Early Life Nutrition and Energy Balance Disorders in Offspring in Later Life

Early-life influences on obesity: from preconception to adolescence

(2015) Mark L. Wahlqvist et al.   Annals of the New York Academy of Sciences

Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring

(2015) Brittany Beauchamp et al.   BIOSCIENCE REPORTS

A genome-wide association study of body mass index across early life and childhood

(2015) N. M. Warrington et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Early leptin intervention reverses perturbed energy balance regulating hypothalamic neuropeptides in the pre- and postnatal calorie-restricted female rat offspring

(2015) Leena Caroline Gibson et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Leptin resistance in obesity: An epigenetic landscape

(2015) Ana B. Crujeiras et al.   LIFE SCIENCES

A Maternal High Fat Diet Has Long-Lasting Effects on Skeletal Muscle Lipid and PLIN Protein Content in Rat Offspring at Young Adulthood

(2015) Rebecca E. K. MacPherson et al.   LIPIDS

Suboptimal maternal nutrition during early-to-mid gestation in the sheep enhances pericardial adiposity in the near-term fetus

(2015) Shalini Ojha et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Maternal health and eating habits: metabolic consequences and impact on child health

(2015) Shalini Ojha et al.   TRENDS IN MOLECULAR MEDICINE

Fetal health locus of control in a sample of pregnant Turkish women

(2015) Sevgi ÖZCAN et al.   Turkish Journal Of Medical Sciences

Considering Maternal Dietary Modulators for Epigenetic Regulation and Programming of the Fetal Epigenome

(2015) Abalo Chango et al.   Nutrients

Developmental programming of hypothalamic neuronal circuits: impact on energy balance control

(2015) Thanuja Gali Ramamoorthy et al.   Frontiers in Neuroscience

Piloting a New Approach to the Treatment of Obesity Using Dexamphetamine

(2015) Alison S. Poulton et al.   Frontiers in Endocrinology

Maternal Obesity in Sheep Increases Fatty Acid Synthesis, Upregulates Nutrient Transporters, and Increases Adiposity in Adult Male Offspring after a Feeding Challenge

(2015) Nathan M. Long et al.   PLoS One

Effects of Maternal Diet and Exercise during Pregnancy on Glucose Metabolism in Skeletal Muscle and Fat of Weanling Rats

(2015) Mukesh Raipuria et al.   PLoS One

Maternal obesity and the developmental programming of hypertension: a role for leptin

(2014) P. D. Taylor et al.   Acta Physiologica

Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep

(2014) Shervi Lie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Epigenetic Mechanisms Affecting Regulation of Energy Balance: Many Questions, Few Answers

(2014) Robert A. Waterland   Annual Review of Nutrition

Mitochondrial alteration in type 2 diabetes and obesity: An epigenetic link

(2014) Zhiyong Cheng et al.   CELL CYCLE

Brown Fat in Humans: Consensus Points and Experimental Guidelines

(2014) Aaron M. Cypess et al.   Cell Metabolism

MicroRNAs Are Required for the Feature Maintenance and Differentiation of Brown Adipocytes

(2014) H.-J. Kim et al.   DIABETES

Multigenerational impact of maternal overnutrition/obesity in the sheep on the neonatal leptin surge in granddaughters

(2014) D R Shasa et al.   INTERNATIONAL JOURNAL OF OBESITY

Early-postnatal changes in adiposity and lipids profile by transgenerational developmental programming in swine with obesity/leptin resistance

(2014) Antonio Gonzalez-Bulnes et al.   JOURNAL OF ENDOCRINOLOGY

Metabolic programming—knowns, unknowns and possibilities

(2014) Susan E. Ozanne   Nature Reviews Endocrinology

In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring

(2014) Sarah J. Borengasser et al.   PHYSIOLOGICAL GENOMICS

Naloxone treatment alters gene expression in the mesolimbic reward system in ‘junk food’ exposed offspring in a sex-specific manner but does not affect food preferences in adulthood

(2014) J.R. Gugusheff et al.   PHYSIOLOGY & BEHAVIOR

DNA methylation signatures link prenatal famine exposure to growth and metabolism

(2014) Elmar W. Tobi et al.   Nature Communications

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

(2014) Paula Dominguez-Salas et al.   Nature Communications

Prenatal programming of obesity in a swine model of leptin resistance: modulatory effects of controlled postnatal nutrition and exercise

(2014) A. Barbero et al.   Journal of Developmental Origins of Health and Disease

Early Life Nutrition, Epigenetics and Programming of Later Life Disease

(2014) Mark Vickers   Nutrients

Epigenetic Modification of the Leptin Promoter in Diet-Induced Obese Mice and the Effects of N-3 Polyunsaturated Fatty Acids

(2014) Wenwen Shen et al.   Scientific Reports

Higher TNF-α, IGF-1, and leptin levels are found in tasters than non-tasters

(2014) Rui Wang   Frontiers in Endocrinology

Locus of Control and Obesity

(2014) Florence Neymotin et al.   Frontiers in Endocrinology

Programming effects of FTO in the development of obesity

(2013) S. Sebert et al.   Acta Physiologica

Animal models of in utero exposure to a high fat diet: A review

(2013) Lyda Williams et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Periconceptional Undernutrition Programs Changes in Insulin-Signaling Molecules and MicroRNAs in Skeletal Muscle in Singleton and Twin Fetal Sheep1

(2013) Shervi Lie et al.   BIOLOGY OF REPRODUCTION

Prenatal programming in an obese swine model: sex-related effects of maternal energy restriction on morphology, metabolism and hypothalamic gene expression

(2013) Cristina Óvilo et al.   BRITISH JOURNAL OF NUTRITION

Developmental Programming of Offspring Obesity, Adipogenesis, and Appetite

(2013) MICHAEL G. ROSS et al.   CLINICAL OBSTETRICS AND GYNECOLOGY

Maternal Undernutrition Programs Tissue-Specific Epigenetic Changes in the Glucocorticoid Receptor in Adult Offspring

(2013) Ghazala Begum et al.   ENDOCRINOLOGY

Differential effects of maternal obesity and weight loss in the periconceptional period on the epigenetic regulation of hepatic insulin-signaling pathways in the offspring

(2013) Lisa M. Nicholas et al.   FASEB JOURNAL

Perinatal Nutrition Programs the Hypothalamic Melanocortin System in Offspring

(2013) J.-S. Wattez et al.   HORMONE AND METABOLIC RESEARCH

Functional Analysis of Seven Genes Linked to Body Mass Index and Adiposity by Genome-Wide Association Studies: A Review

(2013) John R. Speakman   HUMAN HEREDITY

Transgenerational developmental programming

(2013) Catherine E. Aiken et al.   HUMAN REPRODUCTION UPDATE

Impact of birth weight and gender on early postnatal hypothalamic energy balance regulatory gene expression in the young lamb

(2013) C.L. Adam et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

The Beneficial Effects of Early Short-Term Exercise in the Offspring of Obese Mothers are Accompanied by Alterations in the Hypothalamic Gene Expression of Appetite Regulators and FTO (Fat Mass and Obesity Associated) Gene

(2013) V. Caruso et al.   JOURNAL OF NEUROENDOCRINOLOGY

Developmental programming in skeletal muscle in response to overnourishment in the immediate postnatal life in rats

(2013) Hung-Wen Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: Implications of food intake

(2013) LETICIA MANUEL-APOLINAR et al.   Molecular Medicine Reports

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

(2013) Jan-Wilhelm Kornfeld et al.   NATURE

Brown adipose tissue genes in pericardial adipose tissue of newborn sheep are downregulated by maternal nutrient restriction in late gestation

(2013) Shalini Ojha et al.   PEDIATRIC RESEARCH

Epigenetic consequences of a changing human diet

(2013) Paul Haggarty   PROCEEDINGS OF THE NUTRITION SOCIETY

High fat diet induces hypermethylation of the hypothalamic Pomc promoter and obesity in post-weaning rats

(2013) Asaf Marco et al.   PSYCHONEUROENDOCRINOLOGY

Leptin as mediator of the effects of developmental programming

(2012) M.H. Vickers et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Folic acid supplementation in pregnancy: are there devils in the detail?

(2012) Graham C. Burdge et al.   BRITISH JOURNAL OF NUTRITION

Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning

(2012) Ghazala Begum et al.   FASEB JOURNAL

DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial

(2012) Wendy N. Cooper et al.   FASEB JOURNAL

Reproductive, endocrine and metabolic feto-maternal features and placental gene expression in a swine breed with obesity/leptin resistance

(2012) A. Gonzalez-Bulnes et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Maternal high-fat diet induces obesity and adrenal and thyroid dysfunction in male rat offspring at weaning

(2012) J. G. Franco et al.   JOURNAL OF PHYSIOLOGY-LONDON

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

(2012) F.I. Milagro et al.   MOLECULAR ASPECTS OF MEDICINE

Body Size at Birth Is Associated with Food and Nutrient Intake in Adulthood

(2012) Mia-Maria Perälä et al.   PLoS One

Interplay of early-life nutritional programming on obesity, inflammation and epigenetic outcomes

(2012) J. Alfredo Martínez et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease

(2012) Jill S Butler et al.   Epigenomics

Placental expression of the obesity-associated gene FTO is reduced by fetal growth restriction but not by macrosomia in rats and humans

(2012) S. Mayeur et al.   Journal of Developmental Origins of Health and Disease

The early programming of metabolic health: is epigenetic setting the missing link?

(2011) Sylvain Sebert et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Protective effects of leptin during the suckling period against later obesity may be associated with changes in promoter methylation of the hypothalamic pro-opiomelanocortin gene

(2011) M. Palou et al.   BRITISH JOURNAL OF NUTRITION

Epigenetic Gene Promoter Methylation at Birth Is Associated With Child's Later Adiposity

(2011) K. M. Godfrey et al.   DIABETES

Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat

(2011) S. E. Pinney et al.   DIABETOLOGIA

Maternal Diabetes Compromises the Organization of Hypothalamic Feeding Circuits and Impairs Leptin Sensitivity in Offspring

(2011) Sophie M. Steculorum et al.   ENDOCRINOLOGY

Human leptin tissue distribution, but not weight loss-dependent change in expression, is associated with methylation of its promoter

(2011) Matilde Marchi et al.   Epigenetics

Maternal “junk-food” feeding of rat dams alters food choices and development of the mesolimbic reward pathway in the offspring

(2011) Z. Y. Ong et al.   FASEB JOURNAL

Maternal obesity eliminates the neonatal lamb plasma leptin peak

(2011) Nathan M. Long et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hungry in the womb: What are the consequences? Lessons from the Dutch famine

(2011) Tessa J. Roseboom et al.   MATURITAS

MicroRNAs 103 and 107 regulate insulin sensitivity

(2011) Mirko Trajkovski et al.   NATURE

Maternal stress and high-fat diet effect on maternal behavior, milk composition, and pup ingestive behavior

(2011) Ryan H. Purcell et al.   PHYSIOLOGY & BEHAVIOR

Moderate Caloric Restriction during Gestation in Rats Alters Adipose Tissue Sympathetic Innervation and Later Adiposity in Offspring

(2011) Ana Paula García et al.   PLoS One

Offspring of Mothers Fed a High Fat Diet Display Hepatic Cell Cycle Inhibition and Associated Changes in Gene Expression and DNA Methylation

(2011) Kevin J. Dudley et al.   PLoS One

Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

(2011) R. J. A. Frost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early life nutrition and metabolic programming

(2010) Denise S. Fernandez-Twinn et al.   Annals of the New York Academy of Sciences

The involvement of microRNAs in Type 2 diabetes

(2010) David Ferland-McCollough et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Interplay between microRNAs and the epigenetic machinery: An intricate network

(2010) Marilena V. Iorio et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Exposure to the Chinese Famine in Early Life and the Risk of Hyperglycemia and Type 2 Diabetes in Adulthood

(2010) Y. Li et al.   DIABETES

Maternal High-Fat Diet Alters Methylation and Gene Expression of Dopamine and Opioid-Related Genes

(2010) Zivjena Vucetic et al.   ENDOCRINOLOGY

Leptin Treatment During Lactation Programs Leptin Synthesis, Intermediate Metabolism, and Liver Microsteatosis in Adult Rats

(2010) I. H. Trevenzoli et al.   HORMONE AND METABOLIC RESEARCH

Perinatal Exposure to High-Fat Diet Programs Energy Balance, Metabolism and Behavior in Adulthood

(2010) Elinor L. Sullivan et al.   NEUROENDOCRINOLOGY

Developmental origins of metabolic disease: life course and intergenerational perspectives

(2010) Keith M. Godfrey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Genetic Markers of Adult Obesity Risk Are Associated with Greater Early Infancy Weight Gain and Growth

(2010) Cathy E. Elks et al.   PLOS MEDICINE

Perinatal Maternal Fat Intake Affects Metabolism and Hippocampal Function in the Offspring

(2009) Claire-Dominique Walker et al.   Annals of the New York Academy of Sciences

Moderate caloric restriction during gestation results in lower arcuate nucleus NPY- and αMSH-neurons and impairs hypothalamic response to fed/fasting conditions in weaned rats

(2009) A. P. García et al.   DIABETES OBESITY & METABOLISM

Treatment of refractory obesity in severely obese adults following management of newly diagnosed attention deficit hyperactivity disorder

(2009) L D Levy et al.   INTERNATIONAL JOURNAL OF OBESITY

Associations of Gestational Exposure to Famine with Energy Balance and Macronutrient Density of the Diet at Age 58 Years Differ According to the Reference Population Used

(2009) Aryeh D. Stein et al.   JOURNAL OF NUTRITION

Nutritional programming of the metabolic syndrome

(2009) Michael E. Symonds et al.   Nature Reviews Endocrinology

Influence of prenatal nutrition and obesity on tissue specific fat mass and obesity-associated (FTO) gene expression

(2009) S P Sébert et al.   REPRODUCTION

Prenatal exposure to the Dutch famine is associated with a preference for fatty foods and a more atherogenic lipid profile

(2008) Federico Lussana et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Study of hypothalamic leptin receptor expression in low-birth-weight piglets and effects of leptin supplementation on neonatal growth and development

(2008) L. Attig et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring

(2008) Christophe Breton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Effect of Neonatal Leptin Treatment on Postnatal Weight Gain in Male Rats Is Dependent on Maternal Nutritional Status during Pregnancy

(2008) Mark H. Vickers et al.   ENDOCRINOLOGY

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1

(2008) Jun H. Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Maternal High-Fat Diet and Fetal Programming: Increased Proliferation of Hypothalamic Peptide-Producing Neurons That Increase Risk for Overeating and Obesity

(2008) G.-Q. Chang et al.   JOURNAL OF NEUROSCIENCE

Predictive adaptive responses in perspective

(2008) Peter D. Gluckman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Maternal Perinatal Undernutrition Drastically Reduces Postnatal Leptin Surge and Affects the Development of Arcuate Nucleus Proopiomelanocortin Neurons in Neonatal Male Rat Pups

(2007) Fabien Delahaye et al.   ENDOCRINOLOGY