dar, Qamar Taban, Eveline M. Ibeagha-Awemu, Nadeem Shabir, Mohd Isfaqul Hussain, Riaz A. Shah, Nazir A. Ganai
Summary: Research has found that circRNAs are associated with the development of mammary gland and lactation. Comparative analysis of circRNAs in two different cattle breeds revealed their important roles in milk synthesis and their conservation across species.
Article
Biochemistry & Molecular Biology
Artem P. Dysin, Olga Y. Barkova, Marina V. Pozovnikova
Summary: Milk is a complex structural element in mammalian nutrition, with lactation and the mammary gland both being intricate processes. Factors such as nutrition, genetics, epigenetics, disease pathogens, and climatic conditions all impact breast productivity. Studies on epigenetics, particularly on the role of microRNAs in mammary gland development and function, have increased in the last decade.
Article
Agriculture, Dairy & Animal Science
Gian Enrico Magi, Francesca Mariotti, Lorenzo Pallotta, Alessandro Di Cerbo, Franco Maria Venanzi
Summary: The expression of p62 protein is significantly higher in feline mammary carcinoma compared to non-neoplastic mammary glands, similar to human breast cancer. This study suggests that p62 may have oncogenic potential in feline mammary carcinoma.
Article
Agriculture, Dairy & Animal Science
Lenka Valkova, Vladimir Vecerek, Eva Voslarova, Michal Kaluza, Daniela Takacova
Summary: The study evaluated traumatic injuries in cattle, sheep, goats, and pigs in the Czech Republic. Traumatic lesions were found at a low frequency, with cows being the most affected category and small ruminants and bulls having lower rates of traumatic findings. This suggests that factors such as animal housing and rearing environment may impact the occurrence of traumatic injuries.
Review
Cell Biology
Christine J. Watson
Summary: Research on mammary stem cells is currently facing controversies, but with innovative experimental approaches and technologies, there is a reevaluation of the concept of stem and progenitor cell hierarchy in progress.
TRENDS IN CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Swarajit Kumar Biswas, Saswati Banerjee, Ginger Wendolyn Baker, Chieh-Yin Kuo, Indrajit Chowdhury
Summary: The mammary gland, a compound and branched structure, plays a crucial role in mammalian reproduction by producing milk. Its development involves hormonal regulation and different stages of morphogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hye Min Kim, Ja Seung Koo
Summary: This research evaluated the expression of autophagy-related proteins in human adrenal gland tumors, finding differences in expression among different tumor types. P62 positivity in PCC was associated with shorter overall survival, while LC3A, LC3B, beclin-1, and LC3B (ISPC) positivity rates were higher in PCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
J. H. Wald, J. Hatakeyama, I. Printsev, A. Cuevas, W. H. D. Fry, M. J. Saldana, K. VanderVorst, A. Rowson-Hodel, J. M. Angelastro, C. Sweeney, K. L. Carraway
Article
Biochemistry & Molecular Biology
A. R. Rowson-Hodel, J. H. Wald, J. Hatakeyama, W. K. O'Neal, J. R. Stonebraker, K. VanderVorst, M. J. Saldana, A. D. Borowsky, C. Sweeney, K. L. Carraway
Article
Agriculture, Dairy & Animal Science
T. T. Yohe, B. D. Enger, L. Wang, H. L. M. Tucker, C. A. Ceh, C. L. M. Parsons, Z. Yu, K. M. Daniels
JOURNAL OF DAIRY SCIENCE
(2018)
Article
Agriculture, Dairy & Animal Science
T. T. Yohe, H. Schramm, C. L. M. Parsons, H. L. M. Tucker, B. D. Enger, N. R. Hardy, K. M. Daniels
JOURNAL OF DAIRY SCIENCE
(2019)
Article
Agriculture, Dairy & Animal Science
T. T. Yohe, H. Schramm, R. R. White, M. D. Hanigan, C. L. M. Parsons, H. L. M. Tucker, B. D. Enger, N. R. Hardy, K. M. Daniels
JOURNAL OF DAIRY SCIENCE
(2019)
Article
Multidisciplinary Sciences
Andrea Bedford, Linda Beckett, Laura Harthan, Chong Wang, Ning Jiang, Hollie Schramm, Le Luo Guan, Kristy M. Daniels, Mark D. Hanigan, Robin R. White
SCIENTIFIC REPORTS
(2020)
Article
Agriculture, Dairy & Animal Science
L. Beckett, C. B. Gleason, A. Bedford, D. Liebe, T. T. Yohe, M. B. Hall, K. M. Daniels, R. R. White
Summary: The study aimed to characterize the impact of diets with different starch and fiber sources on rumen VFA concentrations, rumen epithelial gene expression, and blood metabolite responses. Results showed that timothy hay had the greatest effect on shifts in VFA molar proportions and epithelial transporters, but did not demonstrate significant shifts in blood metabolite concentrations.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Connor E. Owens, Haley G. Huffard, Alexandra Nin-Velez, Jane Duncan, Chrissy L. Teets, Kristy M. Daniels, Alan D. Ealy, Robert E. James, Katharine F. Knowlton, Rebecca R. Cockrum
Summary: The composition of bacterial communities in a newborn's gut plays a crucial role in their early development and immune system function. This study aimed to characterize maternal and calf microbiomes during peri-partum and post-partum periods, indicating that maternal microbiomes significantly influence calf fecal microbiome throughout the pre-weaning period. Further research on environmental and genetic influences on calf microbiome development is needed.
Article
Agriculture, Dairy & Animal Science
E. S. Richardson, G. Ferreira, K. M. Daniels, H. H. Schramm, R. J. Meakin
Summary: This study demonstrated that feeding non-lactating and pregnant dairy cows an acidogenic diet containing polyhalite as an anionic salt can decrease urine pH and increase urinary calcium output.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2021)
Review
Oncology
Courtney A. Dreyer, Kacey VanderVorst, Savannah Free, Ashley Rowson-Hodel, Kermit L. Carraway
Summary: It has been found that MUC4 protein levels are upregulated in metastatic lesions compared to primary tumors in breast cancer patients, suggesting a possible selective advantage for MUC4 overexpression in metastasis. Studies on genetically engineered mouse models have shown that deletion of MUC4 suppresses metastatic efficiency, indicating its role in CTC viability. Intervening in MUC4 intercellular interactions with binding partners on blood-borne aggregating cells could potentially reduce breast cancer metastatic efficiency.
ENDOCRINE-RELATED CANCER
(2022)
Article
Agriculture, Dairy & Animal Science
C. M. Ylioja, A. J. Carpenter, L. K. Mamedova, K. M. Daniels, P. J. Ross, S. L. Laflin, T. H. Swartz, B. J. Bradford
Summary: The study evaluated the impact of sodium salicylate treatment on mammary gland changes in multiparous Holstein cows. Results showed no significant effects on milk yield or plasma metabolites, but differential gene expression and downregulation of immune-related pathways were observed. Further investigation into epigenetic effects on milk production is warranted.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Oncology
Anastasia L. Berg, Ashley Rowson-Hodel, Michelle Hu, Michael Keeling, Hao Wu, Kacey VanderVorst, Jenny J. Chen, Jason Hatakeyama, Joseph Jilek, Courtney A. Dreyer, Madelyn R. Wheeler, Ai-Ming Yu, Yuanpei Li, Kermit L. Carraway
Summary: Preventing drug resistance in cancer stem cells is crucial for improving treatment outcomes in cancer patients. This study found that cationic amphiphilic drugs can effectively target therapy-resistant cancer stem cell populations by inducing cell death through a different mechanism. This discovery has the potential to improve treatment outcomes for breast cancer patients and reduce the risk of tumor recurrence and metastasis.
Article
Agriculture, Dairy & Animal Science
Tanner P. Price, Vinicius C. Souza, Douglas M. Liebe, Mark D. Elett, Ty C. Davis, Claire B. Gleason, Kristy M. Daniels, Robin R. White
Summary: Lactating dairy cows exhibit rapid responses to small changes in dietary composition, showing potential for increased efficiency in production. Further research is needed to integrate these strategies into automated feeding systems and assess impacts on individual animal feed efficiency and farm profitability.
Article
Agriculture, Dairy & Animal Science
V. C. Souza, D. M. Liebe, T. P. Price, M. D. Ellett, T. C. Davis, C. B. Gleason, K. M. Daniels, R. R. White
Summary: This study aimed to improve feed efficiency of individual cows through algorithm design. Results showed that production performance was enhanced and feeding costs were reduced by optimizing feeding strategies, leading to increased milk yield.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Agriculture, Dairy & Animal Science
C. E. Owens, K. M. Daniels, A. D. Ealy, K. F. Knowlton, R. R. Cockrum
JOURNAL OF DAIRY SCIENCE
(2020)
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)