Journal
ORGANIC LETTERS
Volume 24, Issue 9, Pages 1796-1801Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00148
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Funding
- National Natural Science Foundation of China [21871173]
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In this study, a nickel-catalyzed enantioconvergent hydroalkylation method has been developed for the synthesis of enantioenriched trifluoromethylated alkanes. The reaction utilizes readily available alkenes as alkyl coupling partners and offers mild conditions, a broad substrate scope, and high functional group tolerance. The synthetic utility of this method has been demonstrated through the late-stage functionalization of various drug molecules and natural products.
Here, we report a nickel-catalyzed enantioconvergent hydroalkylation of olefins with trifluoromethyl-containing alpha-alkyl halides for the synthesis of enantioenriched trifluoromethylated alkanes. This reaction employs readily available and bench-stable alkenes as alkyl coupling partners, featuring mild conditions, a broad substrate scope, and high functional group tolerance. The synthetic utility of this method is further demonstrated in the late-stage functionalization of a range of drug molecules and natural products.
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