A Distinct Class of Antibodies May Be an Indicator of Gray Matter Autoimmunity in Early and Established Relapsing Remitting Multiple Sclerosis Patients

MSPrecise: A molecular diagnostic test for multiple sclerosis using next generation sequencing

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Multiple sclerosis—a quiet revolution

(2015) Richard M. Ransohoff et al.   Nature Reviews Neurology

Gray matter damage in multiple sclerosis: Impact on clinical symptoms

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Regional Distribution and Evolution of Gray Matter Damage in Different Populations of Multiple Sclerosis Patients

(2015) Massimiliano Calabrese et al.   PLoS One

Role of T cell—glial cell interactions in creating and amplifying central nervous system inflammation and multiple sclerosis disease symptoms

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A Longitudinal Study of Disability, Cognition and Gray Matter Atrophy in Early Multiple Sclerosis Patients According to Evidence of Disease Activity

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Spinal cord gray matter atrophy correlates with multiple sclerosis disability

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Immunology of Relapse and Remission in Multiple Sclerosis

(2014) Lawrence Steinman   Annual Review of Immunology

Targets of the humoral autoimmune response in multiple sclerosis

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B cells in MS and NMO: pathogenesis and therapy

(2014) Markus Krumbholz et al.   Seminars in Immunopathology

The Antibody Genetics of Multiple Sclerosis: Comparing Next-Generation Sequencing to Sanger Sequencing

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Expansion of CD27high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation

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Specific peripheral B cell tolerance defects in patients with multiple sclerosis

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Distinction and Temporal Stability of Conformational Epitopes on Myelin Oligodendrocyte Glycoprotein Recognized by Patients with Different Inflammatory Central Nervous System Diseases

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Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis

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Antibody-independent B cell effector functions in relapsing remitting Multiple Sclerosis: Clues to increased inflammatory and reduced regulatory B cell capacity

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Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis

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Repetitive hypoxia extends endogenous neurovascular protection for stroke

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Autoantibodies to intracellular antigens: Generation and pathogenetic role

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Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

(2011) Owain W. Howell et al.   BRAIN

Intrathecally synthesized IgG in multiple sclerosis cerebrospinal fluid recognizes identical epitopes over time

(2011) Xiaoli Yu et al.   JOURNAL OF NEUROIMMUNOLOGY

A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis

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Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4+ T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein

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A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis

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Cortical lesions in multiple sclerosis

(2010) Massimiliano Calabrese et al.   Nature Reviews Neurology

Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid

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A nucleic acid-hydrolyzing antibody penetrates into cells via caveolae-mediated endocytosis, localizes in the cytosol and exhibits cytotoxicity

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Polyreactive autoantibodies in systemic lupus erythematosus have pathogenic potential

(2009) Jie Zhang et al.   JOURNAL OF AUTOIMMUNITY

Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis☆

(2009) Elizabeth M. Cameron et al.   JOURNAL OF NEUROIMMUNOLOGY

Transplanted Neural Precursors Enhance Host Brain-Derived Myelin Regeneration

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The brain-specific Neural Zinc Finger transcription factor 2b (NZF-2b/7ZFMyt1) causes suppression of cocaine-induced locomotor activity

(2009) Vijay Chandrasekar et al.   NEUROBIOLOGY OF DISEASE

Gray matter atrophy is related to long-term disability in multiple sclerosis

(2008) Leonora K. Fisniku et al.   ANNALS OF NEUROLOGY

The comparative biology of neuromelanin and lipofuscin in the human brain

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Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin‐specific antibodies

(2008) Hans‐Christian von Büdingen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Arginines in the CDR of anti-dsDNA autoantibodies facilitate cell internalizationviaelectrostatic interactions

(2008) Ying-Chyi Song et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gray matter atrophy correlates with MS disability progression measured with MSFC but not EDSS

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Multiple sclerosis

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B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

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Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

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