Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

Helicobacter pylori CagA oncoprotein interacts with SHIP2 to increase its delivery into gastric epithelial cells

(2020) Yumiko Fujii et al.   CANCER SCIENCE

Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells

(2020) Manikandan Palrasu et al.   JOURNAL OF CLINICAL INVESTIGATION

H. pylori infection alters repair of DNA double-strand breaks via SNHG17

(2020) Taotao Han et al.   JOURNAL OF CLINICAL INVESTIGATION

The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress

(2020) Michael Bauer et al.   Nature Communications

Advances in understanding DNA processing and protection at stalled replication forks

(2019) Kimberly Rickman et al.   JOURNAL OF CELL BIOLOGY

High-Molecular-Weight Hyaluronan Is a Hippo Pathway Ligand Directing Cell Density-Dependent Growth Inhibition via PAR1b

(2019) Takuya Ooki et al.   DEVELOPMENTAL CELL

Defining and Modulating ‘BRCAness’

(2019) Andrea K. Byrum et al.   TRENDS IN CELL BIOLOGY

Strelka2: fast and accurate calling of germline and somatic variants

(2018) Sangtae Kim et al.   NATURE METHODS

Helicobacter pylori Therapy for the Prevention of Metachronous Gastric Cancer

(2018) Il Ju Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of polarity-regulating kinase PAR1b contributes to Helicobacter pylori inflicted DNA Double Strand Breaks in gastric cells

(2018) Andrea Zamperone et al.   CELL CYCLE

The Ambivalent Function of YAP in Apoptosis and Cancer

(2018) Xianbin Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Germline Mutations in PALB2 , BRCA1 , and RAD51C , Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer

(2017) Ruta Sahasrabudhe et al.   GASTROENTEROLOGY

Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins

(2017) Takeru Hayashi et al.   Cell Reports

The Role of CagA in the Gastric Biology of Helicobacter pylori

(2016) Steffen Backert et al.   CANCER RESEARCH

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b

(2016) Hiroko Nishikawa et al.   Scientific Reports

Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs

(2016) Anahita Javaheri et al.   Nature Microbiology

Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA

(2016) Verena Königer et al.   Nature Microbiology

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

(2015) Sina Bartfeld et al.   GASTROENTEROLOGY

Helicobacter pylori Activates and Expands Lgr5+ Stem Cells Through Direct Colonization of the Gastric Glands

(2015) Michael Sigal et al.   GASTROENTEROLOGY

Loss-of-function variants in ATM confer risk of gastric cancer

(2015) Hannes Helgason et al.   NATURE GENETICS

A mutational signature in gastric cancer suggests therapeutic strategies

(2015) Ludmil B. Alexandrov et al.   Nature Communications

Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein

(2015) Nobumi Suzuki et al.   Scientific Reports

Helicobacter pylori Infection Causes Characteristic DNA Damage Patterns in Human Cells

(2015) Max Koeppel et al.   Cell Reports

H. pylori -Induced DNA Strand Breaks Are Introduced by Nucleotide Excision Repair Endonucleases and Promote NF-κB Target Gene Expression

(2015) Mara L. Hartung et al.   Cell Reports

Hereditary Diffuse Gastric Cancer Syndrome

(2015) Samantha Hansford et al.   JAMA Oncology

DNA Repair by Homologous Recombination, But Not by Nonhomologous End Joining, Is Elevated in Breast Cancer Cells

(2015) Zhiyong Mao et al.   NEOPLASIA

Helicobacter pylori CagA and Gastric Cancer: A Paradigm for Hit-and-Run Carcinogenesis

(2014) Masanori Hatakeyama   Cell Host & Microbe

Accumulation of Somatic Mutations in TP53 in Gastric Epithelium With Helicobacter pylori Infection

(2014) Takahiro Shimizu et al.   GASTROENTEROLOGY

A novel human gastric primary cell culture system for modellingHelicobacter pyloriinfection in vitro

(2014) Philipp Schlaermann et al.   GUT

Helicobacter pylori Infection Introduces DNA Double-Strand Breaks in Host Cells

(2014) Katsuhiro Hanada et al.   INFECTION AND IMMUNITY

Global burden of gastric cancer attributable toHelicobacterpylori

(2014) Martyn Plummer et al.   INTERNATIONAL JOURNAL OF CANCER

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

H. pylori virulence factor CagA increases intestinal cell proliferation by Wnt pathway activation in a transgenic zebrafish model

(2013) J. T. Neal et al.   Disease Models & Mechanisms

Replication Stress-Induced Genome Instability: The Dark Side of Replication Maintenance by Homologous Recombination

(2013) Antony M. Carr et al.   JOURNAL OF MOLECULAR BIOLOGY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine

(2013) Markus Stein et al.   Frontiers in Immunology

Tertiary Structure-Function Analysis Reveals the Pathogenic Signaling Potentiation Mechanism of Helicobacter pylori Oncogenic Effector CagA

(2012) Takeru Hayashi et al.   Cell Host & Microbe

PAR-1/MARK: a Kinase Essential for Maintaining the Dynamic State of Microtubules

(2011) Kenji Hayashi et al.   CELL STRUCTURE AND FUNCTION

Risk of cancer other than breast or ovarian in individuals with BRCA1 and BRCA2 mutations

(2011) A. Moran et al.   Familial Cancer

Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling

(2011) Kenji Kikuchi et al.   MICROBES AND INFECTION

Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells

(2011) I. M. Toller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conversion ofHelicobacter pyloriCagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21

(2010) Yasuhiro Saito et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation

(2009) Masato Suzuki et al.   Cell Host & Microbe

Host Cell Interactome of Tyrosine-Phosphorylated Bacterial Proteins

(2009) Matthias Selbach et al.   Cell Host & Microbe

Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates

(2009) Dragana Nes̆ić et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of detergent-resistant membranes of Helicobacter pylori infected gastric adenocarcinoma cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity

(2008) Zaher Zeaiter et al.   CELLULAR MICROBIOLOGY

Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial

(2008) Kazutoshi Fukase et al.   LANCET

PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop

(2008) Eleonora Lapi et al.   MOLECULAR CELL

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

(2008) N. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics

A Transgenic Drosophila Model Demonstrates That the Helicobacter pylori CagA Protein Functions as a Eukaryotic Gab Adaptor

(2008) Crystal M. Botham et al.   PLoS Pathogens