Article
Biochemistry & Molecular Biology
So Dam Lee, Haengdueng Jeong, Bo Ram Hwang, Byeong Min Yu, Yejin Cho, Ki Teak Nam, Hyunki Kim, Yong Chan Lee
Summary: Strains of Helicobacter pylori positive for CagA may contribute to the development of gastric cancer through the induction of CK2 activation and CK28 degradation. The downregulation of CK28 and subsequent activation of AKT and Snail signaling pathways may play a crucial role in the epithelial-to-mesenchymal transition (EMT) in gastric cancer. CK2 could be a potential molecular target for the treatment of H. pylori-infected gastric cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Michelle C. C. Lim, Phatcharida Jantaree, Michael Naumann
Summary: Helicobacter pylori is a pathogenic bacterium that resides in the stomach lining and causes inflammation called type B gastritis. The chronic inflammation induced by H. pylori and other factors may lead to the development of stomach neoplasms and adenocarcinoma. Dysregulation of cellular processes in the stomach lining and microenvironment is a characteristic of H. pylori infection. In this review, we discuss the contradictory role of H. pylori in promoting or suppressing apoptosis in gastric epithelial cells and highlight the key processes in the microenvironment that contribute to apoptosis and gastric carcinogenesis.
Article
Biochemistry & Molecular Biology
Rejina Shrestha, Naoko Murata-Kamiya, Satoshi Imai, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Masanori Hatakeyama
Summary: The initial step in bacterial infection is the adherence of the bacterium to the target cell surface. This study found that the mouse stomach has a much lower expression level of Ceacam1 compared to the human stomach, which leads to the inability of the bacteria to deliver the CagA protein due to the lack of interaction between HopQ and Ceacam1 in mouse gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Aina Ichihara, Hinako Ojima, Kazuyoshi Gotoh, Osamu Matsushita, Susumu Take, Hiroyuki Okada, Akari Watanabe, Kenji Yokota
Summary: This study aimed to explore the association between different antibody reactivities and bacterial genome organization. High-reactive strains showed high gene homology, while inversion around the vacA gene was found in the genome of poorly responsive antigen strains.
Review
Cell Biology
Jacek Baj, Alicja Forma, Monika Sitarz, Piero Portincasa, Gabriella Garruti, Danuta Krasowska, Ryszard Maciejewski
Summary: Gastric cancer is a prevalent malignancy worldwide and ranks as the fourth leading cause of cancer-related deaths. The pathogenesis of gastric cancer involves the interaction between genetic and environmental factors, with Helicobacter pylori infection playing a major role. Understanding the mechanisms of H. pylori pathogenicity is crucial for developing eradication strategies to prevent carcinogenesis.
Article
Infectious Diseases
Mengheng Mi, Fangcao Wu, Jian Zhu, Fang Liu, Guzhen Cui, Xueqing Wen, Yue Hu, Zhaohui Deng, Xiaojuan Wu, Zhengrong Zhang, Tingna Qi, Zhenghong Chen
Summary: The research revealed the presence of heterogeneous Helicobacter pylori strains with resistance to different drugs and virulence within the gastric mucosa of individual patients. Genetic diversity among monoclonal strains influenced antibiotic susceptibility and some strains exhibited genotype variations impacting treatment efficacy.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Microbiology
Xinbo Xu, Chunxi Shu, Xidong Wu, Yaobin Ouyang, Hong Cheng, Yanan Zhou, Huan Wang, Cong He, Chuan Xie, Xingxing He, Junbo Hong, Nonghua Lu, Zhongming Ge, Yin Zhu, Nianshuang Li
Summary: This study reveals the existence of a positive feedback loop between TAZ and beta-catenin in the pathogenesis of H. pylori infection-induced gastric cancer. TAZ inhibition may serve as a potential target for the prevention of H. pylori infection-associated gastric cancer.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Mahjerin Nasrin Reza, Shahin Mahmud, Nadim Ferdous, Ishtiaque Ahammad, Mohammad Uzzal Hossain, Md. Al Amin, A. K. M. Mohiuddin
Summary: In this study, two siRNA molecules were designed to silence the CagA and VacA genes of H. pylori, which are significantly involved in gastric cancer development. These designed siRNAs should effectively silence the CagA and VacA genes during siRNA mediated treatment in gastric cancer.
Review
Microbiology
Seyedeh Zahra Bakhti, Saeid Latifi-Navid
Summary: The oral microbiota may play a role in the development and progression of gastric cancer, but the causal relationship between oral microbiota and gastric cancer remains controversial. Exploring the interaction and relationship between the oral microbiota and Helicobacter pylori in gastric cancer, as well as the impact of oral microbiota on the mechanisms of carcinogenesis, could offer new insights for the diagnosis and prevention of gastric cancer.
Review
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Infection with H. pylori triggers a robust cellular response in the host, potentially leading to gastric cancer. The regulation of cellular processes through ubiquitinylation mechanisms influences various pathologies including cancer, yet the exact impact of H. pylori on this process remains unclear.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Linqi Zhu, Yue Huang, Hong Li, Shihe Shao
Summary: Infection with Helicobacter pylori may promote the occurrence and progression of gastric cancer by influencing the tumor microenvironment (TME).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiujuan Xia, Linfang Zhang, Hao Wu, Feng Chen, Xuanyou Liu, Huifang Xu, Yuqi Cui, Qiang Zhu, Meifang Wang, Hong Hao, De-Pei Li, William P. Fay, Luis A. Martinez-Lemus, Michael A. Hill, Canxia Xu, Zhenguo Liu
Summary: This study found that CagA(+) H. pylori effectively colonizes gastric mucosa and impairs endothelial function, leading to increased atherosclerosis through exosomes-mediated ROS formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Microbiology
Satoshi Imai, Takuya Ooki, Naoko Murata-Kamiya, Daisuke Komura, Kamrunnesa Tahmina, Weida Wu, Atsushi Takahashi-Kanemitsu, Christopher Takaya Knight, Akiko Kunita, Nobumi Suzuki, Adriana A. Del Valle, Mayo Tsuboi, Masahiro Hata, Yoku Hayakawa, Naomi Ohnishi, Koji Ueda, Masashi Fukayama, Tetsuo Ushiku, Shumpei Ishikawa, Masanori Hatakeyama
Summary: Infection with CagA-producing H. pylori leads to gastric cancer development through disrupting DNA repair mechanisms, inhibiting apoptosis of damaged cells, and promoting somatic mutation. This hit-and-run mechanism creates a favorable environment for the initiation and progression of gastric carcinogenesis.
CELL HOST & MICROBE
(2021)
Article
Immunology
Amber C. Beckett, M. Blanca Piazuelo, Jennifer M. Noto, Richard M. Peek, M. Kay Washington, Holly M. Scott Algood, Timothy L. Cover
INFECTION AND IMMUNITY
(2016)
Article
Gastroenterology & Hepatology
Jennifer M. Noto, Abha Chopra, John T. Loh, Judith Romero-Gallo, M. Blanca Piazuelo, Mark Watson, Shay Leary, Amber C. Beckett, Keith T. Wilson, Timothy L. Cover, Simon Mallal, Dawn A. Israel, Richard M. Peek
Article
Microbiology
Jennifer M. Noto, Richard M. Peek
Article
Biochemistry & Molecular Biology
Andela Horvat, Jennifer M. Noto, Balamurugan Ramatchandirin, Elena Zaika, Manikandan Palrasu, Jinxiong Wei, Barbara G. Schneider, Wael El-Rifai, Richard M. Peek, Alexander I. Zaika
Article
Multidisciplinary Sciences
Amber C. Beckett, John T. Loh, Abha Chopra, Shay Leary, Aung Soe Lin, Wyatt J. McDonnell, Beverly R. E. A. Dixon, Jennifer M. Noto, Dawn A. Israel, Richard M. Peek, Simon Mallal, Holly M. Scott Algood, Timothy L. Cover
Article
Multidisciplinary Sciences
Vikas Bhardwaj, Ravindran Caspa Gokulan, Andela Horvat, Liudmila Yermalitskaya, Olga Korolkova, Kay M. Washington, Wael El-Rifai, Sergey I. Dikalov, Alexander I. Zaika
SCIENTIFIC REPORTS
(2017)
Article
Biochemical Research Methods
Jennifer M. Noto, Kristie L. Rose, Amanda J. Hachey, Alberto G. Delgado, Judith Romero-Gallo, Lydia E. Wroblewski, Barbara G. Schneider, Shailja C. Shah, Timothy L. Cover, Keith T. Wilson, Dawn A. Israel, Juan Carlos Roa, Kevin L. Schey, Yana Zavros, M. Blanca Piazuelo, Richard M. Peek
MOLECULAR & CELLULAR PROTEOMICS
(2019)
Article
Microbiology
Jennifer M. Noto, Joseph P. Zackular, Matthew G. Varga, Alberto Delgado, Judith Romero-Gallo, Matthew B. Scholz, M. Blanca Piazuelo, Eric P. Skaar, Richard M. Peek
Article
Pharmacology & Pharmacy
Jun He, Weitao Liu, Xin Ge, Gao-Chan Wang, Vilas Desai, Shaomin Wang, Wei Mu, Vikas Bhardwaj, Erin Seifert, Ling-Zhi Liu, Alok Bhushan, Stephen C. Peiper, Bing-Hua Jiang
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Vikas Bhardwaj, Jun He
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Hua Shen, Gao-Chan Wang, Xiang Li, Xin Ge, Meng Wang, Zhu-Mei Shi, Vikas Bhardwaj, Zi-Xuan Wang, Ralph G. Zinner, Stephen C. Peiper, Andrew E. Aplin, Bing-Hua Jiang, Jun He
Article
Oncology
Neha Sharma, Alok Bhushan, Jun He, Gagan Kaushal, Vikas Bhardwaj
CANCER & METABOLISM
(2020)
Editorial Material
Gastroenterology & Hepatology
Jennifer M. Noto, Richard M. Peek
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Samuel D. R. Dooyema, Jennifer M. Noto, Lydia E. Wroblewski, M. Blanca Piazuelo, Uma Krishna, Giovanni Suarez, Judith Romero-Gallo, Alberto G. Delgado, Richard M. Peek
Summary: In this study, a novel mechanism was identified through which H. pylori actively suppresses STING and RIG-I signaling via downregulation of IRF3 activation, which not only regulates the initial innate immune response, but also drives chronic gastric inflammation and injury.
Article
Medicine, Research & Experimental
Jennifer M. Noto, M. Blanca Piazuelo, Shailja C. Shah, Judith Romero-Gallo, Jessica L. Hart, Chao Di, James D. Carmichael, Alberto G. Delgado, Alese E. Halvorson, Robert A. Greevy, Lydia E. Wroblewski, Ayushi Sharma, Annabelle B. Newton, Margaret M. Allaman, Keith T. Wilson, M. Kay Washington, M. Wade Calcutt, Kevin L. Schey, Bethany P. Cummings, Charles R. Flynn, Joseph P. Zackular, Richard M. Peek
Summary: This study reveals that Helicobacter pylori enhances gastric injury under conditions of iron deficiency and that this phenomenon is closely associated with altered bile acid metabolism. Deoxycholic acid (DCA) is identified as a carcinogenic bile acid that can further exacerbate gastric injury and promote the translocation of the H. pylori oncoprotein CagA into host cells. Conversely, the use of bile acid sequestrants can attenuate H. pylori-induced injury. Furthermore, cumulative use of bile acid sequestrants is significantly associated with a reduced risk of gastric cancer in human populations. These findings demonstrate the importance of bile acid metabolism in H. pylori-induced gastric injury and carcinogenesis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)