The Hippo signal transduction network in skeletal and cardiac muscle

Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells

(2014) Jiji Chen et al.   CELL

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

(2014) Wenjing Zhang et al.   CELL RESEARCH

The Hippo signaling pathway in stem cell biology and cancer

(2014) J.-S. Mo et al.   EMBO REPORTS

The Angiomotins - From discovery to function

(2014) Susana Moleirinho et al.   FEBS LETTERS

Cellular microenvironments reveal defective mechanosensing responses and elevated YAP signaling in LMNA-mutated muscle precursors

(2014) A. T. Bertrand et al.   JOURNAL OF CELL SCIENCE

Screening with a Novel Cell-Based Assay for TAZ Activators Identifies a Compound That Enhances Myogenesis in C2C12 Cells and Facilitates Muscle Repair in a Muscle Injury Model

(2014) Z. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Angiomotins link F-actin architecture to Hippo pathway signaling

(2014) Sebastian Mana-Capelli et al.   MOLECULAR BIOLOGY OF THE CELL

Mst1 Promotes Cardiac Myocyte Apoptosis through Phosphorylation and Inhibition of Bcl-xL

(2014) Dominic P. Del Re et al.   MOLECULAR CELL

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

MST1, a key player, in enhancing fast skeletal muscle atrophy

(2013) Bin Wei et al.   BMC BIOLOGY

Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair

(2013) Georgina M. Ellison et al.   CELL

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

BMP4 is a novel transcriptional target and mediator of mammary cell migration downstream of the Hippo pathway component TAZ

(2013) Dulcie Lai et al.   CELLULAR SIGNALLING

The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy

(2013) Suet Nee Chen et al.   CIRCULATION RESEARCH

Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy

(2013) Anna Ulbricht et al.   CURRENT BIOLOGY

The Hippo superhighway: signaling crossroads converging on the Hippo/Yap pathway in stem cells and development

(2013) Evan R Barry et al.   CURRENT OPINION IN CELL BIOLOGY

Hippo signaling impedes adult heart regeneration

(2013) T. Heallen et al.   DEVELOPMENT

The Hippo Effector Yorkie Controls Normal Tissue Growth by Antagonizing Scalloped-Mediated Default Repression

(2013) Laura M. Koontz et al.   DEVELOPMENTAL CELL

Control of the Hippo Pathway by Set7-Dependent Methylation of Yap

(2013) Menno J. Oudhoff et al.   DEVELOPMENTAL CELL

Mechanisms of impaired differentiation in rhabdomyosarcoma

(2013) Charles Keller et al.   FEBS Journal

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

RecurrentNCOA2gene rearrangements in congenital/infantile spindle cell rhabdomyosarcoma

(2013) Juan Miguel Mosquera et al.   GENES CHROMOSOMES & CANCER

Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy

(2013) Maria Gabriela Morales et al.   HUMAN MOLECULAR GENETICS

Alveolar rhabdomyosarcoma–associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression

(2013) Lisa E.S. Crose et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining the Protein–Protein Interaction Network of the Human Hippo Pathway

(2013) Wenqi Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair

(2013) Mei Xin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth

(2013) C L Yeung et al.   ONCOGENE

Constitutive Expression of Yes-Associated Protein (Yap) in Adult Skeletal Muscle Fibres Induces Muscle Atrophy and Myopathy

(2013) Robert N. Judson et al.   PLoS One

The Tyrosine Phosphatase PTPN14 Is a Negative Regulator of YAP Activity

(2013) Chrysiis Michaloglou et al.   PLoS One

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo pathway effector Yap promotes cardiac regeneration

(2013) Mei Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo Signaling Pathway Interactome

(2013) Y. Kwon et al.   SCIENCE

Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions

(2013) A. L. Couzens et al.   Science Signaling

Signaling and Transcriptional Networks in Heart Development and Regeneration

(2013) B. G. Bruneau   Cold Spring Harbor Perspectives in Biology

Genome-wide Association of Yorkie with Chromatin and Chromatin-Remodeling Complexes

(2013) Hyangyee Oh et al.   Cell Reports

The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense

(2013) Hongtan Wu et al.   Cell Reports

SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage

(2013) Eunjeong Seo et al.   Cell Reports

Embryonic Heart Progenitors and Cardiogenesis

(2013) T. Brade et al.   Cold Spring Harbor Perspectives in Medicine

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Role of TAZ as Mediator of Wnt Signaling

