Chronic Obstructive Pulmonary Disease and Lung Cancer: New Molecular Insights

Gene-environment interactions in chronic obstructive pulmonary disease

(2016) Nestor Molfino   International Journal of Chronic Obstructive Pulmonary Disease

Cisplatin Induces Cytotoxicity through the Mitogen-Activated Protein Kinase Pathways ana Activating Transcription Factor 3

(2015) Carly St. Germain et al.   NEOPLASIA

Reduced miR-146a Increases Prostaglandin E2in Chronic Obstructive Pulmonary Disease Fibroblasts

(2010) Tadashi Sato et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Roles of Peroxisome Proliferator–Activated Receptor–α and –γ in the Development of Non–Small Cell Lung Cancer

(2010) Ming-Yue Li et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Animal and human studies with the mitochondria-targeted antioxidant MitoQ

(2010) Robin A.J. Smith et al.   Annals of the New York Academy of Sciences

Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation

(2010) Hiroyuki Takahashi et al.   CANCER CELL

Treatment Effects of Low-Dose Theophylline Combined With an Inhaled Corticosteroid in COPD

(2010) Paul A. Ford et al.   CHEST

MicroRNA Expression Differentiates Histology and Predicts Survival of Lung Cancer

(2010) M. T. Landi et al.   CLINICAL CANCER RESEARCH

Cancer and Inflammation: Implications for Pharmacology and Therapeutics

(2010) F Balkwill et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches

(2010) Stephen Y. Lai et al.   DRUG RESISTANCE UPDATES

Chromosome 4q31 locus in COPD is also associated with lung cancer

(2010) R. P. Young et al.   EUROPEAN RESPIRATORY JOURNAL

EPHX1 polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis

(2010) J. Lee et al.   EUROPEAN RESPIRATORY JOURNAL

Association of COPD candidate genes with computed tomography emphysema and airway phenotypes in severe COPD

(2010) W. J. Kim et al.   EUROPEAN RESPIRATORY JOURNAL

A role for phosphoinositol 3–kinase δ in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease

(2010) John A. Marwick et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

p300-mediated Acetylation of Histone H3 Lysine 56 Functions in DNA Damage Response in Mammals

(2010) Rahul K. Vempati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci

(2010) Anthony P. Popkie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Promoter Polymorphisms and Transcript Levels of Nicotinic Receptor CHRNA5

(2010) Felicia S. Falvella et al.   JNCI-Journal of the National Cancer Institute

The CXCR4/SDF-1 Chemokine Receptor Axis: A New Target Therapeutic for Non-small Cell Lung Cancer

(2010) Shannon Otsuka et al.   Journal of Thoracic Oncology

The International Epidemiology of Lung Cancer: Geographical Distribution and Secular Trends

(2010) Danny R. Youlden et al.   Journal of Thoracic Oncology

Proteomic Profiling Identifies Pathways Dysregulated in Non-small Cell Lung Cancer and an Inverse Association of AMPK and Adhesion Pathways with Recurrence

(2010) Meera Nanjundan et al.   Journal of Thoracic Oncology

Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study

(2010) Federico Cappuzzo et al.   LANCET ONCOLOGY

Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells

(2010) Wei-Lun Huang et al.   Molecular Cancer

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

(2010) Dan Levy et al.   NATURE IMMUNOLOGY

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate

(2010) F Liu et al.   ONCOGENE

Neutrophils Find Smoke Attractive

(2010) P. J. Barnes   SCIENCE

Airway PI3K Pathway Activation Is an Early and Reversible Event in Lung Cancer Development

(2010) A. M. Gustafson et al.   Science Translational Medicine

Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease

(2010) John A. Marwick et al.   Therapeutic Advances in Respiratory Disease

Update in Lung Cancer 2008

(2009) Sarita Dubey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Safety and Efficacy of an Inhaled Epidermal Growth Factor Receptor Inhibitor (BIBW 2948 BS) in Chronic Obstructive Pulmonary Disease

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Genetic Polymorphisms of Cytochrome P450 and Matrix Metalloproteinase in Chronic Obstructive Pulmonary Disease

(2009) Shih-Lung Cheng et al.   BIOCHEMICAL GENETICS

Targeting PPAR receptors in the airway for the treatment of inflammatory lung disease

(2009) Maria G Belvisi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cancer Statistics, 2009

(2009) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Association of Nonsteroidal Anti-Inflammatory Drugs with Lung Cancer: Results from a Large Cohort Study

(2009) C. G. Slatore et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

A Functional Genetic Variant in microRNA-196a2 Is Associated with Increased Susceptibility of Lung Cancer in Chinese

(2009) T. Tian et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Atypical Protein Kinase C  Is Required for Bronchioalveolar Stem Cell Expansion and Lung Tumorigenesis

(2009) R. P. Regala et al.   CANCER RESEARCH

Genetic Variants on Chromosome 15q25 Associated with Lung Cancer Risk in Chinese Populations

(2009) C. Wu et al.   CANCER RESEARCH

Epigenetic Profiles Distinguish Malignant Pleural Mesothelioma from Lung Adenocarcinoma

(2009) Y. Goto et al.   CANCER RESEARCH

The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans

(2009) N. L. Saccone et al.   CANCER RESEARCH

Nonsmall cell lung cancer in never smokers

(2009) Giorgio V Scagliotti et al.   CURRENT OPINION IN ONCOLOGY

Lung cancer and inflammation: interaction of chemokines and hnRNPs

(2009) Jordi Tauler et al.   CURRENT OPINION IN PHARMACOLOGY

Current concepts on the role of inflammation in COPD and lung cancer

(2009) Hongwei Yao et al.   CURRENT OPINION IN PHARMACOLOGY

COPD prevalence is increased in lung cancer, independent of age, sex and smoking history

(2009) R. P. Young et al.   EUROPEAN RESPIRATORY JOURNAL

High-throughput molecular analysis in lung cancer: insights into biology and potential clinical applications

(2009) S. Ocak et al.   EUROPEAN RESPIRATORY JOURNAL

The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy

(2009) Yong Lin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9

(2009) Yuji Nakamaru et al.   FASEB JOURNAL

Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

(2009) Esther H Lips et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy

(2009) Matthew W. Lawless et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lung Cancer and Chronic Obstructive Pulmonary Disease: Needs and Opportunities for Integrated Research

(2009) A. Punturieri et al.   JNCI-Journal of the National Cancer Institute

Chronic obstructive pulmonary disease in non-smokers

(2009) Sundeep S Salvi et al.   LANCET

Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

(2009) Julian R. Molina et al.   MAYO CLINIC PROCEEDINGS

A small-cell lung cancer genome with complex signatures of tobacco exposure

(2009) Erin D. Pleasance et al.   NATURE

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Phase I Metabolic Genes and Risk of Lung Cancer: Multiple Polymorphisms and mRNA Expression

(2009) Melissa Rotunno et al.   PLoS One

Comparison of Proteomic and Transcriptomic Profiles in the Bronchial Airway Epithelium of Current and Never Smokers

(2009) Katrina Steiling et al.   PLoS One

MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium

(2009) F. Schembri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alveolar Cell Senescence Exacerbates Pulmonary Inflammation in Patients with Chronic Obstructive Pulmonary Disease

(2009) Takao Tsuji et al.   RESPIRATION

Population-Based Trends in Lung Cancer Incidence in Women

(2009) Brian L. Egleston et al.   SEMINARS IN ONCOLOGY

DNA demethylation by DNA repair

(2009) Mary Gehring et al.   TRENDS IN GENETICS

NF- B as a Critical Link Between Inflammation and Cancer

(2009) M. Karin   Cold Spring Harbor Perspectives in Biology

Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung

(2009) R. E. Harris   INFLAMMOPHARMACOLOGY

Airway Wall Thickening and Emphysema Show Independent Familial Aggregation in Chronic Obstructive Pulmonary Disease

(2008) Bipen D. Patel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

(2008) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2008) Saravanan Rajendrasozhan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette Smoke Triggers Code Red

(2008) Rubin M. Tuder et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Down-Regulated NF-E2–Related Factor 2 in Pulmonary Macrophages of Aged Smokers and Patients with Chronic Obstructive Pulmonary Disease

(2008) Masaru Suzuki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regular Adult Aspirin Use Decreases the Risk of Non-Small Cell Lung Cancer among Women

(2008) A. L. Van Dyke et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The Field of Tissue Injury in the Lung and Airway

(2008) K. Steiling et al.   Cancer Prevention Research

A Prediction Model for Lung Cancer Diagnosis that Integrates Genomic and Clinical Features

(2008) Jennifer Beane et al.   Cancer Prevention Research

Activated Cholinergic Signaling Provides a Target in Squamous Cell Lung Carcinoma

(2008) P. Song et al.   CANCER RESEARCH

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

(2008) T. Ohta et al.   CANCER RESEARCH

COX2 and p53 risk-alleles coexist in COPD

(2008) Ehtesham Arif et al.   CLINICA CHIMICA ACTA

Mitogen-Activated Protein Kinase Activation in Lung Adenocarcinoma: A Comparative Study between Ever Smokers and Never Smokers

(2008) G. Mountzios et al.   CLINICAL CANCER RESEARCH

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

(2008) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Gene expression profiling of non-small-cell lung cancer

(2008) Ludovic Lacroix et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

(2008) Stephanie Spange et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

DNA methylomes, histone codes and miRNAs: Tying it all together

(2008) Sònia Guil et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Expression of Non-neuronal Acetylcholine in Lung Cancer Provides a New Target for Cancer Therapy

(2008) Pingfang Song et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer

(2008) Pengyuan Liu et al.   JNCI-Journal of the National Cancer Institute

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

(2008) Thorgeir E. Thorgeirsson et al.   NATURE

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

(2008) Rayjean J. Hung et al.   NATURE

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

(2008) Christopher I Amos et al.   NATURE GENETICS

A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease

(2008) Donald P. Tashkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA Methylation Markers and Early Recurrence in Stage I Lung Cancer

(2008) Malcolm V. Brock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion

(2008) J. S. Dovey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhaled corticosteroids and risk of lung cancer among COPD patients who quit smoking

(2008) Victor A. Kiri et al.   RESPIRATORY MEDICINE

Association between polymorphisms of microsomal epoxide hydrolase and COPD: Results from meta-analyses

(2008) Guoping HU et al.   RESPIROLOGY

Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

(2008) D Goven et al.   THORAX

Cigarette Smoke Induces an Unfolded Protein Response in the Human Lung

(2007) Steven G. Kelsen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

CT detected indeterminate pulmonary nodules in a chemoprevention trial of fluticasone

(2007) Remco M. van den Berg et al.   LUNG CANCER