Article
Materials Science, Multidisciplinary
Pavan Pandit, G. L. Samuel
Summary: In this research, the authors have utilized laser micromachining to fabricate micro features in microfluidic devices for particle separation. By appropriately placing microposts, the authors achieved separation of particles in the size range of 5-17 micrometers. The effect of tilt angles on fluid flow and particle deformation was also studied.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Multidisciplinary Sciences
Colleen Roosa, Lauren Pruett, Juliana Trujillo, Areli Rodriguez, Blaise Pfaff, Nicholas Cornell, Clare Flanagan, Donald Richieri Griffin
Summary: The MAP scaffold is a type of granular hydrogel with cell-scale porosity that can form a structurally stable scaffold through chemical crosslinking. It has been successfully used in various regenerative medicine applications, and this paper describes the methods for its synthesis and characterization.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Editorial Material
Chemistry, Physical
Kwok Soon Wun, In Young Hwang, Matthew Wook Chang
Summary: The prototypical biocomposite block, made up of a blend of bacteria, fungi and feedstock, can be assembled into human-sized living structures with self-healing and environmental sensing capabilities.
Article
Nanoscience & Nanotechnology
Damiano Genovese, Andrea Baschieri, Danilo Vona, Ruxandra Elena Baboi, Fabio Mollica, Luca Prodi, Riccardo Amorati, Nelsi Zaccheroni
Summary: Nitroxides are an important class of radical trapping antioxidants with promising biological activities due to their ability to scavenge peroxyl radicals. The reaction rate constants of TEMPO derivatives with peroxyl radicals were measured, showing a good Marcus relationship between log (k(inh)) and E degrees. The use of nitroxide derivatives in developing novel nanoantioxidants was discussed, highlighting the importance of choosing the best linkage group and the regeneration cycle in determining the duration of inhibition.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Yujie Ban, Weishen Yang
Summary: Membrane separation technology is crucial for modern society, offering higher efficiency, ease of operation, and smaller footprint compared to traditional separation methods. Evolution of membrane structures through different dimensional building blocks can enhance performance and industrial applications.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Yunyun Wu, Claire Liu, Mia Lapiere, Joanna L. Ciatti, Da Som Yang, Jaime Berkovich, Jeffrey B. Model, Anthony Banks, Roozbeh Ghaffari, Jan-Kai Chang, Ralph G. Nuzzo, John A. Rogers
Summary: Wireless, skin-interfaced electronic and microfluidic devices can replace wired, bulky technologies for health monitoring, enabling care outside of hospitals. Yet, commercial adoption of such devices is hindered by difficulties with cost and recycling of traditional materials. Thermoplastic elastomers (TPEs) offer a promising alternative as mass-manufacturable, low-cost, and recyclable materials for these devices. This study reports on the characteristics and applications of three commercially available TPEs, demonstrating their effectiveness as alternatives to current materials for wireless, skin-interfaced devices.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Engineering, Biomedical
Qianyi Ren, Yiyun Cheng, Jia Lv
Summary: Intracellular protein delivery is crucial for biotherapeutics and biotechnologies but faces challenges in terms of protein binding, cellular uptake, endosomal escape, and protein release. Boronate building blocks have shown promise in overcoming these limitations due to their versatile reactivities and stimuli-responsive property. Boronate ligands transport proteins into the cytosol via receptor-mediated endocytosis and can also enhance binding to native proteins on nanocarriers.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Aytug Kara, Athina Vassiliadou, Baris Ongoren, William Keeble, Richard Hing, Aikaterini Lalatsa, Dolores R. Serrano
Summary: The article introduces the method and advantages of manufacturing nanomedicines using 3D printed microfluidic chips, and demonstrates the experimental results of fabricating polymeric nanoparticles. The research shows that nanoparticles manufactured using SLA technology have smaller particle sizes and smoother channel surfaces.
