Visualizing and Manipulating Temporal Signaling Dynamics with Fluorescence-Based Tools

Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module

(2013) Jared E. Toettcher et al.   CELL

The Dynamics of Signaling as a Pharmacological Target

(2013) Marcelo Behar et al.   CELL

Encoding and Decoding Cellular Information through Signaling Dynamics

(2013) Jeremy E. Purvis et al.   CELL

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Ikaros Sets the Potential for Th17 Lineage Gene Expression through Effects on Chromatin State in Early T Cell Development

(2013) Larry Y. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the Protein–Protein Interaction Network of the Human Hippo Pathway

(2013) Wenqi Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Visualization of an endogenous retinoic acid gradient across embryonic development

(2013) Satoshi Shimozono et al.   NATURE

The Hippo Signaling Pathway Interactome

(2013) Y. Kwon et al.   SCIENCE

The CRISPR Craze

(2013) E. Pennisi   SCIENCE

Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions

(2013) A. L. Couzens et al.   Science Signaling

Integration of Protein Abundance and Structure Data Reveals Competition in the ErbB Signaling Network

(2013) C. Kiel et al.   Science Signaling

A Versatile Toolkit to Produce Sensitive FRET Biosensors to Visualize Signaling in Time and Space

(2013) R. D. Fritz et al.   Science Signaling

Automatic Generation of Predictive Dynamic Models Reveals Nuclear Phosphorylation as the Key Msn2 Control Mechanism

(2013) M. Sunnaker et al.   Science Signaling

Transcriptional Dynamics Elicited by a Short Pulse of Notch Activation Involves Feed-Forward Regulation by E(spl)/Hes Genes

(2013) Ben E. Housden et al.   PLoS Genetics

Direct observation of frequency modulated transcription in single cells using light activation

(2013) Daniel R Larson et al.   eLife

Fluorescent proteins for FRET microscopy: Monitoring protein interactions in living cells

(2012) Richard N. Day et al.   BIOESSAYS

Tandem fluorescent protein timers for in vivo analysis of protein dynamics

(2012) Anton Khmelinskii et al.   NATURE BIOTECHNOLOGY

Differential Diffusivity of Nodal and Lefty Underlies a Reaction-Diffusion Patterning System

(2012) P. Muller et al.   SCIENCE

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

The Temporal Pattern of Stimulation Determines the Extent and Duration of MAPK Activation in a Caenorhabditis elegans Sensory Neuron

(2012) T. Tomida et al.   Science Signaling

Robustness and flexibility in nematode vulva development

(2012) Marie-Anne Félix et al.   TRENDS IN GENETICS

Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning

(2012) N. Perrimon et al.   Cold Spring Harbor Perspectives in Biology

Live transgenic reporters of the vertebrate embryo's Segmentation Clock

(2011) Daniele Soroldoni et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The stem cell niche: lessons from the Drosophila testis

(2011) M. de Cuevas et al.   DEVELOPMENT

Intestinal stem cells in the adult Drosophila midgut

(2011) Huaqi Jiang et al.   EXPERIMENTAL CELL RESEARCH

Genome Engineering With Zinc-Finger Nucleases

(2011) Dana Carroll   GENETICS

Signal-dependent dynamics of transcription factor translocation controls gene expression

(2011) Nan Hao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proteomic and Functional Genomic Landscape of Receptor Tyrosine Kinase and Ras to Extracellular Signal-Regulated Kinase Signaling

(2011) A. A. Friedman et al.   Science Signaling

Live Cell Imaging Reveals Continuous STAT6 Nuclear Trafficking

(2010) H.-C. Chen et al.   JOURNAL OF IMMUNOLOGY

Live cell imaging of mechanotransduction

(2010) B. Liu et al.   Journal of the Royal Society Interface

The promise of optogenetics in cell biology: interrogating molecular circuits in space and time

(2010) Jared E Toettcher et al.   NATURE METHODS

EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors

(2010) R. Avraham et al.   Science Signaling

Functional Heterogeneity of Embryonic Stem Cells Revealed through Translational Amplification of an Early Endodermal Transcript

(2010) Maurice A. Canham et al.   PLOS BIOLOGY

The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells

(2009) T. Kobayashi et al.   GENES & DEVELOPMENT

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors

(2009) Kazuhiro Aoki et al.   Nature Protocols

Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors

(2008) Hiromi Shimojo et al.   NEURON

A genetically encoded fluorescent sensor of ERK activity

(2008) C. D. Harvey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA