Article
Chemistry, Physical
Anqi Du, Wenzhe Li, Linjuan Zeng, Yang Peng, Bochun Li, Jincheng Mao, Dingli Wang
Summary: An anionic surfactant, AdEr, based on erucic acid, was synthesized by a neutralization reaction and formed a pH-responsive wormlike micellar viscoelastic system in the presence of KCl. The system showed a dramatic increase in viscosity as the pH increased and could be converted between wormlike micelles and spherical micelles by adjusting the pH.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Weixian Jiao, Zhe Wang, Tongqing Liu, Xuefeng Li, Jinfeng Dong
Summary: This study focused on a novel pH and light dual-responsive Gemini surfactant N3C14AZOC14N3. The self-assembly behaviors of this surfactant in aqueous solutions were highly dependent on pH, and the concentration also affected its physicochemical properties. Additionally, wormlike micelles formed by this surfactant showed pH and light dual-responses, with pH causing protonation variation of amino headgroups and light-induced reversible transition attributed to the isomerization between trans- and cis-azobenzene.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Polymer Science
Kadambari Bairagi, Jiang Tian Liu, Anna Thinphang-nga, Jung Kwon Oh
Summary: Stimuli-responsive degradable amphiphilic block copolymers (SRD-ABPs) have been extensively investigated for the construction of smart nanoassemblies with controlled release of encapsulated molecules. A new approach using conjugated benzoic imine chemistry was developed to achieve dual acidic pH/light responses with a single labile linkage. The synthesized SRD-ABP self-assembled into stable nanoassemblies which degraded upon dual responses to acidic pH and UV/visible light. This work demonstrates the versatility of the new approach for designing advanced nanoassemblies for intracellular drug delivery.
Article
Nanoscience & Nanotechnology
Long-Bao Zhu, Wen-Liang Xu, Wei-Wei Zhang, Ming-Cai Wu, Wan-Zhen Li, Fei Ge, Yu-Gui Tao, Ping Song
Summary: The peptide-tuned self-assembly of DOX using the amphiphilic tumor cell-targeting peptide P14 showed improved targeting and pH-sensitive nano-micelles, leading to enhanced efficacy in inhibiting tumor cell growth and inducing tumor apoptosis in vitro.
Article
Polymer Science
Ruizhen Zhang, Yuting Min, Peipei Ji, Guiyang Zhou, Hong Yin, Dongming Qi, Hangjun Deng, Zan Hua, Tao Chen
Summary: With the increasing demand for treating cancer and cardiovascular diseases, researchers have intensively studied drug delivery therapy using intelligent nanocarriers. In this study, light and temperature dual-responsive micelles were designed and fabricated, and their controlled release property was investigated using a hydrophobic fluorescent dye. Through the manipulation of light and temperature, different degrees of release capabilities were achieved, providing an approach for the construction of controllable drug release carriers.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Luoping Zhai, Chuangwei Luo, Hannan Gao, Shuaifan Du, Jiyun Shi, Fan Wang
Summary: The study designed a dual pH-responsive DOX-encapsulated liposome targeting the acidic tumor microenvironment, utilizing acid-sensitive peptide (DVar7) and acid-sensitive phospholipid (DOPE) responses to increase uptake and controlled release of DOX. Results showed that DVar7 enhanced liposome uptake in tumors and prolonged retention time, with further enhancement in therapeutic efficacy by regulating tumor acidity with glucose injection. This strategy has the potential to improve drug resistance in clinical practice and enhance the therapeutic effect of chemotherapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Polymer Science
Thi Lien Nguyen, Kazuhiko Ishihara, Shin-ichi Yusa
Summary: The self-assembly of pH-responsive random and block copolymers composed of 2-(N,N-diisopropylamino)ethyl methacrylate and 2-methacryloyloxyethyl phosphorylcholine was studied in aqueous media. The copolymers existed as single polymer chains in an acidic environment, but formed separated micelles in a basic environment.
Article
Biochemistry & Molecular Biology
Maozhang Tian, Xi Chen, Xinyuan Zou, Yuchen Qian, Zhang Liu, Yaxun Fan
Summary: The aggregation behavior of anionic gemini surfactant and cationic monomeric surfactant mixtures was studied, showing that pH and total concentration control can affect the formation of different micelle structures. The mixed system exhibits high viscoelasticity at low pH and certain concentrations, which enhances drug delivery efficiency.
