Article
Immunology
Zheng Xu, Boqing Li, Yunqiu Du, Ruiqing Zhang, Xiaohan Tong, Jing Li, Yulong Wu, Xiaofei Ji, Ying Zhang
Summary: The study revealed that ILK plays a role in modulating the Rac1/PAK1 and RhoA/ROCKs signaling pathways, thereby affecting H. pylori-induced autophagy.
MICROBIAL PATHOGENESIS
(2021)
Article
Cell Biology
Olga Sokolova, Gunter Maubach, Michael Naumann
Summary: Helicobacter pylori infection induces a strong inflammatory response in gastric mucosa and alters epithelial integrity and function. The activation of NF-κB transcription factors, specifically by the bacterial heptose metabolites, triggers this innate immune response. Our study reveals that the activation of ALPK1-dependent TIFA in H. pylori-infected gastric epithelial cells is followed by TIFA degradation, which is inhibited by proteasomal and lysosomal inhibitors. TRAF2, TRAF6, TAK1, or NEMO are not involved in TIFA degradation, and H. pylori promotes the interaction of TIFA with protein adaptors involved in lysosomal trafficking.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Myoung-Hee Kang, Seong-il Eyun, Yun-Yong Park
Summary: ESRRG is identified as a candidate factor influencing H. pylori infection-driven gastric cancer, suppressing H. pylori infection and cell growth, and regulating the expression of TFF1, a well-known tumor suppressor in GC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Pragyesh Dixit, Swathi Shivaram Suratkal, Shrikant Babanrao Kokate, Debashish Chakraborty, Indrajit Poirah, Supriya Samal, Niranjan Rout, Shivaram P. Singh, Arup Sarkar, Asima Bhattacharyya
Summary: This study elucidates a novel mechanism of oxidative stress regulation by phosphorylated Siah2 in H. pylori-infected gastric epithelial cancer cells. Phosphorylation of Siah2 enhances the generation of reactive oxygen species (ROS) induced by H. pylori and leads to the degradation of the antioxidant protein GRP78. Surprisingly, cells expressing Siah2 with a phospho-null mutation have lower levels of cellular GRP78 but release more GRP78 and accumulate higher levels of ROS.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Gunter Maubach, Michael Vieth, Francesco Boccellato, Michael Naumann
Summary: NF-03 signaling pathways are crucial for immune response and gastric pathophysiology, and their alterations induced by Helicobacter pylori infection have implications for gastric diseases.
TRENDS IN MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xiaohong Wang, Lianhai Zhang, Francis K. L. Chan, Jiafu Ji, Jun Yu, Jessie Qiaoyi Liang
Summary: GGT7 is frequently downregulated in gastric cancer and its methylation is correlated with patient survival. GGT7 inhibits gastric cancer cell growth and migration by inducing autophagy.
Article
Biotechnology & Applied Microbiology
Boqing Li, Qianyu Rong, Yunqiu Du, Ruiqing Zhang, Jing Li, Xiaohan Tong, Li Geng, Ying Zhang
Summary: Helicobacter pylori infection promotes autophagy and apoptosis in gastric cells, and beta 1-integrin is identified as a novel regulator during this infection.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Review
Immunology
Yihan Yang, Xu Shu, Chuan Xie
Summary: This paper reviews the impact of H. pylori infection on autophagy and the progression of gastric cancer signaling pathways.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jinglei Liu, Fangxu Zhang, Zheming Zhang, Chunning Zheng
Summary: This study found that Everolimus has a pharmacological role in protecting gastric epithelial cells from H.pylori-induced damage. It achieves this by reducing oxidative stress and inhibiting inflammatory response, as well as inhibiting the attachment of monocytes to epithelial cells.
Article
Gastroenterology & Hepatology
M. C. Mommersteeg, I Simovic, B. Yu, S. A. van Nieuwenburg, I. M. J. Bruno, M. Doukas, E. J. Kuipers, M. C. W. Spaander, M. P. Peppelenbosch, N. Castano-Rodriguez, G. M. Fuhler
Summary: The SNP in the ATG16L1 gene is associated with increased intestinal endoplasmic reticulum stress and progression of gastric cancer induced by H. pylori. Individuals with the G-allele are more prone to developing gastric cancer.
Article
Biochemistry & Molecular Biology
Wenshuai Zhu, Duanrui Liu, Yi Lu, Jingguo Sun, Jingyu Zhu, Yuanxin Xing, Xiaoli Ma, Yunshan Wang, Mingyu Ji, Yanfei Jia
Summary: In this study, it was found that Helicobacter pylori infection increased the sensitivity of gastric cancer cells to RSL3-induced ferroptosis. The molecular subtypes mediated by ferroptosis-related genes are associated with tumor microenvironment cell infiltration and patient survival. The expression of PHKG2 was remarkably correlated with H. pylori infection, metabolic biological processes, patient survival, and therapy response.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Cell Biology
Pragyesh Dixit, Shrikant B. Kokate, Indrajit Poirah, Debashish Chakraborty, Duane T. Smoot, Hassan Ashktorab, Niranjan Rout, Shivaram P. Singh, Asima Bhattacharyya
Summary: H. pylori infection induces phosphorylation of Siah2 in gastric epithelial cells, leading to increased tumorigenicity. The phosphorylation of Siah2 by MRCK beta stabilizes Siah2 and enhances the proliferative and invasive capabilities of infected cells.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Review
Biotechnology & Applied Microbiology
Linqi Zhu, Yue Huang, Hong Li, Shihe Shao
Summary: Infection with Helicobacter pylori may promote the occurrence and progression of gastric cancer by influencing the tumor microenvironment (TME).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Oncology
Jamshid Gholizadeh Navashenaq, Arezoo Gowhari Shabgah, Maciej Banach, Tannaz Jamialahmadi, Peter E. Penson, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Gastric cancer is a common cause of cancer deaths and Helicobacter pylori (H. pylori) is considered a primary carcinogen for this type of cancer. H. pylori triggers inflammation, which plays a crucial role in promoting carcinogenesis. The interaction between H. pylori and various cell types is essential for the progression and development of gastric cancer. Understanding the specific mechanisms of interaction between H. pylori and tumor-supportive cells can lead to the development of promising treatment strategies.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Microbiology
Marina A. Senchukova
Summary: H. pylori plays a role in the development of gastric cancer through interactions with pattern-recognition receptors on immune and epithelial cells. In addition to induction, H. pylori may also affect the mechanisms of gastric cancer progression.
CURRENT MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jennifer M. Noto, Abha Chopra, John T. Loh, Judith Romero-Gallo, M. Blanca Piazuelo, Mark Watson, Shay Leary, Amber C. Beckett, Keith T. Wilson, Timothy L. Cover, Simon Mallal, Dawn A. Israel, Richard M. Peek
Article
Materials Science, Biomaterials
Nikolina Hanzic, Angela Horvat, Juraj Bibic, Klaus Unfried, Tanja Jurkin, Goran Drazic, Inga Marijanovic, Neda Slade, Marijan Gotic
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Multidisciplinary Sciences
Amber C. Beckett, John T. Loh, Abha Chopra, Shay Leary, Aung Soe Lin, Wyatt J. McDonnell, Beverly R. E. A. Dixon, Jennifer M. Noto, Dawn A. Israel, Richard M. Peek, Simon Mallal, Holly M. Scott Algood, Timothy L. Cover
Article
Biochemical Research Methods
Jennifer M. Noto, Kristie L. Rose, Amanda J. Hachey, Alberto G. Delgado, Judith Romero-Gallo, Lydia E. Wroblewski, Barbara G. Schneider, Shailja C. Shah, Timothy L. Cover, Keith T. Wilson, Dawn A. Israel, Juan Carlos Roa, Kevin L. Schey, Yana Zavros, M. Blanca Piazuelo, Richard M. Peek
MOLECULAR & CELLULAR PROTEOMICS
(2019)
Article
Microbiology
Jennifer M. Noto, Joseph P. Zackular, Matthew G. Varga, Alberto Delgado, Judith Romero-Gallo, Matthew B. Scholz, M. Blanca Piazuelo, Eric P. Skaar, Richard M. Peek
Editorial Material
Gastroenterology & Hepatology
Jennifer M. Noto, Richard M. Peek
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinghua Peng, Balamurugan Ramatchandirin, Yu Wang, Alexia Pearah, Kopperuncholan Namachivayam, Risa M. Wolf, Kimberley Steele, Krishnan MohanKumar, Liqing Yu, Shaodong Guo, Morris F. White, Akhil Maheshwari, Ling He
Summary: This study reveals the molecular mechanism of how C646, a specific inhibitor of P300 acetyltransferase, improves insulin signaling. The researchers found that P300 levels were increased in the liver hepatocytes of obese patients, and that inhibition of P300 activity by C646 promoted insulin signaling by enhancing IRS1/2 membrane translocation and promoting IR beta interaction with IRS1/2. These findings have important implications for the treatment of obesity and diabetes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Gerald Lossaint, Andela Horvat, Veronique Gire, Katarina Bacevic, Karim Mrouj, Fabienne Charrier-Savournin, Virginie Georget, Daniel Fisher, Vjekoslav Dulic
Summary: The balance between p21 and Chk1 controls cyclin D-CDK activity during cell cycle arrest, with p21 activating RB in non-transformed cells and Chk1 maintaining its activity in cancer cells. The compromised G2 exit in cancer cells is associated with sustained Chk1 activity, delayed p21 induction, untimely cyclin E1 re-expression, and genome reduplication.
JOURNAL OF CELL SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Samuel D. R. Dooyema, Jennifer M. Noto, Lydia E. Wroblewski, M. Blanca Piazuelo, Uma Krishna, Giovanni Suarez, Judith Romero-Gallo, Alberto G. Delgado, Richard M. Peek
Summary: In this study, a novel mechanism was identified through which H. pylori actively suppresses STING and RIG-I signaling via downregulation of IRF3 activation, which not only regulates the initial innate immune response, but also drives chronic gastric inflammation and injury.
Article
Biochemistry & Molecular Biology
Martina Radic, Ignacija Vlasic, Maja Jazvinscak Jembrek, Andela Horvat, Ana Tadijan, Maja Sabol, Marko Duzevic, Maja Herak Bosnar, Neda Slade
Summary: Despite the advancements in melanoma treatment, many patients still develop resistance to drugs, such as the RAF inhibitor vemurafenib. In this study, researchers generated and examined two melanoma-derived cell lines with acquired resistance to vemurafenib. They found that the resistant cells displayed features of epithelial-mesenchymal transition (EMT) and exhibited a hybrid phenotype. Surprisingly, the resistant cells showed decreased migration ability but had a tendency for collective migration. Signaling pathway analysis revealed reactivation of MAPK and activation of the PI3K/AKT pathway in the vemurafenib-resistant cells. The acquired resistance also led to resistance to chemotherapy in the primary melanoma cells. Further investigation is needed to understand the negative regulators of NME proteins in vemurafenib resistance and their impact on PI3K/AKT signaling and melanoma cell characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Jennifer M. Noto, M. Blanca Piazuelo, Shailja C. Shah, Judith Romero-Gallo, Jessica L. Hart, Chao Di, James D. Carmichael, Alberto G. Delgado, Alese E. Halvorson, Robert A. Greevy, Lydia E. Wroblewski, Ayushi Sharma, Annabelle B. Newton, Margaret M. Allaman, Keith T. Wilson, M. Kay Washington, M. Wade Calcutt, Kevin L. Schey, Bethany P. Cummings, Charles R. Flynn, Joseph P. Zackular, Richard M. Peek
Summary: This study reveals that Helicobacter pylori enhances gastric injury under conditions of iron deficiency and that this phenomenon is closely associated with altered bile acid metabolism. Deoxycholic acid (DCA) is identified as a carcinogenic bile acid that can further exacerbate gastric injury and promote the translocation of the H. pylori oncoprotein CagA into host cells. Conversely, the use of bile acid sequestrants can attenuate H. pylori-induced injury. Furthermore, cumulative use of bile acid sequestrants is significantly associated with a reduced risk of gastric cancer in human populations. These findings demonstrate the importance of bile acid metabolism in H. pylori-induced gastric injury and carcinogenesis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Oncology
Andela Horvat, Ana Tadijan, Ignacija Vlasic, Neda Slade
Summary: The p53 family members, including p53, p63, and p73, play crucial roles in carcinogenesis, particularly in colorectal carcinoma. They have the ability to form tetramers that activate the transcription of specific genes, making them potential targets for cancer treatment. Understanding the interactions and activities of the p53 family members can contribute to the development of new targeted therapies for cancer.
Meeting Abstract
Gastroenterology & Hepatology
Andela Horvat, Balamurugan Ramatchandirin, Jennifer M. Noto, Wael M. El-Rifai, Richard M. Peek, Alexander Zaika