Article
Biology
Yang Lyu, Kristina J. Weaver, Humza A. Shaukat, Marta L. Plumoff, Maria Tjilos, Daniel E. L. Promislow, Scott D. Pletcher
Summary: Diet choice affects behavior, metabolism, and lifespan in Drosophila, independent of the amount of nutrients consumed. This study reveals a mechanism of aging that applies in natural conditions, including our own, in which organisms continuously perceive and evaluate nutrient availability to promote fitness and well-being.
Article
Biology
Yang Lyu, Daniel E. L. Promislow, Scott D. Pletcher
Summary: Analyzing metabolic network integrity in Drosophila melanogaster, researchers found that the effects of different macronutrients on the stability of metabolic networks are mediated through serotonin signaling, demonstrating a shift in network state from highly connected and robust to fragmented, fragile, and vulnerable to perturbations.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cell Biology
Jun Zhou, Erica Valentini, Michael Boutros
Summary: Tissue homeostasis is disrupted during tumorigenesis, where tumor cells can outcompete nearby normal cells by influencing cell adhesion and contractility. Tumor growth depends on the activation of the JNK/PGRP-LA/Relish signaling axis to induce death of neighboring normal cells.
DEVELOPMENTAL CELL
(2021)
Article
Multidisciplinary Sciences
Siobhan Gartland, Baosheng Zeng, Michael T. Marr
Summary: Aging is the progressive decline of physiological homeostasis leading to reduced cellular and organismal function. Small RNA pathways, including microRNAs and small interfering RNAs, play a role in aging and regulate important processes such as development, cellular physiology, and innate immunity. The core components of the RNA-induced silencing complexes, Ago1 and Ago2, are regulated by the transcription factor dFOXO, which is involved in stress responses and longevity pathways. Age does not significantly change the abundance of most small RNAs, but it affects RISC loading for a small number of miRNAs.
Article
Cell Biology
Silvia Vaena, Paramita Chakraborty, Han Gyul Lee, Alhaji H. Janneh, Mohamed Faisal Kassir, Gyda Beeson, Zachariah Hedley, Ahmet Yalcinkaya, M. Hanief Sofi, Hong Li, Monica L. Husby, Robert Stahelin, Xue-Zhong Yu, Shikhar Mehrotra, Besim Ogretmen
Summary: This study reveals that activated T cells from aging mice accumulate high levels of C14/C16 ceramide in the mitochondria, leading to mitophagy and mitochondrial dysfunction. The aging-dependent mitochondrial ceramide inhibits protein kinase A, causing mitophagy in activated T cells, which impairs the antitumor functions of T cells.
Review
Biochemistry & Molecular Biology
Shree Padma Metur, Daniel J. Klionsky
Summary: Macroautophagy/autophagy is a crucial cellular process involved in cellular stress responses and maintaining cellular homeostasis. This review focuses on the current understanding of how cells regulate autophagy initiation through nutrient-dependent signaling pathways, which has significant implications for studying diseases.
Article
Endocrinology & Metabolism
Gal Manella, Elizabeth Sabath, Rona Aviram, Vaishnavi Dandavate, Saar Ezagouri, Marina Golik, Yaarit Adamovich, Gad Asher
Summary: The study reveals that the hierarchy between the central and peripheral clocks in mammals has been established, and explores the disparities in responses of peripheral clocks using altered feeding paradigms and liver-clock mutant mice. Despite its significant role in nutrient processing, disruption of the liver-clock does not affect the rhythmicity of other peripheral tissues.
Article
Cell Biology
Yangli Liu, Jun Zhou, Ning Zhang, Xueying Wu, Qian Zhang, Wenfeng Zhang, Xinyu Li, Ye Tian
Summary: Mitochondrial perturbations in neurons can regulate organism-wide mitochondrial homeostasis and adaptability by activating the unfolded protein response in the intestine. This regulation involves the coordinated action of GPCR and its downstream signaling in sensory neurons.
