Raman Spectroscopy for Chemical Biology Research

Double face of cytochrome c in cancers by Raman imaging

(2022) H. Abramczyk et al.   Scientific Reports

Alkyne-Tagged Raman Probes for Local Environmental Sensing by Hydrogen–Deuterium Exchange

(2022) Xiaotian Bi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bessel-beam illumination Raman microscopy

(2022) Kazuki Bando et al.   Biomedical Optics Express

Label-Free Monitoring of Drug-Induced Cytotoxicity and Its Molecular Fingerprint by Live-Cell Raman and Autofluorescence Imaging

(2022) Menglu Li et al.   ANALYTICAL CHEMISTRY

Label-free chemical imaging of cytochrome P450 activity by Raman microscopy

(2022) Menglu Li et al.   Communications Biology

D2O-Probed Raman Microspectroscopy Distinguishes the Metabolic Dynamics of Macromolecules in Organellar Anticancer Drug Response

(2021) Maryam Hekmatara et al.   ANALYTICAL CHEMISTRY

A Palette of Minimally‐Tagged Sucrose Analogues for Real‐time Raman Imaging of Intracellular Plant Metabolism

(2021) Fabio De Moliner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ultra-bright Raman dots for multiplexed optical imaging

(2021) Zhilun Zhao et al.   Nature Communications

Super-resolution vibrational microscopy by stimulated Raman excited fluorescence

(2021) Hanqing Xiong et al.   Light-Science & Applications

Azo-Enhanced Raman Scattering for Enhancing the Sensitivity and Tuning the Frequency of Molecular Vibrations

(2021) Yuchen Tang et al.   ACS Central Science

Mitokyne: A Ratiometric Raman Probe for Mitochondrial pH

(2021) Liam T. Wilson et al.   ANALYTICAL CHEMISTRY

9-Cyanopyronin probe palette for super-multiplexed vibrational imaging

(2021) Yupeng Miao et al.   Nature Communications

Super-resolution label-free volumetric vibrational imaging

(2021) Chenxi Qian et al.   Nature Communications

Multiplexed live-cell profiling with Raman probes

(2021) Chen Chen et al.   Nature Communications

Multiwell Raman plate reader for high-throughput biochemical screening

(2021) Hiroyuki Kawagoe et al.   Scientific Reports

Integration of Raman spectra with transcriptome data in glioblastoma multiforme defines tumour subtypes and predicts patient outcome

(2021) Pierre‐Jean Le Reste et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Multicolor Photoactivatable Raman Probes for Subcellular Imaging and Tracking by Cyclopropenone Caging

(2021) Jiajun Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spectral focusing in picosecond pulsed stimulated Raman scattering microscopy

(2021) Kota Koike et al.   Biomedical Optics Express

Polydiacetylene-based ultrastrong bioorthogonal Raman probes for targeted live-cell Raman imaging

(2020) Sidan Tian et al.   Nature Communications

Imaging lutein and zeaxanthin in the human retina with confocal resonance Raman microscopy

(2020) Binxing Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Raman spectroscopic signatures of carotenoids and polyenes enable label-free visualization of microbial distributions within pink biofilms

(2020) Hiroto Horiue et al.   Scientific Reports

Metabolic Activity Phenotyping of Single Cells with Multiplexed Vibrational Probes

(2020) Zhilun Zhao et al.   ANALYTICAL CHEMISTRY

The Human Genome Project changed everything

(2020) Richard A. Gibbs   NATURE REVIEWS GENETICS

A single-cell Raman-based platform to identify developmental stages of human pluripotent stem cell-derived neurons

(2020) Chia-Chen Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Raman image-activated cell sorting

(2020) Nao Nitta et al.   Nature Communications

Quantitative Drug Dynamics Visualized by Alkyne-Tagged Plasmonic-Enhanced Raman Microscopy

(2020) Kota Koike et al.   ACS Nano

Visualizing Subcellular Enrichment of Glycogen in Live Cancer Cells by Stimulated Raman Scattering

(2020) Dongkwan Lee et al.   ANALYTICAL CHEMISTRY

Quantitative Label-Free Imaging of Lipid Domains in Single Bilayers by Hyperspectral Coherent Raman Scattering

(2020) Alexander Nahmad-Rohen et al.   ANALYTICAL CHEMISTRY

Detection of Penicillin G Produced by Penicillium chrysogenum with Raman Microspectroscopy and Multivariate Curve Resolution-Alternating Least-Squares Methods

(2020) Shumpei Horii et al.   JOURNAL OF NATURAL PRODUCTS

Raman-guided subcellular pharmaco-metabolomics for metastatic melanoma cells

(2020) Jiajun Du et al.   Nature Communications

Multicolor Activatable Raman Probes for Simultaneous Detection of Plural Enzyme Activities

(2020) Hiroyoshi Fujioka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Saturated Stimulated-Raman-Scattering Microscopy for Far-Field Superresolution Vibrational Imaging

(2019) Li Gong et al.   Physical Review Applied

Volumetric chemical imaging by clearing-enhanced stimulated Raman scattering microscopy

(2019) Mian Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multicolor Raman Beads for Multiplexed Tumor Cell and Tissue Imaging and in Vivo Tumor Spectral Detection

(2019) QingQing Jin et al.   ANALYTICAL CHEMISTRY

Cellular Imaging Using Stimulated Raman Scattering Microscopy

(2019) Andrew H. Hill et al.   ANALYTICAL CHEMISTRY

Label-free chemical imaging flow cytometry by high-speed multicolor stimulated Raman scattering

(2019) Yuta Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Higher-order coherent anti-Stokes Raman scattering microscopy realizes label-free super-resolution vibrational imaging

(2019) Li Gong et al.   Nature Photonics

Utilizing Stimulated Raman Scattering Microscopy To Study Intracellular Distribution of Label-Free Ponatinib in Live Cells

(2019) Kristel Sepp et al.   JOURNAL OF MEDICINAL CHEMISTRY

Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis

(2018) Michael M. Gaschler et al.   ACS Chemical Biology

Antibiotic Susceptibility Determination within One Cell Cycle at Single-Bacterium Level by Stimulated Raman Metabolic Imaging

(2018) Weili Hong et al.   ANALYTICAL CHEMISTRY

Alkyne–DNA-Functionalized Alloyed Au/Ag Nanospheres for Ratiometric Surface-Enhanced Raman Scattering Imaging Assay of Endonuclease Activity in Live Cells

(2018) Yanmei Si et al.   ANALYTICAL CHEMISTRY

Raman Microspectroscopic Evidence for the Metabolism of a Tyrosine Kinase Inhibitor, Neratinib, in Cancer Cells

(2018) Karim Aljakouch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two-color vibrational imaging of glucose metabolism using stimulated Raman scattering

(2018) Rong Long et al.   CHEMICAL COMMUNICATIONS

Supermultiplexed optical imaging and barcoding with engineered polyynes

(2018) Fanghao Hu et al.   NATURE METHODS

The alkyne-tag Raman imaging of coronatine, a plant pathogen virulence factor, in Commelina communis and its possible mode of action

(2018) Minoru Ueda et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Noninvasive detection of macrophage activation with single-cell resolution through machine learning

(2018) Nicolas Pavillon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CRISPR tool kit for genome editing and beyond

(2018) Mazhar Adli   Nature Communications

Linear Regression Links Transcriptomic Data and Cellular Raman Spectra

(2018) Koseki J. Kobayashi-Kirschvink et al.   Cell Systems

A ratiometric Raman probe for live-cell imaging of hydrogen sulfide in mitochondria by stimulated Raman scattering

(2018) Chen Zeng et al.   ANALYST

Alkyne-based surface-enhanced Raman scattering nanoprobe for ratiometric imaging analysis of caspase 3 in live cells and tissues

(2018) Xiaojie Qin et al.   ANALYTICA CHIMICA ACTA

Optical imaging of metabolic dynamics in animals

(2018) Lingyan Shi et al.   Nature Communications

Label-free Evaluation of Myocardial Infarct in Surgically Excised Ventricular Myocardium by Raman Spectroscopy

(2018) Tsunehisa Yamamoto et al.   Scientific Reports

Applications of Raman spectroscopy in cancer diagnosis

(2018) Gregory W. Auner et al.   CANCER AND METASTASIS REVIEWS

Raman imaging of macrophages incubated with triglyceride-enriched oxLDL visualizes translocation of lipids between endocytic vesicles and lipid droplets

(2017) Clara Stiebing et al.   JOURNAL OF LIPID RESEARCH

Lipidomics Reveals Dramatic Physiological Kinetic Isotope Effects during the Enzymatic Oxygenation of Polyunsaturated Fatty Acids Ex Vivo

(2017) Aaron R. Navratil et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Super-multiplex vibrational imaging

