Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells

Topoisomerase II and leukemia

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Assessment of DNA damage, cytotoxicity, and apoptosis in human hepatoma (HepG2) cells after flurochloridone herbicide exposure

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Efficacy and safety ofGinkgo bilobaextract EGb 761®in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multi-center trial

(2014) S. I. Gavrilova et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Mechanistic Evaluation of Ginkgo biloba Leaf Extract-Induced Genotoxicity in L5178Y Cells

(2014) Haixia Lin et al.   TOXICOLOGICAL SCIENCES

Sertraline induces endoplasmic reticulum stress in hepatic cells

(2014) Si Chen et al.   TOXICOLOGY

HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved

(2013) Laia Tolosa et al.   ARCHIVES OF TOXICOLOGY

Sertraline, an Antidepressant, Induces Apoptosis in Hepatic Cells Through the Mitogen-Activated Protein Kinase Pathway

(2013) Si Chen et al.   TOXICOLOGICAL SCIENCES

Mechanism study of goldenseal-associated DNA damage

(2013) Si Chen et al.   TOXICOLOGY LETTERS

Flavonoids Acting on DNA Topoisomerases: Recent Advances and Future Perspectives in Cancer Therapy

(2012) P. Russo et al.   CURRENT MEDICINAL CHEMISTRY

Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial

(2012) Bruno Vellas et al.   LANCET NEUROLOGY

Mutagenicity of Flavonoids Assayed by Bacterial Reverse Mutation (Ames) Test

(2012) Flavia Aparecida Resende et al.   MOLECULES

Ginkgo biloba does not improve cognitive function in MS: A randomized placebo-controlled trial

(2012) J. F. Lovera et al.   NEUROLOGY

Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent

(2012) Yan Li et al.   TOXICOLOGICAL SCIENCES

Effect of Ginkgo biloba special extract EGb 761® on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers

(2011) G. Zadoyan et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters

(2011) René V. Bensasson et al.   FREE RADICAL BIOLOGY AND MEDICINE

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1

(2011) Yan Li et al.   TOXICOLOGICAL SCIENCES

Effects of Ginkgo biloba extracts on diazepam metabolism: a pharmacokinetic study in healthy Chinese male subjects

(2010) Xiao-Cong Zuo et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Caffeic acid and quercitrin purified fromHouttuynia cordatainhibit DNA topoisomerase I activity

(2010) Seok-Young Jang† et al.   NATURAL PRODUCT RESEARCH

Plasma Levels and Distribution of Flavonoids in Rat Brain after Single and Repeated Doses of StandardizedGinkgo bilobaExtract EGb 761®

(2010) Laura Rangel-Ordóñez et al.   PLANTA MEDICA

Advantages of Human Hepatocyte-Derived Transformants Expressing a Series of Human Cytochrome P450 Isoforms for Genotoxicity Examination

(2010) Tsuneo Hashizume et al.   TOXICOLOGICAL SCIENCES

Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals

(2009) Teris A. van Beek et al.   JOURNAL OF CHROMATOGRAPHY A

The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells

(2009) Miguel López-Lázaro et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genotoxicity of topoisomerase II inhibitors: An anti-infective perspective

(2008) Daniel J. Smart   TOXICOLOGY