Article
Andrology
Bahadir Ermec, Mehmet Gokhan Culha, Gulay Kocak, Lutfi Canat, Alper Otunctemur, Fatih Altunrende
Summary: This study evaluated the effect of vitamin D replacement in patients with LUTS/ED who did not respond to tadalafil treatment. The results showed that after vitamin D replacement, the erectile function and prostate symptom scores of the patients significantly improved.
Article
Biochemistry & Molecular Biology
Avelina Lee, Iryna Lebedyeva, Wenbo Zhi, Vani Senthil, Herjot Cheema, Michael W. Brands, Weston Bush, Nevin A. Lambert, Madeline Snipes, Darren D. Browning
Summary: Phosphodiesterase-5 inhibitors (PDE5i) are being studied for their potential in preventing colon cancer. However, their side-effects and interactions with other drugs have been a concern. By modifying the prototypical PDE5i sildenafil, we developed a new analog called malonyl-sildenafil which exhibited reduced lipophilicity and showed promising effects on colon epithelium. This analog suppressed proliferation in the colon epithelium, providing a novel approach to developing a first-in-class drug for colon cancer chemoprevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Arun Samidurai, Lei Xi, Anindita Das, Rakesh C. Kukreja
Summary: Cyclic guanosine monophosphate (cGMP) is an important second messenger in cells, and phosphodiesterase 5 (PDE5) is a member of the cyclic nucleotide phosphodiesterase (PDE) family that targets cGMP. PDE5 inhibitors, such as sildenafil and tadalafil, are used for various medical conditions beyond erectile dysfunction. Preclinical studies have shown their potential therapeutic benefits in cardiovascular, cancer, neurological, and aging-related disorders.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Article
Oncology
Yiwen Zhang, Chun-Han Lo, Edward L. Giovannucci
Summary: This study found no evidence of an association between PDE5 inhibitor use and risk of conventional and serrated precursors of colorectal cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Pharmacology & Pharmacy
Shuichi Yanai, Tetsuro Tago, Jun Toyohara, Tomoko Arasaki, Shogo Endo
Summary: This study suggests that long-term use of the PDE3 inhibitor cilostazol can reverse already-impaired memory in aged mice. Cilostazol reduces neuroinflammation and increases glucose uptake in the brain.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Sumon Roy, Robert A. Kloner, Fadi N. Salloum, Ion S. Jovin
Summary: The coexistence of cardiovascular disease and erectile dysfunction is common, possibly due to underlying endothelial dysfunction. The effects of phosphodiesterase-5 (PDE5) inhibitors on the cardiovascular system remain unclear, despite their well-established role in erectile dysfunction therapy. Preclinical studies suggest potential clinical applications for PDE5 inhibitors in cardioprotection, but attempts to translate these findings to clinical trials have faced challenges.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Review
Medicine, General & Internal
Jie Yang, Zhong-Yu Jian, Jia Wang
Summary: Through systematic literature search and network meta-analysis, it was found that on-demand use of Avanafil 200 mg may be the best treatment option among PDE5 inhibitors for erectile dysfunction following nerve-sparing radical prostatectomy (NSRP). Additional randomized controlled trials are needed to further validate this finding.
Article
Surgery
Kari J. Nelson, Pamela Antiquera, J. Stuart Nelson, Kristen M. Kelly, Nadine Abi-Jaoudeh
Summary: Sildenafil has shown benefit in treating some patients with complicated or refractory lymphatic malformations, leading to significant improvement in clinical symptoms.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2021)
Article
Chemistry, Inorganic & Nuclear
O. A. El-Kawy, I. T. Ibrahim, H. A. Shewatah, K. M. El-Azony
Summary: Avanafil, a selective second-generation phosphodiesterase-5 inhibitor, was successfully labeled with iodine-125 via electrophilic reactions. The labeled compound demonstrated in-vitro stability and high yield. Molecular modeling and in-vitro assessment were conducted to confirm the tracer's binding ability. Biodistribution studies in animal models indicated the potential of radiolabeled avanafil as a tracer for erectile dysfunction.
APPLIED RADIATION AND ISOTOPES
(2022)
Article
Andrology
Jongsoo Lee, Hye Rim Kim, Ji Eun Heo, Won Sik Jang, Kwang Suk Lee, Sung Ku Kang, Hyunho Han, Young Deuk Choi
Summary: This study investigated the impact of phosphodiesterase-5 inhibitor (PDE5i) use on survival outcomes after robot-assisted radical prostatectomy (RARP). The results showed that PDE5i use was associated with improved overall survival and reduced risk of death.
WORLD JOURNAL OF MENS HEALTH
(2022)
Review
Urology & Nephrology
Connie J. Wang, Daniel Cukor, Kirsten L. Johansen
Summary: Sexual dysfunction is common in patients with chronic kidney disease and can negatively impact their quality of life. The diagnosis and treatment of sexual dysfunction in these patients can be challenging due to underestimation and multifactorial causes, which require consideration of gender-specific manifestations and various underlying factors.
SEMINARS IN NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shubhandra Tripathi, Rick H. H. Cote, Harish Vashisth
Summary: Phosphodiesterase-5 (PDE5) regulates the concentration of cGMP by hydrolyzing it, and is associated with erectile dysfunction and cardiovascular diseases. The conformational dynamics of several structural motifs in the catalytic domain of PDE5 were evaluated and suggest a regulatory mechanism for PDE5 activation.
Review
Obstetrics & Gynecology
Kamran Hessami, Mauro Cozzolino, Alireza A. Shamshirsaz
Summary: The study found that PDE-5 inhibitors, especially sildenafil, may help improve uteroplacental blood perfusion in pregnancies complicated by fetal growth restriction (FGR), but do not have a significant effect on fetal cerebral blood flow.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Hematology
Cassondra Cramer-Bour, Amy Parker Ruhl, Seyed Mehdi Nouraie, Robert O. Emeh, Nicole F. Ruopp, Swee Lay Thein, Nargues A. Weir, Elizabeth S. Klings
Summary: This study retrospectively reviewed 36 patients with SCD-PH treated with PDE5-I therapy, showing a significant improvement in symptoms as assessed by NYHA Class with long-term tolerability of PDE5-I therapy.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Behzad Abbasi, Nathan M. Shaw, Jason L. Lui, Nizar Hakam, Behnam Nabavizadeh, Benjamin N. Breyer
Summary: The use of PDE5i drugs shows a weaker disproportionality signal for priapism events compared to intracavernousal drugs. The highest reporting odds ratio (ROR) for all PDE5i agents is observed in the 12-17 years age group (9.49, 95% CI: 3.76-19.93), followed by the 2-11 years group (4.31, 95% CI: 1.57-9.4).
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
Leslie C. Thompson, Nicole L. Sheehan, Dianne M. Walters, Robert M. Lust, Jared M. Brown, Christopher J. Wingard
CARDIOVASCULAR TOXICOLOGY
(2019)
Article
Oncology
Kathleen A. Ashcraft, Johanna L. Hannan, Gary Eichenbaum, Xiaojie Zhang, Elena S. Pak, Austin M. Faught, Pranalee Patel, Mark W. Dewhirst, Bridget F. Koontz
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Urology & Nephrology
Shelby A. Powers, Michael R. Odom, Elena S. Pak, Megan A. Moomaw, Kathleen A. Ashcraft, Bridget F. Koontz, Johanna L. Hannan
JOURNAL OF SEXUAL MEDICINE
(2019)
Article
Physiology
Hijab Ahmed, Johanna L. Hannan, John W. Apolzan, Oluwatobiloba Osikoya, Spencer C. Cushen, Steven A. Romero, Styliani Goulopoulou
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Article
Urology & Nephrology
Shelby A. Powers, Terence E. Ryan, Elena S. Pak, Matthew O. Fraser, Joseph M. McClung, Johanna L. Hannan
NEUROUROLOGY AND URODYNAMICS
(2019)
Review
Biology
Shelby A. Powers, Lindsey K. Burleson, Johanna L. Hannan
Article
Urology & Nephrology
Joshua T. Randolph, Elena S. Pak, Bridget F. Koontz, Johanna L. Hannan
JOURNAL OF SEXUAL MEDICINE
(2020)
Article
Oncology
Amarnath Mukherjee, Augene Park, Li Wang, Kelvin P. Davies
Summary: Prostate cancer is associated with overexpression of opiorphin genes, and xenografted cells overexpressing PROL1 develop tumors in nude mice. PROL1 overexpression modulates gene expression in angiogenesis, steroid, and hypoxic response pathways.
Article
Urology & Nephrology
Michael R. Odom, Trevor C. Hunt, Elena S. Pak, Johanna L. Hannan
Summary: The study found that C57BL/6N mice fed a high-fat diet were more prone to obesity and glucose sensitivity compared to C57BL/6J mice, but did not impair pre-penile or penile smooth muscle reactivity. These results suggest that the current mouse model may not accurately represent the clinical phenotype of obesity-induced erectile dysfunction.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2022)
Article
Andrology
Guillermo Villegas, Moses Tarndie Tar, Kelvin Paul Davies
Summary: The study using a rat model demonstrated that pelvic surgery can result in erectile dysfunction even without direct cavernous nerve injury. Post-operative inflammatory response may indirectly lead to cavernous nerve injury and erectile dysfunction through the systemic release of cytokines/chemokines.
Article
Urology & Nephrology
Moses T. Tar, Joel M. Friedman, Andrew Draganski, Kelvin P. Davies
Summary: Our study demonstrated a synergistic effect between orally administered PDE5i and topically applied NO-MP in improving erectile function outcomes in a rat model of RP. Combined therapy of orally administered 0.05 mg/kg sildenafil with topical application of 250 mg NO-MP resulted in significantly more spontaneous erections and a faster onset for the first erectile response, suggesting a potential novel therapeutic approach for treating ED resulting from RP.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2022)
Article
Urology & Nephrology
Eric J. Gonzalez, Michael R. Odom, Johanna L. Hannan, Warren M. Grill
Summary: The study identified impaired voiding function in obese prone rats, with decreased bladder contractility and increased urethral contractility. This suggests that cholinergic and purinergic signaling in the bladder may play a role in poor voiding function, and increased urethral activity may contribute to incomplete emptying.
NEUROUROLOGY AND URODYNAMICS
(2021)
Article
Urology & Nephrology
Alexander C. Turner, Shelby A. Powers, Michael R. Odom, Elena S. Pak, Kathleen A. Ashcraft, Bridget F. Koontz, Johanna L. Hannan
Summary: In a rat model, radiation therapy to the prostate and major pelvic ganglia resulted in early changes in gene expression of ChAT in the MPG, as well as bladder cholinergic axon profiles and smooth muscle content, which normalized over time. Bladder contractility decreased early after therapy but increased by 10 weeks. Long-term changes to the MPG and increased bladder cholinergic axons may contribute to radiation-induced bladder dysfunction in prostate cancer survivors.
NEUROUROLOGY AND URODYNAMICS
(2021)
Article
Education, Scientific Disciplines
Gary Allen, Jenna Garris, Luan Lawson, Timothy Reeder, Jennifer Crotty, Johanna Hannan, Kori Brewer
Summary: This study assessed the feasibility of using Twitter as a platform for real-time dissemination and engagement with student scholarly work. The results showed that using Twitter resulted in a larger viewing community compared to traditional in-person events, and presenting via Twitter allowed students to receive instantaneous feedback and effectively network with wider academic communities. Early evidence suggests that social media platforms may be an alternative to traditional scholarly presentations.
JMIR MEDICAL EDUCATION
(2022)
Article
Physiology
Yi Wang, Moses T. Tar, Kelvin P. Davies
PHYSIOLOGICAL REPORTS
(2020)