Is it possible to improve neurodevelopmental abnormalities in Down syndrome?

α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome

(2011) Mototada Shichiri et al.   FREE RADICAL BIOLOGY AND MEDICINE

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome

(2011) Stefania Trazzi et al.   HUMAN MOLECULAR GENETICS

Overexpression of Dyrk1A Causes the Defects in Synaptic Vesicle Endocytosis

(2011) Yoonju Kim et al.   NEUROSIGNALS

Prevention of Learning Deficit in a Down Syndrome Model

(2011) Maddalena Incerti et al.   OBSTETRICS AND GYNECOLOGY

In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model

(2010) Garikoitz Azkona et al.   AMINO ACIDS

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

(2010) Jason Lockrow et al.   BEHAVIOURAL BRAIN RESEARCH

Widespread Proliferation Impairment and Hypocellularity in the Cerebellum of Fetuses with Down Syndrome

(2010) Sandra Guidi et al.   BRAIN PATHOLOGY

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

(2010) Tao Yu et al.   HUMAN MOLECULAR GENETICS

Dyrk1A Phosphorylates p53 and Inhibits Proliferation of Embryonic Neuronal Cells

(2010) Joongkyu Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of down syndrome

(2010) Victor I. Popov et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down’s syndrome

(2010) D. Pérez-Cremades et al.   JOURNAL OF NEURAL TRANSMISSION

Dyrk1A Overexpression Inhibits Proliferation and Induces Premature Neuronal Differentiation of Neural Progenitor Cells

(2010) O. Yabut et al.   JOURNAL OF NEUROSCIENCE

Early Pharmacotherapy Restores Neurogenesis and Cognitive Performance in the Ts65Dn Mouse Model for Down Syndrome

(2010) P. Bianchi et al.   JOURNAL OF NEUROSCIENCE

Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin

(2010) Yu Fukuda et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

(2010) Lina Chakrabarti et al.   NATURE NEUROSCIENCE

Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations

(2010) Debra Toiber et al.   NEUROBIOLOGY OF DISEASE

Prevention of Developmental Delays in a Down Syndrome Mouse Model

(2010) Laura Toso et al.   OBSTETRICS AND GYNECOLOGY

Lowering β-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model

(2010) William J. Netzer et al.   PLoS One

APP Intracellular Domain Impairs Adult Neurogenesis in Transgenic Mice by Inducing Neuroinflammation

(2010) Kaushik Ghosal et al.   PLoS One

Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome

(2010) Chelsee A. Hewitt et al.   PLoS One

Lithium Restores Neurogenesis in the Subventricular Zone of the Ts65Dn Mouse, a Model for Down Syndrome

(2009) Patrizia Bianchi et al.   BRAIN PATHOLOGY

Enlarged Brain Ventricles and Impaired Neurogenesis in the Ts1Cje and Ts2Cje Mouse Models of Down Syndrome

(2009) Keiichi Ishihara et al.   CEREBRAL CORTEX

Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation

(2009) Y. Katoh et al.   CURRENT MOLECULAR MEDICINE

A Critical Period in Cortical Interneuron Neurogenesis in Down Syndrome Revealed by Human Neural Progenitor Cells

(2009) Anita Bhattacharyya et al.   DEVELOPMENTAL NEUROSCIENCE

Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2

(2009) G. Azkona et al.   GENES BRAIN AND BEHAVIOR

Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome

(2009) M. Galante et al.   HUMAN MOLECULAR GENETICS

A new mouse model for the trisomy of the Abcg1–U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

(2009) Patricia Lopes Pereira et al.   HUMAN MOLECULAR GENETICS

Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A

(2009) J. Fernandez-Martinez et al.   JOURNAL OF CELL SCIENCE

Widespread changes in dendritic and axonal morphology inMecp2-mutant mouse models of rett syndrome: Evidence for disruption of neuronal networks

(2009) Pavel V. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome

(2009) Fabian Fernandez et al.   JOURNAL OF NEUROCHEMISTRY

Increased lipid peroxidation in Down’s syndrome mouse models

(2009) Keiichi Ishihara et al.   JOURNAL OF NEUROCHEMISTRY

The "Down Syndrome Critical Region" Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome

(2009) N. P. Belichenko et al.   JOURNAL OF NEUROSCIENCE

Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres

(2009) Randal X. Moldrich et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

(2009) Kwan-Hyuck Baek et al.   NATURE

Alzheimer's disease

(2009) Lennart Mucke   NATURE

Neural Activity Regulates Synaptic Properties and Dendritic Structure In Vivo through Calcineurin/NFAT Signaling

(2009) Neil Schwartz et al.   NEURON

Infantile Spasms and Down Syndrome: A New Animal Model

(2009) Miguel A Cortez et al.   PEDIATRIC RESEARCH

Prevalence of Down Syndrome Among Children and Adolescents in 10 Regions of the United States

(2009) M. Shin et al.   PEDIATRICS

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

(2009) Fayçal Guedj et al.   PLoS One

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

(2008) Jerzy Wegiel et al.   ACTA NEUROPATHOLOGICA

Phase 2 Safety Trial Targeting Amyloid β Production With a γ-Secretase Inhibitor in Alzheimer Disease

(2008) Adam S. Fleisher et al.   ARCHIVES OF NEUROLOGY

NAP and D-SAL: neuroprotection against the β amyloid peptide (1–42)

(2008) Illana Gozes et al.   BMC NEUROSCIENCE

Cell Cycle Elongation Impairs Proliferation of Cerebellar Granule Cell Precursors in the Ts65Dn Mouse, an Animal Model for Down Syndrome

(2008) Andrea Contestabile et al.   BRAIN PATHOLOGY

Genotype–phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

(2008) Robert Lyle et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Mental retardation and associated neurological dysfunctions in Down syndrome: A consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways

(2008) Mohammed Rachidi et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model

(2008) Jason Lockrow et al.   EXPERIMENTAL NEUROLOGY

Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801

(2008) A. Siddiqui et al.   GENES BRAIN AND BEHAVIOR

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of down syndrome

(2008) Pavel V. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Chronic Fluoxetine Stimulates Maturation and Synaptic Plasticity of Adult-Born Hippocampal Granule Cells

(2008) J.-W. Wang et al.   JOURNAL OF NEUROSCIENCE

Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome

(2008) E. Morice et al.   LEARNING & MEMORY

Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome

(2008) X. Altafaj et al.   NEUROBIOLOGY OF DISEASE

Effects of Memantine on Neuronal Structure and Conditioned Fear in the Tg2576 Mouse Model of Alzheimer's Disease

(2008) Hongxin Dong et al.   NEUROPSYCHOPHARMACOLOGY

Abnormal expression of synaptic proteins and neurotrophin-3 in the down syndrome mouse model Ts65Dn

(2008) G. Pollonini et al.   NEUROSCIENCE

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

(2008) S. V. Voronov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

(2008) Thorsten Müller et al.   PROGRESS IN NEUROBIOLOGY

Supplementation with antioxidants and folinic acid for children with Down’s syndrome: randomised controlled trial

(2008) Jill M Ellis et al.   BMJ-British Medical Journal

Episodic-like memory in Ts65Dn, a mouse model of Down syndrome

(2007) Fabian Fernandez et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome

(2007) N RUEDA   BEHAVIOURAL BRAIN RESEARCH

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer’s disease

(2007) Soo-Ryoon Ryoo et al.   JOURNAL OF NEUROCHEMISTRY

Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome

(2007) Qing Chang et al.   NEUROBIOLOGY OF LEARNING AND MEMORY