Combined inhibition of PI3K  and PI3K  reduces fat mass by enhancing  -MSH-dependent sympathetic drive

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis

(2013) Shingo Kajimura et al.   Annual Review of Physiology

Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons

(2013) Jong-Woo Sohn et al.   CELL

White, Brown, Beige/Brite: Different Adipose Cells for Different Functions?

(2013) Marta Giralt et al.   ENDOCRINOLOGY

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

How brown is brown fat? It depends where you look

(2013) Jan Nedergaard et al.   NATURE MEDICINE

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Cardiac sympathetic neurons provide trophic signal to the heart via β2-adrenoceptor-dependent regulation of proteolysis

(2012) Tania Zaglia et al.   CARDIOVASCULAR RESEARCH

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

(2012) Isabel Garcia-Cao et al.   CELL

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

(2012) Ana Ortega-Molina et al.   Cell Metabolism

Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure

(2012) Peng Li et al.   EXPERIMENTAL PHYSIOLOGY

Central nervous system control of metabolism

(2012) Martin G. Myers et al.   NATURE

Brown Fat Develops aBriteFuture

(2012) Martin Klingenspor et al.   Obesity Facts

Leukocyte and Cardiac Phosphoinositide 3-Kinase γ Activity in Pressure Overload–Induced Cardiac Failure

(2012) Alessia Perino et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Quantitative dynamics of adipose cells

(2012) Junghyo Jo et al.   Adipocyte

Intracellular fatty acids suppress β-adrenergic induction of PKA-targeted gene expression in white adipocytes

(2011) Emilio P. Mottillo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

(2011) Jari Rossi et al.   Cell Metabolism

Melanocortin control of energy balance: evidence from rodent models

(2011) Bart C. De Jonghe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lack of cAMP-response Element-binding Protein 1 in the Hypothalamus Causes Obesity

(2011) Franck Chiappini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

The global obesity pandemic: shaped by global drivers and local environments

(2011) Boyd A Swinburn et al.   LANCET

Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ

(2011) Alessia Perino et al.   MOLECULAR CELL

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons

(2011) Tim Klöckener et al.   NATURE NEUROSCIENCE

Intracellular Leptin-Signaling Pathways in Hypothalamic Neurons: The Emerging Role of Phosphatidylinositol-3 Kinase-Phosphodiesterase-3B-cAMP Pathway

(2011) Abhiram Sahu   NEUROENDOCRINOLOGY

Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance

(2011) N. Kobayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K  within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance

(2011) B. Becattini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of phosphoinositide 3-kinase β in platelet aggregation and thromboxane A2generation mediated by Gisignalling pathways

(2010) Analia Garcia et al.   BIOCHEMICAL JOURNAL

PI3K Signaling in the Ventromedial Hypothalamic Nucleus Is Required for Normal Energy Homeostasis

(2010) Yong Xu et al.   Cell Metabolism

Distribution and Development of Brown Adipocytes in the Murine and Human Adipose Organ

(2010) Andrea Frontini et al.   Cell Metabolism

The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions

(2010) Jan Nedergaard et al.   Cell Metabolism

The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology

(2010) Ya-Xiong Tao   ENDOCRINE REVIEWS

Brown adipose tissue in humans

(2010) S Enerbäck   INTERNATIONAL JOURNAL OF OBESITY

Differential effects of insulin on sympathetic nerve activity in agouti obese mice

(2010) Donald A Morgan et al.   JOURNAL OF HYPERTENSION

Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility

(2010) Elisa Ciraolo et al.   MOLECULAR BIOLOGY OF THE CELL

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons

(2009) Hind Al-Qassab et al.   Cell Metabolism

Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis

(2009) Jennifer W. Hill et al.   ENDOCRINOLOGY

Pertussis Toxin-sensitive Signaling of Melanocortin-4 Receptors in Hypothalamic GT1-7 Cells Defines Agouti-related Protein as a Biased Agonist

(2009) Thomas R. H. Büch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms mediating renal sympathetic activation to leptin in obesity

(2008) Donald A. Morgan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Myocardial Pitx2 Differentially Regulates the Left Atrial Identity and Ventricular Asymmetric Remodeling Programs

(2008) Alessandra Tessari et al.   CIRCULATION RESEARCH

Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin

(2008) K. Rahmouni et al.   DIABETES

Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies

(2008) Kyriaki Gerozissis   EUROPEAN JOURNAL OF PHARMACOLOGY

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

(2008) Jennifer W. Hill et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

(2008) Shidong Jia et al.   NATURE

Modulation of Blood Pressure by Central Melanocortinergic Pathways

(2008) Jerry R. Greenfield et al.   NEW ENGLAND JOURNAL OF MEDICINE

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide 3-Kinase p110  Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

(2008) E. Ciraolo et al.   Science Signaling