Article
Chemistry, Analytical
Kiran Giri, Chia-Wen Tsao
Summary: This review paper summarizes the bonding processes for thermoplastic microfluidic devices and compares different bonding strategies to assist researchers in finding suitable bonding methods for microfluidic device assembly.
Article
Chemistry, Physical
Ilin Sadeghi, Xueguang Lu, Morteza Sarmadi, Robert Langer, Ana Jaklenec
Summary: Soft lithography is a convenient and effective method for fabricating microdevices, but the formation of continuous films instead of discrete features has been a problem. A novel approach has been demonstrated to fabricate discrete, multilayered, fillable, and harvestable microparticles directly from thermoplastic polymers, and soluble biologics can be loaded into the microwells using screen-printing.
Article
Polymer Science
Elena Platonova, Polina Ponomareva, Zalina Lokiaeva, Alexander Pavlov, Vladimir Nelyub, Alexander Polezhaev
Summary: The ability to form blends between the prepolymer and curing agent is crucial for efficient healing in self-healing materials. This study presents a new series of di- and tetrafuranic isocyanate-related ureas as promising curing agents for the development of polyurethanes-like self-healing materials. The self-healing properties of the materials were investigated by thermal analysis, and the resulting polyurethane showed thermally induced self-healing abilities.
Review
Engineering, Biomedical
Mei-chen Wan, Wen Qin, Chen Lei, Qi-hong Li, Meng Meng, Ming Fang, Wen Song, Ji-hua Chen, Franklin Tay, Li-na Niu
Summary: Marine resources hold great potential for developing high-value biomaterials, with materials such as chitin, marine-derived collagen, and more showcasing excellent biocompatibility, biodegradability, and bioactive characteristics. These marine biomaterials find important applications in medical, antimicrobial, drug delivery, rehabilitation, and industrial areas.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Niclas Weigel, Evgeny Grigoryev, Nicole Fertala, Julian Thiele
Summary: This work utilizes an aspiration-based process involving a hole-bearing glass plate to align and interconnect microgels and creates mechanically stable, freestanding microgel constructs. Segmentation control of the aspiration process enables the formation of multimaterial sheets consisting of different microgel species. This research is a crucial step towards fabricating hydrogel-based materials with spatially controlled functionality.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Chemistry, Multidisciplinary
Patrick Zwick, Diana Dulic, Herre S. J. van der Zant, Marcel Mayor
Summary: The review highlights the direct measurement of single-molecule electrical transparency by break junction experiments, focusing on the use of porphyrins as molecular components and their potential for future device construction. Various examples illustrate the features provided by porphyrins, such as low level misalignments and very low attenuation factors, showcasing the potential and limitations of these molecular junctions.
Review
Pharmacology & Pharmacy
Gyan Prakash, Ahmed Shokr, Niels Willemen, Showkeen Muzamil Bashir, Su Ryon Shin, Shabir Hassan
Summary: Gene therapy has emerged as a potential platform for treating dreaded and rare diseases. Viral vectors, due to their efficient nucleic acid delivery ability, have been widely explored in gene therapy. However, their lack of precision in delivery has led to off-target toxicities. As an alternative, non-viral gene delivery vehicles have been developed and are currently used in various therapies, including the SARS-CoV-2 vaccine.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Karla Perez-Toralla, Abhiteja Konda, John J. Bowen, Emily E. Jennings, Christos Argyropoulos, Stephen A. Morin
ADVANCED FUNCTIONAL MATERIALS
