Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue

Logical transformation of genome-scale metabolic models for gene level applications and analysis

(2015) Cheng Zhang et al.   BIOINFORMATICS

The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling

(2015) Cecilia Lindskog et al.   BMC GENOMICS

Using Genome-scale Models to Predict Biological Capabilities

(2015) Edward J. O’Brien et al.   CELL

Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome

(2015) Saeed Shoaie et al.   Cell Metabolism

New paradigms for metabolic modeling of human cells

(2015) Adil Mardinoglu et al.   CURRENT OPINION IN BIOTECHNOLOGY

Incidence and remission of type 2 diabetes in relation to degree of obesity at baseline and 2 year weight change: the Swedish Obese Subjects (SOS) study

(2015) Kajsa Sjöholm et al.   DIABETOLOGIA

Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance

(2015) Aimo Kannt et al.   DIABETOLOGIA

Modeling cancer metabolism on a genome scale

(2015) K. Yizhak et al.   Molecular Systems Biology

Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism

(2015) Francesco Gatto et al.   Scientific Reports

Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling

(2015) Pouyan Ghaffari et al.   Scientific Reports

Proteome- and Transcriptome-Driven Reconstruction of the Human Myocyte Metabolic Network and Its Use for Identification of Markers for Diabetes

(2015) Leif Väremo et al.   Cell Reports

The genetics of fat distribution

(2014) Dorit Schleinitz et al.   DIABETOLOGIA

The human liver-specific proteome defined by transcriptomics and antibody-based profiling

(2014) Caroline Kampf et al.   FASEB JOURNAL

Association of Bariatric Surgery With Long-term Remission of Type 2 Diabetes and With Microvascular and Macrovascular Complications

(2014) Lars Sjöström et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Defining the Human Adipose Tissue Proteome To Reveal Metabolic Alterations in Obesity

(2014) Adil Mardinoglu et al.   JOURNAL OF PROTEOME RESEARCH

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

(2014) K. Yizhak et al.   Molecular Systems Biology

Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling

(2014) R. Agren et al.   Molecular Systems Biology

Defining the human gallbladder proteome by transcriptomics and affinity proteomics

(2014) Caroline Kampf et al.   PROTEOMICS

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease

(2014) Adil Mardinoglu et al.   Nature Communications

Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

(2014) Keren Yizhak et al.   eLife

MicroRNA profiling links miR-378 to enhanced adipocyte lipolysis in human cancer cachexia

(2013) Agné Kulyté et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Managing obesity in primary care practice: a narrative review

(2013) Raymond Carvajal et al.   Annals of the New York Academy of Sciences

Genome-scale modeling of human metabolism - a systems biology approach

(2013) Adil Mardinoglu et al.   Biotechnology Journal

Can medical therapy mimic the clinical efficacy or physiological effects of bariatric surgery?

(2013) A D Miras et al.   INTERNATIONAL JOURNAL OF OBESITY

Gene expression profiling in subcutaneous, visceral and epigastric adipose tissues of patients with extreme obesity

(2013) G S Gerhard et al.   INTERNATIONAL JOURNAL OF OBESITY

Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery

(2013) L. Sjöström   JOURNAL OF INTERNAL MEDICINE

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Integration of clinical data with a genome-scale metabolic model of the human adipocyte

(2013) A. Mardinoglu et al.   Molecular Systems Biology

Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods

(2013) Leif Väremo et al.   NUCLEIC ACIDS RESEARCH

Integrated analysis of transcript-level regulation of metabolism reveals disease-relevant nodes of the human metabolic network

(2013) Mafalda Galhardo et al.   NUCLEIC ACIDS RESEARCH

Model-based identification of drug targets that revert disrupted metabolism and its application to ageing

(2013) Keren Yizhak et al.   Nature Communications

Understanding the interactions between bacteria in the human gut through metabolic modeling

(2013) Saeed Shoaie et al.   Scientific Reports

Not All Fat Is Equal

(2012) Susan C. Modesitt et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Bariatric Surgery and Long-term Cardiovascular Events

(2012) Lars Sjöström et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

Reconstruction of Genome-Scale Active Metabolic Networks for 69 Human Cell Types and 16 Cancer Types Using INIT

(2012) Rasmus Agren et al.   PLoS Computational Biology

Determinants of Human Adipose Tissue Gene Expression: Impact of Diet, Sex, Metabolic Status, and Cis Genetic Regulation

(2012) Nathalie Viguerie et al.   PLoS Genetics

Clinical Relevance of Adipokines

(2012) Matthias Blüher   Diabetes & Metabolism Journal

Diet, the Global Obesity Epidemic, and Prevention

(2011) Ruth W. Kimokoti et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

The impact of extended care on the long-term maintenance of weight loss: a systematic review and meta-analysis

(2011) K. M. Ross Middleton et al.   Obesity Reviews

Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders

(2011) Stefan Lehr et al.   Proteomics Clinical Applications

Adipose tissue transcriptome reflects variations between subjects with continued weight loss and subjects regaining weight 6 mo after caloric restriction independent of energy intake

(2010) et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Global prevalence and trends of overweight and obesity among preschool children

(2010) Mercedes de Onis et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Validation of endogenous reference genes for qRT-PCR analysis of human visceral adipose samples

(2010) Rohini Mehta et al.   BMC MOLECULAR BIOLOGY

Adipose tissue pathways involved in weight loss of cancer cachexia

(2010) I Dahlman et al.   BRITISH JOURNAL OF CANCER

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

(2010) Riekelt H. Houtkooper et al.   ENDOCRINE REVIEWS

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Lipolysis-Not inflammation, cell death, or lipogenesis-Is involved in adipose tissue loss in cancer cachexia

(2008) Mikael Rydén et al.   CANCER

Evidence for an Important Role of CIDEA in Human Cancer Cachexia

(2008) J. Laurencikiene et al.   CANCER RESEARCH

Cidea is associated with lipid droplets and insulin sensitivity in humans

(2008) V. Puri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

(2008) Corneliu Henegar et al.   GENOME BIOLOGY

Adipose Tissue Lipin-1 Expression Is Correlated with Peroxisome Proliferator-Activated Receptor α Gene Expression and Insulin Sensitivity in Healthy Young Men

(2007) Jimmy Donkor et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM