Article
Chemistry, Analytical
Cecilia Rustichelli, Emanuela Monari, Rossella Avallone, Elisa Bellei, Stefania Bergamini, Aldo Tomasi, Anna Ferrari
Summary: Migraine is a very common disorder, especially among women, and is associated with various comorbidities. Neuroactive steroids may play a role in the pathogenesis of migraine and its comorbidities. Exploratory study found that levels of neuroactive steroids in migraine patients were negatively correlated with migraine years and frequency, consistent with previous research findings.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Fernanda dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri dos Santos, Regis Mateus Hozer, Felippo Bifi, Cristiane Matte, Christianne Gazzana Salbego, Vera Maria Treis Trindade
Summary: This study evaluated the protective effect of genistein against Aβ(1-42)-induced cognitive impairment and elucidated some possible mechanisms involved in its neuroprotective effects in the hippocampus, including attenuation of synaptotoxicity, prevention of Tau hyperphosphorylation, and inactivation of ERK.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Marta Zamarbide, Eva Martinez-Pinilla, Francisco Gil-Bea, Masashi Yanagisawa, Rafael Franco, Alberto Perez-Mediavilla
Summary: The study demonstrates the presence of the FFA3 receptor in the human brain and its involvement in cognitive processes. Inactivating the FFA3 gene can prevent AD-like cognitive decline and pathological hallmarks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sareer Ahmad, Myeung Hoon Jo, Muhammad Ikram, Amjad Khan, Myeong Ok Kim
Summary: The study revealed that Luteolin has protective effects against amyloid-beta-induced neuroinflammation, amyloidogenesis, and synaptic dysfunction in mice, potentially through inhibition of JNK signaling and modulation of inflammatory and cell death markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Bibin Anand, Qi Wu, Maryam Nakhaei-Nejad, Govindarajan Karthivashan, Lyudmyla Dorosh, Sara Amidian, Abhishek Dahal, Xiuju Li, Maria Stepanova, Holger Wille, Fabrizio Giuliani, Satyabrata Kar
Summary: Native PLGA nanoparticles show therapeutic potential in the treatment of Alzheimer's disease by suppressing aggregation of beta-amyloid peptides, triggering their disassembly, reducing phosphorylation of tau protein, enhancing neuronal viability, and attenuating memory deficits and A beta levels in animal models of AD.
BIOACTIVE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Pallabi Sil Paul, Jae-Young Cho, Qi Wu, Govindarajan Karthivashan, Emily Grabovac, Holger Wille, Mariana Kulka, Satyabrata Kar
Summary: The study found that native PLGA can inhibit the aggregation of A beta peptides and disassemble existing aggregates, protecting neurons from toxicity associated with Alzheimer's disease pathology at temperatures outside the physiological range. These findings support the unique therapeutic potential of PLGA nanoparticles in the treatment of AD.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell Biology
Muhammad Ikram, Myeung Hoon Jo, Kyonghwan Choe, Amjad Khan, Sareer Ahmad, Kamran Saeed, Min Woo Kim, Myeong Ok Kim
Summary: Cycloastragenol demonstrated positive effects against oxidative stress, neurogenic dysfunction, MAP kinase activation, mitochondrial apoptosis, and memory impairment in an A beta-induced mouse model of Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Katerina Konstantoulea, Patricia Guerreiro, Meine Ramakers, Nikolaos Louros, Liam D. Aubrey, Bert Houben, Emiel Michiels, Matthias De Vleeschouwer, Yulia Lampi, Luis F. Ribeiro, Joris Wit, Wei-Feng Xue, Joost Schymkowitz, Frederic Rousseau
Summary: The study found that proteins enriched in homologous sequences to Aβ aggregation-prone regions are present in Aβ plaques from AD patients, suggesting heterotypic amyloid interactions may occur. These proteins can modify Aβ assembly kinetics, fibril morphology, and deposition pattern in vitro. Additionally, it was discovered that transient expression of three of these proteins in an Aβ reporter cell line promotes Aβ amyloid aggregation, indicating a potential role of heterotypic APR interactions in amyloid-deposition diseases.
Article
Engineering, Biomedical
Bibin G. Anand, Qi Wu, Govindarajan Karthivashan, Kiran P. Shejale, Sara Amidian, Holger Wille, Satyabrata Kar
Summary: The study showed that surface-functionalized gold nanoparticles with mimosine can inhibit Aβ aggregation and stabilize it in its monomeric state, reducing neuronal toxicity associated with AD. Additionally, MimoAuNPs can trigger the disassembly of mature Aβ fibers, presenting a potential therapeutic effect on AD-related pathologies.
BIOACTIVE MATERIALS
(2021)
Article
Biology
Sukhvir K. Wright, Richard E. Rosch, Max A. Wilson, Manoj A. Upadhya, Divya R. Dhangar, Charlie Clarke-Bland, Tamara T. Wahid, Sumanta Barman, Norbert Goebels, Jakob Kreye, Harald Pruess, Leslie Jacobson, Danielle S. Bassett, Angela Vincent, Stuart D. Greenhill, Gavin L. Woodhall
Summary: Sukhvir Wright and colleagues developed a rat model of encephalitis induced by NMDAR antibodies, finding that reduction of NMDARs increases excitability and seizure activity. This study highlights the potential use of receptor-specific treatments in antibody-mediated seizures and epilepsy.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qi Wu, Govindarajan Karthivashan, Maryam Nakhaei-Nejad, Bibin G. Anand, Fabrizio Giuliani, Satyabrata Kar
Summary: Biodegradable poly(lactic-co-glycolic acid)(PLGA) nanoparticles have excellent biocompatibility and can be used to deliver drugs to target tissues. This study found that native PLGA without any drug/agent can protect neurons against A beta-induced toxicity and influence the expression of AD-related genes/proteins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Behavioral Sciences
Darrell W. Brann, Yujiao Lu, Jing Wang, Quanguang Zhang, Roshni Thakkar, Gangadhara R. Sareddy, Uday P. Pratap, Rajeshwar R. Tekmal, Ratna K. Vadlamudi
Summary: This review provides a comprehensive overview of the localization, regulation, sex differences, and roles of brain-derived estrogen in various physiological and pathological processes. The research using specific inhibitors and knockout mouse models reveals that neuron-derived estrogen plays a critical role in synaptic plasticity, memory, socio-sexual behavior, sexual differentiation, reproduction, and neuroprotection. Astrocyte-derived estrogen is also induced after brain injury/ischemia and contributes to reactive gliosis and cognitive preservation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Neurosciences
Rachel R. Corrigan, Helen Piontkivska, Gemma Casadesus
Summary: The metabolic peptide hormone amylin plays an important role in metabolic homeostasis and is closely linked to Alzheimer's disease. It self-aggregates like amyloid-beta and has been reported to contribute to the pathogenesis of both Type II diabetes mellitus and Alzheimer's disease. However, studies have shown neuroprotective effects of amylin and its analog pramlintide, suggesting that pharmacological therapies targeting the amylin receptor may be beneficial for AD development. The nature of amylin receptor signaling in the central nervous system is complex and not well understood, hence the need for further research.
CURRENT NEUROPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Victor Valverde-Salazar, Daniel Ruiz-Gabarre, Vega Garcia-Escudero
Summary: Alzheimer's disease (AD) is a common form of dementia characterized by memory decline, cognitive impairment, and several pathological changes in the brain. Oxidative stress and inflammation play important roles in the development of AD. Green tea and its active compound EGCG have shown potential therapeutic effects in modulating AD through their antioxidative and anti-inflammatory properties. EGCG can regulate inflammatory processes, reduce protein aggregation, and promote neuronal survival pathways, making it a suitable candidate for the treatment of neurodegenerative disorders involving oxidative stress and inflammation.
Article
Biochemistry & Molecular Biology
Amjad Khan, Jun Sung Park, Min Hwa Kang, Hyeon Jin Lee, Jawad Ali, Muhammad Tahir, Kyonghwan Choe, Myeong Ok Kim
Summary: Caffeic acid has the potential to be used as a therapeutic agent for Alzheimer's disease due to its antioxidant and cognitive-enhancing effects. It reduces oxidative stress, regulates the expression of related proteins, decreases inflammation markers, enhances synaptic markers, and reduces the expression of Alzheimer's disease-related proteins.
Article
Behavioral Sciences
Parthena Martin, Tangui Maurice, Arnold Gammaitoni, Gail Farfel, Brooks Boyd, Bradley Galer
Summary: Fenfluramine is an effective anti-seizure medication for patients with Dravet syndrome. It acts as a serotonin releaser and positive modulator of the sigma-1 receptor. The study showed that Fenfluramine enhances the low-dose effects of neuro(active) steroids and involves the 5-HT1A and 5-HT2A receptors in memory function.
EPILEPSY & BEHAVIOR
(2022)
Article
Chemistry, Medicinal
Francesca S. Abatematteo, Philip D. Mosier, Mauro Niso, Leonardo Brunetti, Francesco Berardi, Fulvio Loiodice, Marialessandra Contino, Benjamin Delprat, Tangui Maurice, Antonio Laghezza, Carmen Abate
Summary: The sigma-1 receptor is important in physiological and pathological processes, and the phenoxyalkylpiperidine compounds show potential as high-affinity agonists. Compound 1a, in particular, exhibits strong activity and warrants further investigation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Lucie Crouzier, Alberto Danese, Yuko Yasui, Elodie M. Richard, Jean-Charles Lievens, Simone Patergnani, Simon Couly, Camille Diez, Morgane Denus, Nicolas Cubedo, Mireille Rossel, Marc Thiry, Tsung-Ping Su, Paolo Pinton, Tangui Maurice, Benjamin Delprat
Summary: This study found that activating the S1R receptor can counteract the functional abnormalities of MAMs in Wolfram syndrome. The S1R agonist restores calcium ion transfer and mitochondria! respiration, corrects increased autophagy and mitophagy, and alleviates behavioral symptoms.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Shao-Ming Wang, Hsiang-En Wu, Yuko Yasui, Michal Geva, Michael Hayden, Tangui Maurice, Mauro Cozzolino, Tsung-Ping Su
Summary: Autophagy is a crucial cellular process with implications in various diseases. In this study, researchers discovered that the molecular chaperone SIGMAR1 is involved in the transport of TFEB into the nucleus by chaperoning the NP protein POM121, which is responsible for recruiting KPNB1. The disruption of this process in ALS-FTD patients with the C9orf72 subtype leads to impaired autophagy. However, overexpression of SIGMAR1 or POM121, as well as treatment with pridopidine, a SIGMAR1 agonist, can rescue these deficits, suggesting their potential therapeutic use.
Article
Chemistry, Multidisciplinary
Julian Hofmann, Philipp Spatz, Rasmus Walther, Marcus Gutmann, Tangui Maurice, Michael Decker
Summary: Flavonoids have potential as disease-modifying agents against neurodegenerative disorders, including Alzheimer's disease. Hybridization of taxifolin and silibinin with cinnamic acid showed synergistic effects in phenotypic screening assays. By replacing the flavonoid part and improving the chemical bond, the activity of the compounds was enhanced. Taxifolin and quercetin derivatives were the most active compounds.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Lucie Crouzier, Elodie M. Richard, Camille Diez, Hala Alzaeem, Morgane Denus, Nicolas Cubedo, Thomas Delaunay, Emily Glendenning, Sarah Baxendale, Jean-Charles Lievens, Tanya T. Whitfield, Tangui Maurice, Benjamin Delprat
Summary: Researchers report on the phenotypical characterization of two loss-of-function zebrafish mutant lines, highlighting the critical role of wfs1a and wfs1b in cellular function and potential therapeutic approaches for WS.
HUMAN MOLECULAR GENETICS
(2022)
Article
Cell Biology
Yvette Akwa, Chiara Di Malta, Fatima Zallo, Elise Gondard, Adele Lunati, Lara Z. Diaz-de-Grenu, Angela Zampelli, Anne Boiret, Sara Santamaria, Maialen Martinez-Preciado, Katia Cortese, Jeffrey H. Kordower, Carlos Matute, Andres M. Lozano, Estibaliz Capetillo-Zarate, Thomas Vaccari, Carmine Settembre, Etienne E. Baulieu, Davide Tampellini
Summary: Synaptic stimulation promotes TFEB-mediated clearance of pathological MAPT/Tau, which provides neuroprotection. Deep brain stimulation activates TFEB and reduces MAPT/Tau levels in Parkinson disease patients, leading to neuroprotection.
Review
Biochemistry & Molecular Biology
Lea El Chemali, Yvette Akwa, Liliane Massaad-Massade
Summary: This review provides an overview of the functions of Translocator protein (TSPO) in the brain and peripheral nervous system. It highlights its contributions to important physiological functions such as mitochondrial homeostasis, energy metabolism, and steroidogenesis, as well as its involvement in neuroinflammation, brain injury, and diseases of the nervous system.
BIOCHEMICAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Allison Carles, Audrey Schlernitzauer, Michel Vignes, Gerard Cros, Richard Magous, Tangui Maurice, Catherine Oiry
Summary: This study aims to analyze the consequences of mice's exposure to different concentrations of C4F7N gas at different time points. The results show that exposure to C4F7N gas can lead to memory impairments and brain toxicity, particularly in female mice.
Article
Biochemistry & Molecular Biology
Christelle Lasbleiz, Amandine Peyrel, Pauline Tarot, Jerome Sarniguet, Lucie Crouzier, Nicolas Cubedo, Benjamin Delprat, Mireille Rossel, Tangui Maurice, Jean-Charles Lievens
Summary: This study demonstrates that PRE-084 can prevent mutant TDP43 toxicity by enhancing the ER stress response and antioxidant cascade through the NRF2 signaling pathway.
Article
Medicine, Research & Experimental
Lucie Crouzier, Elodie M. Richard, Camille Diez, Morgane Denus, Amandine Peyrel, Hala Alzaeem, Nicolas Cubedo, Thomas Delaunay, Tangui Maurice, Benjamin Delprat
Summary: Wolfram syndrome (WS) is a rare neurodegenerative disease with no current treatment options. The mutated gene WFS1 encodes a protein called Wolframin, which plays a role in regulating calcium transfer and mitochondrial activity. Using a zebrafish model of WS, researchers found that overexpression of the NCS1 protein can restore mitochondrial dysfunction and excessive locomotion, suggesting a potential therapeutic strategy for WS.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2022)
Article
Environmental Sciences
Sophie Sakkaki, Noemie Cresto, Raphael Chancel, Emma Zub, Pierre Sicard, Tangui Maurice, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre, Nicola Marchi, Julie Perroy
Summary: This study investigates the risk of continuous exposure to glyphosate from prenatal to adulthood and the impact of Shank3 synaptic gene mutation on neurological adaptations. The results show that prenatal exposure to glyphosate increases embryonic mortality rate and leads to neuroinflammation and behavioral adaptations in progenies of Shank3(Delta C/+) mice.
ENVIRONMENT INTERNATIONAL
(2023)
Editorial Material
Biochemistry & Molecular Biology
Carmen Abate, Tangui Maurice
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Philippe Liere, Guo-Jun Liu, Antoine Pianos, Ryan J. J. Middleton, Richard B. B. Banati, Yvette Akwa
Summary: This study found that complete deletion of the Tspo gene in male mice does not impair de novo steroidogenesis in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Philipp Spatz, Thomas Zimmermann, Sophie Steinmueller, Julian Hofmann, Tangui Maurice, Michael Decker
Summary: This study designed a series of benzimidazole-carbamate compounds that selectively inhibit BChE based on docking studies, showing potential for the treatment of AD.
RSC MEDICINAL CHEMISTRY
(2022)