Article
Dentistry, Oral Surgery & Medicine
Dan-Ying Tao, Jia-Lin Zhu, Chun-Yu Xie, Yan-Ping Kuang, Wei-Ran Chai, Edward Chin Man Lo, Wei Ye, Fei Li, Xi-Ping Feng, Hai-Xia Lu
Summary: A case-control study found that men with semen abnormalities had a higher prevalence of chronic periodontitis compared to men with normozoospermia. Logistic regression analysis showed that men with moderate/severe periodontitis were more likely to have semen abnormalities.
Article
Endocrinology & Metabolism
Xiangfeng Chen, Bin Wu, XiaoRong Shen, Xin Wang, Ping Ping, Maohua Miao, Ningning Liang, Huiyong Yin, Huijuan Shi, Jun Qian, Tiancheng Zhang
Summary: This study aimed to investigate the effects of PUFA-derived metabolites in seminal plasma on male fertility and evaluate the potential of PUFA as a biomarker for normozoospermic male infertility. Semen samples were collected from 564 men, and the levels of PUFA-derived metabolites were analyzed. The results showed significant differences in the concentrations of certain metabolites between fertile and infertile men with normozoospermia and oligoasthenozoospermia. The metabolites 7(R)-MaR1, 11,12-DHET, 17(S)-HDHA, LXA5, and PGJ2 were identified as potential diagnostic biomarkers for infertility in normozoospermic men.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biology
Rebeca Serrano, Luis J. Garcia-Marin, Maria J. Bragado
Summary: Approximately 24% of men undergoing assisted reproductive technology (ART) have idiopathic male infertility, which cannot be accurately diagnosed by current standard semen analysis. Proteomics, especially phosphoproteomics, has provided valuable insights into the regulation of sperm functions, such as motility, and male fertility. Further studies combining proteomic techniques with other omics technologies could enhance our understanding of the molecular mechanisms underlying sperm physiology and quality.
Review
Medicine, General & Internal
Michal Jeseta, Anna Pospisilova, Lenka Mekinova, Katerina Franzova, Pavel Ventruba, Eva Lousova, Bartosz Kempisty, Tomas Ozdian, Jana Zakova, Igor Crha
Summary: The compounds in seminal plasma have potential as biomarkers for male fertility and can be used for diagnosing different types of azoospermia. Distinguishing between obstructive and non-obstructive azoospermia is important for effective treatment. Proteins in seminal plasma, particularly testicular and epididymal proteins, can serve as biomarkers for diagnosing azoospermia. Combining multiple biomarkers, such as TEX101 and ECM1 or TEX101 and SPAG1, can improve diagnostic accuracy.
Article
Biochemistry & Molecular Biology
Guohui Zhang, Chuan Jiang, Yushang Yang, Yan Wang, Haimeng Zhou, Siyu Dai, Mohan Liu, Yanting Yang, Li Yang, Qiongyan Shen, Tao Zhang, Xiaodong Zhang, Yihong Yang, Ying Shen
Summary: In this study, we reported male infertility patients with a hemizygous nonsense mutation in the cancer-testis antigen 55 (CT55) gene, which resulted in extreme disruption in sperm production, morphology, and locomotion. Our functional experiments revealed that CT55 acts as a novel autophagic manipulator involved in spermatogenesis.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Agriculture, Dairy & Animal Science
Maria Iniesta-Cuerda, Jirina Havrankova, Hedvika Rimnacova, Olga Garcia-Alvarez, Jan Nevoral
Summary: Deficiency of the SIRT1 protein plays a significant role in the acquisition of hyperactivated motility during capacitation. Sirt1(+/-) males exhibit mitochondrial injury and motility defects, leading to decreased fertilization rate. Therefore, Sirt1(+/-) males can serve as a model for studying age-related infertility.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Andrology
Geng Luo, Meiqi Hou, Bo Wang, Zhenxing Liu, Wenqiang Liu, Tiantian Han, Dazhi Zhang, Xiaopei Zhou, Weimin Jia, Yang Tan, Yanling Wu, Jiarui Wang, Xianqin Zhang
Summary: This study demonstrates that deficiency of the Tsga10 gene can lead to male infertility in mice, as TSGA10 is involved in the correct arrangement of the mitochondrial sheath in spermatozoa. Further research is needed to explore the underlying mechanisms of TSGA10 in spermatogenesis, early embryonic development, and the GnRH network.