(2012) Luca Azzolin et al.   CELL

Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP

(2012) Eric Miller et al.   CHEMISTRY & BIOLOGY

Colonization of the Satellite Cell Niche by Skeletal Muscle Progenitor Cells Depends on Notch Signals

(2012) Dominique Bröhl et al.   DEVELOPMENTAL CELL

YAP regulates neuronal differentiation through Sonic hedgehog signaling pathway

(2012) Yi-Ting Lin et al.   EXPERIMENTAL CELL RESEARCH

Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene

(2012) Christian J. Gaffney et al.   GENE

Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs)

(2012) J.-S. Mo et al.   GENES & DEVELOPMENT

PTPN14 is required for the density-dependent control of YAP1

(2012) W. Wang et al.   GENES & DEVELOPMENT

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Genome-wide identification of enhancers in skeletal muscle: the role of MyoD1

(2012) R. Blum et al.   GENES & DEVELOPMENT

Yes-associated Protein Isoform 1 (Yap1) Promotes Cardiomyocyte Survival and Growth to Protect against Myocardial Ischemic Injury

(2012) Dominic P. Del Re et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCFβ-TrCP-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition

(2012) Wei Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Threonine-120 Phosphorylation Regulated by Phosphoinositide-3-Kinase/Akt and Mammalian Target of Rapamycin Pathway Signaling Limits the Antitumor Activity of Mammalian Sterile 20-Like Kinase 1

(2012) Filiz Kisaayak Collak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yap1 Protein Regulates Vascular Smooth Muscle Cell Phenotypic Switch by Interaction with Myocardin

(2012) Changqing Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin stress fibers - assembly, dynamics and biological roles

(2012) S. Tojkander et al.   JOURNAL OF CELL SCIENCE

The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells

(2012) R. N. Judson et al.   JOURNAL OF CELL SCIENCE

PAX3/FOXO1Fusion Gene Status Is the Key Prognostic Molecular Marker in Rhabdomyosarcoma and Significantly Improves Current Risk Stratification

(2012) Edoardo Missiaglia et al.   JOURNAL OF CLINICAL ONCOLOGY

Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells

(2012) Y. Wen et al.   MOLECULAR AND CELLULAR BIOLOGY

A High-Throughput Chromatin Immunoprecipitation Approach Reveals Principles of Dynamic Gene Regulation in Mammals

(2012) Manuel Garber et al.   MOLECULAR CELL

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

(2012) Karen Tumaneng et al.   NATURE CELL BIOLOGY

LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap

(2012) H B Nguyen et al.   ONCOGENE

PTPN14 interacts with and negatively regulates the oncogenic function of YAP

(2012) X Liu et al.   ONCOGENE

YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy

(2012) A. von Gise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo signaling in mammalian stem cells

(2012) Annie M. Tremblay et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Protein kinases of the Hippo pathway: Regulation and substrates

(2012) Joseph Avruch et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Genome-Wide Analysis of N1ICD/RBPJ Targets In Vivo Reveals Direct Transcriptional Regulation of Wnt, SHH, and Hippo Pathway Effectors by Notch1

(2012) Yaochen Li et al.   STEM CELLS

Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-β Pathways

(2012) Eric Aragón et al.   STRUCTURE

Structural and Functional Similarity between the Vgll1-TEAD and the YAP-TEAD Complexes

(2012) Ajaybabu V. Pobbati et al.   STRUCTURE

Wnt signaling in myogenesis

(2012) Julia von Maltzahn et al.   TRENDS IN CELL BIOLOGY

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Transcription factor TEAD4 regulates expression of Myogenin and the unfolded protein response genes during C2C12 cell differentiation

(2011) A Benhaddou et al.   CELL DEATH AND DIFFERENTIATION

An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration

(2011) C. Lepper et al.   DEVELOPMENT

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Effective fiber hypertrophy in satellite cell-depleted skeletal muscle

(2011) J. J. McCarthy et al.   DEVELOPMENT

Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments

(2011) Ricardo Ribas et al.   DEVELOPMENTAL BIOLOGY

A Smad action turnover switch operated by WW domain readers of a phosphoserine code

