Phenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteins

Structure- and sequence-analysis inspired engineering of proteins for enhanced thermostability

(2013) Hein J Wijma et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases

(2013) Valeria A. Risso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolutionary biochemistry: revealing the historical and physical causes of protein properties

(2013) Michael J. Harms et al.   NATURE REVIEWS GENETICS

Experimental evidence for the thermophilicity of ancestral life

(2013) S. Akanuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation of Protein Structure over Four Billion Years

(2013) Alvaro Ingles-Prieto et al.   STRUCTURE

Reconstitution of translation from Thermus thermophilus reveals a minimal set of components sufficient for protein synthesis at high temperatures and functional conservation of modern and ancient translation components

(2012) Ying Zhou et al.   NUCLEIC ACIDS RESEARCH

Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59

(2012) O. Khersonsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-ray evidence of a native state with increased compactness populated by tryptophan-less B. licheniformis β-lactamase

(2012) Valeria A. Risso et al.   PROTEIN SCIENCE

Probing the Mutational Interplay between Primary and Promiscuous Protein Functions: A Computational-Experimental Approach

(2012) Hector Garcia-Seisdedos et al.   PLoS Computational Biology

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

(2011) Arren Bar-Even et al.   BIOCHEMISTRY

Utilizing natural diversity to evolve protein function: applications towards thermostability

(2011) Megan F Cole et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Single-molecule paleoenzymology probes the chemistry of resurrected enzymes

(2011) Raul Perez-Jimenez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of conservative mutations in protein multi-property adaptation

(2010) David Rodriguez-Larrea et al.   BIOCHEMICAL JOURNAL

Counterdiffusion methods applied to protein crystallization

(2009) Fermín Otálora et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Intense Neutral Drifts Yield Robust and Evolvable Consensus Proteins

(2008) Shimon Bershtein et al.   JOURNAL OF MOLECULAR BIOLOGY

Palaeotemperature trend for Precambrian life inferred from resurrected proteins

(2008) Eric A. Gaucher et al.   NATURE

Surface Sites for Engineering Allosteric Control in Proteins

(2008) J. Lee et al.   SCIENCE