Cytotoxic metabolites from the endophytic fungus Penicillium chermesinum: discovery of a cysteine-targeted Michael acceptor as a pharmacophore for fragment-based drug discovery, bioconjugation and click reactions

Recent advances in C–S bond formation via C–H bond functionalization and decarboxylation

(2015) Chao Shen et al.   CHEMICAL SOCIETY REVIEWS

Bioactive Metabolites from Mangrove Endophytic Fungus Aspergillus sp. 16-5B

(2015) Yayue Liu et al.   Marine Drugs

Bio-inspired dimerisation of prenylated quinones directed towards the synthesis of the meroterpenoid natural products, the scabellones

(2015) Susanna T.S. Chan et al.   TETRAHEDRON LETTERS

Generation of ArS-substituted flavone derivatives using aryl thiols as sulfenylating agents

(2015) Wannian Zhao et al.   RSC Advances

Bioconjugation of Gold Nanoparticles through the Oxidative Coupling of ortho-Aminophenols and Anilines

(2014) Stacy L. Capehart et al.   BIOCONJUGATE CHEMISTRY

A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases

(2014) Stefan G. Kathman et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-Terminal Modification of Proteins with o-Aminophenols

(2014) Allie C. Obermeyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational Analysis

(2014) Shyam Krishnan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification and nomenclature of the genus Penicillium

(2014) C.M. Visagie et al.   STUDIES IN MYCOLOGY

A taxonomic and phylogenetic revision of Penicillium section Aspergilloides

(2014) J. Houbraken et al.   STUDIES IN MYCOLOGY

Benzylidene-linked thiohydantoin derivatives as inhibitors of tyrosinase and melanogenesis: importance of the β-phenyl-α,β-unsaturated carbonyl functionality

(2014) Hye Rim Kim et al.   MedChemComm

Functionalization of cellulose nanocrystal films via “thiol–ene” click reaction

(2014) Jian-Lin Huang et al.   RSC Advances

Synthesis of heteroaryl containing sulfides via enaminone ligand assisted, copper-catalyzed C–S coupling reactions of heteroaryl thiols and aryl halides

(2014) Yunyun Liu et al.   RSC Advances

New eremophilane-type sesquiterpenes from an Antarctic deep-sea derived fungus, Penicillium sp. PR19 N-1

(2013) Aiqun Lin et al.   ARCHIVES OF PHARMACAL RESEARCH

Drug discovery considerations in the development of covalent inhibitors

(2013) Robert Mah et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease

(2013) Núria R. Roqué Rosell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification by in silico and in vitro screenings of small organic molecules acting as reversible inhibitors of kallikreins

(2013) Xiao Tan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma WithEGFRMutations

(2013) Lecia V. Sequist et al.   JOURNAL OF CLINICAL ONCOLOGY

Efficacious Cyclic N-Acyl O-Amino Phenol Duocarmycin Prodrugs

(2013) Amanda L. Wolfe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Native Chemical Ligation,Thiol–Ene Click: A Methodology for the Synthesis of Functionalized Peptides

(2013) Lyn Markey et al.   JOURNAL OF ORGANIC CHEMISTRY

Experimental and Theoretical Studies of Selective Thiol–Ene and Thiol–Yne Click Reactions Involving N-Substituted Maleimides

(2013) Robert M. Stolz et al.   JOURNAL OF ORGANIC CHEMISTRY

Secondary Metabolites of a Mangrove Endophytic Fungus Aspergillus terreus (No. GX7-3B) from the South China Sea

(2013) Chun-Mei Deng et al.   Marine Drugs

Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia

(2013) John C. Byrd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prospective use of molecular field points in ligand-based virtual screening: efficient identification of new reversible Cdc25 inhibitors

(2013) James C. Collins et al.   MedChemComm

Synthesis of thiolated and acrylated nanoparticles using thiol-ene click chemistry: towards novel mucoadhesive materials for drug delivery

(2013) Anna Štorha et al.   RSC Advances

Clinical perspectives for irreversible tyrosine kinase inhibitors in cancer

(2012) Caterina Carmi et al.   BIOCHEMICAL PHARMACOLOGY

Fragment-Based Approaches in Drug Discovery and Chemical Biology

(2012) Duncan E. Scott et al.   BIOCHEMISTRY

Largazole: From discovery to broad-spectrum therapy

(2012) Jiyong Hong et al.   NATURAL PRODUCT REPORTS

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

(2012) Iana M Serafimova et al.   Nature Chemical Biology

Untapped mutualistic paradigms linking host plant and endophytic fungal production of similar bioactive secondary metabolites

(2012) Souvik Kusari et al.   PHYTOCHEMISTRY

Nitrone formation in phosphate buffer and aqueous solutions: novel chemistry inspired by a natural product

(2012) Acharavadee Pansanit et al.   TETRAHEDRON LETTERS

Azaphilones andp-Terphenyls from the Mangrove Endophytic FungusPenicillium chermesinum(ZH4-E2) Isolated from the South China Sea

(2011) Hongbo Huang et al.   JOURNAL OF NATURAL PRODUCTS

Glutathione in Cancer Cell Death

(2011) Angel L. Ortega et al.   Cancers

The Tunable Functionality of α,β-Unsaturated Carbonyl Compounds Enables Their Differential Application in Biological Systems

(2010) Sabine Amslinger   ChemMedChem

Targeted covalent drugs of the kinase family

(2010) Juswinder Singh et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine

(2010) Margit Hagel et al.   Nature Chemical Biology

Synthesis and Preliminary in Vitro Biological Evaluation of 4-[(4-Hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-Mercaptophenol Derivative Designed As a Novel Bifunctional Antimelanoma Agent

(2009) Paolo Ruzza et al.   JOURNAL OF MEDICINAL CHEMISTRY

Covalent Modifiers: An Orthogonal Approach to Drug Design

(2009) Michele H. Potashman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Beyond Picomolar Affinities: Quantitative Aspects of Noncovalent and Covalent Binding of Drugs to Proteins

(2008) Adam J. T. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

The first total synthesis and structural determination of TMC-264

(2008) Kuniaki Tatsuta et al.   TETRAHEDRON LETTERS