(2011) E. Aragon et al.   GENES & DEVELOPMENT

Sequentially acting Sox transcription factors in neural lineage development

(2011) M. Bergsland et al.   GENES & DEVELOPMENT

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription

(2011) Y. Bao et al.   JOURNAL OF BIOCHEMISTRY

Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin

(2011) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy

(2011) María Gabriela Morales et al.   JOURNAL OF PATHOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The 2012 version of the gene table of monogenic neuromuscular disorders

(2011)   NEUROMUSCULAR DISORDERS

Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP

(2011) L Angus et al.   ONCOGENE

Yes-Associated Protein 65 (YAP) Expands Neural Progenitors and Regulates Pax3 Expression in the Neural Plate Border Zone

(2011) Stephen T. Gee et al.   PLoS One

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size

(2011) M. Xin et al.   Science Signaling

The muscle satellite cell at 50: the formative years

(2011) Juergen Scharner et al.   Skeletal Muscle

Fibre types in skeletal muscle: a personal account

(2010) S. Schiaffino   Acta Physiologica

Yap is a novel regulator of C2C12 myogenesis

(2010) Kevin I. Watt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling

(2010) Tsutomu Oka et al.   BIOCHEMICAL JOURNAL

Sarcopenia: characteristics, mechanisms and functional significance

(2010) M. V. Narici et al.   BRITISH MEDICAL BULLETIN

BMP signalling permits population expansion by preventing premature myogenic differentiation in muscle satellite cells

(2010) Y Ono et al.   CELL DEATH AND DIFFERENTIATION

Myocyte Turnover in the Aging Human Heart

(2010) Jan Kajstura et al.   CIRCULATION RESEARCH

Upstream Regulation of the Hippo Size Control Pathway

(2010) Felix A. Grusche et al.   CURRENT BIOLOGY

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

Genome-wide MyoD Binding in Skeletal Muscle Cells: A Potential for Broad Cellular Reprogramming

(2010) Yi Cao et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

TAZ as a novel enhancer of MyoD-mediated myogenic differentiation

(2010) Hana Jeong et al.   FASEB JOURNAL

Expression and functional activity of four myocardin isoforms

(2010) Masaaki Imamura et al.   GENE

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCPE3 Ligase

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PP1 Cooperates with ASPP2 to Dephosphorylate and Activate TAZ

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice

(2010) Dominic P. Del Re et al.   JOURNAL OF CLINICAL INVESTIGATION

Muscling in: Uncovering the origins of rhabdomyosarcoma

(2010) Simone Hettmer et al.   NATURE MEDICINE

Modularity in the Hippo signaling pathway

(2010) Marius Sudol et al.   TRENDS IN BIOCHEMICAL SCIENCES

YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human diseaseThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

(2009) Kainan Wang et al.   Biochemistry and Cell Biology

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

Distinct and dynamic myogenic populations in the vertebrate embryo

(2009) Margaret Buckingham et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

(2009) A. Fernandez-L et al.   GENES & DEVELOPMENT

Phosphoinositide 3-Kinase/Akt Inhibits MST1-Mediated Pro-apoptotic Signaling through Phosphorylation of Threonine 120

(2009) Zengqiang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

Mutation in BAG3 causes severe dominant childhood muscular dystrophy

(2008) Duygu Selcen et al.   ANNALS OF NEUROLOGY

MOBKL1A/MOBKL1B Phosphorylation by MST1 and MST2 Inhibits Cell Proliferation

(2008) Maria Praskova et al.   CURRENT BIOLOGY

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

(2008) Shian Wu et al.   DEVELOPMENTAL CELL

YAP regulates neural progenitor cell number via the TEA domain transcription factor

(2008) X. Cao et al.   GENES & DEVELOPMENT

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Mst2 and Lats Kinases Regulate Apoptotic Function of Yes Kinase-associated Protein (YAP)

(2008) Tsutomu Oka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of TEAD-1 in Transgenic Mouse Striated Muscles Produces a Slower Skeletal Muscle Contractile Phenotype

(2008) Richard W. Tsika et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

(2008) Q.-Y. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY

MCAT Elements and the TEF-1 Family of Transcription Factors in Muscle Development and Disease

(2007) Tadashi Yoshida   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy

(2007) Guilian Sun et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES