Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs Created by DNA Transposition of a Human PCSK9 Gain-of-Function Mutant

Simvastatin preserves diastolic function in experimental hypercholesterolemia independently of its lipid lowering effect

(2011) Dallit Mannheim et al.   ATHEROSCLEROSIS

Unexpected roles for PCSK9 in lipid metabolism

(2011) Anne K Soutar   CURRENT OPINION IN LIPIDOLOGY

Why not screen for subclinical atherosclerosis?

(2011) Henrik Sillesen et al.   LANCET

Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial

(2011) Zahi A Fayad et al.   LANCET

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

A Prospective Natural-History Study of Coronary Atherosclerosis

(2011) Gregg W. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atherosclerosis Drug Development in Jeopardy: The Need for Predictive Biomarkers of Treatment Response

(2011) D. A. Fryburg et al.   Science Translational Medicine

Strategies for selection marker-free swine transgenesis using the Sleeping Beauty transposon system

(2011) Daniel F. Carlson et al.   TRANSGENIC RESEARCH

Swine as Models in Biomedical Research and Toxicology Testing

(2011) M. M. Swindle et al.   VETERINARY PATHOLOGY

ApoE-Deficient Mice on Cholate-Containing High-Fat Diet Reveal a Pathology Similar to Lung Sarcoidosis

(2010) Andriy O. Samokhin et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased Secretion of Lipoproteins in Transgenic Mice Expressing Human D374Y PCSK9 Under Physiological Genetic Control

(2010) Bronwen Herbert et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pig genome sequence - analysis and publication strategy

(2010) Alan L Archibald et al.   BMC GENOMICS

Intracoronary Optical Coherence Tomography and Histology at 1 Month and 2, 3, and 4 Years After Implantation of Everolimus-Eluting Bioresorbable Vascular Scaffolds in a Porcine Coronary Artery Model

(2010) Yoshinobu Onuma et al.   CIRCULATION

Unreliable Assessment of Necrotic Core by Virtual Histology Intravascular Ultrasound in Porcine Coronary Artery Disease

(2010) Troels Thim et al.   Circulation-Cardiovascular Imaging

Atherosclerotic lesions in mouse and man: is it the same disease?

(2010) Jacob Fog Bentzon et al.   CURRENT OPINION IN LIPIDOLOGY

Pregnancies and piglets from large white sow recipients after two transfer methods of cloned and transgenic embryos of different pig breeds

(2010) M. Schmidt et al.   THERIOGENOLOGY

Pig transgenesis by Sleeping Beauty DNA transposition

(2010) Jannik E. Jakobsen et al.   TRANSGENIC RESEARCH

Porcine models of coronary atherosclerosis and vulnerable plaque for imaging and interventional research

(2010) Juan Granada et al.   EuroIntervention

Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies

(2010) Troels Thim et al.   EuroIntervention

Genetic and Metabolic Determinants of Plasma PCSK9 Levels

(2009) Susan G. Lakoski et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis

(2009) S. A. Mousavi et al.   JOURNAL OF INTERNAL MEDICINE

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

(2009) Lajos Mátés et al.   NATURE GENETICS

Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer’s disease-causing dominant mutation APPsw

(2009) Peter M. Kragh et al.   TRANSGENIC RESEARCH

Evidence Mandating Earlier and More Aggressive Treatment of Hypercholesterolemia

(2008) Daniel Steinberg et al.   CIRCULATION

Drug-Eluting Stents in Preclinical Studies

(2008) Robert S. Schwartz et al.   Circulation-Cardiovascular Interventions

Atherosclerosis Inflammation Imaging with 18F-FDG PET: Carotid, Iliac, and Femoral Uptake Reproducibility, Quantification Methods, and Recommendations

(2008) J. H.F. Rudd et al.   JOURNAL OF NUCLEAR MEDICINE

Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

(2008) Robert L Wilensky et al.   NATURE MEDICINE

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular basis for LDL receptor recognition by PCSK9

(2008) H. J. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA