Article
Biochemistry & Molecular Biology
Erik Wahlen, Frida Olsson, Doroteya Raykova, Ola Soderberg, Johan Heldin, Johan Lennartsson
Summary: This study investigates the internalization process of EGFR and PDGFR-β using immunofluorescent microscopy. The results show that these two receptors utilize separate internalization routes, but merge in a common endosomal compartment after 45 minutes of stimulation. The association between EGFR and caveolin-1 is stronger compared to PDGFR-β, and disruption of lipid rafts affects the signaling of EGFR and PDGFR-β differently.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Tsuyoshi Hirashima, Naoya Hino, Kazuhiro Aoki, Michiyuki Matsuda
Summary: This article reviews the critical regulatory role of extracellular signal-regulated kinase (ERK) in various physiological and pathological processes and highlights the signaling mechanisms governing ERK activation via biochemical regulations with upstream molecules, particularly receptor tyrosine kinases (RTKs). However, recent research has revealed the role of mechanical forces in activating the RTK-ERK signaling pathways, opening new avenues of research into mechanochemical interplay in multicellular tissues.
CURRENT OPINION IN CELL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Yan-Ting Chen, Ainun Nizar Masbuchin, Yi-Hsien Fang, Ling-Wei Hsu, Sheng-Nan Wu, Chia-Jui Yen, Yen-Wen Liu, Yu-Wei Hsiao, Ju-Ming Wang, Mohammad Saifur Rohman, Ping-Yen Liu
Summary: A study found that HCC patients may experience heart dysfunction after TKI treatment. Inhibition of PTX3 was found to improve this dysfunction. These findings suggest the therapeutic potential of PTX3 inhibition for TKI-associated cardiotoxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Juying Jiao, Linjie Ruan, Chien-shan Cheng, Fengjiao Wang, Peiwen Yang, Zhen Chen
Summary: In this study, aberrantly expressed kinases in pancreatic cancer (PC) were identified, and the role of RIPK2 kinase was validated in promoting cancer cell proliferation, migration, and invasion. RIPK2 knockout inhibited tumor growth and metastasis in PC, and also affected autophagosome formation, ROS production, and cell apoptosis. Additionally, the interaction between oncogenic kinase PRKCI and RIPK2 was found to enhance the downstream phosphorylation of NF-κB, JNK, and ERK.
MOLECULAR MEDICINE
(2023)
Article
Biology
Shuhao Lin, Daiki Hirayama, Gembu Maryu, Kimiya Matsuda, Naoya Hino, Eriko Deguchi, Kazuhiro Aoki, Ryo Iwamoto, Kenta Terai, Michiyuki Matsuda
Summary: EGFR ligands exhibit remarkable redundancy in the propagation of ERK activation waves during collective cell migration.
LIFE SCIENCE ALLIANCE
(2022)
Article
Biology
Payam E. Farahani, Xiaoyu Yang, Emily Mesev, Kaylan A. Fomby, Ellen H. Brumbaugh-Reed, Caleb J. Bashor, Celeste M. Nelson, Jared E. Toettcher
Summary: pYtags is a modular approach for monitoring the activity of a specific RTK by live-cell microscopy. It enables monitoring of a specific RTK on different time and space scales with high specificity. Using pYtag biosensors, signaling dynamics can be quantitatively characterized with different activating ligands. The specificity and modularity of pYtags open the door to robust biosensors of multiple tyrosine kinases.
Review
Biochemistry & Molecular Biology
Teresa de los Reyes Corrales, Maria Losada-Perez, Sergio Casas-Tinto
Summary: The JNK signaling pathway is crucial in the central nervous system, playing a central role in combating pathophysiological insults during development and adulthood. It is involved in various diseases such as glioblastoma, regeneration/repair after injury, neurodegeneration, and neuronal cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jongmin Park, Guk-Yeol Park, Jongeun Lee, Joonyoung Park, Soeun Kim, Eunjeong Kim, Seung-Yeol Park, Jong Hyuk Yoon, Yoontae Lee
Summary: The disruption of intramolecular interaction of CIC by ERK is crucial for the cytoplasmic translocation of CIC, suggesting a potential strategy for cancer therapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Cell Biology
Ching-Chia Cheng, Chih-Feng Lin, Yong-Chong Lin, Tai-Horng Young, Pei-Jen Lou
Summary: The study modified gene expression of ACs by transfection of the GnT-V-overexpression plasmid, leading to increased proliferation and stemness properties of ACs. High levels of GnT-V were positively correlated with ALDH1A3 expression by increasing phosphorylation of cell surface receptors and activating downstream signaling transduction. This indicates that GnT-V plays a significant role in cell immortalization through the EGFR/ERK/ALDH1A3 signaling pathway in the ACs model.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biology
Michal Otreba, Johanna Johansson Sjolander, Morten Grotli, Per Sunnerhagen
Summary: The small molecule INR119 enhances the activity of protein kinases in fission yeast and human cells under oxidative stress, with a potential conservation of its mechanism of action between yeast and humans.
Article
Immunology
Jenna M. DeLuca, Maegan K. Murphy, Xin Wang, Timothy J. Wilson
Summary: Regulation of FCRL1 signaling plays a crucial role in modulating B cell development and antibody responses by inhibiting ERK activation. FCRL1 has the potential to regulate peripheral B cell tolerance, homeostasis, and activation through its role in suppressing ERK activation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Oncology
Jia Zhou, Yishi Li, Yangli Zhang, Haiyun Dai, Shuliang Guo
Summary: The T790M mutation is a major cause of drug resistance in lung cancer patients receiving EGFR-TKIs, with biomarkers such as brain metastases and longer initial treatment period of EGFR-TKIs linked to higher expression of T790M. Different rebiopsy methods may impact the progression time of patients.
Review
Biochemistry & Molecular Biology
Oana-Stefana Purcaru, Stefan-Alexandru Artene, Edmond Barcan, Cristian Adrian Silosi, Ilona Stanciu, Suzana Danoiu, Stefania Tudorache, Ligia Gabriela Tataranu, Anica Dricu
Summary: The research on the interactions between cancer and viruses has evolved over many decades, with potential applications of virus-induced cancer treatments in COVID-19 management; Therapeutic agents targeting TKRs may hinder certain mechanisms of cancer cells, which can potentially be repurposed for managing coronaviruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ji-Cheng Huang, Cui-Cui Duan, Shan Jin, Chuan-Bo Sheng, Yu-Si Wang, Zhan-Peng Yue, Bin Guo
Summary: This study found that HB-EGF is abundant in PCOS patients and may induce excessive estrogen secretion, mitochondrial dysfunction, and granulosa cell apoptosis. The results reveal the important role of HB-EGF in the pathogenesis of PCOS.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Jordan C. LeSarge, Pierre Thibeault, Lihai Yu, Marina D. Childs, Victor M. Mirka, Qi Qi, Matthew S. Fox, Michael S. Kovacs, Rithwik Ramachandran, Leonard G. Luyt
Summary: This article reports the strategic design, synthesis, and biological evaluation of a series of novel 4-fluorobenzoylated PAR2-targeting peptides, with Isox-Cha-Chg-Ala-Arg-Dpr(4FB)NH2 being the lead candidate. This 18F-labeled tracer is the first reported PAR2 imaging agent with potential for use in vivo.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Neurosciences
Ryuichi Tsujita, Maho Tsubota, Yusuke Hayashi, Haruka Saeki, Fumiko Sekiguchi, Atsufumi Kawabata
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Yusuke Hayashi, Ryuichi Tsujita, Maho Tsubota, Haruka Saeki, Fumiko Sekiguchi, Goichi Honda, Atsufumi Kawabata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Neurosciences
Fumiko Sekiguchi, Risa Domoto, Kana Nakashima, Daichi Yamasoba, Hiroki Yamanishi, Maho Tsubota, Hidenori Wake, Masahiro Nishibori, Atsufumi Kawabata
Article
Health Care Sciences & Services
Tomoyoshi Miyamoto, Masanori Fujitani, Hiroki Fukuyama, Shigekatsu Hatanaka, Yuichi Koizumi, Atsufumi Kawabata
JOURNAL OF PALLIATIVE MEDICINE
(2019)
Article
Pharmacology & Pharmacy
Sachi Matsuda, Hiroyuki Nishikawa, Anna Fukatsu, Yuko Kurokawa, Maho Tsubota, Fumiko Sekiguchi, Shogo Tokuyama, Atsufumi Kawabata
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Shiori Tomita, Fumiko Sekiguchi, Tomoyo Deguchi, Takaya Miyazaki, Yuya Ikeda, Maho Tsubota, Shigeru Yoshida, Huy Du Nguyen, Takuya Okada, Naoki Toyooka, Atsufumi Kawabata
Article
Biochemistry & Molecular Biology
Maho Tsubota, Kenta Uebo, Koki Miki, Fumiko Sekiguchi, Akihiko Ishigami, Atsufumi Kawabata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Pharmacology & Pharmacy
Kazuki Matsui, Maho Tsubota, Saaya Fukushi, Nene Koike, Hiroshi Masuda, Yoshihito Kasanami, Takaya Miyazaki, Fumiko Sekiguchi, Tsuyako Ohkubo, Shigeru Yoshida, Yutaro Mukai, Akira Oita, Mitsutaka Takada, Atsufumi Kawabata
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2019)
Article
Immunology
Maho Tsubota, Ryotaro Fukuda, Yusuke Hayashi, Takaya Miyazaki, Shin Ueda, Rika Yamashita, Nene Koike, Fumiko Sekiguchi, Hidenori Wake, Shuji Wakatsuki, Yuka Ujiie, Toshiyuki Araki, Masahiro Nishibori, Atsufumi Kawabata
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Pharmacology & Pharmacy
Kazuki Matsui, Yuka Terada, Maho Tsubota, Fumiko Sekiguchi, Atsufumi Kawabata
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Yuhei Irie, Maho Tsubota, Mariko Maeda, Shiori Hiramoto, Fumiko Sekiguchi, Hiroyasu Ishikura, Hidenori Wake, Masahiro Nishibori, Atsufumi Kawabata
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Fumiko Sekiguchi, Atsufumi Kawabata
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is resistant to most existing medicines and is one of the major dose-limiting side effects of chemotherapeutic agents. HMGB1 plays a key role in the development of CIPN, while TMα is effective in preventing CIPN in both animal models and patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Risa Domoto, Fumiko Sekiguchi, Maho Tsubota, Atsufumi Kawabata
Summary: Neuroimmune crosstalk plays a crucial role in both somatic and visceral pathological pain, with macrophages interacting with neurons to regulate pain signals in peripheral tissues; recent studies have uncovered different characteristics and mediators of macrophages from various sources, highlighting their multitasking abilities in homeostatic conditions.
Article
Cell Biology
Maho Tsubota, Takaya Miyazaki, Yuya Ikeda, Yusuke Hayashi, Yui Aokiba, Shiori Tomita, Fumiko Sekiguchi, Dengli Wang, Masahiro Nishibori, Atsufumi Kawabata
Summary: Bortezomib-induced chemotherapy-induced peripheral neuropathy (CIPN) involves caspase-dependent release of HMGB1 from macrophages, leading to the activation of RAGE and CXCR4 receptors. Preventative measures for CIPN include the use of anti-HMGB1-neutralizing antibodies, thrombomodulin alfa, RAGE and CXCR4 antagonists, or macrophage depletion.
Article
Pharmacology & Pharmacy
Tomoka Ozaki, Maho Tsubota, Fumiko Sekiguchi, Atsufumi Kawabata
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2018)