Article
Andrology
Yiling Zhou, Yaling Wang, Jingwen Chen, Bangguo Wu, Shuyan Tang, Feng Zhang, Chunyu Liu, Lingbo Wang
Summary: This study uncovers the role of the Dnali1 gene in sperm motility and male fertility in mice. It also demonstrates that ICSI can overcome male infertility associated with Dnali1 mutations, providing guidance for the diagnosis and genetic counseling of DNALI1-associated human infertility.
BASIC AND CLINICAL ANDROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shengnan Cong, Jingjing Zhang, Feng Pan, Lianjun Pan, Aixia Zhang, Jiehua Ma
Summary: Ion channels in the sperm tail, such as CatSper and KSper, play a crucial role in triggering essential physiological reactions necessary for successful fertilization, like progressive motility and hyperactivation. Other ion channels like Hv1, sNHE, ENaC, TRP channels, and CFTR are also found in the flagellum. This review discusses the recent advancements in these ion channels' understanding in the flagellum, their impact on sperm function, and the interplay between them through factors like PH, membrane potential, and cAMP. These ion channels may have potential clinical applications in treating infertility.
Review
Cell Biology
John Charles Rotondo, Carmen Lanzillotti, Chiara Mazziotta, Mauro Tognon, Fernanda Martini
Summary: Research has shown a correlation between sperm DNA methylation and male infertility, with various genes displaying differential methylation patterns in impaired spermatogenesis and reproductive dysfunction. Specifically, DNA methylation defects in MEST and H19 within imprinted genes, as well as MTHFR within non-imprinted genes, have been linked to male infertility. Further studies are needed to better understand the mechanisms affecting methylation in sperm and its impact on male infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Andrology
Thomas Greither, Mario Dejung, Hermann M. Behre, Falk Butter, Holger Herlyn
Summary: Through proteomic analysis of spermatozoa from 76 infertile men, we identified abnormal proteins related to sperm motility, fertilization capacity, and male reproductive development. These findings provide insights into the molecular mechanisms underlying male infertility.
Article
Multidisciplinary Sciences
Ferran Barrachina, Kiera Ottino, Maia Lina Elizagaray, Maria Gracia Gervasi, Leona J. Tu, Styliani Markoulaki, Raul G. Spallanzani, Diane Capen, Dennis Brown, Maria Agustina Battistone
Summary: Regulatory T cells play a crucial role in maintaining the tolerogenic state of the testis and epididymis. Depletion of Tregs leads to autoimmune orchitis and epididymitis, affecting sperm production and leading to fertility defects. Understanding these immunoregulatory mechanisms could aid in the development of new treatments for male infertility and immunocontraception.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Tanja Turunen, Martina Magris, Marjo Malinen, Jukka Kekalainen
Summary: This study investigates the effects of seminal plasma (SP) identity and protein composition on human sperm function. The results show that SP identity and its protein composition play a role in sperm swimming velocity, viability, and hyperactivation. The interaction between sperm and SP donor also affects sperm performance. Additionally, specific SP proteins, such as DPP4 and NEP, are positively associated with sperm swimming velocity and hyperactivation.
Article
Andrology
Alaa Eisa, Souvik Dey, Alex Ignatious, Wesam Nofal, Rex A. Hess, Manabu Kurokawa, Douglas Kline, Srinivasan Vijayaraghavan
Summary: Spermatogenesis is a complex biological process involving the synthesis and activation of proteins, with 14-3-3 proteins playing critical roles in regulating cell cycle and apoptosis. Among the seven isoforms, 14-3-3 epsilon has been identified as essential for normal sperm function and male fertility, with specific roles in spermatogenesis and sperm motility.
Article
Biochemistry & Molecular Biology
Rita I. Pacheco, Maria I. Cristo, Sandra I. Anjo, Andreia F. Silva, Maria Ines Sousa, Renata S. Tavares, Ana Paula Sousa, Teresa Almeida Santos, Mariana Moura-Ramos, Francisco Caramelo, Bruno Manadas, Joao Ramalho-Santos, Sandra Gomes Amaral
Summary: The global trend of rising (male) infertility is concerning. This study aimed to understand unknown origin male infertility (UOMI) by evaluating the male gamete. The study found that idiopathic (ID) patients had the worst sperm functional profile, while unexplained male infertility (UMI) patients were similar to controls. Proteomic analysis identified several differentially expressed proteins in ID and UMI samples. SACA4 and LAMB2 were identified as potential biomarkers for distinguishing ID and UMI patients.
Article
Urology & Nephrology
S. Fu, K. P. Davies
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2015)
Review
Urology & Nephrology
Biljana Musicki, Anthony J. Bella, Trinity J. Bivalacqua, Kelvin P. Davies, Michael E. DiSanto, Nestor F. Gonzalez-Cadavid, Johanna L. Hannan, Noel N. Kim, Carol A. Podlasek, Christopher J. Wingard, Arthur L. Burnett
JOURNAL OF SEXUAL MEDICINE
(2015)
Article
Endocrinology & Metabolism
Yi Wang, Gary G. Deng, Kelvin P. Davies
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2016)
Article
Microbiology
Mohammed S. Ahmadi, Hiu Ham Lee, David A. Sanchez, Adam J. Friedman, Moses T. Tar, Kelvin P. Davies, Joshua D. Nosanchuk, Luis R. Martinez
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2016)
Article
Microbiology
Mircea Radu Mihu, Vitor Cabral, Rodney Pattabhi, Moses T. Tar, Kelvin P. Davies, Adam J. Friedman, Luis R. Martinez, Joshua D. Nosanchuk
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)
Review
Urology & Nephrology
Carol A. Podlasek, John Mulhall, Kelvin Davies, Christopher J. Wingard, Johanna L. Hannan, Trinity J. Bivalacqua, Biljana Musicki, Mohit Khera, Nestor F. Gonzalez-Cadavid, Arthur L. Burnett
JOURNAL OF SEXUAL MEDICINE
(2016)
Article
Urology & Nephrology
Joshua M. Stern, Saman Moazami, Yunping Qiu, Irwin Kurland, Zigui Chen, Ilir Agalliu, Robert Burk, Kelvin P. Davies
Article
Multidisciplinary Sciences
Yi Wang, Gary G. Deng, Kelvin P. Davies
Article
Biochemistry & Molecular Biology
Shibo Fu, Moses Tarndie Tar, Arnold Melman, Kelvin Paul Davies
Article
Genetics & Heredity
Rani Fritz, Amarnath Mukherjee, Sahar Zaghi, Ilir Agalliu, Sangita Jindal, Alexandre K. Tashima, Lloyd D. Fricker, Kelvin P. Davies
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2019)
Article
Oncology
Amarnath Mukherjee, Augene Park, Li Wang, Kelvin P. Davies
Summary: Prostate cancer is associated with overexpression of opiorphin genes, and xenografted cells overexpressing PROL1 develop tumors in nude mice. PROL1 overexpression modulates gene expression in angiogenesis, steroid, and hypoxic response pathways.
Article
Andrology
Guillermo Villegas, Moses Tarndie Tar, Kelvin Paul Davies
Summary: The study using a rat model demonstrated that pelvic surgery can result in erectile dysfunction even without direct cavernous nerve injury. Post-operative inflammatory response may indirectly lead to cavernous nerve injury and erectile dysfunction through the systemic release of cytokines/chemokines.
Article
Urology & Nephrology
Moses T. Tar, Joel M. Friedman, Andrew Draganski, Kelvin P. Davies
Summary: Our study demonstrated a synergistic effect between orally administered PDE5i and topically applied NO-MP in improving erectile function outcomes in a rat model of RP. Combined therapy of orally administered 0.05 mg/kg sildenafil with topical application of 250 mg NO-MP resulted in significantly more spontaneous erections and a faster onset for the first erectile response, suggesting a potential novel therapeutic approach for treating ED resulting from RP.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2022)
Article
Physiology
Yi Wang, Moses T. Tar, Kelvin P. Davies
PHYSIOLOGICAL REPORTS
(2020)
