IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage

Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient

(2020) Neil McCarthy et al.   Cell Stem Cell

ImmGen at 15

(2020)   NATURE IMMUNOLOGY

IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration

(2019) Hiroaki Katsura et al.   Stem Cell Reports

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

(2019) Alberto Mantovani et al.   IMMUNITY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Emerging diverse roles of telocytes

(2019) Ayano Kondo et al.   DEVELOPMENT

Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells

(2019) Yi Wang et al.   CELL

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon

(2019) Christine Harnack et al.   Nature Communications

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

CRISPR off-target analysis in genetically engineered rats and mice

(2018) Keith R. Anderson et al.   NATURE METHODS

PDGFRα+pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo

(2018) Gediminas Greicius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells

(2018) Anping Song et al.   Scientific Reports

Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease

(2018) James Kinchen et al.   CELL

Subepithelial telocytes are an important source of Wnts that supports intestinal crypts

(2018) Michal Shoshkes-Carmel et al.   NATURE

GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells

(2018) Bahar Degirmenci et al.   NATURE

CD34+mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury

(2017) Igor Stzepourginski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells

(2017) Pedro Lee et al.   eLife

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

(2016) Joep Beumer et al.   DEVELOPMENT

Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis

(2016) Isabella Dotti et al.   GUT

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

(2016) Henner F. Farin et al.   NATURE

Innate lymphoid cell function in the context of adaptive immunity

(2016) Jennifer K Bando et al.   NATURE IMMUNOLOGY

Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes

(2016) Jingyao Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis

(2016) Tomas Valenta et al.   Cell Reports

Interleukin-1 (IL-1) Signaling in Intestinal Stromal Cells Controls KC/CXCL1 Secretion, Which Correlates with Recruitment of IL-22-Secreting Neutrophils at Early Stages of Citrobacter rodentium Infection

(2015) Yong-Soo Lee et al.   INFECTION AND IMMUNITY

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function

(2015) Elaine E. Storm et al.   NATURE

Intestinal macrophages arising from CCR2+ monocytes control pathogen infection by activating innate lymphoid cells

(2015) Sang-Uk Seo et al.   Nature Communications

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

(2014) Jianwei Wang et al.   CELL

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts

(2014) Z. Kabiri et al.   DEVELOPMENT

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

(2014) W. de Lau et al.   GENES & DEVELOPMENT

Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis

(2014) M. Roulis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Function of the intestinal epithelium and its dysregulation in inflammatory bowel disease

(2010) Paul Henderson et al.   INFLAMMATORY BOWEL DISEASES

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Mechanisms of Asymmetric Stem Cell Division

(2008) Juergen A. Knoblich   CELL

Neural stem cells: balancing self-renewal with differentiation

(2008) C. Q. Doe   DEVELOPMENT

Interleukin-1 Receptor Signaling Protects Mice from Lethal Intestinal Damage Caused by the Attaching and Effacing Pathogen Citrobacter rodentium

(2008) S. L. Lebeis et al.   INFECTION AND IMMUNITY

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE