- Home
- Publications
- Publication Search
- Publication Details
Title
The challenges of clinical trials in fragile X syndrome
Authors
Keywords
Fragile X syndrome, Autism spectrum disorder, FMRP, mGluR5, <em class=EmphasisTypeItalic >FMR1</em>, Disease modification, Mavoglurant, AFQ056, GABA, Arbaclofen
Journal
PSYCHOPHARMACOLOGY
Volume 231, Issue 6, Pages 1237-1250
Publisher
Springer Nature
Online
2013-10-30
DOI
10.1007/s00213-013-3289-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A Randomized Double-Blind, Placebo-Controlled Trial of Minocycline in Children and Adolescents with Fragile X Syndrome
- (2013) Mary Jacena S. Leigh et al. JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
- Impact of acamprosate on behavior and brain-derived neurotrophic factor: an open-label study in youth with fragile X syndrome
- (2013) Craig A. Erickson et al. PSYCHOPHARMACOLOGY
- Fragile X Syndrome
- (2012) Yingratana McLennan et al. CURRENT GENOMICS
- Feasibility, reliability, and clinical validity of the Test of Attentional Performance for Children (KiTAP) in Fragile X syndrome (FXS)
- (2012) Andrew Knox et al. Journal of Neurodevelopmental Disorders
- FMRP targets distinct mRNA sequence elements to regulate protein expression
- (2012) Manuel Ascano et al. NATURE
- Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice
- (2012) Aubin Michalon et al. NEURON
- De Novo Gene Disruptions in Children on the Autistic Spectrum
- (2012) Ivan Iossifov et al. NEURON
- Fragile Mental Retardation Protein Interacts with the RNA-Binding Protein Caprin1 in Neuronal RiboNucleoProtein Complexes
- (2012) Rachid El Fatimy et al. PLoS One
- Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial
- (2012) E. M. Berry-Kravis et al. Science Translational Medicine
- Metabotropic Glutamate Receptor 5 Upregulation in Children with Autism is Associated with Underexpression of Both Fragile X Mental Retardation Protein and GABAA Receptor Beta 3 in Adults with Autism
- (2011) S. Hossein Fatemi et al. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
- FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
- (2011) Jennifer C. Darnell et al. CELL
- Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function
- (2011) H. S. Bateup et al. JOURNAL OF NEUROSCIENCE
- Mutations causing syndromic autism define an axis of synaptic pathophysiology
- (2011) Benjamin D. Auerbach et al. NATURE
- AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome
- (2011) Josien Levenga et al. NEUROBIOLOGY OF DISEASE
- Therapeutic Strategies in Fragile X Syndrome: Dysregulated mGluR Signaling and Beyond
- (2011) Christina Gross et al. NEUROPSYCHOPHARMACOLOGY
- A prospective open-label study of aripiprazole in fragile X syndrome
- (2011) Craig A. Erickson et al. PSYCHOPHARMACOLOGY
- Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056
- (2011) S. Jacquemont et al. Science Translational Medicine
- Dysregulation of fragile × mental retardation protein and metabotropic glutamate receptor 5 in superior frontal cortex of individuals with autism: a postmortem brain study
- (2011) S Hossein Fatemi et al. Molecular Autism
- Open-label add-on treatment trial of minocycline in fragile X syndrome
- (2010) Carlo Paribello et al. BMC Neurology
- Dysregulation of mTOR Signaling in Fragile X Syndrome
- (2010) A. Sharma et al. JOURNAL OF NEUROSCIENCE
- Potential therapeutic interventions for fragile X syndrome
- (2010) Josien Levenga et al. TRENDS IN MOLECULAR MEDICINE
- Fragile X and autism: Intertwined at the molecular level leading to targeted treatments
- (2010) Randi Hagerman et al. Molecular Autism
- The tuberous sclerosis complex
- (2009) Ksenia A. Orlova et al. Annals of the New York Academy of Sciences
- Age-dependent cognitive impairment in a Drosophila Fragile X model and its pharmacological rescue
- (2009) Catherine H. Choi et al. BIOGERONTOLOGY
- A pilot open label, single dose trial of fenobam in adults with fragile X syndrome
- (2009) E Berry-Kravis et al. JOURNAL OF MEDICAL GENETICS
- A Quantitative ELISA Assay for the Fragile X Mental Retardation 1 Protein
- (2009) Christine Iwahashi et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- Fragile X syndrome
- (2008) Kathryn B Garber et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Open-Label Treatment Trial of Lithium to Target the Underlying Defect in Fragile X Syndrome
- (2008) Elizabeth Berry-Kravis et al. JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
- A solution to limitations of cognitive testing in children with intellectual disabilities: the case of fragile X syndrome
- (2008) David Hessl et al. Journal of Neurodevelopmental Disorders
- Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice
- (2008) Femke M.S. de Vrij et al. NEUROBIOLOGY OF DISEASE
- FMRP Acts as a Key Messenger for Dopamine Modulation in the Forebrain
- (2008) Hansen Wang et al. NEURON
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation