New hypothesis and treatment targets of depression: an integrated view of key findings

Glucocorticoid receptor activation impairs hippocampal plasticity by suppressing BDNF expression in obese mice

(2014) Marlena Wosiski-Kuhn et al.   PSYCHONEUROENDOCRINOLOGY

Inflammation: a mechanism of depression?

(2014) Qiu-Qin Han et al.   Neuroscience Bulletin

GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists

(2013) Joseph R Moskal et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Rivastigmine reverses cognitive deficit and acetylcholinesterase activity induced by ketamine in an animal model of schizophrenia

(2013) Alexandra I. Zugno et al.   METABOLIC BRAIN DISEASE

GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects

(2013) Jeffrey Burgdorf et al.   NEUROPSYCHOPHARMACOLOGY

Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: A meta-analysis

(2013) Kyoung-Sae Na et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

(2013) Adrian L. Lopresti et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Ketamine, Sleep, and Depression: Current Status and New Questions

(2013) Wallace C. Duncan et al.   Current Psychiatry Reports

Role of BDNF/TrkB signaling in antidepressant-like effects of a group II metabotropic glutamate receptor antagonist in animal models of depression

(2012) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Antidepressant Efficacy of Ketamine in Depressed Patients

(2012) Gonzalo Laje et al.   BIOLOGICAL PSYCHIATRY

The Role of Eukaryotic Elongation Factor 2 Kinase in Rapid Antidepressant Action of Ketamine

(2012) Lisa M. Monteggia et al.   BIOLOGICAL PSYCHIATRY

Chronic social defeat up-regulates expression of the serotonin transporter in rat dorsal raphe nucleus and projection regions in a glucocorticoid-dependent manner

(2012) Jia Zhang et al.   JOURNAL OF NEUROCHEMISTRY

New antidepressant strategy based on acute siRNA silencing of 5-HT1A autoreceptors

(2012) A Bortolozzi et al.   MOLECULAR PSYCHIATRY

Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex

(2012) Eunice Y. Yuen et al.   NEURON

Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice

(2012) Yukio Ago et al.   NEUROPHARMACOLOGY

Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors’ and Longitudinal ‘Targets’

(2012) Annamaria Cattaneo et al.   NEUROPSYCHOPHARMACOLOGY

A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists

(2012) R. S. Duman et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise

(2012) H. Y. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sigma-1 receptor chaperone and brain-derived neurotrophic factor: Emerging links between cardiovascular disease and depression

(2012) Kenji Hashimoto   PROGRESS IN NEUROBIOLOGY

Morning and nocturnal serum melatonin rhythm levels in patients with major depressive disorder: an analytical cross-sectional study

(2012) Shahnaz Khaleghipour et al.   Sao Paulo Medical Journal

Inflammatory Factors Contribute to Depression and Its Comorbid Conditions

(2012) H. Anisman et al.   Science Signaling

Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor

(2012) Michiko Fujimoto et al.   SYNAPSE

REM Sleep Rebound as an Adaptive Response to Stressful Situations

(2012) Deborah Suchecki et al.   Frontiers in Neurology

Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

(2011) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence

(2011) Fani L. Neto et al.   Current Neuropharmacology

Circadian Rhythms, Melatonin and Depression

(2011) M. A. Quera Salva et al.   CURRENT PHARMACEUTICAL DESIGN

Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB

(2011) Emi Kumamaru et al.   FEBS LETTERS

Melatonin Exerts Direct Inhibitory Actions on ACTH Responses in the Human Adrenal Gland

(2011) C. Campino et al.   HORMONE AND METABOLIC RESEARCH

mTOR activation is required for the antidepressant effects of mGluR2/3 blockade

(2011) Jason M. Dwyer et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Ongoing or re-emerging subjective insomnia symptoms after full/partial remission or recovery of major depressive disorder mainly with the selective serotonin reuptake inhibitors and risk of relapse or recurrence: A 52-week follow-up study

(2011) Mustafa Gulec et al.   JOURNAL OF AFFECTIVE DISORDERS

Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice

(2011) E Beurel et al.   MOLECULAR PSYCHIATRY

Hippocampal Volumes and the Brain-Derived Neurotrophic Factor val66met Polymorphism in Geriatric Major Depression

(2010) Dora Kanellopoulos et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Elevated Macrophage Migration Inhibitory Factor (MIF) is associated with depressive symptoms, blunted cortisol reactivity to acute stress, and lowered morning cortisol

(2010) Kate M. Edwards et al.   BRAIN BEHAVIOR AND IMMUNITY

Role of the mTOR signaling pathway in the rapid antidepressant action of ketamine

(2010) Kenji Hashimoto   Expert Review of Neurotherapeutics

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression and memory-related behaviors

(2010) L Conboy et al.   MOLECULAR PSYCHIATRY

Circadian rhythms and treatment implications in depression

(2010) Palmiero Monteleone et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus?

(2009) Mitchel A. Kling et al.   DEPRESSION AND ANXIETY

Glucocorticoids increase impairments in learning and memory due to elevated amyloid precursor protein expression and neuronal apoptosis in 12-month old mice

(2009) Wei-Zu Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

σ-1 receptors in major depression and anxiety

(2009) Shrinivas K Kulkarni et al.   Expert Review of Neurotherapeutics

Whither proBDNF?

(2009) Philip A Barker   NATURE NEUROSCIENCE

Sigma-1 receptor knockout mice display a depressive-like phenotype

(2008) Valentina Sabino et al.   BEHAVIOURAL BRAIN RESEARCH

Circadian rhythm disturbances in depression

(2008) Anne Germain et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death

(2008) Boyoung Lee et al.   JOURNAL OF NEUROCHEMISTRY

A Causal Role for Brain-Derived Neurotrophic Factor in the Homeostatic Regulation of Sleep

(2008) U. Faraguna et al.   JOURNAL OF NEUROSCIENCE

Association of Polymorphism (Val66Met) of Brain-Derived Neurotrophic Factor with Suicide Attempts in Depressed Patients

(2008) Marco Sarchiapone et al.   NEUROPSYCHOBIOLOGY

Chronic treatment with a selective ligand for the sigma-1 receptor chaperone, SA4503, up-regulates BDNF protein levels in the rat hippocampus

(2008) Kazue Kikuchi-Utsumi et al.   NEUROSCIENCE LETTERS

Increased oxidative stress as a mechanism for decreased BDNF levels in acute manic episodes

(2008) Flávio Kapczinski et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Proposed cycles for functional glutamate trafficking in synaptic neurotransmission

(2007) Paul K. Maciejewski et al.   NEUROCHEMISTRY INTERNATIONAL

Cytokine-induced enhancement of calcium-dependent glutamate release from astrocytes mediated by nitric oxide

(2007) Tomoaki Ida et al.   NEUROSCIENCE LETTERS

Rapid desensitization of somatodendritic 5-HT1A receptors by chronic administration of the high-efficacy 5-HT1A agonist, F13714: a microdialysis study in the rat

(2006) M-B Assié et al.   BRITISH JOURNAL OF PHARMACOLOGY