Article
Cell Biology
Shelby E. Bollen, Joseph J. Bass, Satoshi Fujita, Daniel Wilkinson, Martin Hewison, Philip J. Atherton
Summary: Muscle atrophy and sarcopenia can impact an individual's health, and vitamin D deficiency may worsen this effect. The mechanisms linking vitamin D and sarcopenia are not fully understood, but research has shown the importance of vitamin D in skeletal muscle functioning.
CELLULAR SIGNALLING
(2022)
Review
Biochemistry & Molecular Biology
Clara Crescioli
Summary: Skeletal muscle cells are finely controlled by vitamin D through genomic and non-genomic mechanisms, constantly undergoing cell remodeling to maintain tissue integrity. Vitamin D insufficiency promotes cell maladaptation, while restoring vitamin D levels can enhance myogenic programming.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Miguel Agoncillo, Josephine Yu, Jenny E. Gunton
Summary: Vitamin D is strongly associated with skeletal muscle regeneration and function, with studies showing its role in regulating muscle cell growth and gene expression. Animal experiments and human studies support the benefits of vitamin D in muscle function and recovery, particularly in the elderly and post-operative patients. However, its role may be less significant in muscle/ligament tear repair.
Review
Nutrition & Dietetics
Karina Romeu Montenegro, Milene Amarante Pufal, Philip Newsholme
Summary: Vitamin D has positive effects on muscle development at the cell and animal levels, but its impact on muscle in the ageing population is inconclusive according to human studies. Well-designed trials and standardized measurements are needed for accurate comparison across different experimental models.
Article
Endocrinology & Metabolism
Wen-Xiong Li, Xian-Hui Qin, Christina Chui-Wa Poon, Man-Sau Wong, Rui Feng, Jing Wang, Fu-Hui Lin, Yue-Li Sun, Shu-Fen Liu, Yong-Jun Wang, Yan Zhang
Summary: The study found that vitamin D protects against muscle atrophy by suppressing the renin-angiotensin system, and there is an association between vitamin D levels and muscle strength. Treatment with calcitriol can improve muscle function.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Luciano Ferrada, Rocio Magdalena, Maria Jose Barahona, Eder Ramirez, Cristian Sanzana, Jose Gutierrez, Francisco Nualart
Summary: Vitamin C plays a crucial role in regulating various cellular processes, such as proliferation, differentiation, and cell death, through its dual mechanism of action. It acts as a regulator of signaling pathways associated with gene expression and can also function as a modulator of kinases.
Article
Nutrition & Dietetics
Claire L. Wood, Robert Tinnion, Kieren G. Hollingsworth, Michael I. Trenell, Mark S. Pearce, Tim D. Cheetham, Nicholas D. Embleton
Summary: This study examines the relationship between gestational age and muscle metabolism in adolescents born preterm. The results suggest that gestational age is associated with oxidative muscle function and serum vitamin D levels are related to phosphocreatine recovery time. This study implies that preterm birth may have a long-term impact on muscle metabolism.
Article
Multidisciplinary Sciences
Mathieu Forget, Sandrine Adiba, Silvia De Monte
Summary: In Dictyostelium chimeras, cheaters are strains that bias their contribution to the pool of spores, gaining a selective advantage. However, the relative role of genetic and plastic differences in spore bias is unclear.
Article
Immunology
Margaret K. Seeley-Fallen, Michelle Lazzaro, Chaohong Liu, Quan-Zhen Li, Arpita Upadhyaya, Wenxia Song
Summary: Actin-mediated B-cell contraction negatively regulates B-cell receptor (BCR) signaling, while non-muscle myosin II (NMII) participates in B-cell development and antibody responses by regulating B-cell membrane contraction and antigen clustering. Inhibition of NMII enhances BCR signaling, reduces antibody affinity, and increases levels of autoantibodies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jisoo Song, Jiyeon Ham, Taeyeon Hong, Gwonhwa Song, Whasun Lim
Summary: Fraxetin extracted from Fraxinus rhynchophylla shows anticancer effects in hepatocellular carcinoma (HCC) cells by inhibiting cell proliferation, inducing apoptosis, and disrupting cellular environments. It has the potential to be a therapeutic agent against HCC progression.
Article
Biochemistry & Molecular Biology
Karina Piatek, Andrzej Kutner, Dan Cacsire Castillo-Tong, Teresa Manhardt, Nadja Kupper, Urszula Nowak, Michal Chodynski, Ewa Marcinkowska, Enikoe Kallay, Martin Schepelmann
Summary: This study found that newly developed low calcemic vitamin D analogs (an1,25Ds) can be used as anticancer agents in ovarian cancer cells, with PRI-5202 showing the best efficacy. The potency of these analogs and their ability to increase CYP24A1 expression in HGSOC cell lines were dependent on the cell line and chemical structure, suggesting that further optimization of the analogs' structure may lead to new treatment options for ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Cristina Russo, Maria Stella Valle, Antonino Casabona, Lucia Spicuzza, Gianluca Sambataro, Lucia Malaguarnera
Summary: Skeletal muscle dysfunction is often associated with COPD, which is characterized by chronic inflammation and oxidative stress. Vitamin D deficiency also affects oxidative stress and mitochondrial function, impacting muscle function in COPD patients.
Review
Nutrition & Dietetics
Marni E. Shoemaker, Owen F. Salmon, Cory M. Smith, Maria O. Duarte-Gardea, Joel T. Cramer
Summary: There is conflicting evidence regarding the roles of vitamin D and iron in muscle health, with vitamin D having a positive effect on muscle mass and iron having a positive effect on aerobic and anaerobic performance. However, studies have reported mixed results for both vitamin D and iron on muscle strength and function. While deficiency in both vitamin D and iron commonly occur together, there is limited research on their effects on muscle health and inflammation. Nutrients within food sources may be more effective in improving skeletal muscle health compared to isolated nutrients such as iron and vitamin D.
Review
Pharmacology & Pharmacy
Nathalie Fuentes, Morgan McCullough, Reynold A. Panettieri, Kirk M. Druey
Summary: Asthma is a prevalent disorder characterized by chronic lung inflammation and reversible airways obstruction, with features including increased airway narrowing, excessive mucus secretion, airway remodeling, and airways hyperresponsiveness. Environmental factors such as allergens, viruses, and air pollution can promote asthma, leading to symptoms like cough, wheezing, and shortness of breath. G-protein-coupled receptors play a central role in asthma, with various treatments targeting these receptors to regulate airway smooth muscle tone and lung inflammation.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Neurosciences
Natacha Dreumont, Khalid Mimoun, Carine Pourie, Edward V. Quadros, Jean-Marc Alberto, Remy Umoret, Deborah Helle, Aurelie Robert, Jean-Luc Daval, Jean-Louis Gueant, Gregory Pourie
Summary: This study investigated the molecular mechanisms of cognitive dysfunction in mice with Cbl deficiency, finding that impaired learning memory in Cd320KO mice could be alleviated by moderate stress and increased levels of plasma corticosterone. These findings suggest potential therapeutic targets for cognitive manifestations in patients with poor response to conventional Cbl treatment.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ana P. Irazoqui, Nadia B. Heim, Ricardo L. Boland, Claudia G. Buitrago
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Biology
Ana Paula Irazoqui, Pablo De Genaro, Claudia Buitrago, Heinrich Bachmann, Veronica Gonzalez-Pardo, Ana Russo de Boland