(2018)
Article
Chemistry, Multidisciplinary
John J. Bowen, Mark A. Rose, Abhiteja Konda, Stephen A. Morin
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Article
Chemistry, Multidisciplinary
Abhiteja Konda, Advaith Rau, Michael A. Stoller, Jay M. Taylor, Abdul Salam, Gabriel A. Pribil, Christos Argyropoulos, Stephen A. Morin
ADVANCED FUNCTIONAL MATERIALS
(2018)
Article
Nanoscience & Nanotechnology
Ali J. Mazaltarim, Jay M. Taylor, Abhiteja Konda, Michael A. Stoller, Stephen A. Morin
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Chemistry, Physical
Matthew Kottwitz, Yuanyuan Li, Robert M. Palomino, Zongyuan Liu, Guangjin Wang, Qin Wu, Jiahao Huang, Janis Timoshenko, Sanjaya D. Senanayake, Mahalingam Balasubramanian, Deyu Lu, Ralph G. Nuzzo, Anatoly I. Frenkel
Article
Chemistry, Multidisciplinary
Abhiteja Konda, Abhinav Prakash, Gregory A. Moss, Michael Schmoldt, Gregory D. Grant, Supratik Guha
Article
Chemistry, Physical
Chengsi Pan, Minjeong Shin, Deyu Liu, Matthew Kottwitz, Ruixian Zhang, Ralph G. Nuzzo, Andrew A. Gewirth
JOURNAL OF PHYSICAL CHEMISTRY C
(2020)
Correction
Chemistry, Multidisciplinary
Abhiteja Konda, Abhinav Prakash, Gregory Moss, Mike Schmoldt, Gregory Grant, Supratik Guha
Letter
Chemistry, Multidisciplinary
Abhiteja Konda, Abhinav Prakash, Gregory A. Moss, Michael Schmoldt, Gregory D. Grant, Supratik Guha
Article
Multidisciplinary Sciences
Yuanyuan Li, Matthew Kottwitz, Joshua L. Vincent, Michael J. Enright, Zongyuan Liu, Lihua Zhang, Jiahao Huang, Sanjaya D. Senanayake, Wei-Chang D. Yang, Peter A. Crozier, Ralph G. Nuzzo, Anatoly Frenkel
Summary: This study reveals the dynamic characteristics of a Pt/CeO2 system for the water gas shift reaction, showing the formation and transformation of perimeter Pt-0-O vacancy-Ce3+ sites that regulate adsorbate behaviors and play a key role in the catalytic mechanism. The dynamic nature of these sites is crucial for understanding the reaction mechanism.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Michael J. Enright, Dipti Jasrasaria, Mathilde M. Hanchard, David R. Needell, Megan E. Phelan, Daniel Weinberg, Brinn E. McDowell, Haw-Wen Hsiao, Hamidreza Akbari, Matthew Kottwitz, Maggie M. Potter, Joeson Wong, Jian-Min Zuo, Harry A. Atwater, Eran Rabani, Ralph G. Nuzzo
Summary: The development of bright, near-infrared-emissive quantum dots (QDs) is crucial for various technology applications. This study successfully synthesized bright, near-infrared luminescent InAs/InP/ZnSe QDs using theoretical and experimental approaches. The research identified material attributes and optimized the optical properties of these QDs, resulting in improved emissive qualities. Additionally, the study explored the behavior of charge carriers at the nanoscale and their interaction with interfacial atomic structures.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Review
Chemistry, Multidisciplinary
Matthew Kottwitz, Yuanyuan Li, Haodong Wang, Anatoly I. Frenkel, Ralph G. Nuzzo
Summary: Single atom catalysts have the potential to exhibit higher activity, stability, and selectivity compared to nanoparticle catalysts, but fundamental questions regarding their physicochemical properties remain unanswered. The main challenge in research is how to accurately characterize the single atom environments while considering complicating factors such as low weight loadings, strong metal-support interactions, and atomic and multiscale heterogeneity.
Article
Chemistry, Physical
Jay M. Taylor, Abhiteja Konda, Stephen A. Morin
Article
Chemistry, Physical
Michael A. Stoller, Matthew Gromowsky, Maddee Rauhauser, Marcus Judah, Abhiteja Konda, Christopher P. Jurich, Stephen A. Morin
Article
Automation & Control Systems
Abhiteja Konda, Donghee Lee, Taesun You, Xiaoyan Wang, Sangjin Ryu, Stephen A. Morin
ADVANCED INTELLIGENT SYSTEMS
(2019)