Article
Chemistry, Physical
Dong Wan, Qinan Zhu, Jianxin Zhang, Xi Chen, Fangzhou Li, Yi Liu, Jie Pan
Summary: Cancer has become a major cause of human death, and traditional chemotherapeutic drugs have limitations in their effectiveness and side effects. Researchers have developed responsive nanocarriers that can release drugs in the tumor microenvironment or inside cells to enhance the anti-tumor effect. These nanocarriers have shown promise in improving the therapeutic outcome of cancer treatment.
Article
Chemistry, Physical
Dong Wan, Qinan Zhu, Jianxin Zhang, Xi Chen, Fangzhou Li, Yi Liu, Jie Pan
Summary: The incidence of cancer has been increasing and has become a major cause of human death. To improve the effectiveness of chemotherapy and reduce side effects, researchers have developed responsive nanocarriers that can target tumor cells. In this study, prodrugs responsive to extracellular and intracellular enzymes were synthesized and encapsulated in micelles. These micelles can circulate in the bloodstream, accumulate in tumor tissue, and be taken up by tumor cells. The released drugs induce tumor cell apoptosis and enhance cytotoxicity.
Article
Pharmacology & Pharmacy
Shanshan Zheng, Yue Cai, Yulu Hong, Yubei Gong, Licheng Gao, Qingyong Li, Le Li, Xuanrong Sun
Summary: The lytic peptide PTP7-drug paclitaxel conjugate assembling nanoparticles (PPP) is a targeted anti-tumor drug that can respond to dual stimuli in the tumor microenvironment, providing passive tumor-targeted delivery and on-demand release of a tumor lytic peptide (PTP-7) as well as a chemotherapeutic agent of paclitaxel (PTX).
Article
Chemistry, Physical
Guozheng Wang, Mengying Lin, Qianqian Xu, Jianzhong Jiang, Raojun Zheng, Yibo He
Summary: In this study, pH and light dual-stimuli responsive wormlike micelles (WLMs) were prepared using (4-butylphenyl)-2-(4-trimethylammoniumhexyloxyphen-yl) diazene (C(4)AzoC(6)N) and sodium oleate (NaOA). The viscoelasticity of the system was tested by steady state and dynamic rheology. The WLMs can be controlled by pH and UV light, making them suitable for various applications in functional materials and fluid drag reducers.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Meng Mu, Xing Zhang, Yan Jiang, Qiang Li, Pingping Lu, Shanjuan Zhao, Yongmin Zhang
Summary: Responsive viscoeslastic fluids based on wormlike micelles have attracted significant interest due to their intelligent rheological response. However, pH-responsive worm-based viscoelastic fluids remain challenging. In this study, a novel pH-responsive worm-based viscoelastic fluid was fabricated using a dynamic covalent gemini surfactant. The gemini imine surfactant could be damaged under acidic conditions and reformed under alkali conditions, allowing the solution to switch between a water-like fluid and a worm-based viscoelastic fluid. Changing the precursors can also tailor the properties of the fluid.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Polymer Science
Harpal S. Dhiraj, Fumi Ishizuka, Maria Saeed, Amr Elshaer, Per B. Zetterlund, Fawaz Aldabbagh
Summary: Higher order morphologies, such as rods and worms, can be formed by combining core-shell nanoparticles with boronic acid moieties under basic conditions. For the first time, it is observed that lactate, an anaerobic metabolite, can bind to the BA moiety of amphiphilic block copolymers at a lower physiological pH of 7.4. Self-assembly experiments show that the resulting nanoparticles have similar structures to those formed by reacting with glucose.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Applied
Lakshmi Priya Datta, Triparna Mukherjee, Tapan Kumar Das
Summary: The rampant use of antibiotics and emergence of zoonotic diseases have led to serious global health hazards. Fungal infections, particularly those caused by Aspergillus species, are challenging due to their eukaryotic nature. Researchers have developed pH responsive cationic biocompatible polymers based on amino acids inspired by antimicrobial peptides, which have demonstrated effective fungicidal activities against Aspergillus niger. The mechanism of action involves inhibition of hyphal growth and distortion of conidiophores, with the aqueous solution properties of the side chain groups of individual amino acids significantly influencing the fungicidal activities.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Chemistry, Physical
Yurong Zhao, Hao Qi, Limin Zhang, Chunyong He, Feng Wei, Dong Wang, Jie Li, Kai Qi, Xuzhi Hu, Jiqian Wang, Yubin Ke, Chunqiu Zhang, Jian R. Lu, Hai Xu
Summary: This study investigates the morphology transition of peptide self-assembly and finds that shifting the position of the terminal residue can achieve the transition from nanofibers to nanotubes. The underlying mechanism is revealed, and it is found that the formation of giant nanotubes with a bilayer shell structure is promoted by inter-molecular C-terminal H-bonding. This morphological transformation method is applicable to other analogues and provides a convenient approach for predicting peptide nanostructures.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Jingjing Wu, Yang Liu, Meiwen Cao, Nannan Zheng, Hongchao Ma, Xiandong Ye, Nanyan Yang, Zhihong Liu, Wangjun Liao, Li Sun
