Article
Chemistry, Physical
Yan-Ning Wang, Hao Xu, Shao-Dan Wang, Xue-Ping Chang, Yi-Tong Wang, Qing-Chen Qiu, Jun-Tai Bai, Yuan Mo, Wu-Yi Feng, Meng-Han Zhang, Qing-Feng Yang
Summary: In this study, a novel nickel(II)-based coordination polymer with great thermal and chemical stability was successfully designed and synthesized. This material exhibits strong fluorescence and can be used for the highly selective and sensitive detection of various substances.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Multidisciplinary
Xunfan Liao, Wenchao Xie, Zeyao Han, Yongjie Cui, Xinxin Xia, Xueliang Shi, Zhaoyang Yao, Xiaobao Xu, Xinhui Lu, Yiwang Chen
Summary: Non-fullerene acceptors (NFAs) with strong absorption and optical response in the near-infrared region (NIR) were developed. The effect of 2D central core fluorination on the molecular self-assembly and optoelectronic properties was explored. The results showed that NFAs based on 2D fluorinated acceptors exhibited higher efficiency and improved performance.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Zhuo Lin, Wenjing Li, Quan Chen, Ling Chen, Chi Zhang, Jinfang Zhang
Summary: A novel photochromic organic ligand was successfully synthesized and used to construct a sensor material with high sensitivity. By studying its photochromic mechanism and sensing properties, it was found that the material exhibited extremely high sensitivity and selectivity in detecting MnO4-.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Chemistry, Organic
Wenqing Guo, Li Cheng, Guobin Ma, Weiqi Tong, Fan Wu
Summary: In this study, a nickel-catalyzed enantioconvergent hydroalkylation method has been developed for the synthesis of enantioenriched trifluoromethylated alkanes. The reaction utilizes readily available alkenes as alkyl coupling partners and offers mild conditions, a broad substrate scope, and high functional group tolerance. The synthetic utility of this method has been demonstrated through the late-stage functionalization of various drug molecules and natural products.
Article
Materials Science, Multidisciplinary
Dan Klein, Karen Michaeli
Summary: Thermoelectric devices have the potential to replace mechanical work with electric power, but their practical use is hindered by their low performance. A new design using chiral organic molecules connected to magnetic electrodes shows promise in increasing the efficiency and power generation of thermoelectric devices.
Article
Chemistry, Multidisciplinary
Bahiru Punja Benke, Tobias Kirschbaum, Juergen Graf, Juergen H. Gross, Michael Mastalerz
Summary: This study presents a new method to induce catenation by adding methoxy or thiomethyl groups to one of the precursors during the synthesis of chiral organic cages. The catenation is mainly driven by weak interactions derived from the substituents rather than pi-stacking. The study sheds light on the formation of catenated structures beyond macrocycles.
Article
Chemistry, Multidisciplinary
Jinfang Zhang, Zhuo Lin, Yinlong Yue, Qinghan Chen, Dejing Yin, Chi Zhang
Summary: This work developed a photochromic organic molecule as a sensor material and achieved high sensitivity and selectivity detection of specific ions through fluorescence quenching effects.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Kumbam Lingeshwar Reddy, Jikson Pulparayil Mathew, Sonia Maniappan, Catherine Tom, Elizabeth Shiby, Ravi Kumar Pujala, Jatish Kumar
Summary: Mandelic acid derivatives were designed and synthesized, and their aggregation properties in solvent mixtures were investigated. These compounds self-assemble into robust chiral gels and serve as efficient templates for the assembly of luminescent carbon nanodots. Circularly polarized luminescence signals were observed from the hybrid nanocomposites, allowing for the fabrication of multicolour chiral light-emitting materials.
Article
Chemistry, Multidisciplinary
Julia A. Schmidt, Joseph A. Weatherby, Isaac J. Sugden, Alejandro Santana-Bonilla, Francesco Salerno, Matthew J. Fuchter, Erin R. Johnson, Jenny Nelson, Kim E. Jelfs
Summary: Designing molecular materials is challenging due to the subtle variations in packing arrangements caused by soft intermolecular interactions. A rapid screening approach was developed to predict charge-transfer properties of helicene compounds, bridging the gap between single-molecule design and resulting charge-carrier mobilities. Results showed that fluorination significantly improved electron transport, while side groups with triple bonds led to improved transfer integrals.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Astronomy & Astrophysics
Karlis Dzenis, Alexandre Faure, B. A. McGuire, A. J. Remijan, P. J. Dagdigian, C. Rist, R. Dawes, E. Quintas-Sanchez, F. Lique, M. Hochlaf
Summary: The theoretical rotational cross sections for propylene oxide colliding with cold He atoms were obtained using a high-accuracy potential energy surface. The results were combined with radiative data and analyzed using a non-LTE radiative transfer model, revealing the cold gas characteristics of propylene oxide in the Sgr B2(N) molecular cloud.
ASTROPHYSICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Haozhen Wang, Chao Yang, Fangshuai Chen, Gengfeng Zheng, Qing Han
Summary: The TF50-COF catalyst, a partially fluorinated, metal-free, imine-linked two-dimensional triazine covalent organic framework, demonstrates high selectivity and stability in O-2 photoreduction into H2O2. By varying the proportion of fluorine substitution, the catalyst maximizes interlayer interactions, improves crystallinity, accelerates carrier transfer, and enhances photostability. The catalyst achieves a high H2O2 yield rate of 1739 mu mol h(-1) g(-1) and an apparent quantum efficiency of 5.1 % at 400 nm, surpassing the performance of previously reported nonmetal COF-based photocatalysts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Daiki Tomon, Satoru Arimitsu
Summary: The acetyl group of chiral α-fluorinated dicarbonyl compounds was converted to nonaflates through a reaction with perfluorobutanesulfonyl fluoride in the presence of DBU, with yields ranging from 82% to 95%. These nonaflates were used in Suzuki and Sonogashira coupling reactions to produce chiral tertiary allylic fluorides with gem-disubstituted terminal alkenes and excellent optical purities (45-91%, ≥94% ee). Additionally, chiral tertiary propargylic fluorides were obtained from the reaction of nonaflates with DBU (73-86%, ≥94% ee).
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Zhongkui Li, Hao Su, Yanhong Zhu, Li Yan, Hui Li
Summary: In this study, four copper coordination complexes were synthesized under different solvent and reaction time conditions. The structural analysis revealed that these complexes exhibited diverse crystal structures and chirality properties, and could undergo structural transformations under specific conditions.
Article
Chemistry, Multidisciplinary
Ying Zhang, Jimin Yang, Yu-Long Ruan, Ling Liao, Chuang Ma, Xiao-Song Xue, Jin-Sheng Yu
Summary: This study developed an unprecedented nickel-catalyzed enantioselective hydromonofluoromethylation reaction, enabling the synthesis of valuable monofluoromethyl-tethered chiral allenes that were previously inaccessible. The method exhibits broad substrate scope, good functionality tolerance, mild reaction conditions, and the ability to construct other valuable fluorinated compounds.
Article
Chemistry, Physical
Sajal Kumar Giri, George C. Schatz
Summary: This study reports the manipulation of electronic excitations using the unique temporal and spectral features of pulsed entangled photons. A comprehensive optimization protocol based on Bayesian optimization is developed to selectively excite electronic states. The results show that entangled light significantly enhances two-photon absorption probability and enables selective excitation.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Tetsuya Ezawa, Yoshihiro Sohtome, Daisuke Hashizume, Masaya Adachi, Mai Akakabe, Hiroyuki Koshino, Mikiko Sodeoka
Summary: This study explores stereo-chemical dynamics in Ni(II)-catalyzed reactions, demonstrating a wide substrate scope and high selectivity in forming CN-containing building blocks with adjacent stereocenters. Computational investigations indicate that enantioselectivity is governed by the deprotonation process, while unique syn addition is controlled by noncovalent interactions between the nitrone and ligand.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Hiroyuki Kawagoe, Jun Ando, Miwako Asanuma, Kosuke Dodo, Tetsuya Miyano, Hiroshi Ueda, Mikiko Sodeoka, Katsumasa Fujita
Summary: A high-throughput Raman screening system has been developed, allowing for simultaneous analysis of multiple samples and high-speed chemical mapping.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Takahiro Moriyama, Daiki Mizukami, Makoto Yoritate, Kazuteru Usui, Daisuke Takahashi, Eisuke Ota, Mikiko Sodeoka, Tadashi Ueda, Satoru Karasawa, Go Hirai
Summary: Minimalist photo-reactive probes, consisting of a photo-reactive group and a tag for detection of target proteins, are valuable tools in chemical biology. In this study, minimalist probes based on a 2-thienyl-substituted alpha-ketoamide with an alkyne group on the thiophene ring were developed. The 3-alkyne probe showed the highest photo-affinity labeling efficiency.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Masumi Sugawara, Miki Sawamura, Mai Akakabe, Boobalan Ramadoss, Yoshihiro Sohtome, Mikiko Sodeoka
Summary: This study investigates the oxidative cross-dehydrogenative coupling reaction of monomers and dimers. The reactivity of the monomers is found to be lower than that of the dimers under aerobic conditions. The reactivity of the monomers can be significantly improved by using a modified catalyst, enabling them to undergo the oxidative cross-dehydrogenative coupling reaction with catechols.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Syusuke Egoshi, Kosuke Dodo, Mikiko Sodeoka
Summary: This article reviews the applications of Raman microscopy in deducing the distributions of endogenous biomolecules without exogenous labeling. It also discusses the use of deuterated fatty acids for lipid analysis and observing intracellular metabolic activities.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kohei Toh, Kosuke Nishio, Reiko Nakagawa, Syusuke Egoshi, Masahiro Abo, Amelie Perron, Shin-ichi Sato, Naoki Okumura, Noriko Koizumi, Kosuke Dodo, Mikiko Sodeoka, Motonari Uesugi