(2017) Lu Wei et al.   NATURE

Imaging drug uptake by bioorthogonal stimulated Raman scattering microscopy

(2017) William J. Tipping et al.   Chemical Science

Noncanonical Function of a Small-Molecular Virulence Factor Coronatine against Plant Immunity: An In Vivo Raman Imaging Approach

(2017) Minoru Ueda et al.   ACS Central Science

Alkyne-Tag SERS Screening and Identification of Small-Molecule-Binding Sites in Protein

(2016) Jun Ando et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-resolution confocal Raman microscopy using pixel reassignment

(2016) Clemens Roider et al.   OPTICS LETTERS

Light sheet Raman micro-spectroscopy

(2016) Walter Müller et al.   Optica

Resonance Raman Probes for Organelle-Specific Labeling in Live Cells

(2016) Andrey N. Kuzmin et al.   Scientific Reports

Bioorthogonal chemical imaging of metabolic activities in live mammalian hippocampal tissues with stimulated Raman scattering

(2016) Fanghao Hu et al.   Scientific Reports

Non-label immune cell state prediction using Raman spectroscopy

(2016) Taro Ichimura et al.   Scientific Reports

Imaging Complex Protein Metabolism in Live Organisms by Stimulated Raman Scattering Microscopy with Isotope Labeling

(2015) Lu Wei et al.   ACS Chemical Biology

Vibrational Imaging of Glucose Uptake Activity in Live Cells and Tissues by Stimulated Raman Scattering

(2015) Fanghao Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Coherent Raman Scattering Microscopy in Biology and Medicine

(2015) Chi Zhang et al.   Annual Review of Biomedical Engineering

Organelle specific imaging in live cells and immuno-labeling using resonance Raman probe

(2015) Yuee Li et al.   BIOMATERIALS

Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior

(2015) Jin Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A sensitive and specific Raman probe based on bisarylbutadiyne for live cell imaging of mitochondria

(2015) Hiroyuki Yamakoshi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SERS Nanoparticles in Medicine: From Label-Free Detection to Spectroscopic Tagging

(2015) Lucas A. Lane et al.   CHEMICAL REVIEWS

Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy

(2015) Jun Ando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intraoperative brain cancer detection with Raman spectroscopy in humans

(2015) Michael Jermyn et al.   Science Translational Medicine

Structured line illumination Raman microscopy

(2015) Kozue Watanabe et al.   Nature Communications

Time-lapse Raman imaging of osteoblast differentiation

(2015) Aya Hashimoto et al.   Scientific Reports

Super-Spatial- and -Spectral-Resolution in Vibrational Imaging via Saturated Coherent Anti-Stokes Raman Scattering

(2015) Yasuo Yonemaru et al.   Physical Review Applied

Assessing Cholesterol Storage in Live Cells and C. elegans by Stimulated Raman Scattering Imaging of Phenyl-Diyne Cholesterol

(2015) Hyeon Jeong Lee et al.   Scientific Reports

Bright Building Blocks for Chemical Biology

(2014) Luke D. Lavis et al.   ACS Chemical Biology

Live-cell vibrational imaging of choline metabolites by stimulated Raman scattering coupled with isotope-based metabolic labeling

(2014) Fanghao Hu et al.   ANALYST

Live-Cell Stimulated Raman Scattering Imaging of Alkyne-Tagged Biomolecules

(2014) Senlian Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SERS Imaging of Cell-Surface Biomolecules Metabolically Labeled with Bioorthogonal Raman Reporters

(2014) Ming Xiao et al.   Chemistry-An Asian Journal

In Vivo Metabolic Fingerprinting of Neutral Lipids with Hyperspectral Stimulated Raman Scattering Microscopy

(2014) Dan Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multicolor Live-Cell Chemical Imaging by Isotopically Edited Alkyne Vibrational Palette

(2014) Zhixing Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering

(2014) Dan Fu et al.   Nature Chemistry

Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering

(2014) Lu Wei et al.   NATURE METHODS

High-speed coherent Raman fingerprint imaging of biological tissues

(2014) Charles H. Camp Jr et al.   Nature Photonics

Background-Free Stimulated Raman Spectroscopy and Microscopy

(2014) Pascal Berto et al.   PHYSICAL REVIEW LETTERS

Visualizing Cell State Transition Using Raman Spectroscopy

(2014) Taro Ichimura et al.   PLoS One

Tracking heavy water (D2O) incorporation for identifying and sorting active microbial cells

(2014) David Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Visualization of De novo Lipogenesis in Single Living Cells

(2014) Junjie Li et al.   Scientific Reports

Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy

(2013) Samir F. El-Mashtoly et al.   ANALYST

A Bioorthogonal Raman Reporter Strategy for SERS Detection of Glycans on Live Cells

(2013) Liang Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Label-free detection of anticancer drug paclitaxel in living cells by confocal Raman microscopy

(2013) H. Salehi et al.   APPLIED PHYSICS LETTERS

Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy

(2013) Hiroyuki Yamakoshi et al.   CHEMICAL COMMUNICATIONS

Molecular imaging of live cells by Raman microscopy

(2013) Almar F Palonpon et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Molecular component distribution imaging of living cells by multivariate curve resolution analysis of space-resolved Raman spectra

(2013) Masahiro Ando et al.   JOURNAL OF BIOMEDICAL OPTICS

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

(2013) Thomas G. Gant   JOURNAL OF MEDICINAL CHEMISTRY

Raman and SERS microscopy for molecular imaging of live cells

(2013) Almar F Palonpon et al.   Nature Protocols

Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy

(2013) L. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noninvasive Imaging of Intracellular Lipid Metabolism in Macrophages by Raman Microscopy in Combination with Stable Isotopic Labeling

(2012) Christian Matthäus et al.   ANALYTICAL CHEMISTRY

SERS Tags: Novel Optical Nanoprobes for Bioanalysis

(2012) Yunqing Wang et al.   CHEMICAL REVIEWS

Quantitative Chemical Imaging with Multiplex Stimulated Raman Scattering Microscopy

(2012) Dan Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alkyne-Tag Raman Imaging for Visualization of Mobile Small Molecules in Live Cells

(2012) Hiroyuki Yamakoshi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-speed molecular spectral imaging of tissue with stimulated Raman scattering

(2012) Yasuyuki Ozeki et al.   Nature Photonics

Light sheet-excited spontaneous Raman imaging of a living fish by optical sectioning in a wide field Raman microscope

(2012) Yusuke Oshima et al.   OPTICS EXPRESS

Mapping of Redox State of Mitochondrial Cytochromes in Live Cardiomyocytes Using Raman Microspectroscopy

(2012) Nadezda A. Brazhe et al.   PLoS One

Noncanonical Amino Acids in the Interrogation of Cellular Protein Synthesis

(2011) John T. Ngo et al.   ACCOUNTS OF CHEMICAL RESEARCH

High contrast images of uterine tissue derived using Raman microspectroscopy with the empty modelling approach of multivariate curve resolution-alternating least squares

(2011) Imran I. Patel et al.   ANALYST

Imaging of EdU, an Alkyne-Tagged Cell Proliferation Probe, by Raman Microscopy

(2011) Hiroyuki Yamakoshi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic SERS Imaging of Cellular Transport Pathways with Endocytosed Gold Nanoparticles

(2011) Jun Ando et al.   NANO LETTERS

Label-free Raman observation of cytochrome c dynamics during apoptosis

(2011) M. Okada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Label-Free Imaging of Metal-Carbonyl Complexes in Live Cells by Raman Microspectroscopy

(2010) Konrad Meister et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multifocus confocal Raman microspectroscopy for fast multimode vibrational imaging of living cells

(2010) Masanari Okuno et al.   OPTICS LETTERS

Fluorescent Proteins and Their Applications in Imaging Living Cells and Tissues

(2010) Dmitriy M. Chudakov et al.   PHYSIOLOGICAL REVIEWS

Quantitative Assessment of Hepatic Fat of Intact Liver Tissues with Coherent Anti-Stokes Raman Scattering Microscopy

(2009) Yao-Ming Wu et al.   ANALYTICAL CHEMISTRY

Noninvasive Imaging of Protein Metabolic Labeling in Single Human Cells Using Stable Isotopes and Raman Microscopy

(2008) Henk-Jan van Manen et al.   ANALYTICAL CHEMISTRY

Raman microscopy for dynamic molecular imaging of living cells

(2008) Keisaku Hamada et al.   JOURNAL OF BIOMEDICAL OPTICS

Multiplexed Multicolor Raman Imaging of Live Cells with Isotopically Modified Single Walled Carbon Nanotubes

(2008) Zhuang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New Ways of Imaging Uptake and Intracellular Fate of Liposomal Drug Carrier Systems inside Individual Cells, Based on Raman Microscopy

(2008) Christian Matthäus et al.   MOLECULAR PHARMACEUTICS

A chemical method for fast and sensitive detection of DNA synthesis in vivo

(2008) A. Salic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring RNA transcription and turnover in vivo by using click chemistry

(2008) C. Y. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA