Article
Multidisciplinary Sciences
Xu Han, Tianyu Liu, Jiabao Zhai, Chang Liu, Wanyu Wang, Chuang Nie, Qi Wang, Xiaojie Zhu, Haibo Zhou, Wenjing Tian
Summary: This study found that EPHA5 methylation is associated with the risk and prognosis of gastric cancer. In peripheral blood leukocytes, EPHA5 positive methylation is more significantly associated with gastric cancer risk in elderly individuals and those without H. pylori infection. Additionally, the combined effects of EPHA5 methylation and environmental risk factors such as H. pylori infection, alcohol consumption, and salty food intake are observed. However, no convincing association is found between EPHA5 methylation and gastric cancer prognosis.
Article
Oncology
Chuang Nie, Xu Han, Rongrong Wei, Anastasiia Leonteva, Jia Hong, Xinyu Du, Jing Wang, Lin Zhu, Yashuang Zhao, Yingwei Xue, Haibo Zhou, Wenjing Tian
Summary: High ZNF331 methylation may significantly reduce the risk of gastric cancer, especially in males, while WIF1 methylation is not associated with gastric cancer risk. Additionally, there are significant combined effects between ZNF331 methylation and the intake of green vegetables and garlic, but neither ZNF331 nor WIF1 methylation affects the prognosis of gastric cancer.
Article
Peripheral Vascular Disease
Jacob. K. K. Kresovich, Zongli Xu, Katie. M. M. O'Brien, Christine. G. G. Parks, Clarice. R. R. Weinberg, Dale. P. P. Sandler, Jack. A. A. Taylor
Summary: This study found that shifts in lymphocyte subsets occur before the development of hypertension, followed by changes to neutrophils and additional lymphocytes.
Article
Oncology
Tian Tian, JinMing Fu, DaPeng Li, YuPeng Liu, HongRu Sun, Xuan Wang, XianYu Zhang, Ding Zhang, Ting Zheng, Yashuang Zhao, Da Pang
Summary: Abnormal DNA methylation of immune-related genes in peripheral blood leukocytes is associated with breast cancer risk. Five potential biomarkers were identified through a case-control study and analysis of different cell subtypes. These findings could be used to predict breast cancer risk.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jinming Fu, Lei Zhang, Dapeng Li, Tian Tian, Xuan Wang, Hongru Sun, Anqi Ge, Yupeng Liu, Xianyu Zhang, Hao Huang, Shuhan Meng, Ding Zhang, Liyuan Zhao, Simin Sun, Ting Zheng, Chenyang Jia, Yashuang Zhao, Da Pang
Summary: This study identified the CpG sites of imprinted genes associated with breast cancer risk by using public datasets. The methylation of KCNQ1, KCNQ1OT1, and PHLDA2 in peripheral blood was found to be related to breast cancer susceptibility. The hypermethylation of the KCNQ1OT1 region was associated with a lower risk of breast cancer. These findings suggest that the KCNQ1OT1 region could be a potential biomarker for breast cancer risk assessment.
Article
Neurosciences
Maren Stolp Andersen, Ingvild Sorum Leikfoss, Ina Skaara Brorson, Chiara Cappelletti, Conceicao Bettencourt, Mathias Toft, Lasse Pihlstrom
Summary: Understanding the contribution of immune mechanisms to Parkinson's disease pathogenesis is important for potential therapeutic implications. This study investigated epigenome-wide DNA methylation in different peripheral immune cell types and identified differential methylation patterns in CD14+ monocytes and CD8+ T cells. Methylation changes upstream of RAB32, a gene linked to LRRK2, were found in monocytes and correlated negatively with mRNA expression.
NPJ PARKINSONS DISEASE
(2023)
Article
Medical Laboratory Technology
Stephanie Sontag, Ledio Bocova, Wouter H. G. Hubens, Selina Nuechtern, Matthis Schnitker, Thomas Look, Kema M. Schroeder, Birgit Pluemaekers, Vithurithra Tharmapalan, Martina Wessiepe, Thomas Kraus, Jan Kramer, Lothar Rink, Steffen Koschmieder, Wolfgang Wagner
Summary: The study further optimized and validated targeted DNAm assays for leukocyte deconvolution using blood samples from healthy donors, ring trial participants, and patients with hematological diseases. Results showed that relative leukocyte quantification correlated with conventional blood counts using pyrosequencing or ddPCR, but outliers in epigenetic leukocyte counts were observed in some patients, especially those with hematopoietic malignancies. Further optimization of assays is needed for accurate absolute quantification.
CLINICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Olga Bushueva, Ekaterina Barysheva, Anton Markov, Andrey Belykh, Iuliia Koroleva, Egor Churkin, Alexey Polonikov, Vladimir Ivanov, Maria Nazarenko
Summary: This study revealed an association between hypomethylation of CpG sites in GCLM and MPO in blood leukocytes with acute phase cerebral stroke (CS).
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Ljiljana Stojkovic, Manja Zec, Maja Zivkovic, Maja Bundalo, Maja Boskovic, Marija Glibetic, Aleksandra Stankovic
Summary: The study aimed to investigate the effects of polyphenol-rich Aronia melanocarpa juice on individuals at moderate risk of cardiovascular disease. Results suggest that habitual consumption of this juice may have cardioprotective effects through modifications of DNA methylation patterns and PUFA profiles.
FRONTIERS IN NUTRITION
(2021)
Article
Genetics & Heredity
Massimo Santoro, Mariacristina Siotto, Marco Germanotta, Alessia Mastrorosa, Dionysia Papadopoulou, Irene Aprile
Summary: The study investigated the methylation profile of SLC6A4 in 50 patients with subacute stroke and concluded that 5-HTTLPR polymorphisms and SLC6A4 promoter methylation could serve as potential biological markers for recovery in stroke patients undergoing rehabilitation. Significant changes in methylation levels were observed in specific CpG sites after rehabilitation, with a significant relationship found between LL, LS, and SS alleles and the outcome of rehabilitation interventions. Patients with LL and SS genotypes showed significant differences in favorable outcomes after rehabilitation.
Article
Biochemistry & Molecular Biology
Yifan Xu, Chia-Wen Tsai, Wen-Shin Chang, Yuyan Han, Maosheng Huang, Curtis A. Pettaway, Da-Tian Bau, Jian Gu
Summary: This study identified differentially methylated CpG sites and genes between aggressive and nonaggressive prostate cancer in African American men, suggesting the potential of leukocyte DNA methylation as valuable biomarkers for aggressive PCa and providing biological insights into the modulation of immune response by aggressive PCa.
Article
Oncology
Rong Qiao, Mengxia Li, Runbo Zhong, Yujie Wei, Jun Wang, Zheng Zhang, Ling Wang, Tian Xu, Yue Wang, Liping Dai, Wanjian Gu, Baohui Han, Rongxi Yang
Summary: The study revealed that abnormal DNA methylation levels within the PNPLA2 gene are associated with early-stage lung cancer, particularly in women and younger individuals. This novel association between blood-based PNPLA2 methylation and very early-stage LC suggests the potential for early detection of the disease.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jialie Jin, Chao Zhu, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study reveals a strong association between blood-based hypermethylation of ACTB and the risk of coronary heart disease (CHD), especially in male patients and those with heart failure. The combination of ACTB methylation levels can efficiently differentiate CHD cases and specific subgroups from controls.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Sarah Boukezzi, Sara Costi, Lisa M. Shin, Seunghee Kim-Schulze, Flurin Cathomas, Abigail Collins, Scott J. Russo, Laurel S. Morris, James W. Murrough
Summary: This study found that patients with depression showed heightened neural response to threat, and it was correlated with inflammatory response and anxious arousal. The findings suggest that inflammation and amygdala activation may partially mediate the effect of stress on anxious arousal.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemical Research Methods
Oleksii Nikolaienko, Per Eystein Lonning, Stian Knappskog
Summary: With recent advances in the field of epigenetics, there is a growing focus on rare transmitted constitutional epimutations. The research team developed a method called ramr to identify aberrantly methylated DNA regions and confirmed its applicability for cancer risk analysis.
Article
Public, Environmental & Occupational Health
Naomi Hofsink, Dorieke J. Dijkstra, Violeta Stojanovska, Sicco A. Scherjon, Torsten Ploesch
Summary: Exposure to pregnancy complications, such as preeclampsia (PE), has long-term effects on the health of offspring. This study examines the molecular changes in the fetal brain and liver caused by PE exposure, with a focus on gene transcription and DNA methylation. The results show altered gene expression and DNA methylation in several key regulatory genes in both fetal brain and liver, suggesting potential effects on glucose metabolism in the liver and neurogenesis in the brain. The observed sex-specific growth restriction pattern does not align with the molecular data, indicating that PE drives the molecular phenotype of the offspring rather than tissue growth.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Infectious Diseases
Anette Veringa, Roger J. Bruggemann, Lambert F. R. Span, Bart J. Biemond, Mark G. J. de Boer, Edwin R. van den Heuvel, Saskia K. Klein, Doris Kraemer, Monique C. Minnema, Niek H. J. Prakken, Bart J. A. Rijnders, Jesse J. Swen, Paul E. Verweij, Marielle J. Wondergem, Paula F. Ypma, Nicole Blijlevens, Jos G. W. Kosterink, Tjip S. van der Werf, Jan-Willem C. Alffenaar
Summary: This study investigated whether TDM-guided voriconazole treatment is superior to standard treatment for invasive aspergillosis. The results showed no significant difference in treatment outcome and adverse reactions between the TDM and non-TDM groups, but a higher proportion of voriconazole concentrations within the acceptable range were found in the TDM group.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Elze R. Timmers, J. Casper Swarte, Ranko Gacesa, Johannes R. Bjoerk, Rinse K. Weersma, Marina A. Tijssen, Tom J. de Koning, Hermie J. M. Harmsen, Klary E. Niezen-Koning
Summary: This study investigates the relationship between gut microbiome and (non-)motor symptoms in dystonia, and finds differences in abundance of certain bacteria and alterations in related neuro-active metabolic pathways. It suggests the involvement of the gut-brain axis in the pathophysiology of dystonia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Statistics & Probability
Michiel H. J. Paus, Edwin R. van den Heuvel, Marc J. M. Meddens
Summary: This study proposes a quantile-based prediction (QBP) method for binary disease classification, which selects multiple continuous biomarkers and utilizes the tail differences in biomarker distributions between cases and controls. QBP outperforms alternative methods when biomarkers predominantly show variance differences.
JOURNAL OF NONPARAMETRIC STATISTICS
(2023)
Article
Statistics & Probability
Roxana A. Ion, Chris A. J. Klaassen, Edwin R. van den Heuvel
Summary: This article proves sharp upper bounds for the probability of a standardized random variable taking on a value outside a possibly asymmetric interval around 0. Six classes of distributions for the random variable are considered, namely the general class of 'distributions', the class of 'symmetric distributions', 'concave distributions', 'unimodal distributions', 'unimodal distributions with coinciding mode and mean', and 'symmetric unimodal distributions'. The results generalize previous work by Gauss (1823), Bienayme (1853), Chebyshev (1867), and Cantelli (1928), and provide alternative proofs for some known inequalities such as Gauss inequality.
Article
Psychiatry
Sandip V. George, Yoram K. Kunkels, Arnout Smit, Marieke Wichers, Evelien Snippe, Arie M. van Roon, Harriette Riese
Summary: It is unclear whether cardiac dynamics can predict future depression and whether changes in these dynamics precede the recurrence of depression. A study was conducted on individuals with a history of depression who were tapering their antidepressants, where electrocardiogram (ECG) data was collected over a 4-month period. Results showed that there were no consistent trends in cardiac dynamics before increases in depressive symptoms within individuals, but lower entropy of cardiac dynamics predicted the recurrence of depression. These findings suggest that entropy could be a potential digital phenotype for assessing the risk of depression recurrence in the short term while tapering antidepressants.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Tingting Chen, Nad'a Majernikova, Alejandro Marmolejo-Garza, Marina Trombetta-Lima, Angelica Maria Sabogal-Guaqueta, Yuequ Zhang, Ruth ten Kate, Minte Zuidema, Patty P. M. F. A. Mulder, Wilfred den Dunnen, Reinoud Gosens, Elisabeth Verpoorte, Carsten Culmsee, Ulrich L. M. Eisel, Amalia M. Dolga
Summary: Transplanting exogenous mitochondria into neuronal cells can protect cells from ferroptotic cell death by reducing lipid peroxidation and mitochondrial superoxide production. The function of mitochondrial complexes is crucial for the neuroprotective effects of exogenous mitochondria.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Clinical Neurology
Lino von Klipstein, Michelle N. Servaas, Femke Lamers, Robert A. Schoevers, Klaas J. Wardenaar, Harriette Riese
Summary: Experience sampling studies show that depressed individuals react more strongly to positive and negative stimuli than non-depressed individuals, particularly on negative affect. However, these findings may be influenced by floor/ceiling effects and assumption violations. Using data from 346 participants, it was found that depressed individuals showed increased positive affect reactivity when accounting for assumption violations, but no evidence of increased negative affect reactivity. The results highlight the importance of considering modeling choices in affective reactivity studies.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
Erika Kuzminskaite, Christiaan H. Vinkers, Arnout C. Smit, Wouter van Ballegooijen, Bernet M. Elzinga, Harriette Riese, Yuri Milaneschi, Brenda W. J. H. Penninx
Summary: Childhood trauma is associated with greater affective dysregulation, characterized by higher variability and instability of emotional symptoms. However, the effects of childhood trauma on affect fluctuations are entirely explained by differences in mean affect levels.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yordi van de Vegte, Ruben P. Eppinga, M. Yldau van der Ende, Yanick Hagemeijer, Yuvaraj V. Mahendran, Elias Y. Salfati, Albert E. Smith, Vanessa Tan, Dan V. Arking, Ioanna Ntalla, Emil A. Appel, Claudia Schurmann, Jennifer Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina U. Mononen, Kirsi F. Auro, Anne Jackson, Lawrence Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Mueller-Nurasyid, Carolina E. Roselli, Weihua Zhang, Marcus J. Kleber, Xiuqing Guo, Henry E. Lin, Francesca Pavani, Tessel Galesloot, Raymond E. Noordam, Yuri Milaneschi, Katharina Schraut, Marcel den Hoed, Frauke E. Degenhardt, Stella Trompet, Marten van den Berg, Giorgio Pistis, Yih-Chung S. Tham, Stefan L. Weiss, Xueling J. Sim, Hengtong M. Li, Peter van der Most, Ilja Nolte, Leo-Pekka R. Lyytikaeinen, M. Abdullah Said, Daniel Witte, Carlos M. Iribarren, Lenore S. Launer, Susan Ring, Paul de Vries, Peter P. Sever, Allan Linneberg, Erwin M. Bottinger, Sandosh Padmanabhan, Bruce Psaty, Nona Sotoodehnia, Ivana Kolcic, Delnaz D. Roshandel, Andrew O. Paterson, David F. Arnar, Daniel Gudbjartsson, Hilma Holm, Beverley T. Balkau, Claudia H. Silva, Christopher Newton-Cheh, Kjell Nikus, Perttu L. Salo, Karen A. Mohlke, Patricia Peyser, Heribert Schunkert, Mattias Lorentzon, Jari C. Lahti, Dabeeru C. Rao, Marilyn D. Cornelis, Jessica A. Faul, Jennifer Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie F. Waldenberger, Moritz Sinner, Konstantin E. Strauch, Graciela D. Delgado, Kent Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline de Graaf, Renee de Mutsert, Eco J. C. de Geus, Asa K. Johansson, Peter K. Joshi, Lars Lind, Andre W. Franke, Peter V. Macfarlane, Kirill Tarasov, Nicholas B. Tan, Stephan Felix, E-Shyong Q. Tai, Debra Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia P. Lindgren, Andrew T. Morris, Olli Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur J. Gudnason, Nicholas C. Timpson, Alanna B. Morrison, Patricia P. Munroe, David Strachan, Niels Grarup, Ruth J. F. R. Loos, Susan Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif J. Groop, Nicholas M. Wareham, Cornelia F. van Duijn, Mary J. Feitosa, Christopher O'Donnell, Mika Kaehoenen, Markus Perola, Michael Boehnke, Sharon L. R. Kardia, Jeanette Erdmann, Colin N. A. Palmer, Claes J. Ohlsson, David G. Porteous, Johan Eriksson, Claude Bouchard, Susanne Moebus, Peter R. Kraft, David Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kaeaeb, Annette C. Peters, John S. Chambers, Jaspal Kooner, Winfried I. Maerz, Jerome A. Rotter, Andrew Hicks, J. Gustav Smith, Lambertus A. L. M. O. Kiemeney, Dennis Mook-Kanamori, Brenda W. J. H. Penninx, Ulf F. Gyllensten, James Wilson, Stephen Burgess, Johan Sundstroem, Wolfgang Lieb, J. Wouter Jukema, Mark Eijgelsheim, Edward L. M. Lakatta, Ching-Yu Cheng, Marcus Doerr, Tien-Yin Wong, Charumathi J. Sabanayagam, Albertine Oldehinkel, Harriette Riese, Terho Lehtimaeki, Niek Verweij, Pim van der Harst
Summary: This study identifies new genetic variants associated with resting heart rate (RHR) and demonstrates that higher genetically predicted RHR is associated with a decreased risk of atrial fibrillation and ischemic stroke. Genome-wide analysis reveals multiple genetic variants in cardiomyocyte-related genes and provides insights into their electrocardiogram (ECG) signature. Mendelian randomization analyses indicate that higher genetically predicted RHR increases the risk of dilated cardiomyopathy, but reduces the risk of atrial fibrillation, ischemic stroke, and cardio-embolic stroke.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Bart R. J. van Dijken, Hanne-Rinck Jeltema, Justyna Klos, Peter Jan van Laar, Roelien H. Enting, Ronald G. H. J. Maatman, Klaas Bijsterveld, Wilfred F. A. Den Dunnen, Rudi A. Dierckx, Paul E. Sijens, Anouk van der Hoorn
Summary: This study proposes a straightforward method for 2-HG quantification by MR spectroscopy for IDH mutation status detection and directly compares in vivo 2-HG MR spectroscopy with ex vivo 2-HG concentration measured in resected tumor tissue. The study shows that in vivo 2-HG MR spectroscopy can non-invasively determine IDH status in glioma and demonstrates a strong correlation with ex vivo 2-HG concentration in patients with lower-grade glioma.
Article
Clinical Neurology
Bianca M. Dijkstra, Julie Nonnekens, Wouter Nagengast, Schelto Kruijff, Gert Jan Meersma, Wilfred F. A. den Dunnen, Frank A. E. Kruyt, Rob J. M. Groen
Summary: The feasibility of using bevacizumab-IRDye800CW to target VEGFa in a CH-157MN xenografted mouse model was investigated. Results showed that the fluorescent agent specifically targeted meningioma and could be used for tumor monitoring and guidance during surgery. The next step is to evaluate the feasibility of using the clinically available bevacizumab-IRDye800CW in a human trial for optimizing meningioma resection.
JOURNAL OF NEUROSURGERY
(2023)
Article
Psychology, Clinical
Anne Alkema, Mattia Marchi, Jeroen A. J. van der Zaag, Danielle van der Sluis, Varun Warrier, Roel A. Ophoff, Rene S. Kahn, Wiepke Cahn, Jacqueline G. F. M. Hovens, Harriette Riese, Floortje Scheepers, Brenda W. J. H. Penninx, Charlotte Cecil, Albertine J. Oldehinkel, Christiaan H. Vinkers, Marco P. M. Boks
Summary: Childhood abuse and neglect are associated with different risks for psychiatric symptoms and disorders, with abuse having a stronger association with schizophrenia and neglect having a stronger association with bipolar disorder. Additionally, abuse is associated with hallucinations and suicide attempts, while neglect is associated with agitation and decreased need for sleep.
PSYCHOLOGICAL MEDICINE
(2023)
Meeting Abstract
Psychiatry
A. -S. Koning, S. H. Booij, O. C. Meijer, H. Riese, E. J. Giltay
EUROPEAN PSYCHIATRY
(2023)
Meeting Abstract
Psychiatry
F. van der Does, W. van Eeden, F. Lamers, B. Penninx, H. Riese, E. Vermetten, K. Wardenaar, N. van der Wee, E. Giltay
EUROPEAN PSYCHIATRY
(2023)
