De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones

Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion

(2016) Yusuke Yamamoto et al.   Nature Communications

Metastatic Stem Cells: Sources, Niches, and Vital Pathways

(2014) Thordur Oskarsson et al.   Cell Stem Cell

TGF  signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium

(2014) H. A. McCauley et al.   DEVELOPMENT

Insights into the biological functions of Dock family guanine nucleotide exchange factors

(2014) M. Laurin et al.   GENES & DEVELOPMENT

DCF (docetaxel, cisplatin and 5-fluorouracil) chemotherapy is a promising treatment for recurrent advanced squamous cell anal carcinoma

(2013) S. Kim et al.   ANNALS OF ONCOLOGY

TGFβ and CCN2/CTGF mediate actin related gene expression by differential E2F1/CREB activation

(2013) Noel Faherty et al.   BMC GENOMICS

Novel mutations and expression alterations inSMAD3/TGFBR2genes in oral carcinoma correlate with poor prognosis

(2013) Vadakke Peringode Sivadas et al.   GENES CHROMOSOMES & CANCER

Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche

(2013) Andrea Flesken-Nikitin et al.   NATURE

Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis

(2013) Hongyan Li et al.   Nature Communications

Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression

(2013) Shannon Patricia Fortin Ensign et al.   Frontiers in Oncology

Gastric tumor development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature

(2012) Ki Taek Nam et al.   LABORATORY INVESTIGATION

A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer

(2012) M. Herfs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Boundaries, junctions and transitions in the gastrointestinal tract

(2011) Adrianna K. San Roman et al.   EXPERIMENTAL CELL RESEARCH

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1

(2011) Hendrik Ungefroren et al.   Molecular Cancer

A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumours

(2011) Benjamin Beck et al.   NATURE

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-  and integrin/focal adhesion kinase (FAK) signaling

(2011) M. Schober et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Overexpression of engulfment and cell motility 1 promotes cell invasion and migration of hepatocellular carcinoma

(2011) JIARUI JIANG et al.   Experimental and Therapeutic Medicine

Rac and Rho GTPases in cancer cell motility control

(2010) Matteo Parri et al.   Cell Communication and Signaling

Identification of epithelial label-retaining cells at the transition between the anal canal and the rectum in mice

(2010) Laura A. Runck et al.   CELL CYCLE

Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy?

(2010) Galit Lazer et al.   CELLULAR SIGNALLING

RGS16 Is a Marker for Prognosis in Colorectal Cancer

(2009) Norikatsu Miyoshi et al.   ANNALS OF SURGICAL ONCOLOGY

Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer

(2009) E. Charafe-Jauffret et al.   CLINICAL CANCER RESEARCH

Sox2 Is Required for Maintenance and Differentiation of Bronchiolar Clara, Ciliated, and Goblet Cells

(2009) David H. Tompkins et al.   PLoS One

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

Rho GTPases in cancer cell biology

(2008) Francisco M. Vega et al.   FEBS LETTERS

Coordinate expression of cytokeratin 8 and cytokeratin 17 immunohistochemical staining in cervical intraepithelial neoplasia and cervical squamous cell carcinoma: An immunohistochemical analysis and review of the literature

(2008) Katsuhide Ikeda et al.   GYNECOLOGIC ONCOLOGY

Parallel Phosphatidylinositol 3-Kinase (PI3K)-dependent and Src-dependent Pathways Lead to CXCL8-mediated Rac2 Activation and Chemotaxis

(2008) Jiqing Sai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of novel Smad2 and Smad3 associated proteins in response to TGF-β1

(2008) Kimberly A. Brown et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification

(2008) Jiri Kalabis et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of Smad2 and Smad4 in cervical cancer: absent nuclear Smad4 expression correlates with poor survival

(2008) Judith N Kloth et al.   MODERN PATHOLOGY

An α-Helical Extension of the ELMO1 Pleckstrin Homology Domain Mediates Direct Interaction to DOCK180 and Is Critical in Rac Signaling

(2008) David Komander et al.   MOLECULAR BIOLOGY OF THE CELL

Comparative lesion sequencing provides insights into tumor evolution

(2008) S. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA