Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease

Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110  but Not p110  Promotes Optimal Allergic Responses In Vivo

(2014) K. Ali et al.   JOURNAL OF IMMUNOLOGY

Effect of allergen challenge on the percentage of natural killer T cells in patients with atopic asthma

(2010) Michael Rock et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Inhibition of PI3Kδ Restores Glucocorticoid Function in Smoking-induced Airway Inflammation in Mice

(2009) John A. Marwick et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation

(2009) Stephen G. Ward et al.   BIOCHEMICAL JOURNAL

Mast cells: makers and breakers of allergic inflammation

(2009) Kayvan Hakim-Rad et al.   Current Opinion in Allergy and Clinical Immunology

PI 3-kinase and cancer: changing accents

(2009) Peter K Vogt et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

COPD prevalence is increased in lung cancer, independent of age, sex and smoking history

(2009) R. P. Young et al.   EUROPEAN RESPIRATORY JOURNAL

Fine tuning the immune response with PI3K

(2009) David A. Fruman et al.   IMMUNOLOGICAL REVIEWS

Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis

(2009) Borna Mehrad et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Advances in mechanisms of asthma, allergy, and immunology in 2008

(2009) Joshua A. Boyce et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase γ–deficient mice

(2009) Masahide Takeda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cystic fibrosis

(2009) Brian P O'Sullivan et al.   LANCET

Glucocorticoid resistance in inflammatory diseases

(2009) Peter J Barnes et al.   LANCET

Requirement of Phosphatidylinositol(3,4,5)Trisphosphate in Phosphatidylinositol 3-Kinase-Induced Oncogenic Transformation

(2009) A. Denley et al.   MOLECULAR CANCER RESEARCH

Inhibitor hijacking of Akt activation

(2009) Tatsuya Okuzumi et al.   Nature Chemical Biology

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Immunologic Aspects of Chronic Obstructive Pulmonary Disease

(2009) Manuel G. Cosio et al.   NEW ENGLAND JOURNAL OF MEDICINE

PI3K  Adaptor Subunits Define Coupling to Degranulation and Cell Motility by Distinct PtdIns(3,4,5)P3 Pools in Mast Cells

(2009) T. Bohnacker et al.   Science Signaling

COPD and cancer mortality: the influence of statins

(2009) Y R B M van Gestel et al.   THORAX

Regulation of phosphoinositide 3-kinase expression in health and disease

(2009) Klaartje Kok et al.   TRENDS IN BIOCHEMICAL SCIENCES

PI3Kγ-deficient mice have reduced levels of allergen-induced eosinophilic inflammation and airway remodeling

(2008) Dae Hyun Lim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Effects of oncogenic p110α subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase

(2008) Jeffrey D. Carson et al.   BIOCHEMICAL JOURNAL

Allergic asthma: a tale of many T cells

(2008) R. Afshar et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Ibuprofen therapy for cystic fibrosis lung disease: revisited

(2008) Michael W Konstan   CURRENT OPINION IN PULMONARY MEDICINE

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

(2008) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Genetic or pharmaceutical blockade of p110δ phosphoinositide 3-kinase enhances IgE production

(2008) Ting-ting Zhang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling

(2008) Jennifer Kearley et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP

(2008) B. Heit et al.   JOURNAL OF CELL SCIENCE

The cytokine network in asthma and chronic obstructive pulmonary disease

(2008) Peter J. Barnes   JOURNAL OF CLINICAL INVESTIGATION

The p110δ of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation

(2008) Hailong Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis

(2008) Hong Xia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The development of allergic inflammation

(2008) Stephen J. Galli et al.   NATURE

Lipid signalling in disease

(2008) Matthias P. Wymann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphoinositide 3-Kinase p110  Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

(2008) E. Ciraolo et al.   Science Signaling

Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma

(2008) P Bhavsar et al.   THORAX

The multiple roles of phosphoinositide 3-kinase in mast cell biology

(2008) Mi-Sun Kim et al.   TRENDS IN IMMUNOLOGY

Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation

(2008) John M. Hallett et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Role of Inflammation in the Pathogenesis of Idiopathic Pulmonary Fibrosis

(2007) Benjamin D. Bringardner et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting phosphoinositide 3-kinase—Moving towards therapy

(2007) Romina Marone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS