期刊
NUTRIENTS
卷 7, 期 6, 页码 5020-5050出版社
MDPI
DOI: 10.3390/nu7065020
关键词
calcitriol; cancer; inflammation; vitamin D deficiency; oncogenesis
资金
- PAPIIT, UNAM, Mexico [IN202515]
- Consejo Nacional de Ciencia y Tecnologia (CONACyT), Mexico [239250]
- CONACyT [557940]
Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the active vitamin D metabolite, has a broad variety of actions including anticancer effects that are mediated either transcriptionally and/or via non-genomic pathways. In the context of cancer, calcitriol regulates the cell cycle, induces apoptosis, promotes cell differentiation and acts as anti-inflammatory factor within the tumor microenvironment. In this review, we address the different mechanisms of action involved in the antineoplastic effects of calcitriol.
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