Article
Ecology
Yue Zhao, Xiao Fu, Jose I. Lopez, Andrew Rowan, Lewis Au, Annika Fendler, Steve Hazell, Hang Xu, Stuart Horswell, Scott T. C. Shepherd, Lavinia Spain, Fiona Byrne, Gordon Stamp, Tim O'Brien, David Nicol, Marcellus Augustine, Ashish Chandra, Sarah Rudman, Antonia Toncheva, Lisa Pickering, Erik Sahai, James Larkin, Paul A. Bates, Charles Swanton, Samra Turajlic, Ben Challacombe, Simon Chowdhury, William Drake, Archana Fernando, Nicos Fotiadis, Andrew Furness, Emine Hatipoglu, Karen Harrison-Phipps, Peter Hill, Catherine Horsfield, Teresa Marafioti, Jonathon Olsburgh, Alexander Polson, Sergio Quezada, Mary Varia, Hema Verma, Kevin Litchfield
Summary: The study combines whole-tumour images and genomic data to reveal more aggressive subclonal growth and metastasizing subclones in the tumor center. Spatial dynamics strongly correlate with genomic alterations and play a significant role in tumor evolution.
NATURE ECOLOGY & EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
V. B. Sameer Kumar, K. Anjali
Summary: One of the major reasons for the non-effectiveness of anticancer therapeutics targeting tumour angiogenesis is the complexity of cellular communication in the tumour micro-environment. Recent research has highlighted the importance of signaling events mediated by exosomes in tumor progression and angiogenesis. This review collates information on the role of exosomal cargo, especially exosomal miRNAs, in modulating tumor angiogenesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Fisheries
Min Cao, Ningning Wang, Xu Yan, Ning Yang, Qiang Fu, Xiaoyan Zhang, Yong Zhang, Chao Li
Summary: This study identified TNFSF genes and their receptors in S. schlegelii through a genome-wide survey. The study found that these genes experienced duplication and whole genome duplication events, and performed clustering analysis through molecular phylogenetic analysis. Protein domain and motif analysis revealed the structural features of TNFSF and TNFRSF. Synteny analysis showed significant changes in neighboring genes of TNFSF and TNFRSF compared to other species. Additionally, qRT-PCR and protein-protein interaction network analysis demonstrated differential expression of these genes after infection. This study provides new insights into the characterization and evolution of TNFSF genes and their receptors in S. schlegelii.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Hyun-Jin Kim, Ho-young Son, Philiip Park, Jae Moon Yun, Hyuktae Kwon, Belong Cho, Jong-Il Kim, Jin-Ho Park
Summary: Blood pressure is a complex trait, and individuals have different genetic susceptibilities to changes in blood pressure induced by air pollution exposure. This study aimed to identify genetic loci for blood pressure that interact with exposure to air pollutants in Korean adults. The researchers discovered several genetic loci, including NR2F2, that may be associated with blood pressure levels in individuals exposed to PM10.
SCIENTIFIC REPORTS
(2023)
Letter
Peripheral Vascular Disease
Yara Onetti, Roland E. Kaelin, Bettina Pitter, Mengzhuo Hou, Victor Arribas, Rainer Glass, Eloi Montanez
Summary: Endothelial alpha-pv is necessary for tumor angiogenesis and progression. Using an inducible knockout approach, researchers found that loss of endothelial alpha-pv reduces vessel density and vascular complexity in the pathological neo-vasculature of brain tumor-bearing mice. This reduction in tumor vascularization is associated with increased tumor cell apoptosis and decreased tumor volume.
Review
Gastroenterology & Hepatology
Cassandra Marie Townsend, Fiona Lovegrove, Reena Khanna, Aze Suzanne Wilson
Summary: This article reviews the evidence and provides a comprehensive guide for the management of paradoxical psoriasis in patients with inflammatory bowel disease (IBD). Paradoxical psoriasis is considered a contradictory effect of TNF antagonist therapy, with an underlying pathogenesis related to inflammatory cytokine imbalance. Treatment options should be tailored based on individual patient characteristics.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Anna La Salvia, Raffaella Carletti, Monica Verrico, Tiziana Feola, Giulia Puliani, Massimiliano Bassi, Franz Sesti, Angelina Pernazza, Rossella Mazzilli, Giuseppe Lamberti, Alessandra Siciliani, Massimiliano Mancini, Chiara Manai, Federico Venuta, Mohsen Ibrahim, Silverio Tomao, Giulia D'Amati, Cira Di Gioia, Elisa Giannetta, Federico Cappuzzo, Antongiulio Faggiano
Summary: This study suggests a biological rationale for different angiogenesis and hypoxia according to the location of lung neuroendocrine tumors (Lu-NETs). Left primary tumors are less vascularized and more likely to present hypoxia compared to right primary tumors. This finding could have potentially useful prognostic and predictive implications for Lu-NETs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Hieronymus T. W. Smeele, Esther Roder, Annemarie G. M. G. J. Mulders, Eric A. P. Steegers, Radboud J. E. M. Dolhain
Summary: This study is the first to show that the use of TNFi during pregnancy is associated with increased birth weight in offspring of women with well-controlled RA. Further research is needed to explore the underlying mechanism of TNF inhibition on birth weight and its long-term consequences for the offspring.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Caterina Defendenti, Maciej Tarkowski, Simona Borille, Andrea Cassinotti, Alessandro Massari, Sarah Birindelli, Agostino Riva, Sandro Ardizzone, Mauro Panteghini
Summary: In patients with IBD, the frequency of peripheral blood CD70+ T cells was significantly reduced by treatment with anti-TNF alpha antibodies, indicating a 'cooling' effect of the biological therapy. However, CD19+27+ memory B cells did not show significant differences between groups. Monitoring of these lymphocyte subtypes may provide better insight into disease progression and therapy application in IBD patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Dermatology
Muslih Alzahrani, Victor Coste, Maria Polina Konstantinou, Ziad Reguiai, Axel Villani, Claire Hotz, Manuelle Viguier, Christelle Pruvost-Balland, Alain Dupuy, Pierre Wolkenstein, Aurore Brun, Francois Aubin, Irene Gallais Serezal
Summary: A multicentre retrospective study confirms the efficacy of anti-TNF agents in treating patients with dissecting cellulitis of the scalp that is resistant to conventional therapies.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Review
Oncology
Anette L. Magnussen, Ian G. Mills
Summary: The article emphasizes the importance of a functional vascular system for drug delivery and responsiveness of the tumour microenvironment, as well as the beneficial role of vessel normalisation in anti-cancer treatments. The article highlights the challenges of controlled neovascular remodelling and how vascular normalisation can impact disease management.
BRITISH JOURNAL OF CANCER
(2021)
Article
Gastroenterology & Hepatology
Laurent Peyrin-Biroulet, Ailsa Hart, Peter Bossuyt, Millie Long, Matthieu Allez, Pascal Juillerat, Alessandro Armuzzi, Edward Loftus, Elham Ostad-Saffari, Astrid Scalori, Young S. Oh, Swati Tole, Akiko Chai, Jennifer Pulley, Stuart Lacey, William J. Sandborn
Summary: This study evaluated the efficacy and safety of etrolizumab in patients with moderately to severely active ulcerative colitis who had been previously treated with anti-TNF agents. The results showed that etrolizumab significantly improved remission rates at week 14 compared to placebo, but there was no significant difference between the two groups in remission rates at week 66.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Rheumatology
Siri Lillegraven, Nina Paulshus Sundlisaeter, Anna-Birgitte Aga, Joseph Sexton, Inge Christoffer Olsen, Ase Stavland Lexberg, Tor Magne Madland, Hallvard Fremstad, Christian A. Hoili, Gunnstein Bakland, Cristina Spada, Hilde Haukeland, Inger Myrnes Hansen, Ellen Moholt, Till Uhlig, Daniel H. Solomon, Desiree Van der Heijde, Tore K. Kvien, Espen A. Haavardsholm
Summary: This study aimed to assess the effect of tapering tumor necrosis factor inhibitor (TNFi) to withdrawal compared with stable treatment on the risk of disease activity flares in patients with rheumatoid arthritis (RA) in remission for more than 1 year. The results showed that in the tapering TNFi group, 63% experienced a flare during 12 months, compared to 5% in the stable TNFi group. Therefore, tapering TNFi to discontinuation is not non-inferior to continued stable treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Oncology
Longwei Liu, Yunjia Qu, Leonardo Cheng, Chi Woo Yoon, Peixiang He, Abdula Monther, Tianze Guo, Sarah Chittle, Yingxiao Wang
Summary: Cell-based immunotherapy, such as CAR-T cell immunotherapy, has revolutionized cancer treatment, but its application for solid tumors is limited by factors such as insufficient T cell tracking, tumor heterogeneity, inhibitory tumor microenvironment, and T cell exhaustion. Developing methods to overcome these limitations is critical for improving the effectiveness of immunotherapy for solid tumors.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Robert Lakin, Nazari Polidovitch, Sibao Yang, Mihir Parikh, Xueyan Liu, Ryan Debi, Xiaodong Gao, Wenliang Chen, Camilo Guzman, Simona Yakobov, Farzad Izaddoustdar, Marianne Wauchop, Qian Lei, Weimin Xu, Sergei A. Nedospasov, Vincent M. Christoffels, Peter H. Backx
Summary: Our findings indicate that adverse atrial remodeling and AF vulnerability induced by intense exercise require TNF in atrial cardiomyocytes, while the impact of endothelial-derived TNF is limited to hypertrophy modulation.
CARDIOVASCULAR RESEARCH
(2023)
Article
Anatomy & Morphology
Jumpei Tomiyasu, Anna Korzekwa, Yusuke K. Kawai, Christian A. Robstad, Frank Rosell, Daisuke Kondoh
Summary: This study investigated the specificities of the beaver vomeronasal system by histologically and immunohistochemically analyzing the VNO and AOB of Eurasian beavers. The results showed that beavers can recognize volatile odorants and nonvolatile substances using the vomeronasal system. The findings highlight the importance of the vomeronasal system in beaver chemical communication.
JOURNAL OF ANATOMY
(2022)
Article
Oncology
Angela Riedel, Moutaz Helal, Luisa Pedro, Jonathan J. Swietlik, David Shorthouse, Werner Schmitz, Lisa Haas, Timothy Young, Ana S. H. da Costa, Sarah Davidson, Pranjali Bhandare, Elmar Wolf, Benjamin A. Hall, Christian Frezza, Thordur Oskarsson, Jacqueline D. Shields
Summary: Communication between tumors and tumor-draining lymph nodes alters the structure and function of the lymph nodes before metastasis. Tumor-derived lactic acid modulates the function of lymph node fibroblasts, resembling activated fibroblasts, and alters mitochondrial function. The role of lymph nodes in supporting cancer metastasis remains unclear.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Tomasz Jasinski, Lukasz Zdrojkowski, Graca Ferreira-Dias, Ewa Kautz, Edyta Juszczuk-Kubiak, Malgorzata Domino
Summary: Endometrosis, a common disease that affects mares' fertility, is associated with alterations in epithelial and stromal cells, as well as degeneration and fibrosis of the endometrium. The study reveals a potential involvement of the NF-kappa B pathway in the pathogenesis of endometrosis, showing differential transcription of profibrotic genes between different phases of the estrous cycle. Additionally, the transcription of estrogen and progesterone receptors is found to be decreased with the severity of fibrosis and degeneration of the endometrium in horses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fay M. Allen, Ana S. H. Costa, Anja Gruszczyk, Georgina R. Bates, Hiran A. Prag, Efterpi Nikitopoulou, Carlo Viscomi, Christian Frezza, Andrew M. James, Michael P. Murphy
Summary: The study developed a rapid fractionation procedure to stabilize the distribution of metabolites between mitochondria and the cytosol. The procedure revealed the compartmentation of mitochondrial metabolites in vivo and allows for the assessment of metabolite distribution between the cytosol and mitochondria in various situations.
Article
Biochemistry & Molecular Biology
Anna Dziekonska, Magdalena Koziorowska-Gilun, Wladyslaw Kordan, Nicoletta M. Neuman, Angelika M. Kotlarczyk, Anna J. Korzekwa
Summary: The aim of this study was to assess the quality and fertilizing potential of red deer epididymal spermatozoa stored in a liquid state for up to 11 days. The results showed a decrease in sperm quality during storage, with differences in fertilizing potential observed between different storage days.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S. H. Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R. Zecchini, Sabrina H. Rossi, Charlie Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent Gnanapragasam, Anne Y. Warren, Grant D. Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Summary: Metabolic flexibility occurs during ccRCC progression, and the reprogramming of branched-chain amino acid catabolism and urea cycle allows for metabolic flexibility in renal cancer progression.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Angelika M. Kotlarczyk, Julia Kaczmarczyk, Olga Witkowska-Pilaszewicz, Malgorzata Kotula-Balak, Anna J. Korzekwa
Summary: This study found that reproductive and condition parameters in seasonally reproducing ruminants such as red deer are dependent on immune status. There is an interaction between immune system activation and AA-metabolite production in the uterus throughout different reproductive stages. IgG, cAMP, haptoglobin, and 6-keto-PGF1 alpha concentrations are valuable markers of reproductive status in hinds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ana Amaral, Nelio Cebola, Anna Szostek-Mioduchowska, Maria Rosa Rebordao, Pawel Kordowitzki, Dariusz Skarzynski, Graca Ferreira-Dias
Summary: This study aims to evaluate the inhibitory effect of noscapine on collagen type 1 (COL1) induced by myeloperoxidase. The results show that myeloperoxidase increases the transcription of COL1A2 gene and the abundance of COL1 protein, while noscapine is able to reduce this effect, with a time/estrous cycle phase-dependent manner (in follicular phase explants, at 24 h of treatment).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Alexander Hooftman, Christian G. Peace, Dylan G. Ryan, Emily A. Day, Ming Yang, Anne F. McGettrick, Maureen Yin, Erica N. Montano, Lihong Huo, Juliana E. Toller-Kawahisa, Vincent Zecchini, Tristram A. J. Ryan, Alfonso Bolado-Carrancio, Alva M. Casey, Hiran A. Prag, Ana S. H. Costa, Gabriela de los Santos, Mariko Ishimori, Daniel J. Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alexander Von Kriegsheim, Michael P. Murphy, Caroline Jefferies, Christian Frezza, Luke A. J. O'Neill
Summary: Metabolic rewiring through an inflammatory aspartate-argininosuccinate shunt induces fumarate-mediated protein succination and inflammatory effects in macrophages. Inhibition of fumarate hydratase (FH) increases fumarate levels, suppresses mitochondrial respiration, and enhances interferon responses. FH inhibition may play a pathogenic role in systemic lupus erythematosus. These findings highlight the importance of FH in regulating macrophage functions and cytokine responses.
Article
Multidisciplinary Sciences
Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joelle Janssen, Inge M. N. Wortel, Jordan L. Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana S. H. Costa, Goncalo C. Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dora Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith Samarajiwa, Maxine Tran, Thomas Mitchell, Mark Johnson, Julien Prudent, Christian Frezza
Summary: The loss of FH in the kidney leads to early changes in mitochondrial morphology and the release of mtDNA into the cytosol, which activates the cGAS-STING-TBK1 pathway and induces an inflammatory response. This phenomenon is mediated by mitochondrial-derived vesicles and depends on SNX9. These findings demonstrate that increased levels of intracellular fumarate trigger a remodelling of the mitochondrial network and the generation of mitochondrial-derived vesicles, resulting in the release of mtDNA in the cytosol and the activation of the innate immune response.
Article
Veterinary Sciences
Junwei Li, Wenming Zhao, Jiaqiao Zhu, Huiming Ju, Ming Liang, Shuaibiao Wang, Shufang Chen, Graca Ferreira-Dias, Zongping Liu
Summary: This study aims to explore the activation of AMP-activated protein kinase (AMPK) in boar spermatozoa under oxidative stress. The results show that oxidative stress promotes the activation of AMPK, which is positively correlated with sperm quality and functionality. This sheds light on the mechanism of sperm resistance to oxidative stress and provides valuable information for selecting antioxidants to improve reproductive outcomes.
VETERINARY SCIENCES
(2023)
Article
Multidisciplinary Sciences
Anna J. Korzekwa, Anna Kononiuk, Wladyslaw Kordan, Aleksandra Orzolek
Summary: Metalloproteinases (MMPs) play key roles in various developmental processes and are involved in stem cell biology. This study aimed to investigate the effects of retinoic acid (RA) on MMPs in antler stem cells (ASCs). The results showed that RA increased the expression and output of MMP-3 and TIMP-3 in ASCs, while it had no significant effect on the expression and output of MMP-1 and TIMP-1. The expression profiles of MMPs and TIMPs varied during the differentiation of ASCs into different lineages. These findings provide valuable insights into the physiological and differentiation processes of stem cells.
Article
Agriculture, Dairy & Animal Science
Junwei Li, Wenming Zhao, Jiaqiao Zhu, Shuaibiao Wang, Huiming Ju, Shufang Chen, Athina Basioura, Graca Ferreira-Dias, Zongping Liu
Summary: Temperature changes during semen transport greatly damage boar sperm quality and functionality by promoting sperm apoptosis. Heat shock proteins and AMP-activated protein kinase play important roles in boar sperm resistance to temperature changes.
Article
Food Science & Technology
Anna Koscielak, Zuzanna Koziara, Ana Pons Maria, Rafal Platek, Agnieszka Bartoszek
Summary: Dietary nucleic acids (dietNAs) are important food components, and microscopic imaging with cryosections can be a useful tool for determining their abundance and distribution in food products.