DEVELOPMENTAL CELL
(2022)
Article
Multidisciplinary Sciences
Zuri A. Sullivan, William Khoury-Hanold, Jaechul Lim, Chris Smillie, Moshe Biton, Bernardo S. Reis, Rachel K. Zwick, Scott D. Pope, Kavita Israni-Winger, Roham Parsa, Naomi H. Philip, Saleh Rashed, Noah Palm, Andrew Wang, Daniel Mucida, Aviv Regev, Ruslan Medzhitov
Summary: Research has shown that carbohydrate intake plays a vital role in regulating intestinal epithelial gene expression and the enzymes and transport proteins required for carbohydrate digestion and absorption; gamma delta T cells regulate this process by suppressing interleukin-22 production by type 3 innate lymphoid cells; nutrient availability affects the tissue localization and transcriptome of gamma delta T cells, as well as the cellular remodeling of the epithelial compartment.
Article
Biochemistry & Molecular Biology
Nuria Pujol-Carrion, Monica Pavon-Verges, Javier Arroyo, Maria Angeles de la Torre-Ruiz
Summary: Iron is crucial for life, and in yeast, the MAPK Slt2 phosphorylates and negatively regulates Aft1 activity to control lifespan. This regulation is direct and independent of other signaling pathways.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Immunology
Christian B. Cox, Elaine E. Storm, Varun N. Kapoor, Joseph Chavarria-Smith, David L. Lin, Lifen Wang, Yun Li, Noelyn Kljavin, Naruhisa Ota, Travis W. Bainbridge, Keith Anderson, Merone Roose-Girma, Soren Warming, Joseph R. Arron, Shannon J. Turley, Frederic J. de Sauvage, Menno van Lookeren Campagne
Summary: After intestinal epithelial damage, IL-1R1 signaling in GREM1(+) mesenchymal cells increases production of RSPO3 and IL-22, promoting epithelial hyperplasia and regeneration to restore intestinal function.
SCIENCE IMMUNOLOGY
(2021)
Article
Environmental Sciences
Zhongmin Sui, Chaoqing Wei, Xuan Wang, Huihui Zhou, Chengdong Liu, Kangsen Mai, Gen He
Summary: Ammonia has significant impacts on the growth and health of crustaceans, leading to oxidative stress and metabolic disorders. However, little is known about its effects on nutrient metabolism and signaling pathways. This study provides important insights into the metabolic responses and nutrient signaling under ammonia stress, enhancing our understanding of the physiological responses and growth performance in shrimp.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Hua Yan, Comzit Opachaloemphan, Francisco Carmona-Aldana, Giacomo Mancini, Jakub Mlejnek, Nicolas Descostes, Bogdan Sieriebriennikov, Alexandra Leibholz, Xiaofan Zhou, Long Ding, Maria Traficante, Claude Desplan, Danny Reinberg
Summary: Reproduction is correlated with shorter life span in most organisms. However, in Harpegnathos ants, workers can switch to reproductive pseudo-queens and exhibit a prolonged life span. Increased insulin expression in the gamergate brain leads to increased lipid synthesis and vitellogenin production in the fat body, extending their longevity. The anti-insulin Imp-L2 in the gamergate developing ovary decreases signaling in the fat body, consistent with their extended life span.
Article
Multidisciplinary Sciences
Nathalie Arquier, Marianne Bjordal, Philippe Hammann, Lauriane Kuhn, Pierre Leopold
Summary: It has been found in a study that a group of neurons in the Drosophila larval brain controls insulin response in peripheral tissues through AdipoR signaling, affecting metabolism and growth. The study also identified the inhibitory effect of Grp78 on AdipoR function, as well as the mechanism by which AdipoR signaling inhibits JH response and promotes insulin signaling.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Naohiro Kon, Hsin-tzu Wang, Yoshiaki S. Kato, Kyouhei Uemoto, Naohiro Kawamoto, Koji Kawasaki, Ryosuke Enoki, Gen Kurosawa, Tatsuto Nakane, Yasunori Sugiyama, Hideaki Tagashira, Motomu Endo, Hideo Iwasaki, Takahiro Iwamoto, Kazuhiko Kume, Yoshitaka Fukada
Summary: Temperature compensation of circadian rhythms is achieved through NCX-mediated Ca2+ signaling, which plays essential roles in maintaining temperature-compensated oscillations.
