Article
Materials Science, Multidisciplinary
Guo-Bin Ding, Xiaohui Ma, Xue Meng, Peng Yang, Roland H. Stauber, Zhuoyu Li
Summary: The acidic microenvironment of tumors promotes tumor survival and progression. pH-responsive nanovehicles targeting the overexpressed enzyme PKM2 in tumors show potential for effective cancer therapy through RNA interference.
MATERIALS & DESIGN
(2021)
Article
Multidisciplinary Sciences
Alexander A. Svoronos, Donald M. Engelman
Summary: The study investigates the determinants of pHLIP insertion, targeting, and delivery through computational modeling. It develops a mathematical model to describe the transmembrane insertion process and integrates it into a pharmacokinetic model to predict the biodistribution of pHLIPs. The analysis explores how changing pHLIP properties can influence tumor targeting and delivery efficacy, predicting optimal pHLIP phenotypes for superior tumor targeting and delivery capabilities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Mengjie Liu, Jiaqing Lei, Kai Yuan, Yuting Zhao, Junhao Zhang, Dan Li, Hua Zheng
Summary: pH-responsive nanomicelles were developed to co-deliver chemotherapy drugs and photosensitizers, achieving synergistic effects between chemotherapy and photodynamic therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shiya Chen, Mingjian Chen, Jinfeng Yang, Xianqing Zeng, Yibo Zhou, Sheng Yang, Ronghua Yang, Quan Yuan, Jing Zheng
Summary: Hypoxia and acidic pH are chosen as dual stimuli to fabricate a dual lock-and-key fluorescent nanoprobe for highly specific and precise imaging of tumor cells. This nanoprobe successfully applies in a tumor-bearing mice model, indicating the potential for early diagnosis and assessment of cancer treatment.
Article
Pharmacology & Pharmacy
Shanshan Zheng, Yue Cai, Yulu Hong, Yubei Gong, Licheng Gao, Qingyong Li, Le Li, Xuanrong Sun
Summary: The lytic peptide PTP7-drug paclitaxel conjugate assembling nanoparticles (PPP) is a targeted anti-tumor drug that can respond to dual stimuli in the tumor microenvironment, providing passive tumor-targeted delivery and on-demand release of a tumor lytic peptide (PTP-7) as well as a chemotherapeutic agent of paclitaxel (PTX).
Article
Engineering, Biomedical
Jingjing Xu, Xianjiao Tang, Xiaojing Yang, Mei-Xia Zhao
Summary: We developed a pH/glutathione (GSH) dual-responsive smart nano-drug delivery system for targeted release of a chemotherapeutic drug at the breast tumor site. The PEG-SS-CA-DOX micelles achieved efficient and rapid release of DOX in the tumor microenvironment due to stimulation by weak acidic pH and high GSH content. In vivo experiments demonstrated high inhibition rate of PEG-SS-CA-DOX against 4T1 breast cancer cells with good biosafety.
BIOMEDICAL MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Antonia Antoniou, Sabrina Giofre, Pierfausto Seneci, Daniele Passarella, Sara Pellegrino
Summary: Liposomes are lipidic supramolecular aggregates with the ability to encapsulate and carry molecules of various natures, making them ideal for drug delivery systems. Recent advancements in chemical modifications have led to the development of smart liposome-based drug delivery systems with tunable features and disease-directed capabilities.
DRUG DISCOVERY TODAY
(2021)
Article
Pharmacology & Pharmacy
Eirik A. L. Rustad, Susannah von Hofsten, Robin Kumar, Eirik A. Laensman, Gerd Berge, Natasa Skalko-Basnet
Summary: Nanomedicine has been successful in developing superior anticancer therapies, but there are still challenges in treating certain tumors, such as glioblastoma. In this study, pH-responsive liposomes were used to deliver drugs to glioblastoma cells, taking advantage of the acidic extracellular environment. The results showed improved intracellular uptake of drugs in glioblastoma cells compared to non-pH-responsive liposomes, regardless of the length of PEG.
Article
Nanoscience & Nanotechnology
X. Hai, M. Ji, K. Yu, T. Tian, Z. Cui, S. Bi, X. Zhang
Summary: DNA nanotechnology has been utilized to construct a DNA-Au nanomachine with active/passive dual-targeting capacity for lysosomal acidic microenvironment-activated combinational chemo-photothermal therapy of cervical carcinoma. The nanomachine consists of three-dimensional DNA nanoflowers and BSA-modified gold nanoparticles, allowing for targeted chemotherapy and photothermal therapy. In vitro and in vivo studies demonstrate the potential of this nanomachine for targeted combinational therapy of cancer.
MATERIALS TODAY NANO
(2023)
Article
Pharmacology & Pharmacy
Jafrin Jobayer Sonju, Achyut Dahal, Sitanshu S. Singh, Xin Gu, William D. Johnson, Chandra Mohan Reddy Muthumula, Sharon A. Meyer, Seetharama D. Jois
Summary: This research focuses on the use of a pH-sensitive liposomal formulation and a targeting ligand conjugated cytotoxic drug to achieve targeted delivery of chemotherapy. The results showed promising in vitro and in vivo studies, indicating improved anticancer treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Qianqian Duan, Jiaying Shi, Lan Zhou, Boye Zhang, Xiaoyuan Wang, Shengbo Sang
Summary: A novel pH-responsive drug delivery system based on carbon quantum dots (CDs) was proposed, with bovine serum albumin (BSA) introduced to prepare a stable drug delivery system BSA@CDs-DOX. The system showed enhanced stability and prolonged release profile, with significantly reduced drug side effects on normal cells and improved killing effect on cancerous cells. Excellent and sustained migration resistance was observed, indicating good application prospect in chemotherapy of tumors.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Pharmacology & Pharmacy
Jie Zhu, Rui Gao, Zhongshi Wang, Zhiming Cheng, Zhonghua Xu, Zaiyang Liu, Yiqun Wu, Min Wang, Yuan Zhang
Summary: A pH-responsive nonapeptide hydrogel was designed and fabricated for tumor-targeted drug delivery, which exhibited good injectability and biocompatibility. The drug-loaded hydrogel showed high sensitivity to acidic conditions and could amplify the therapeutic effect and increase drug accumulation at the tumor site in vivo.
Article
Chemistry, Physical
Yinglan Yu, Chang Zu, Dongsheng He, Yanan Li, Qinying Chen, Qian Chen, Huimin Wang, Ruijuan Wang, Birendra Chaurasiya, Jennica L. Zaro, Yiran Wang, Jiasheng Tu, Chunmeng Sun
Summary: Artemisinin, well known as an antimalarial drug, can also be used for inflammation and cancer treatment. Studies have shown that utilizing a reversibly activatable cell-penetrating peptide can enhance the concentration of artemisinin in tumors, leading to improved antitumor effects.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Qinghe Wu, You Zhang, Guoping Jia, Mengfei Hou, Yifei Jiang, Weijun Wei, Ping Liu, Gang Huang, Jianhua Zou, Jingjing Zhang, Wangxi Hai, Min Zhang, Biao Li, Xiaoyuan Chen, Chunfu Zhang
Summary: This study proposes a dual-locked strategy for safe and effective Cerenkov radiation-induced therapy (CRIT), using pH-activatable photosensitizers. The strategy shows promising results in tumor models, highlighting the potential of pH-activatable photosensitizers in cancer therapy.
Article
Pharmacology & Pharmacy
Mohamadreza Amin, Mercedeh Mansourian, Peter C. Burgers, Bahareh Amin, Mahmoud Reza Jaafari, Timo L. M. ten Hagen
Summary: Modification with polyethylene glycol (PEGylation) and the use of rigid phospholipids improve the pharmacokinetics of chemotherapeutics and reduce side-effects. However, cellular delivery and tumor heterogeneity are the main obstacles against tumor targeting. This study designed liposomes decorated with two ligands for enhanced cellular delivery and targeting of tumor vasculature and tumor cells.
Article
Biochemical Research Methods
Hannan Gao, Chuangwei Luo, Guangjie Yang, Shuaifan Du, Xiaoda Li, Huiyun Zhao, Jiyun Shi, Fan Wang
BIOCONJUGATE CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Xin Zeng, Jie Sun, Suping Li, Jiyun Shi, Han Gao, Wei Sun Leong, Yiqi Wu, Minghui Li, Chengxin Liu, Ping Li, Jing Kong, Yi-Zhou Wu, Guangjun Nie, Yuming Fu, Gen Zhang
NATURE COMMUNICATIONS
(2020)
Article
Biochemical Research Methods
Shuaifan Du, Chuangwei Luo, Guangjie Yang, Hannan Gao, Yanpu Wang, Xiaoda Li, Huiyun Zhao, Qi Luo, Xiaotu Ma, Jiyun Shi, Fan Wang
BIOCONJUGATE CHEMISTRY
(2020)
Article
Biochemical Research Methods
Haitao Zhao, Hannan Gao, Chuangwei Luo, Guangjie Yang, Xiaoyu Zhao, Shi Gao, Qingjie Ma, Bing Jia, Jiyun Shi, Fan Wang
Summary: The study showed that integrin alpha(v)beta(6)/alpha(5)beta(1)-bitargeted probes can accurately visualize tumors in a pancreatic adenocarcinoma model, providing a potential noninvasive approach for detecting pancreatic adenocarcinoma.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Qi Luo, Yunwei Zhang, Zihua Wang, Yining Sun, Linqing Shi, Yue Yu, Jiyun Shi, Zhiyuan Hu, Fan Wang
Summary: This study developed a Tc-99m-labeled PD-L2-targeting peptide as a SPECT tracer for non-invasive imaging of tumor PD-L2 expression. The peptide exhibited high PD-L2-binding specificity and successfully visualized PD-L2-positive tumors in vivo. The findings suggest that this peptide has potential in guiding immunotherapy for cancer.
CHINESE CHEMICAL LETTERS
(2022)
Article
Oncology
Yu Gao, Qi Luo, Zhichen Sun, Hannan Gao, Yue Yu, Yining Sun, Xiaotu Ma, Chuanhui Han, Jiyun Shi, Fan Wang
Summary: A new SPECT/CT imaging probe Tc-99m-sum IL-2 was developed to target tumor-infiltrating T cells and predict immune response and guide immunotherapy. The probe successfully identified tumor-infiltrating T cells and showed treatment efficacy through imaging.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Chemistry, Medicinal
Yu Liu, Qian Zhang, Yuwei Zhang, Jingnan Wang, Yitian Wu, Guangjie Yang, Jiyun Shi, Fan Wang, Zuojun Xu, Hongli Jing
Summary: This study evaluated Tc-99m-HFAPI imaging in IPF patients and found that it is a promising new imaging modality with correlations to HRCT and PFT results.
Article
Chemistry, Multidisciplinary
Xiaotu Ma, Meinan Yao, Jiyun Shi, Xiaoda Li, Yu Gao, Qi Luo, Rui Hou, Xiaolong Liang, Fan Wang
Article
Oncology
Hannan Gao, Yue Wu, Jiyun Shi, Xin Zhang, Tianyu Liu, Biao Hu, Bing Jia, Yakun Wan, Zhaofei Liu, Fan Wang
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)