Summary: Here, a multifunctional composite nanoplatform, the peptide/Ce6/MnO2 nanocomposite (RKCM), has been constructed to alleviate tumor hypoxia and increase the efficacy of photodynamic therapy (PDT). The peptide fibrils were designed to encapsulate chlorin e6 (Ce6) inside and mineralize MnO2 nanoparticles on the surface. As a result, RKCM significantly improved the PDT efficacy by increasing reactive oxygen species (ROS) generation and inhibiting tumor growth and metastasis. Besides, it also presented with an abscopal effect to block the occurrence of lung metastasis by remolding the pre-metastasis immune microenvironment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Wenliang Liu, Yan Wang, Yuqi Wang, Xiaohan Li, Kai Qi, Jiqian Wang, Hai Xu
Summary: Cancers are a leading cause of death and conventional treatments have limitations. Plasma photothermal therapy, utilizing plasmonic nanoparticles, has gained attention for its low toxicity and high efficiency. This study presents a unique black noble-metal core-shell nanostructure, with silver nanocubes as the core and amino acid-encoded highly branched gold nanorods as the shells. These nanocomposites exhibited excellent photothermal conversion, particularly D-CAggAu with the highest efficiency of 87.28%. The therapeutic efficacy was evaluated in vitro and in vivo, showing potential for photothermal tumor therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Yan Zhang, Qi Li, Haoran Wu, Yancheng Wang, Yan Wang, Sigal Rencus-Lazar, Yurong Zhao, Jiqian Wang, Deqing Mei, Hai Xu, Ehud Gazit, Kai Tao
Summary: Amino acids are bio-building blocks that play various roles in metabolic activities. Supramolecular structures formed by amino acids exhibit amyloid-like characteristics, which are driven by hydrogen bonds and play critical roles in the properties and applications of amino acid assemblies. Tyrosine-based superstructures have diverse properties and functions, making them promising next-generation biomaterials for biomedical applications. However, modulating the energetically stable supramolecular structures of tyrosine-based organizations is challenging. By assembling L-Y and D-Y, the secondary structures of the supramolecular assemblies can be modulated, leading to distinct organization kinetics and modulation of physicochemical properties.
Editorial Material
Chemistry, Multidisciplinary
Meiwen Cao
Article
Materials Science, Multidisciplinary
Jinhui Liang, Jiahui Liu, Liqian Zhu, Shuyuan Gao, Yuanyuan Liu, Xinyuan Teng, Run Wang, Xiaojuan Wang, Shengjie Wang, Jiqian Wang, Yongqing Xia
Summary: This study presents an artificial intelligent skin that can change color by stretching and has self-healing ability. It mimics the color changing feature of chameleon skin and may promote the application of photonic crystals in optical devices.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Roja Hadianamrei, Mhd Anas Tomeh, Jiqian Wang, Stephen Brown, Xiubo Zhao
Summary: In this study, two new surfactant-like peptides (SLPs), named (IA)4K and (IG)4K, were developed for selective delivery of antisense oligodeoxynucleotides (ODNs) and small interfering RNA (siRNA) to cancer cells. The interaction of the peptides with nucleic acids, their transfection efficiency, and cytotoxicity were investigated. Both SLPs showed high transfection efficiency and selectivity for cancer cells, and exhibited low cytotoxicity. This study provides insights into the structural features required for nucleic acid complexation and delivery, and serves as a guide for the design of new SLPs for selective gene delivery to minimize adverse effects in healthy tissues.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Shike Lai, Debo Yang, Yuqi Wang, Xinfeng Ju, Wenliang Liu, Hui Li, Dong Wang, Yurong Zhao, Jiqian Wang, Hai Xu
Summary: In this study, an artificial peroxidase was fabricated through the co-assembly of two types of short peptides and hemin. The coordination between hemin and the peptide nanofibers preserved the handedness of the nanofibers. The chiral selectivity of the artificial peroxidases towards D- and L-DOPA substrates was determined by the conformation of histidine residues and the handedness of the peptide nanofibers.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Energy & Fuels
Chuanjin Yao, Jia Zhao, Zemin Ji, Meiwen Cao, Liang Xu, Yuanbo Ma
Summary: In this paper, six CO2 huff-n-puff cooperative combination methods were investigated for their displacement characteristics, utilization law, and development effect. The result showed that the surfactant- and water-disturbance-assisted CO2 huff-n-puff method had the highest oil recovery among all modes.
Article
Chemistry, Physical
Dong Wang, Zhihao Fan, Haofeng Min, Xinhao Wang, Hui Li, Jiqian Wang
Summary: Delivery of antitumor drugs to tumor cells by targeted lipopeptide carriers, which can be specifically degraded by MMP-7, enables targeted release of hydrophobic drugs and improves chemotherapy efficiency. Different encapsulation and release behaviors are observed due to the different hydrophobicity of lipopeptides and antitumor drugs. This study demonstrates the biocompatibility and low toxicity of enzyme-sensitive targeting lipopeptides, indicating their potential in efficient drug delivery for biomedical oncology therapy. (c) 2023 Elsevier B.V. All rights reserved.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Applied
Wenliang Liu, Xiaohan Li, Yuqi Wang, Debo Yang, Zongzhen Guo, Mengfei Liu, Jiqian Wang
Summary: A two-step synthesis strategy is developed to obtain a multi-branched high-curvature AgAuPt heterostructure, which effectively enhances the electrocatalytic hydrogen evolution performance. The intrinsic mechanism of promoting the performance is investigated and revealed in-depth through FDTD simulations and DFT calculations. The catalyst also shows efficient and stable hydrogen evolution in a proton exchange membrane electrolyzer.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Article
Engineering, Environmental
Wentao Wang, Zhen Liu, Ruyi Wang, Meiwen Cao, Yan Chen, Xingjie Lu, Hongchao Ma, Tongtao Yue, Taihong Yan
Summary: A temperature-responsive phase separation system based on PNIPAM and GO has been developed for efficient removal of metal ions from polluted water. GO sheets can be transferred to the gel phase and adsorb metal ions efficiently due to their interactions with PNIPAM molecules. The gel phase can then be separated from the water phase, achieving easy removal of the pollutant metal ions. This method has high versatility, easy treatment and separation, and good reusability, making it highly potential for practical industry applications in metal ion pollution treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Zemin Ji, Zijin Zhang, Weifeng Lv, Yanyao Shi, Kai Wang, Shumin Ni, Hongchao Ma, Meiwen Cao
Summary: By using ZIF-90 nanoparticles to mimic the active center of natural carbonic anhydrase, CO2 can be efficiently captured with enhanced adsorption capacity. This approach is facile and costless, providing a new direction for the development of industrial CO2 capture catalysts.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Energy & Fuels
Mingxuan Li, Xi Chen, Wanjun Chen, Jiqian Wang, Longli Zhang
Summary: Air injection is a promising method for increasing the recovery efficiency of light crude oil. This study investigated the oxidation behavior and interactions of SARA components during low-temperature oxidation (LTO) of two light crude oils from the Xinjiang oilfield under air and nitrogen atmospheres. The results showed that oxidation under air greatly affected crude oil stability at temperatures above 150 degrees C. The asphaltene component exhibited the highest oxidative activity, leading to the introduction of more oxygen and further oxidation of C-O groups and sulphoxides on the asphaltene surface. These findings provide valuable insights into SARA component oxidation and interactions during LTO, which can be applied in future air injection techniques.
Article
Energy & Fuels
Xuanyu Zhang, Hui Li, Fengguang Li, Xuan Dong, Zongzhen Guo, Han Han, Jiqian Wang
Summary: In this study, two strains of bacteria, SCE2 and NMYGYB4, isolated from oilfield slickwater, were identified as Tistrella bauzanensis and Brucella sp., respectively. The optimal biodegradation conditions for HPAM by these strains were determined. The HPAM removal rate reached 75.3% and 63.59% for Tistrella bauzanensis SCE2 and Brucella sp. NMYGYB4, respectively, under the optimal conditions.
GEOENERGY SCIENCE AND ENGINEERING
(2023)