Summary: Research has shown that visible light, especially in the blue region, can cause cell dysfunction and contribute to cellular aging and age-related pathologies by generating singlet oxygen. A chemoproteomic approach has been used to map blue-light-damaged proteins in live mammalian cells, revealing that cell surface proteins are more prone to oxidation compared to other susceptible proteins. The integrin family of cell surface receptors, including ITGB1, was found to be highly impacted, leading to loss of functionality in cell adhesion and proliferation. This study highlights the importance of understanding light-induced protein damages and their effects on cellular functions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Kosuke Dodo, Katsumasa Fujita, Mikiko Sodeoka
Summary: This article introduces the application of Raman spectroscopy in chemical biology research, including label-free Raman imaging of biomolecules and Raman imaging of small molecules using Raman tags. Raman probes represent the next-generation probes in chemical biology.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Applied
Shintaro Kawamura, Pablo Barrio, Santos Fustero, Jorge Escorihuela, Jianlin Han, Vadim A. Soloshonok, Mikiko Sodeoka
Summary: The difunctionalizative trifluoromethylation of unsaturated C-C bonds is a highly useful and efficient method for synthesizing trifluoromethyl compounds. This review focuses on reactions that simultaneously form C-heteroatom and C-H bonds, providing useful CF3 group-containing building blocks. The comprehensive survey categorizes reactions into those that are synthetically mature and those with room for further development.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Applied
Takuma Tagami, Yusuke Mitani, Shintaro Kawamura, Mikiko Sodeoka
Summary: Given the significance of difluoromethylated molecules in drug and agrochemical development, the establishment of synthetic protocols for their synthesis has gained much attention. This study reports a general and practical Cu-catalyzed method for the difluoromethylation of alkenes using difluoroacetic anhydride (DFAA) as a CF2H source. The reaction proceeds via the in situ generation of bis(difluoroacetyl) peroxide (BDFAP) from DFAA and H2O2. The obtained results enable the simple and efficient synthesis of a wide range of difluoromethylated species for their practical applications in medicinal and agricultural chemistry.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Kenji Hayamizu, Kota Koike, Kosuke Dodo, Miwako Asanuma, Hiromichi Egami, Mikiko Sodeoka
Summary: Palladium enolates derived from β-ketocarbonyl compounds are stable in air and moisture. This stability was utilized to develop a peptide purification system using β-ketoamide as a small affinity tag in aqueous media. A solid-supported palladium complex efficiently captured and released β-ketoamide-tagged molecules, allowing for the purification and identification of ligand-binding sites in proteins.
Article
Chemistry, Medicinal
Yoshihiro Sohtome, Mikiko Sodeoka
Summary: Researchers have found through computational analysis that the key steps in the synthesis of chiral molecules are regulated by multiple factors including isomerism of the complex, isomerism of the enolate, and spatial repulsion between reactants and ligands.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Kazuki Sasaki, Michihiro Suzuki, Takeshi Sonoda, Tilman Schneider-Poetsch, Akihiro Ito, Motoki Takagi, Shinya Fujishiro, Yoshihiro Sohtome, Kosuke Dodo, Takashi Umehara, Hiroyuki Aburatani, Kazuo Shin-ya, Yoichi Nakao, Mikiko Sodeoka, Minoru Yoshida
Summary: This study developed an FRET-based probe that successfully traces dynamic changes in H3K9me3 and revealed subtle alterations that occur during mitosis.
CELL CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Organic
Subrata Mukherjee, Shintaro Kawamura, Mikiko Sodeoka
Summary: Fluoroalkylation is an important strategy for enhancing the drug-like properties and bioactivities of compounds. This mini-review focuses on intramolecular difunctionalization-type fluoroalkylations of alkenes using Togni reagent and fluorine-containing carboxylic anhydrides. These reactions yield fluoroalkyl-group-containing carbo- and heterocycles as potential bioactive compounds.
Article
Chemistry, Multidisciplinary
Go Hirai, Marie Kato, Hiroyuki Koshino, Eri Nishizawa, Kana Oonuma, Eisuke Ota, Toru Watanabe, Daisuke Hashizume, Yuki Tamura, Mitsuaki Okada, Taeko Miyagi, Mikiko Sodeoka
Summary: Glycoconjugates are important bio-molecules that regulate biological events in cells. This study successfully synthesized sialidase-resistant analogues of ganglioside GM3, demonstrating their inhibitory activity on EGF receptor autophosphorylation.
Article
Biochemistry & Molecular Biology
Mingming Chen, Miwako Asanuma, Mari Takahashi, Yuichi Shichino, Mari Mito, Koichi Fujiwara, Hironori Saito, Stephen N. Floor, Nicholas T. Ingolia, Mikiko Sodeoka, Kosuke Dodo, Takuhiro Ito, Shintaro Iwasaki
Summary: The translation inhibitor Rocaglamide A shows promising antitumor activity by clamping eIF4A and DDX3 onto polypurine RNA for selective translational repression. Analysis of a de novo-assembled transcriptome from the natural source of RocA, plant Aglaia, reveals the amino acid critical for RocA binding. The dominant-negative effect of RocA on eIF4A and DDX3 leads to strong translational repression in cancer cells, indicating its tumor toxicity.
CELL CHEMICAL BIOLOGY
(2021)